Önal, CemKepekçi Tekkeli, Şerife EvrimÖnal, Armağan2024-10-162024-10-162024Önal, C., Kepekçi Tekkeli, Ş. E., & Önal, A. (2024). A simple UFLC method for the determination of Montelukast in human plasma. Journal of Chemical Metrology, pp. 1-5. http://doi.org/10.25135/jcm.114.2407.32621307-6183https://hdl.handle.net/20.500.13055/819http://doi.org/10.25135/jcm.114.2407.3262In this investigation, an UFLC technique utilizing fluorimetric detection was reported for the analysis of Montelukast (MON) in plasma. The method involves pre-column derivatization using 4-bromomethyl-7- methoxycoumarin (BrMmC). The calibration curve linear concentrations from 10 to 1000 ng/mL. The method exhibited an average recovery rate of 95.49%. The newly developed method was effectively utilized to assess the pharmacokinetics of Montelukast (MON) following the administration of a single 10 mg tablet to a healthy male volunteer.eninfo:eu-repo/semantics/openAccessMontelukastUltrafast Liquid ChromatographyFluorescence Detection4-Bromomethyl-7-Methoxy CoumarinHuman PlasmaArticle10.25135/jcm.114.2407.326215Q3WOS:001328944200001Q3