Fertility Preservation in Breast Cancer Patients

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Marin, L., Turan, V., & Oktay, K. (2022). Fertility Preservation in Breast Cancer Patients. Female and Male Fertility Preservation, pp. 185-198. https://doi.org/10.1007/978-3-030-47767-7_14 Abstract
Breast cancer is the most common malignancy in
women as it currently represents 15.2% of all
new cancer cases in the United States with
268,600 estimated new cases in 2019 [1]. Under
45 years of age, the percentage of new cases is
10.3% as it is the most common of all in women
of childbearing age. Due to the increasingly
advanced diagnostic and therapeutic techniques,
the mortality rate remains low in recent years.
For stages I and II, the 5-year survival is estimated
to be respectively 95% and 85–70%
(depending on whether they are IIA and IIB),
while in advanced stages, survival rates are
between 18 and 52% (for stages IIIA and B) [1].
Because the number of young cancer survivors
is increasing and as women tend to have
children in later reproductive ages, increasing
attention has been paid to chemotherapy-related
ovarian toxicity [2]. Most women with breast
cancer are likely to undergo neoadjuvant or adjuvant
chemotherapy that may result in premature
ovarian failure and infertility [3–5].