İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Advancing sustainable food preservation: Ultrasound and thermosonication as novel approaches to enhance nutritional and bioactive properties of broccoli juice
(Elsevier, 2025) Yıkmış, Seydi; Türkol, Melikenur; Dülger Altıner, Dilek; Duman Altan, Aylin; Sağlam, Kübra; Abdi, Gholamreza; Tokatlı, Nazlı; Çelik, Güler; Aadil, Rana Muhammad
To meet the challenges of sustainability and nutritional quality, innovative food processing technologies are essential. This study investigates the application of ultrasound and thermosonication- emerging non-thermal preservation techniques- to improve the functional properties of broccoli juice. Using Response Surface Meth odology (RSM) and Adaptive Neuro-Fuzzy Inference System (ANFIS), the processes were optimised to maximize chlorophyll and ascorbic acid content. Optimal ultrasound parameters (4 min, 91.1 % amplitude) achieved 12.29 mg/100 mL chlorophyll and 79.38 mg/100 g ascorbic acid. Thermosonication (6.9 min, 66 % amplitude, 40 ◦C) gave comparable results. Both treatments significantly improved phenolic composition and mineral content, demonstrating superior preservation of bioactive compounds and reduced nutrient degradation compared to traditional methods. The results highlight the potential of ultrasound and thermosonication for sustainable food systems by improving nutritional quality and shelf life, thereby contributing to reduced food waste and environmentally friendly processing. This research provides valuable insights into the integration of non-thermal technologies in the production of functional beverages, supporting the development of circular food systems and sustainable innovation.
Design, synthesis and anti‐influenza virus activity of 4‐tert‐butyl‐n‐(3‐oxo‐1‐thia‐4‐azaspiro[4.5]dec‐4‐yl) benzamide derivatives that target hemagglutinin‐mediated fusion
(Wiley, 2025) Çınar, Gözde; Alikadıoğlu, Zeynep; Soylu Eter, Özge; Naesens, Lieve; Cihan Üstündağ, Gökçe
Hemagglutinin (HA) is a viral glycoprotein that mediates influenza virus entry into the host cell and is considered a relevant viral target. We here report the identification of a class of 4‐tert‐butylphenyl‐substituted spirothiazolidinones as HA‐mediated fusion inhibitors with specific activity against influenza A/H3N2 virus. The novel spirocyclic compounds were achieved by using one‐pot cyclocondensation method and the chemical structures were characterized by IR, 1 H NMR, 13C NMR, and elemental analysis. Compound 2c, bearing methyl substitutions at positions 2‐ and 8‐ of the spiro ring displayed an EC50 value against influenza A/H3N2 virus of 1.3 μM and an antiviral selectivity index of 30. The fusion‐inhibiting effect of compound 2c was revealed in the polykaryon assay which is based on cell‐cell fusion when influenza virus H3 HA‐transfected cells are exposed to low pH. Computer‐aided docking was performed to predict the possible binding pocket in the H3 HA trimer. Resistance data and in silico studies indicated that compound 2c has an overlapping binding pocket in the stem region of H3 HA with the known fusion inhibitors TBHQ and arbidol.
Cartoon-assisted visual/auditory distraction usage in paediatric dental care, assessment of effects on patient anxiety, pain, and behaviour: A randomised crossover clinical trial
(Springer Nature, 2025) Üstün, Nilüfer; Ballı Akgöl, Beyza; Bayram, Merve
Objectives This randomized crossover clinical trial designed to evaluate the impact of visual and auditory distraction techniques on pediatric patients’ anxiety, pain perception, and behavior during dental treatment. The study specifically focuses on children, aiming to determine whether distraction methods can effectively reduce anxiety levels, alleviate pain experiences, and improve cooperative behavior in a clinical setting. Method and materials Children aged 4 to 9 years receiving routine dental care at the Pediatric Dentistry Clinic, Istanbul Medipol University, were randomly assigned to Group 1 (distraction first, then tell-show-do) or Group 2 (tell-show-do first, then distraction), with a two-week washout period before switching interventions. Anxiety was assessed using the Venham Picture Test and pulse rate, pain perception with the Sounds, Eyes, and Motor Scale during local anesthesia and the Wong-Baker FACES Pain Rating Scale during treatment, while cooperation and behavior were evaluated using the Houpt Scale. Statistical analysis was conducted using Mann-Whitney U, Student’s t-test, Paired t-test, and Wilcoxon test, with the significance level set at 0.025 using the Bonferroni correction. Results Sixty-eight patients (37 female, 31 male) with a mean age of 6.69±1.08 years completed the study (Group 1: n=32, Group 2: n=36). The cartoon-assisted distraction technique did not significantly reduce anxiety compared to the tell-show-do method. A non-significant reduction in pain perception was observed during local anesthesia with distraction. However, this technique significantly reduced self-reported pain during treatment (p<0.025) and improved child cooperation and behavior. Conclusion Cartoon-assisted visual and auditory distraction can alleviate pain perception and improve behavior during pediatric dental procedures. However, it does not appear to reduce dental anxiety or pain perception during local anesthesia. Integrating this technique with the traditional tell-show-do approach may enhance the pediatric dental experience.
