Çetin, FerhatGöncüoğlu, Enver ŞükrüAbalı, SaygınArslanoğlu, İlknurDeyneli, OğuzhanTelci Çaklılı, ÖzgeYalın Turna, HülyaŞahiner, ElifGüzel, DilaYılmaz, Mehmet Temel2025-05-072025-05-072025Çetin, F., Göncüoğlu, E. Ş., Abalı, S., Arslanoğlu, İ., Deyneli, O., Telci Çaklılı, Ö., Yalın Turna, H., Şahiner, E., Güzel, D., & Yılmaz, M. T. (2025). Early stage effectiveness of the automated insulin delivery system—is artificial intelligence really effective?. Endocrinology Research and Practice, 29(2), pp. 101-106. https://doi.org/10.5152/erp.2025.246182822-6135https://doi.org/10.5152/erp.2025.24618https://hdl.handle.net/20.500.13055/978Objective: This study aimed to evaluate the effectiveness of the self-learning capabilities of artificial intelligence (AI) algorithms. The hypothesis was that if the success of closed-loop insulin delivery is mainly attributed to AI algorithms, then the improvement in glycemic control would be more signifi cant just after the “learning” phase. Methods: The Medtrum A8 TouchCare® Nano system was used on 15 patients with type 1 diabetes. Daily continuous glucose monitoring (CGM) data pre-automated insulin delivery (AID) was statisti cally compared with the post-AID period. Results: Patients (median age 32 (6-54) years, 40% female) had a median HbA1c of 8.4% (5.3-10.7) before initiation of AID and a median GMI of 6.6% (5.8-8.3) after 2 weeks. The shifts in glycemia and glycemic variability between the 5-day period pre-AID vs. the first day and the 3 5-day periods post-AID were significant (pre-AID vs. 1-5-10-15 days; time in range (TIR, %): 55.9 vs. 76.6-81.7-83.8- 81.5 (P=.001); Q1 (mg/dL): 123 vs. 112-108-106-110 (P=.009); Q3 (mg/dL): 204 vs. 176-173-168-169 (P=.004); inter-quarter range (IQR, mg/dL): 78 vs. 57.2-56.6-53-55 (P=.002)). The biggest shift in TIR was achieved in the first day (10.1%). Comparative analysis of the 5-day intervals post-AID was insig nificant by means of the improvement in glycemia (P > .05). No significant change in glycemic param eters between 15, 30, and 90 days were noted (P > .05). Conclusion: Artificial intelligence-augmented AID becomes effective at the very early stages of initia tion. There is a need for further research into glycemic changes in the early days of AID initiation to better define the principles of initiating AID systems.eninfo:eu-repo/semantics/openAccessArtificial PancreasGlycemic ControlAutomated Insulin DeliveryType 1 DiabetesArticle10.5152/erp.2025.246182921011062-s2.0-105003181819Q4