Buran, Keremİnan, YiğitAkyüz, Gülşah SelinDervişoğlu Özdemir, CelileKocabaş, Fatih2024-10-172024-10-172024Buran, K., İnan, Y., Akyüz, G. S., Dervişoğlu Özdemir, C. & Kocabas, F. (2024). Phenylsulfonylpiperazines as α-Glucosidase enzyme inhibitors: Design, synthesis, DFT calculations, docking and ADME studies. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, 13(3), pp. 723–730. https://doi.org/10.17798/bitlisfen.14792922147-31292147-3188https://doi.org/10.17798/bitlisfen.1479292https://hdl.handle.net/20.500.13055/826Diabetes mellitus (DM) is one of the most common diseases affecting people all over the world. An important treatment for DM is the inhibition of the α-glucosidase enzyme. A wide range of biological activities of piperazine and sulfonamide moieties are known. In this study, five phenylsulfonyl piperazine derivatives were synthesized. Their inhibitory capacities were evaluated. The analogues (1-5) showed a good degree of inhibition of α-glucosidase enzyme. Compound 1 has the highest inhibition potential for the α-glucosidase enzyme. Its inhibition percentages (83.52±0.41) were higher than the reference molecule quercetin (81.41±0.02). In silico molecular docking studies were performed for the most potent compound 1 for α-glucosidase enzyme to determine possible protein-ligand interactions. Furthermore, a DFT study was carried out for the evaluation of the quantum mechanical and electronic properties. Finally, ADME profiles of the compounds were theoretically analyzed.eninfo:eu-repo/semantics/openAccessDiabetes Mellitusα-GlucosidaseSulfonamidePiperazineDFT CalculationsArticle10.17798/bitlisfen.14792921337237301267345