Kıvrak, UlviyeÇiçek, FatihKöle, Mehmet TolgaKaya Adaş, BüşraKandemir, İbrahim2025-08-162025-08-162025Kıvrak, U., Çiçek, F., Köle, M. T., Kaya Adaş, B., & Kandemir, İ. (2025). Evaluation of posterior segment changes in pediatric asthma patients with and without inhaled corticosteroid therapy. Scientific Reports, 15, pp. 1-8. https://doi.org/10.1038/s41598-025-14024-w2045-2322https://doi.org/10.1038/s41598-025-14024-whttps://hdl.handle.net/20.500.13055/1075This study aimed to evaluate and compare changes in the posterior segment of pediatric asthma patients, potentially associated with asthma or inhaled corticosteroids. A retrospective analysis was conducted on children aged 7–17 diagnosed with atopic asthma. The participants were categorized into groups: Group 1 (no inhaled corticosteroids) and Group 2 (inhaled corticosteroid treatment). A control group of healthy children was also included. Demographic data, clinical findings, and laboratory results (e.g., eosinophil count, IgE, CRP levels) were collected. Optical coherence tomography (OCT) and OCT angiography (OCTA) were used to measure posterior segment parameters. Asthma patients demonstrated a statistically significant reduction in subfoveal choroidal thickness, the superficial capillary plexus in the superior and nasal quadrants, the choriocapillaris in the foveal quadrant, and the peripapillary vascular density in the inferior and superior quadrants compared to controls. Inflammation markers such as eosinophil count and CRP showed significant correlations with changes in vascular density. Asthma, as a chronic inflammatory and hypoxic condition, can significantly affect posterior segment parameters, leading to potential visual function impairments in children. Regular monitoring with OCT and OCTA can help detect early microvascular changes, allowing for timely interventions to preserve visual health.eninfo:eu-repo/semantics/openAccessAsthmaInhaled CorticosteroidOptic Coherence Tomography AngiographyVascular DensityArticle10.1038/s41598-025-14024-w1518Q1PMID: 40770020Q1