BIST sürdürülebilirlik endeksinde yer alan şirketlerin BIST 100 endeksindeki diğer şirketler ile getiri ve risk açısından karşılaştırılması
(Bartın Üniversitesi Yayınları, 2024) Zelka, Ahmet; Bayram, Abdullah; Saban, Metin
BIST şirketleri arasından sürdürülebilirlik faaliyetleri değerlendirilerek seçilen 25 şirketin yer aldığı BIST Sürdürülebilirlik 25 endeksinin bu endekste yer almayan ancak BIST 100 endeksinde yer alan şirketler ile karşılaştırılması amaçlanmaktadır. Bu karşılaştırma yapılırken şirketlere ait hisse senedi getirileri ve hisse senedi risklerinin 2023 Temmuz sonu ile 2024 Temmuz sonu arasındaki dönemi kapsayan 248 günlük veri seti kullanılmıştır. BIST Sürdürülebilirlik 25 endeksinde yer alan şirketlerin tümü aynı zamanda BIST 100 endeksinde de yer almaktadır. BIST 100 endeksinde yer alan şirketlerden sekizi incelenen dönem içinde ilk defa halka arz edildiğinden yeterli günlük verileri bulunmamaktadır. Bu nedenle sürdürülebilirlik endeksinde yer almayan 75 BIST 100 firmasından 67’si analize dahil edilmiştir. Analizde kullanılan değişkenler hisse senedinin sürdürülebilirlik endeksinde yer alıp almadığını ifade eden iki kategoride incelenmiştir. Değişkenlerin günlük ortalama getirileri geometrik ortalama ile hesaplanmış ve bir diğer seri bu şekilde oluşturulmuştur. Hisse senetlerinin standart sapma değerlerini içeren başka bir seri de hisse senedi riskini temsilen kullanılmıştır. BIST Sürdürülebilirlik 25 endeksinde yer alan değişkenlerin getiri ve risk değerlerinde anlamlı bir değişiklik olup olmadığı t testi ile analiz edilmiştir. Gerçekleştirilen t testi sonucuna göre BIST Sürdürülebilirlik 25 endeksinde yer alan firmalarla endekste yer almayan BIST 100 firmaları arasında hem hisse senedi riski hem de hisse senedi getirisi açısından anlamlı bir farklılık olduğu sonucuna ulaşılmıştır. İncelenen dönem için BIST Sürdürülebilirlik 25 endeksinde yer alan firmaların daha yüksek oranda günlük getiri sağladığı ve daha düşük oranda riske sahip olduğu tespit edilmiştir. Yatırımcıların hisse senedine yatırım yaparken hisse senedinin sadece getirisine veya sadece riskine odaklanması hatalı seçim yapmasına sebep olabilir. Hisse seçimi yaparken hem getiriyi hem de riski dikkate alan değişim katsayısı göz önünde bulundurulmalıdır. Risk ve getiri değerleri kullanılarak oluşturulan değişim katsayısı, hisse senedine ait bir birim ilave getiri için katlanılan ilave risk oranını ifade etmektedir. Bu çalışmadan elde edilen sonuca göre BIST Sürdürülebilirlik 25 endeksinde yer alan şirketlerin getirilerinin anlamlı bir şekilde yüksek olması ve risklerinin de anlamlı bir şekilde düşük olması değişim katsayılarının da anlamlı bir şekilde düşük olacağı şeklinde ifade edilebilir.
Localization of the zygomaticotemporal foramen on the zygomatic bone and its relationship with other foramina
(Harran University, 2024) Nteli Chatzioglou, Gkionoul; Nas, Emine; Coşkun, Osman; Kale, Ayşin; Gayretli, Özcan
Background: The zygomaticotemporal foramen (ZTF) is located in the temporal surface of the zygomatic bone. The zygomaticotemporal branch, a zygomatic nerve (V2) branch, passes through it and distributes in the fore head and temporal region. The aim of our study was to determine the frequency of ZTF and its connections with other foramina in the zygomatic bone. Materials and Methods: A total of 171 unilateral zygomatic bones in the Department of Anatomy, Faculty of Medicine, Istanbul University were included in our study. The number(s) of ZTF and its relationship with other foramina were determined. The distances between the ZTF and the marginal tubercle and frontozygomatic su ture were measured. Results: A total of 328 ZTFs were found in 171 zygomatic bones. In total, 95 of the 328 ZTFs were found to be connected to other foramina through a canal. The vertical distance between the ZTF and the marginal tubercle as well as the frontozygomatic suture were measured as mean 9.26+2.12mm and 21.78+2.48mm, respectively. The transverse distance from the ZTF and the marginal tubercle was measured as 5.46+1.56mm. Conclusions: he ZTF is an important anatomical component with implications for interventions on the zygomatic bone. The incidence and location of the ZTF may differ between individuals and between one side of the same individual. It has provided plastic surgeons and anaesthetists with detailed anatomical findings for the protec tion of the zygomaticotemporal nerves passing through the relevant foramen and thus at risk of injury.
