Now showing items 1-5 of 5
Loteprednol loaded nanoformulations for corneal delivery by quality by design concepts: Optimization, characterization, and anti infammatory activity
Loteprednol etabonate (LE) is a topical corticosteroid that uses inflammatory conditions of the eye. It has a low ocular bioavailability and side effects such as corneal disorder, eye discharge, and ocular discomfort. ...
Design and characterization of dexamethasone loaded microsponges for the management of ulcerative colitis
Ulcerative colitis is an inflammatory condition with ulcerations throughout the colon. The existing remedies have some limitations such as drug inactivation, poor absorption, and adverse reactions. The present study aimed ...
Timolol-loaded ethosomes for ophthalmic delivery: Reduction of high intraocular pressure in vivo
The beta-adrenoceptor blocker timolol maleate (TML) is a commonly used pharmaceutical agent for the management of glaucoma. Conventional eye drops have limitations due to biological or pharmaceutical factors. Therefore, ...
Preparation and characterization studies of dorzolamide loaded ophthalmic implants for the treatment of glaucoma
(Turkish Pharmacists Association, 2023)
Objectives: This study aimed to construct dorzolamide loaded ophthalmic implants for extended drug delivery and increased drug retention. Materials and Methods: Carboxymethyl cellulose and Chitosan were used to formulate ...
Development of lipid nanoparticles for transdermal loteprednol etabonate delivery
(Taylor and Francis, 2022)
Aim Loteprednol etabonate (LE) is a new generation corticosteroid that is used for the treatment of inflammatory and allergic conditions of the eye. Therefore, solid lipid nanoparticles (SLN) and nanostructured lipid ...