İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Comparison of stem cell CD45/34 fluorescence intensity with stem cell mobilization in patients under and over 65 years of age
(2024) Meriç, Neslihan; Parmaksız, Ayhan; Gülbaş, Zafer
In our research, we attempted to compare CD45/34 MFI (Mean Fluorescent Intensity) in patients younger and over 65 years of age with hematopoietic stem cell mobilization (HSCM).The research involved a group of 76 individuals who had different types of cancer and were identified at the Bone Marrow Transplantation (BMT) Unit of Anadolu Medical Center Hospital from 2015 to 2016. To mobilize HSCs, participants were administered daily granulocyte colony-stimulating factor (G-CSF) (10 µg/kg/day) under the skin for 7-8 days. Calculating the appropriate level of peripheral blood (PB) CD34+ took into account the patients' WBC (White Blood Cell) counts. Our research revealed that HSCM patients above 65 had statistically greater CD45/34 MFI values than those under that age. Although the age factor for HSCM is important, according to our findings, age is not seen as a negative mobilization factor for HSCM in patients aged 65 and over, and should be supported by larger studies. Our research revealed that patients over 65 who underwent HSCM had statistically greater CD45/34 MFI values than younger patients. Given the decline in SC production observed in individuals aged 65 and above, along with the potential for other accompanying diseases, our results hold promise for elderly patients. However, it is important to validate these findings through multicenter studies with a larger patient population, while also taking into account the presence of other subsequent diseases in the patients under observation.
Analysis of graduate theses related to leadership carried out in the field of nursing in Turkish universities
(Aydın Adnan Menderes Üniversitesi, 2024) Aydoğdu, Ana Luiza Ferreira
Objective: This study aimed to analyze different variables of graduate theses related to leadership conducted in the field of nursing in Turkish Universities. Methods: This is a bibliometric and descriptive study. The search for the theses was carried out in May 2022 in the National Thesis Center of the Council of Higher Education using “leadership” and “nursing” as descriptors. Results: A total of 48 theses were included. Most theses (45.83%) were published between 2017 and 2022. 66.67% of the theses were conducted at public universities. Almost all the theses were produced by the departments of nursing, nursing management, or nursing fundamentals and management. In most of the theses, the samples consisted of staff nurses. Quantitative approaches were present in all the theses and scales were the most used data collection instruments (56.25%). The most discussed topics were “leadership behaviors” (29.17%), “leadership styles” (20.83%), and “transformational leadership” (14.58%). Conclusion: It is suggested that leadership be more widely discussed across different nursing departments and featured in a greater number of doctoral theses, primarily through qualitative approaches. Nursing students should be considered more as research samples, as it is important to investigate future nurses’ opinions and knowledge about leadership.
Microwave-assisted synthesis of antimony oxide nanoparticles for the determination of trace cadmium in mulberry leaf tea matrices by flame atomic absorption spectrophotometry
(Springer, 2024) İnce, Merve Nur; Serbest, Hakan; Bakırdere, Sezgin
In this study, a rapid, sensitive and accurate analytical method was optimized for the determination of trace levels of cadmium (Cd) by fame atomic absorption spectrophotometry (FAAS) after antimony oxide nanoparticles (AO NPs)-based dispersive solid-phase extraction (DSPE). The AO-NPs were synthesized with a specifc microwave tem perature program, and they exhibited high purity and good surface morphology, making them appropriate sorbent material for the preconcentration/separation of a heavy metal. All experimental parameters afecting the extraction efciency were optimized univariately. Under the optimum operational conditions (35 mL sample volume, 0.75 mL of pH 8.0 bufer, 15 mg of sorbent, 5 s vortex and 100 µL of 1.0 M of HNO3), the limit of detection (LOD) and the limit of quantitation (LOQ) values were determined as 0.27 and 0.89 µg L−1, respectively. Thanks to the developed method, a 164.8-fold improvement in the sensitivity of the conventional FAAS system was achieved. Reusability tests showed that the AO-NPs can be employed 5 times. The feasibility of the method was confrmed by recovery tests with mul berry leaf tea matrices, and good recovery results between 77.6 and 115.8% were obtained using the matrix matching calibration method.
Evaluation of the extraction methods prior to ICP-MS determination of metal levels in kinetic (magic) sand samples used for children’s play
(Taylor & Francis, 2024) Özdemir Olgun, Fatoş Ayça
Kinetic (magic) sand is widely used in preschool activities in order toimprove the children’s creative abilities. Despite its popularity, thisstudy will be the first in literature to assess the heavy metal contentof kinetic sand samples. Focusing on the determination of metalcontent (Hg, Cd, Sb, Sn, Al, Ni, Co, Cu, Pb) of 10 different brands ofkinetic sand samples sold in Turkish markets, the significance ofsample preparation step was further discussed with the applicationof wet digestion and microwave digestion methods, prior to analy-sis by ICP-MS. Based on the acute toxicity classes defined byEuropean Union (EU) As, Cd, Hg belongs to Class 1; Ni, CrVI, Pbbelongs to Class 2, whereas Zn and Cu belongs to Class 3. Amongthe potential toxic elements studied, the Al content of samplesattracts attention with its high level exceeding the limits ofdirectives.
Optimization of bioactive compounds and sensory quality in thermosonicated black carrot juice: A study using response surface methodology, gradient boosting, and fuzzy logic
(Elsevier, 2025) Yıkmış, Seydi; Türkol, Melikenur; Paçal, İshak; Duman Altan, Aylin; Tokatlı, Nazlı; Abdi, Gholamreza; Tokatlı Demirok, Nazan; Aadil, Rana Muhammad
This study investigates the optimization of bioactive components in thermosonicated black carrot juice using response surface methodology (RSM) and gradient boosting (GB) modeling techniques. Thermosonication, a combination of ultrasound and heat, was applied to enhance the nutritional quality of black carrot juice, which is rich in anthocyanins, phenolic compounds, and antioxidants. The study examined the effects of temperature, processing time, and ultrasonic amplitude on total carotenoid content (TCC), total anthocyanin content (TAC), ferric reducing antioxidant power (FRAP), and total phenolic content. RSM demonstrated higher prediction accuracy compared to GB, identifying optimal processing conditions at 48.68 °C, 11.15 minutes, and 82.62% amplitude. Thermosonication significantly increased total phenolic content to 414.28 mg GAE/L, surpassing traditional pasteurization. Sensory analysis, conducted via fuzzy logic, indicated improved sensory properties, including aroma, taste, and color, in thermosonicated samples. This study undercomes thermosonication as a promising method for improving both bioactive compounds and sensory quality in black carrot juice. Chemical compounds Chlorogenıc acid (PubChem CD:1794427); caffeic acid (PubChem CD: 689043); vanillin (PubChem CD: 1183); rutin (PubChem CD: 5280805); naringin (PubChem CD: 442428); rosmarinic acid (PubChem CD: 5281792); t-ferulic acid (PubChem CD: 445858); o- coumaric acid (PubChem CD: 637540); (PubChem CD: quercetin 5280459); 4-hyroxybenzoic acid (PubChem CD: 135).
