Pirinçci Tok, YağmurDemiralp, BurcuGüngör, SevgiSarıkaya, Ali OsmanAldeniz, Emre ErolDude, Udaya KumarÖzsoy, Yıldız2026-02-122026-02-122026Pirinçci Tok, Y., Demiralp, B., Güngör, S., Sarıkaya, A. O., Aldeniz, E. E., Dude, U. K., & Özsoy, Y. (2026). Influence of drying methods on redispersibility and dissolution of canagliflozin nanocrystals: A comparative approach. Pharmaceuticals, 19(2), pp. 1-24. https://doi.org/10.3390/ph190202401424-8247https://doi.org/10.3390/ph19020240https://hdl.handle.net/20.500.13055/1326Background/Objectives: Canagliflozin (CFZ) is the first sodium glucose co-transporter 2 (SGLT-2) inhibitor and is characterized by poor water solubility and permeability, resulting in low oral bioavailability. In this study, a CFZ nanosuspension (CFZ-NS) was converted into a solid form to improve the physical stability of CFZ nanocrystals (CFZ-NCs) and to enable formulation as a tablet dosage form. Methods: To achieve adequate redispersibility of dried CFZ-NCs, fluid bed granulation and spray-drying methods were employed, and the effects of critical process parameters were investigated. The stability of spray dried nanocrystal tablets (NCs-SD-TAB) was evaluated over a three-month period under storage conditions of 25 ± 2 ◦C with 60 ± 5% relative humidity (RH) and 40 ± 2 ◦C with 75 ± 5% RH. Results: The highest redispersibility index (94%) was obtained using the spray-drying method. Tablets prepared with spray-dried NCs-SD-TAB exhibited a significantly higher in vitro dissolution rate under non-sink conditions compared with control tablets prepared using unprocessed CFZ with the same excipients, as well as the marketed product. NCs-SD-TAB showed an approximately three-fold increase in drug release at 15 min in 0.1 N HCl, with a pH 4.5 acetate buffer and pH 6.8 phosphate buffer, which simulate gastrointestinal pH conditions, relative to the marketed product. Conclusions: Overall, these results indicate that nanocrystal technology represents a promising approach for CFZ as an improved oral drug-delivery system, primarily due to its solubility enhancement capabilities.eninfo:eu-repo/semantics/openAccessNanocrystalSolidificationSpray-DryingFluidized Bed GranulationImproved Dissolution RateArticle10.3390/ph19020240192126Q1Q1