İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Güncel Gönderiler
Fibromyalgia syndrome (FMS): Neural therapy as a key to pain reduction and quality of life
(Salient Visionary Publications LLC, 2025) Nazlıkul, Hüseyin; Ural Nazlıkul, Fatma Gülçin
Fibromyalgia syndrome (FMS) is a complex chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive impairments. Its global prevalence is estimated at 2–3%, with women between the ages of 30 and 60 being most commonly affected. The pathophysiology of FMS is multifactorial, involving central sensitization processes, dysfunctions of pain inhibition mechanisms, and chronic inflammatory and neuroendocrine disturbances. Pathophysiological Mechanisms: Central sensitization: Increased pain processing in the central nervous system. Neuroendocrine dysfunction: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, altered cortisol and serotonin levels. Lymphatic dysfunction: Edema, inflammation, and accumulation of toxins. Silent inflammation: Chronic inflammatory processes with elevated cytokine activity (e.g., TNF-α, IL-6). Neural Therapy as a Treatment Approach Neural therapy addresses autonomic dysregulation and restores the balance between the sympathetic and parasympathetic nervous systems. Key therapeutic strategies include: Local infiltrations: Procaine or lidocaine injections to reduce pain sensitivity. Segmental therapy: Treatment of spinal reflex zones to regulate the autonomic nervous system. Interference field therapy: Identification and treatment of chronic irritative foci. Adjunctive measures, such as manual lymphatic drainage, anti-inflammatory nutrition, and micronutrient therapy, can enhance treatment efficacy. The combination of neural therapy and regulatory medicine shows promising results in reducing pain, improving sleep quality, and restoring quality of life.
The effect of patient education in treatment of fibromyalgia: A randomized controlled trial
(Kare Publishing, 2025) Aşık, Hatice Kübra; Demir, Saliha Eroğlu; Özaras, Nihal; Rezvani, Aylin; Aydın, Teoman; Güler, Mustafa; Poşul, Sevde; Poyraz, Emine
Objective: Fibromyalgia syndrome (FMS) can be treated with a variety of pharmaceutical and non-pharmacological approaches. The purpose of this study was to evaluate the effects of patient education and a home exercise program on FMS patients' pain, fatigue, functioning, and quality of life. Materials and Methods: The study included patients who satisfied the American College of Rheumatology's FMS criteria. They were split up into two groups at random. A schedule of at-home exercise was given to both groups. Furthermore, Group 2 patients participated in patient education sessions. At baseline and eight weeks later, both groups underwent examinations. Evaluation criteria included the Nottingham Health Profile (NHP) for quality of life, the Beck Depression Inventory (BDI) for psychological status, the Visual Analogue Scale for pain severity (VASp) and exhaustion (VASf), and the Fibromyalgia Impact Questionnaire (FIQ) for functional status. Results: The primary clinical and demographic characteristics of the two groups were comparable at baseline. Although the values of VASp (p=0.014), VASf (p=0.011), BDI (p=0.043), NHP subscales (p<0.05), FIQ (p=0.012) showed statistically significant improvements in Group 2, only Group 1's FIQ score significantly improved (p=0.027). There were substantial differences in VASp (p=0.026), VASf (p<0.001), BDI (p<0.001), and all NHP subscales except sleep problems, FIQ scores (p=0.036) between the two groups in favor of Group 2 at the end of eight weeks. Conclusion: Patients with FMS should receive patient education in addition to home-based exercise, which is an effective treatment for reducing symptoms, enhancing psychological well-being, and improving quality of life.
Determination of anti-mullerian hormone and inhibin b reference ranges according to pubertal stages in children and adolescent girls
(Karger, 2024) Kaynar, Özge; Turan, Hande; Tarçın, Gürkan; Karakaş, Hasan; Evliyaoğlu, Olcay; Turan, Volkan; Bayramoğlu, Elvan
Determination of Anti-Mullerian Hormone and Inhibin B Reference Ranges According to Pubertal Stages in Children and Adolescent Girls
An anatomical investigation regarding the parietal foramen in 174 adult parietal bones
(Erciyes University Faculty of Medicine Publications, 2025) Sağlam, Latif; Allahverdiyev, İrşad; Sordi, Ali Efruz; Öztürk, Adnan
Objective: Investigating all anatomical aspects of the parietal foramen (PF) is essential. This study aimed to examine the anatomical features of the PF. Materials and Methods: A total of 174 dry adult human parietal bones (81 right and 93 left) were carefully examined. The frequency, shape, and direction of the PF were recorded. Measurements included the diameter of the PF (DPF), the distance of the PF to the sagittal suture (DSS), the distance of the PF to the occipital angle (DPO), and the length of the sagittal suture (LSS). Additionally, to determine the topography of the PF (TPF), the LSS/DPO ratio was calculated. The DPF was measured using needles of various diameters, while all distances were measured using a digital caliper. Results: Among the parietal bones, 112 (64.3%) had the PF, while 62 (35.7%) had none. A total of 118 PFs were identified on the 112 bones: 52 on the right side, 58 on the left side, and 8 on the sagittal suture. The foramen was single in 90.7% of cases, double in 6.8%, and triple in 2.5%. The parietal foramen appeared circular in 94.1% and oval in 5.9% of cases. Most foramina were oriented in a posteroanterior direction. The mean measurements for DPF, DSS, DPO, and LSS were 1.7±0.6 mm, 6.81±3.40 mm, 33.81±12.43 mm, and 108.94±6.91 mm, respectively. Additionally, the TPF was approximately 3:1. Conclusion: The data obtained in this study may be important for enhancing the success rate of invasive procedures involving the PF or its adjacent structures, as well as for reducing or preventing complications.
Photocatalytic performance of ag-humic acid magnetic nanoparticles for degradation of methylene blue in aqueous medium
(Istanbul University Faculty of Aquatic Sciences, 2024) Özdemir Olgun, Fatoş Ayça; Kaba, İbrahim
The discharge of organic dyes from industrial plants processing pharmaceuticals, textile fabrics, leather, and petrochemicals is a great concern in terms of water contamination. Even in small amounts less than 1 mgL-1 , dyes have serious effects on the water quality of the aquatic environment. In this study, methylene blue was chosen as a model to represent the azo-dye class that is non-biodegradable, toxic and mutagenic. Photocatalytic degradation is a sustainable and eco-friendly remediation process to eliminate the undesired effects of dye contamination. The morphology of the catalyst highly influences the properties and the efficiency of the catalytic reaction. A novel composite magnetic nanoparticle was synthesized in core-shell structure and characterized with the aid of Scanning Electron Microscope (SEM) images combined with an elemental distribution image (EDX mapping), Zeta Potential, Dynamic Light Scattering (DLS) analyses and Raman Spectrometer. The electronic properties of the fabricated material were enlightened by Mott Schottky measurements. In optical studies, direct band-gap energies were calculated with the aid of Ultraviolet-Visible Diffuse Reflectance Spectroscopy (UV-DRS). The effective photocatalytic degradation of methylene blue in aqueous medium was maintained with optimum parameters defined within the study. The results support the applicability of the proposed novel magnetic nanoparticle as a catalyst for the degradation of methylene blue in aquatic environment.
