Phthalocyanines bearing silazane group for colorectal cancer
Artuç, Gamze Özgül
Guler, Eray Metin
Görgülü, Ahmet Orhan
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CitationOzdemir, M., Artuc, G. O., Guler, E. M., Yalcin, B., Salan, U., Bozali, K., Gorgulu, A. O., & Bulut, M. (Dec 2021). Phthalocyanines bearing silazane group for colorectal cancer. Dyes and Pigments, 196, pp. 1-12. 109832. https://doi.org/10.1016/j.dyepig.2021.109832
The synthesis of bis(trimethylsilyl)amine substituted zinc(II), and indium(III) chloride phthalocyanine complexes have been performed. The obtained compounds were characterized by spectroscopic methods. All synthesized phthalocyanine derivatives were evaluated for cytotoxic, genotoxic, and apoptotic activities on LoVo cell lines which are the standard colorectal cancer cell lines derived from metastatic site: left supraclavicular region. Nonperipheral silazane substituted zinc phthalocyanine (5) showed quite different behavior from all the other compounds analyzed and found to be the best cytotoxic, genotoxic, and apoptotic compound. All derivatives showed no proliferative effect at all doses. All phthalocyanine compounds increased cytotoxicity, DNA damage, apoptosis, and intracellular ROS dose-dependent manner. To explain and verify in vitro tests, phthalocyanine compound structures were optimized using density functional theory, and in silico molecular docking studies on B-DNA dodecamer were performed. Both the experimental and theoretical findings comply with each other.