Bostanabad, Saber YariÖzdemir, SametSaadati, MahrokhKaraca, BanuŞener, Alper2025-11-052025-11-052025Bostanabad, S. Y., Özdemir, S., Saadati, M., Karaca, B., & Şener, A. (2025). Polyherbal ointment with bromelain for chronic diabetic wounds: Insights from a clinical case series. Journal of Pharmaceutical Innovation, 20(1), pp. 1-11. https://doi.org/10.1007/s12247-025-10195-11939-80421872-5120https://doi.org/10.1007/s12247-025-10195-1https://hdl.handle.net/20.500.13055/1161Purpose Chronic diabetic wounds are characterized by prolonged inflammation and impaired healing. This study evaluates a novel polyherbal ointment, W Cura D Plus®, which contains Azadirachta indica oil, Hypericum perforatum oil, and bro melain from Ananas comosus. After initial debridement with W Cura D Plus®, treatment continued with W Cura G Plus®. To our knowledge, this is the first clinical report examining this specific combination in the treatment of chronic diabetic wounds. Methods A single-center clinical case series was conducted in 13 diabetic patients with Wagner grade 2–3 diabetic foot ulcers of at least 4 weeks’ duration. All patients were on standard type 2 diabetes therapy (oral agents and/or insulin) and routine wound care prior to enrollment. W Cura D Plus® was applied daily for 7 days to promote debridement, followed by W Cura G Plus® until complete closure or no further reduction in ulcer size for two consecutive weeks. Clinical endpoints included wound area, closure percentage, and recovery time. White blood cell (WBC) and C-reactive protein (CRP) levels were monitored. Results Fourteen wound observations were analyzed. Mean wound area decreased from 25.07±24.56 cm² at baseline to 7.38±5.15 cm² (p=0.0103), and mean closure rate was 64.15±0.23% (p=0.0108), surpassing the 50% benchmark for clini cally meaningful improvement. Recovery time averaged 97.7 days compared to baseline (initial status prior to treatment). WBC and CRP significantly declined (p<0.0001). No adverse events were reported. Conclusion This polyherbal formulation may represent a safe adjunct to standard care, but larger controlled trials are needed to confirm efficacy.eninfo:eu-repo/semantics/closedAccessDiabetic Wound HealingBromelainPolyherbal FormulationTopical PhytotherapyEnzymatic DebridementArticle10.1007/s12247-025-10195-1201111Q2Q2