Alparslan, LeventTorkay, GülşahBal Öztürk, AyçaKöksal Karayıldırım, ÇinelÖzdemir, Samet2025-08-202025-08-202025Alparslan, L., Torkay, G., Bal Öztürk, A., Köksal Karayıldırım, Ç., & Özdemir, S. (2025). Smart thermoresponsive sol–gel formulation of polyhexanide for rapid and painless burn and wound management. Polymers, 17(15), pp. 1-18. https://doi.org/10.3390/polym171520792073-4360https://doi.org/10.3390/polym17152079https://hdl.handle.net/20.500.13055/1083Traditional wound and burn treatments often fall short in balancing antimicrobial efficacy, patient comfort, and ease of application. This study introduces a novel, transparent, ther moresponsive sol–gel formulation incorporating polyhexamethylene biguanide (PHMB) for advanced topical therapy. Utilizing Poloxamer 407 as a biocompatible carrier, the formulation remains a sprayable liquid at room temperature and instantly gels upon contact with body temperature, enabling painless, pressure-free application on sensitive, injured skin. Comprehensive in vitro and in vivo evaluations confirmed the formulation’s broad-spectrum antimicrobial efficacy (≥5 log10 reduction in 30 s), high biocompatibility (viability > 70% in fibroblasts), non-irritancy (OECD 425-compliant), and physical stabil ity across three months. Importantly, the formulation maintained fibroblast migration capacity—crucial for wound regeneration—while exhibiting rapid sol-to-gel transition at ~34 ◦C. These findings highlight the system’s potential as a next-generation wound dressing with enhanced user compliance, transparent monitoring capability, and rapid healing support, particularly in disaster or emergency scenarios.eninfo:eu-repo/semantics/openAccessAntisepticBurn CarePoloxamer 407PolyhexanideSol–GelThermoreversible GelWound TreatmentArticle10.3390/polym171520791715118Q12-s2.0-105013345443PMID: 40808127Q1