İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Quantification of agnuside in human plasma with a novel high-performance liquid chromatographic method and pharmacokinetic study
(Oxford University Press, 2025) Egeli, Derya; Tiris, Gizem; Kepekçi Tekkeli, Şerife Evrim
This study presents a combination of High Performance Liquid Chromatography (HPLC) and ultraviolet (UV) detection that provides the quantification of agnuside in human plasma specimens. Reverse-phase chromatographic separation was carried out with C18 column (150 mm × 4.6 mm × 5 μm), at 25°C with isocratic elution of the mobile phase containing methanol: 0.1% formic acid (35:65 v/v) at 0.6 mL/min flow rate. Experiments were carried out at a wavelength of 258 nm. The retention time of the analyte is 9.70 ± 0.01 min. The developed technique was validated based on the International Conference on Harmonization guideline. The correlation coefficient of the technique was 0.9915, and the calibration range was 5–125 μg/mL. The recovery value of the proposed method was found to be 101.4%, and the precision of the method was calculated as 6.35 with the highest RSD% value. A pharmacokinetic study was performed by administering agnuside to a healthy volunteer.
Diaphragmatic dysfunctions and their treatment: Neural therapy and manual medicine as effective approaches
(Salient Visionary Publications, 2025) Ural Nazlıkul, Fatma Gülçin; