İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Investigation of the attitudes of faculties of medicine, dentistry, and pharmacy students towards brain drain in terms of future anxiety and satisfaction with life levels
(Bülent DİLMAÇ, 2025) Keçeci, Berra; Gül, Zehra Betül; Özekinci, Ayşe Ekin
The aim of this study is to examine the attitudes of medical, dentistry and pharmacy faculty students towards brain drain in terms of future anxiety and life satisfaction levels. 308 university students enrolled in a foundation university in Istanbul were included in the study. Descriptive statistics, correlation, multiple regression, one-way ANOVA and independent sample t-test analysis were used in the analysis of the data. The regression analysis results showed that hopelessness about the future, future anxiety and life satisfaction were significant predictors of attitudes towards brain drain. According to the independent samples t-test analysis results, it was found that the tendency towards brain drain was higher in male students and students in the clinical education process, while the tendency towards brain drain was lower in dentistry students than in medical and pharmacy students. The study results provide important data for the development of policies to reduce brain drain in the health sector in Türkiye.
Determinants of foreign direct investment in the textile sector: A research with IT2 Fuzzy TOPSIS methodology
(Institute National Cercetare-Dezvoltare Textiles Pielarie, 2025) Şahin, Recep Uğurcan; Nalbant, Kemal Gökhan; Keskin, Abdulkadir; Özdemir, Yavuz; Keskin, Abdurrahman
This study aims to identify the determinants of foreign direct investment (FDI) in the textile sectors in Poland, Romania, Hungary, Slovakia, Czechia and Türkiye. The study assesses these criteria through paired comparisons conducted by experts who have a minimum of 10 years of professional experience in the field and analyses them using the IT2 Fuzzy Technique for Order of Preference by Similarity to the Ideal Solution (TOPSIS) technique. According to the findings, the criteria with the highest degree of importance are national security, inflation rate, patent and trademark protection, transportation networks and market size. On a country-by-country basis, Poland has a higher investment attraction potential compared to other countries according to the criteria of openness, corruption, legal regulations and privatization policies, import and export quotas, education and professional status, renewable energy resources, sustainability, intellectual property protection, patent and trademark protection and national security. Hungary scores highest on import and export quotas and tax rates, while Slovakia stands out on import and export quotas and waste management/environmental regulations. Romania scores highest on profitability and debt financing, labour costs and import and export quotas. Czechia scores highest on inflation rate, political stability, legal regulations and privatization policies, economic incentives, general trade policies, import and export quotas and cultural situation and lifestyle. Türkiye scores the highest in terms of market size, GDP growth rate, access to raw materials and markets, technological infrastructure and innovation, transport networks, production sites, energy production, import and export quotas and business-friendly approaches.
Development of an HPLC method for the determination of fampridine (dalfampridine) in human plasma by fluorimetric derivatization and application to a prototype pharmacokinetic study
(Editions de l'Academie Republique Populaire, 2025) Ceylan, Burhan; Önal, Cem; Önal, Armağan
Fampridine (dalfampridine) is used to improve walking in people who have multiple sclerosis. In this study, a new, fast and sensitive HPLC method with fluorometric detection was developed for the determination of fampridine in human plasma and applied to a pharmacokinetic study. Fampridine was precolumn derivatized with 7-chloro-4-nitrobenzofurazan (NBD-Cl) and the fluorescent derivative was separated on a C18 (150 × 4.6 mm × 2.6 μm) analytical column at 30 ºC using a mobile phase composed of acetonitrile – 0.1% o-phosphoric acid in water (80:20, v/v) by isocratic elution with flow rate of 1.0 mL min–1 . The method was based on the measurement of the derivative using fluorescence detection (λex= 310 nm, λem = 365 nm). The retention time of fampridine is 4.10 ± 0.02 min. This currently developed method was validated according to EMA criteria by evaluating the specificity, linearity, precision, accuracy and robustness. The method was determined to be linear in a concentration range of 0.01–20 ng mL–1 with the correlation coefficient of 0.9996. LOD and LOQ were found to be 0.003 and 0.01 ng mL–1 , respectively. Intraday and interday RSD values were less than 2.45%. The plasma concentration-time profile and pharmacokinetic parameters such as AUC0–t, AUC0–∞, Cmax, tmax, t1/2, were calculated according to the assays. The presented method can certainly be used for bioequivalence and bioavailability investigations and routine analysis of the drug in plasma.
Principles and applications of computeraided design (cad) and computeraided manufacturing (cam) in maxillofacial surgery
(Turkiye Klinikleri Yayınevi, 2025) Koçyiğit Daştan, Hayrunisa; Sağlam, Reyhan
Maxillofacial surgery requires precise repair and treatment of complex anatomical structures. Accord ingly, computeraided design and manufacturing (CAD/CAM) systems provide significant advantages in designing patientspecific implants, producing surgical guides and optimizing preoperative planning processes. In particular, 3D printing technology offers a revolutionary innovation in the production of personalized implants and surgical guides. In maxillofacial surgery, biocompatible materials such as titanium, PEEK (polyetheretherketone), bioceramics and biological graft materials are frequently preferred for their tissue compatibility, mechanical durability and aesthetic advantages. CAD/CAM systems have advantages such as surgical precision, shorter operative times and patient satisfaction. However, there are challenges such as limitations of the technology and high cost. CAD/CAM systems are expected to develop further in the future. The potential offered by nextgeneration technologies in the field of maxillofacial surgery is demonstrated, and it is expected that these innovations will be increasingly used in clinical practice.
Fluorimetric derivatization-based HPLC-FL method for the prototype pharmacokinetic analysis of selexipag in human plasma
(Taras Shevchenko National University, 2025) Ceylan, Burhan; Çayci, Meltem; Önal, Cem; Önal, Armağan
A simple and cost-effective HPLC-FL method has been developed for measuring selexipag in human plasma, showcasing its suitability for pharmacokinetic research. Selexipag was precolumn derivatized with 7-chloro-4-nitrobenzofurazan (NBD-Cl) and the fluorescent derivative was separated on a C18 (150 mm × 4.6 mm × 2.6 μm) analytical column at 30 ºC using a mobile phase composed of acetonitrile – 0.1% o-phosphoric acid in water (70:30, v/v) by isocratic elution with flow rate of 1.0 mL min-1. The method was based on measuring the derivative using fluorescence detection (λex = 380 nm, λem = 420 nm). The retention time of selexipag is 6.40 ± 0.01 min. This currently developed method was validated according to EMA criteria by evaluating the specificity, linearity, precision, accuracy, and robustness. The method was determined to be linear in a concentration range of 0.01-20 ng mL-1 with a correlation coefficient of 0.9998. LOD and LOQ were found to be 0.003 and 0.01 ng mL-1, respectively. Intraday and interday RSD values were less than 1.75%. The plasma concentration-time profile and pharmacokinetic parameters such as AUC0–t, AUC0–∞, Cmax, tmax, t1/2, were calculated according to the assays. The presented method can be effectively used for bioequivalence and bioavailability investigations, as well as for routine analysis of the drug in plasma.
