Özdemir, SametÇakırlı, EgemenSürücü, BilgeAygüler, Cemre İremÜner, BurcuÇelebi, Ali Rıza Cenk2022-12-312022-12-312023Özdemir, S., Çakırlı, E., Bilge S., Aygüler, C. İ., Üner, B. & Çelebi, A. R. C. (2023). Preparation and characterization studies of dorzolamide loaded ophthalmic implants for the treatment of glaucoma. The Turkish Journal of Pharmaceutical Sciences, 20(3), pp. 149-156. https://doi.org/10.4274/tjps.galenos.2022.957521304-530Xhttps://doi.org/10.4274/tjps.galenos.2022.95752https://hdl.handle.net/20.500.13055/351Objectives: This study aimed to construct dorzolamide loaded ophthalmic implants for extended drug delivery and increased drug retention. Materials and Methods: Carboxymethyl cellulose and Chitosan were used to formulate the ophthalmic implants. The implants were prepared by solvent casting technique in existence of polyethylene glycol 6000 as plasticizer. Physiochemical characterization studies including mechanical characteristics (tensile strength, elongation at break, and Young’s modulus), bioadhesion studies, in vitro and ex vivo drug release studies were conducted. Results: Tensile strength of drug loaded ophthalmic implants were 10.70 and 11.68 MPa respectively. Elongation at break of Carboxymethyl cellulose and Chitosan implants were 62.00% and 59.05% respectively. The in vitro release profiles fit into the Higuchi type kinetic model. Ex vivo release study results for both implants were correlated with in vitro release investigations. Conclusion: Carboxymethyl cellulose and Chitosan based implants provide extended drug delivery. Implants were prepared by using carboxymethyl cellulose provide significantly slower in vitro release rate, and the drug retention on ocular surfaces has been increased. Thus, it has been concluded that, dorzolamide loaded carboxymethyl cellulose implants could provide effective treatment for glaucomaeninfo:eu-repo/semantics/openAccessDorzolamideCarboxymethyl CelluloseChitosanOcular ImplantArticle10.4274/tjps.galenos.2022.95752203149156WOS:0010410926000032-s2.0-85163830768PMID: 37417193Q31189385