İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
In vivo reflectance confocal microscopy for detecting cutaneous metastasis in breast cancer
(Mattioli 1885, 2025) Duman, Nilay; Yaman, Banu; Oraloğlu, Göktürk; Kararaslan, Işıl
A 45-year-old female with a history of invasive ductal breast carcinoma (IDBC) presented with an asymptomatic erythematous nodule on the right mastectomy scar. Dermos copy revealed erythematous peripheral border, polymor phous and atypical vessels, focal scaling, and multiple white structureless areas appearing as white clods and strands. Reflectance confocal microscopy (RCM) revealed a normal epidermis with a preserved honeycombed pattern, with der mal tumoral clusters of varying sizes consisting of highly polymorphous hyporeflective cells with different sizes and shapes.
Mental health consequences of earthquakes in various countries
(Turkiye Klinikleri Yayınevi, 2025) Tütüncü, Selen; Hızlı Sayar, Gökben; Çınaroğlu, Metin
Earthquakes are among the most devastating natural disasters, causing significant loss of life, widespread destruction of infrastructure, and long-term psychological and physical impacts on survivors. These events, which often occur without warning, pose a global public health concern due to their suddenness, uncontrollability, and large-scale effects. Unlike other events, earthquakes represent an ongoing series of impacts, with their effects continuing long after the immediate danger has passed, sometimes lasting for years. The psychological consequences, in particular, can persist for months and may even outlast physical injuries caused by the disaster. This chapter explores the mental health consequences of major earthquakes with high fatality rates in various countries, with a particular focus on post-traumatic stress disorder, depression, and anxiety symptoms. The mental health effects of earthquakes on populations in China, Haiti, Iran, Japan, Nepal, Pakistan, Syria, and Turkey are specif- ically analyzed. Earthquakes are handled differently in various countries, depending on the resources available and the interventions that can be made. In developing countries, earthquakes are especially challenging because health systems are often overwhelmed by the large number of people needing help for trauma. This chapter explores how earthquakes affect mental health and what factors can help protect and support people during recovery, with a focus on different countries. Overall, the need for global cooperation in addressing the mental health impacts of natural disasters, particularly in less-developed regions, where resources and infrastructure are limited are emphasized.
A subjective multi-criteria assessment of the lean and green production by using hesitant fuzzy sets
(Springer Nature Link, 2025) Göçer, Fatmanur; Tüysüz, Fatih
Lean Production, which has been implemented in a wide range of areas for many years, mainly aims to meet customer satisfaction while reducing waste and keeping efficiency at the maximum level. The Green Production tries to minimize the negative impact of production on environment while to increase the efficient utilization of natural resources. The analogy of these two concepts may sometimes encourage the joint application. Analysis of the factors affecting the success of Lean and Green production requires a multi-dimensional evaluation of experts as either researchers or practitioners. In this way, the problem on hand becomes a typical multi-criteria decision making problem and also contains uncertainty inherent in subjective evaluation of decision makers. Due to this reason, this study presents a fuzzy multi-criteria evaluation methodology by using hesitant sets. A real life application of the approach which considers the case of Türkiye is also presented.
Evaluation of enamel surface roughness and volumetric change after resin remnant removal following orthodontic bracket debonding
(Quintessence Publishing Deutschland, 2025) Korkut, Bora; Uzun, Kadir Emre; Hacıali, Çiğdem; Ünal, Tuna; Tağtekin, Dilek
Purpose: To evaluate surface roughness and volumetric change of enamel after using different resin remnant removal (RRR) techniques, following orthodontic bracket debonding. Materials and Methods: Metal orthodontic brackets (Mini Twin Brackets, RMO) were bonded to 60 human (central or lateral) labial mid-third surfaces, and debonded 24 h after by a single orthodontist. The remaining composites were completely removed with the fluorescence light guidance by the D-Light-Pro led curing unit (GC/detection mode). The removal procedures were performed without magnification (n = 30) or with 20× magnification/5500 K illumination by a dental microscope (OMS2000, Zumax) (n = 30). Three RRR techniques were used: 12-bladed carbide bur (Horico), red-banded diamond bur (Horico), SofLex Disc (medium/40 μm, fine/24 μm, and superfine/8 µm; 3M). Surface changes were evaluated visually through microscope photographs by enamel surface index (ESI) and volumetrically by overlapping the three-dimensional images of a laser scanner device (LAS-20, SD-Mechatronik) in the Geomagic Design X (3D Systems) software. The deemed significance was set at 0.050 for the statistical analyses. Results: A positive, strong correlation was found between visual and volumetric change scores (P 0.001). Lesser volumetric loss (P 0.001) and roughness (P = 0.009) were observed for all RRR techniques when the magnification was used. Volumetric loss (mm3) by diamond bur was significantly the highest [1.85(1–3)a], followed by SofLex Disc [1.1(1–1)c] and carbide bur [0.59(0–1)b](P 0.001). Visual surface roughness scores (Ra) were significantly higher for diamond bur [4.5(4–5)b](P 0.001), followed by carbide bur 2(1–3)a and SofLex Disc 1(1–2)a. Conclusion: Surface roughness should always be assessed together with the volumetric enamel loss for the selection of RRR technique. Red-banded diamond bur should not be used for RRR. Even though the least surface roughness can be provided by SofLex Disc system, it can provide more intact enamel surface loss than the carbide bur. Magnification was considered useful for the RRR to provide a smoother surface while better preserving the intact enamel tissue.
Presence of myositis specific autoantibodies including anti synthetase antibodies predict favorable outcomes to rituximab in patients with idiopathic inflammatory myositis: Retrospective observational study
(Elsevier, 2025) Oğuz, Eyüp; Koca, Nevzat; Bektaş, Murat
Background: Idiopathic inflammatory myositis (IIM) is a group of disorders that mainly affect skeletal muscle, joints, skin, and lungs. Objectives: This study aimed to evaluate the autoantibody profile including myositis-associated autoantibodies (MAAs) and myositis-specific autoantibodies (MSAs) and their influence on outcomes, response rates, and associated factors to Rituximab (RTX) treatment in patients with IIM who followed up in a single tertiary center. Methods: Data from the patients with IIM who follow-up between 2019 and 2023 years and met the Bohan and Peter and/or the ACR/EULAR 2017 and/or the ENMC criteria were retrospectively reviewed. RTX was initiated in patients who had an inadequate response to at least one immonomudulatory/immunosuppressive treatment (refractory group) or as a first-line treatment in patients who had critical/severe disease manifestations such as respiratory failure due to severe intertitial lung disease (ILD), respiratory muscle involvement, and dysphagia. RTX was administered at a dose of 1 g every 6 months on days 0-15, and the dose was repeated at month 6 in patients who responded to treatment. Remission was defined as the patients who met all of the following criteria during at least 6 months: i) absence of a sign of muscle inflammation by manual muscle test (normalization of muscle strength in patients without damage) alongside muscle enzymes (normalization in CK and LDH levels), ii) improvement or no progression in respiratory symptoms alongside pulmonary function tests (less than 10% decline in FVC and/or DLCO) in patients who had ILD at baseline, iii) disappearance of active skin lesions among dermatomyositis (DM) patients iv) resolution of other features attributed to several manifestations such as arthritis, heart involvement and gastrointestinal symptoms if present.
