İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Kalıcı mıknatıslı senkron motorun modellemesi ve kontrolü
(Yıldız Technical University Publishing, 2025) Miran, Ömer Faruk; Bayraktar, Meral; Tunçer, Erdal
Bu çalışmada, Tesla Model 3’te kullanılan İçten Mıknatıslı Senkron Motorun (IPMSM) matematiksel modeli oluşturulmuş ve alan yönlendirmeli kontrol (FOC) algoritması uygulanmıştır. Motorun kontrolü için klasik PI kontrol yapısı ve SVPWM (Space Vector PWM) modülasyonu kullanılarak hız ve akım regülasyonu gerçekleştirilmiştir.
Harnessing generative pre-trained transformer technology for clinical decision support in retinal detachment
(Galenos Publishing House, 2025) Ağın, Abdullah; Öztürk, Yücel; Kıvrak, Ulviye
Aim: Considering the increasing incorporation of artificial intelligence (AI) in healthcare, it is crucial to comprehend the advantages and constraints of these technologies within ophthalmologic settings for their secure and efficient clinical utilization. This study aims to comprehensively assess the efficacy of three leading Generative Pre-trained Transformer (GPT) -based platforms in providing clinical decision-support for retinal detachment (RD). Methods: This cross-sectional comparative study was conducted between April 2024 and May 2024. Fifty questions were created based on the American Academy of Ophthalmology “Retina Book”, specifically targeting RD. The answers were produced by three different platforms and assessed by three independent reviewers who used Likert scales to evaluate their comprehensiveness and accuracy. Six readability metrics, including the Flesch-Kincaid Grade Level (FKGL) and Flesch Reading Ease Score (FRES), average words per sentence, average syllables per word, total sentence count, and total word count, were assessed. Results: Gemini earned the most outstanding results for comprehensiveness (4.11±0.72) and accuracy (1.49±0.61), followed by ChatGPT and Copilot. ChatGPT had superior readability metrics, achieving an FKGL of 15.62±2.85 and a FRES of 62.54±12.34, establishing it as the most accessible platform. ChatGPT demonstrated significantly higher performance compared to other platforms in the metrics of average syllables per word (p=0.0421) and total word count (p=0.0115). At the same time, no significant differences were found among the platforms in the metrics of average words per sentence (p=0.0842) and total sentence count (p=0.1603). Intraclass correlation coefficient (ICC) values indicated strong inter-rater agreement for comprehensiveness (ICC >0.74) and moderate to-high agreement for accuracy (ICC >0.56). Conclusion: Gemini’s detailed and accurate responses position it as a robust tool for professional use, while ChatGPT’s superior readability makes it suitable for patient education. These findings emphasize the synergistic advantages of AI platforms in research and development management and show the necessity for hybrid systems that integrate accessibility with accuracy.
Making health out of recycling: The innovative role of hawthorn seed waste in diabetes management
(Springer Nature Link, 2025) Savcı, Serap; Kocadağ Kocazorbaz, Ebru; Menfaatli, Esra; Gündeğer, Ersin
Diabetes mellitus (DM) is a chronic metabolic disorder that affects millions of people worldwide, and its prevalence is increasing due to global population growth and lifestyle changes. One of the key strategies in managing DM is the inhibition of enzymes such as α-glucosidase and Dipeptidyl Peptidase-IV (DPP-IV), as well as reducing protein glyca tion. In this study, the antidiabetic potential of Crataegus monogyna (hawthorn) seeds, which are generally considered agricultural waste, was investigated. Hawthorn seeds were extracted using water, ethanol, and methanol as solvents, and the obtained extracts were analyzed for their phytochemical composition, total phenolic and flavonoid content, antioxi dant activity, enzyme inhibitory effects, and antiglycation potential. The methanol extract exhibited the highest phenolic content (53.21±4.69 mg GAE/g) and antioxidant activity, while the ethanol and methanol extracts showed strong anti glycation effects. The water extract demonstrated the highest inhibitory activity against DPP-IV (IC50: 0.21 mg/mL) and α-glucosidase (IC50: 85.23 µg/mL). In silico molecular docking and dynamics simulations revealed that procyanidin A2 and procyanidin B1 exhibited strong binding affinities for DPP-IV and α-glucosidase, respectively, and that these complexes were stable. These results suggest that hawthorn seeds, traditionally considered waste, possess significant pharmacological potential and could offer a new, natural, and sustainable therapeutic option for diabetes management. This study serves as an important example for the valorization of biomass and the repurposing of waste materials in the pharmaceutical field.
Thermosonication-assisted fortification of kiwi juice with bee bread: Enhancing nutritional and functional properties through ANFIS-RSM optimization
(Frontiers Media S. A., 2025) Yıkmış, Seydi; Duman Altan, Aylin; Türkol, Melikenur; Tokatlı, Nazlı; Yıldırım Maviş, Çiğdem; Tokatlı Demirok, Nazan; Aadil, Rana Muhammad; Karrar, Emad; Aljobair, Moneera O.; Mohamed Ahmed, Isam A.
This study investigated the effects of thermosonication on the preservation and enhancement of bioactive components in kiwi juice fortified with bee bread. Response Surface Methodology (RSM) and Adaptive Neuro-Fuzzy Inference System (ANFIS) were employed to optimize processing parameters by evaluating FRAP, total phenolics, total chlorophyll, and ascorbic acid levels. Thermosonication significantly enhanced the levels of phenolic compounds (127.97 GAE mg/100 mL) and ascorbic acid (14.89 mg/100 mL), while a reduction in chlorophyll content was observed. The ANFIS model provided more accurate predictions compared to RSM, particularly under optimal processing conditions. Additionally, the thermosonication-treated kiwi juice with bee bread (TS-KJB) exhibited the highest antioxidant capacity, total flavonoid, and dietary fiber content. The findings demonstrate that thermosonication is an effective and sustainable technique for improving the functional and nutritional properties of bee bread-fortified kiwi juice. This approach offers a promising alternative for the production of additive- and preservative-free functional fruit juices.
Regenerative dentistry: Applications of bioactive materials in dentin-pulp complex
(Springer Nature Link, 2025) Şişmanoğlu, Soner; Işık, Vasfiye; Erçal, Pınar
Tissue engineering in dentistry is revolutionizing the regeneration of dental pulp. The dental pulp is a specialized connective tissue that plays an important role in maintaining tooth health and supporting healing processes. However, exposure of the pulp to harmful factors, such as infections or trauma, can negatively impact its function, leading to inflammation, tissue necrosis, and ultimately pulp loss. As a solution to these challenges, tissue-engineered vital pulp therapies (VPTs) are emerging as an alternative to conventional root canal treatments. These therapies aim to preserve the vitality of the pulp, stimulate natural healing processes, and restore the dentin-pulp structure. Regenerative dentistry is also exploring tissue repair through innovations such as three-dimensional (3D) bioprinting, exosome-based therapies, and novel scaffold structures.This chapter explores the potential of tissue engineering in dental pulp regeneration, focusing on the role of stem cells, growth factors, scaffolds, and bioactive materials. In particular, stem cells derived from dental pulp are critical to this process due to their ability to differentiate into odontoblast-like cells and promote dentin production. The combination of these stem cells with bioactive scaffolds that release growth factors can significantly enhance the healing of pulp tissue. Furthermore, innovative materials, such as calcium silicate-based materials and bioactive glasses, have shown promising results in pulp regeneration and restorative dentin formation. While the future of these therapies is promising, challenges such as clinical application, long-term efficacy, and cost-effectiveness remain. As research advances, the importance of interdisciplinary collaboration and clinical trials will grow in overcoming these barriers.
