İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Güncel Gönderiler
Effect of adding soybean oil to diesel fuel on engine characteristics
(Trakya University, 2024) Akal, Dinçer; Tunçer, Erdal; Kaya, Yalçın; Beşer, Necmi; Efendioğlu, Ayşegül; Acar, Mustafa
Biodiesel fuels are seen as an important resource due to the environmental damage caused by exhaust emissions from the use of fossil fuels, the increase in global warming and the rise in oil prices. As an alternative, the use of biodiesel by blending certain percentages of biodiesel into diesel fuel is preferred due to both sustainability and some advantages. In this study, 10% soybean oil was added to the fuel used in a single-cylinder diesel engine and the changes in engine power, fuel consumption and exhaust emissions were experimentally investigated. According to the results of the study, it was observed that the engine power was almost the same with the addition of soybean oil to the diesel fuel, but there was an increase in exhaust emissions with some increase in fuel consumption. For this reason, it is clear that further experimental studies should be carried out by adding soybean oil with different characteristics and proportions to be used in diesel engines.
Management of acute variceal bleeding: Updated APASL guidelines
(Springer Nature Link, 2025) Lesmana, Cosmas Rinaldi Adithya; Shukla, Akash; Kumar, Ashish; Shalimar; Qi, Xiaolong; Gani, Rino Alvani; Dökmeci, Abdul Kadir; Örmeci, Necati; Sarin, Shiv Kumar
Acute variceal bleeding (AVB) is a common life-threatening complication of portal hypertension (PHT), having a six-week mortality of 10%-20%. Major advances in the hemodynamic management, risk stratification, pharmacotherapy, endoscopy techniques, hemostatic devices and radiological interventions have led to improved management and outcome of AVB patients in the recent past. Therefore, the APASL Portal Hypertension Working Party, chose a panel of experts, primarily from the Asia–Pacific region, to identify important developments and controversial areas in the field of AVB. They discussed through a pre-defined and structured process, advances in the field and proposed updates to the previous APASL AVB guidelines. These included emphasis on safe transportation, defining time frames for AVB episodes and re-bleeding, reporting of clinical outcomes, optimizing early intervention strategies, pharmacotherapy, medical management, endoscopic therapies, and salvage modalities, including TIPS and self-expanding metal stents. The current updates also cover variceal bleeding in special populations and situations, the skill sets required for managing AVB patients, and the research priorities in the field. The updated guidelines are based on the latest evidence and incorporate emerging trends to provide a contemporary template for management of AVB in both patients with cirrhosis and non-cirrhotic portal hypertension.
Palatal donor site management using tissue adhesives with adjunctive coconut oil in a randomized clinical trial
(Springer Nature, 2025) Yılmaz, Melis; Balcı, Nur; Günay, Bestegül; Parlak, Hanife Merva; Parmaksız, Ayhan; Toygar, Hilal; Keçeli, Hüseyin Gencay
Management of the complications occurring in the donor area after epithelialized gingival graft (EGG) harvesting still poses a challenge for clinicians. This study aimed to evaluate the influence of gelatin sponge (GS), cyanoacrylate (CY), and coconut oil (CO) combination in comparison with GS+CY in donor site management. Fifty EGG were harvested from the lateral palate in 50 patients, who were subsequently randomized to receive the GS+CY (control) or GS+CY+CO combination (test). Postoperative pain perception (PP), quantity of analgesics (QA), epithelization level (EL), color match (CM), sensation loss (SL), postoperative discomfort (PD), and delayed bleeding (DB) were evaluated. The GS+CY+CO group showed lower PP scores compared to the GS+CY (p<0.05). The QA intake was similar in both groups. On day 14, the GS+CY+CO group achieved 80% full EL rate, which was higher than the GS+CY group (32%) (p=0.002). CM scores were higher in the GS+CY+CO group at all follow up periods (p<0.001). Both groups reported similar SL, PD, and DB values (p>0.05). GS+CY+CO combination is more effective in reducing pain compared to GS+CO in donor site management after EGG harvesting. Additionally, GS+CY+CO combination may accelerate epithelialization and improve color match compared to GS+CY alone.
Endometrial sampling in the absence of hysteroscopy: Insights from more than 1000 dilatation and curettage cases
(Wiley, 2025) Şentürk, Şenol; Aydın, Gerçek; Can Bayrak, Çiğdem; Hatırnaz, Şafak; Stojković, Marta; Sparic, Radmila; Pecorella, Giovanni; Tinelli, Andrea
Objectives: The aim of this epidemiological study is to present the distribution of histopathological results of endometrial biopsies performed for indications in women and their relationship with symptoms. Methods: A retrospective analysis was conducted on patients with abnormal uterine bleeding (AUB) assessed by endometrial biopsy between January 2020 and July 2022. Analyzing the distribution and association of patients' demographic traits, biopsy motivations, and histopathologic findings was the main goal of the study. Results: A total of 1216 patients were included in the study, and their average age was 48.48 ± 8.79 years. AUB was found to be the most common reason for biopsy (n= 616; 50.7%). The most common diagnosis among the histologic findings (320; 26.3%) was endometrial polyp. The most common symptoms among individuals with premalignant and malignant diseases were AUB, endometrial thickening, and postmenopausal hemorrhage. Additionally, it was determined that 21 (6.3%) postmenopausal patients had inadequate material. Conclusions: The most common histologic diagnosis from the procedure was endometrial polyp. It is important to make sure that the sample taken includes the entire uterine cavity because postmenopausal women may have insufficient biopsy samples. This is especially true if a hysteroscopy with biopsy cannot be performed (for a variety of reasons). In fact, suspect endometrial cancers should be thoroughly evaluated by hysteroscopy in patients with postmenopausal bleeding, endometrial thickness, and atypical uterine bleeding.
Improving physiological solubility and gene transfer efficiency of chitosan via 3-nitrobenzaldehyde and amino acid conjugation
(Elsevier, 2025) Bal, Kevser; Kaplan, Özlem; Şentürk, Sema; Küçükertuğrul Çelik, Sibel; Demir, Kamber; Gök, Mehmet Koray
In this study, chitosan was chemically modified with 3-nitrobenzaldehyde (3NBA) and three amino acids (arginine, cysteine, and histidine) to enhance its gene delivery performance. 3-NBA was selected for its known DNA binding properties, while the amino acids were chosen based on their functional groups, which can improve solubility, facilitate cellular uptake, and contribute to endosomal escape. The modified chitosan polymers were characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance Spectroscopy (NMR). Nanoparticles were prepared using the ionotropic gelation method, and their particle size, polydispersity index (PDI), zeta potential were analyzed by dynamic light scattering (DLS). The particle sizes ranged from 105.07 ± 3.45 to 206.15 ± 10.39 nm, with PDI values between 0.29 ± 0.01 and 0.39 ± 0.02. Zeta potentials were measured between 32.05 ± 0.49 mV and 51.95 ± 0.35 mV. The cysteine-modified chitosan (Chi-3NBACys) exhibited approximately 8.4-fold higher solubility than unmodified chitosan. In vitro studies demonstrated that the modified chitosan nanoparticles exhibited low cytotoxicity in HEK293T cells. Among the tested formulations, Chi-3NBACys showed the highest transfection efficiency, comparable to commercial agent Lipofectamine™ 2000. These findings suggest that chitosan nanoparticles modified with 3-NBA and amino acids can be safe and efficient non-viral gene delivery vectors.
