Liu, YannaTang, TianyuÖrmeci, NecatiHuang, YifeiWang, JitaoLi, XiaoguoLi, ZhiweiAn, WeiminLiu, DengxiangZhang, ChunqingLiu, ChangchunLiu, JinqiangLiu, ChuanWang, GuangchuanMosconi, CristinaCappelli, AlbertaBruno, AntonioAkçalar, SerayÇelebioğlu, EmrecanÜstüner, EvrenBilgiç, SadıkEllik, ZeynepAsiller, Özgün Ömer2021-12-222021-12-222021Liu, Y., Tang, T., Örmeci, N., Huang, Y., Wang, J., Li, X., Li, Z., An, W., Liu, D., Zhang, C., Liu, C., Liu, J., Liu, C., Wang, G., Mosconi, C., Cappelli, A., Bruno, A., Akçalar, S., Çelebioğlu, E., … Qi, X. (2021). Noncontrast-enhanced MRI-based noninvasive score for portal hypertension (CHESS1802): An international multicenter study. Journal of Clinical and Translational Hepatology, 9(6), pp. 818-827. https://doi.org/10.14218/JCTH.2021.00177https://doi.org/10.14218/JCTH.2021.00177https://hdl.handle.net/20.500.13055/105Background and Aims This study aimed to determine the performance of the non-invasive score using noncontrast-enhanced MRI (CHESS-DIS score) for detecting portal hypertension in cirrhosis. Methods In this international multicenter, diagnostic study (ClinicalTrials.gov, NCT03766880), patients with cirrhosis who had hepatic venous pressure gradient (HVPG) measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China (n=4) and Turkey (n=1) between December 2018 and April 2019. A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017. After segmentation of the liver on fat-suppressed T1-weighted MRI maps, CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity. Results A total of 149 patients were included, of which 124 were from four Chinese hospitals (training cohort) and 25 were from two international hospitals (validation cohort). A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36 (p<0.0001) and 0.55 (p<0.01) for the training and validation cohorts, respectively. The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension (CSPH) was 0.81 and 0.9 in the training and validation cohorts, respectively. The intraclass correlation coefficients for assessing the inter- and intra-observer agreement were 0.846 and 0.841, respectively. Conclusions A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG. Besides, this score could be used to detect CSPH in patients with cirrhosis.eninfo:eu-repo/semantics/openAccessLiver CirrhosisAdvanced Chronic Liver DiseaseHepatic Venous Pressure GradientLiver Surface NodularityImagingArticle10.14218/JCTH.2021.0017796818827Q2WOS:0007025481000012-s2.0-8512198782PMID: 34966645Q2