İbrahimov, AkbarBoyraz, Gökhan2026-02-112026-02-112025İbrahimov, A., & Boyraz, G. (2025). Incidence and prognostic factors of isolated para-aortic lymph node metastasis in endometrial cancer: A single-center study. Chirurgia, 38(6), pp. 418-427. https://doi.org/10.23736/S0394-9508.25.05879-60394-95081827-1782https://doi.org/10.23736/S0394-9508.25.05879-6https://hdl.handle.net/20.500.13055/1320Para-aortic lymph node metastasis (PALNM) is a key prognostic factor in endometrial cancer (EC). This study aimed to de- termine the incidence and prognostic factors of lymph node metastasis (LNM) and isolated PALNM in endometrioid-type EC patients. METHODS: EC patients treated surgically between 2000 and 2015, staged by FIGO 2009 criteria, were retrospectively analyzed. Included were patients with endometrioid histology grades I-III who underwent pelvic and PALN dissection. Excluded were those without lymph node dissec tion or with non-endometrioid histology. RESULTS: A total of 417 patients met the criteria. Of these, 246 (59%) were grade I, 117 (28.1%) grade II, and 46 (11%) grade III. Pelvic LNM (PLNM) was found in 43 (10.3%), and PALNM in 22 (5.3%). Five patients (1.19%) had isolated PALNM. PALNM was more frequent in patients with stage III, tumors >2 cm, cervical glandular/stromal involvement, deep myometrial invasion, positive peritoneal cytology, adnexal involvement, PLNM, and LVSI. Isolated PALNM was notably higher with adnexal involvement. Independent predictors of PALNM were cer vical glandular involvement and LVSI. Deep myometrial invasion, LNM, PLNM, LVSI, and adnexal involvement were linked to disease-free survival (DFS), while peritoneal cytology, PLNM, and LVSI were linked to recurrence. There was no significant difference in recurrence and DFS between PALNM and isolated PALNM. CONCLUSIONS: Isolated PALNM without PLNM is rare in EC patients but should be assessed for optimal staging and treatment.eninfo:eu-repo/semantics/openAccessEndometrial NeoplasmsLymphatic MetastasisPrognosisArticle10.23736/S0394-9508.25.05879-6386418427Q4Q4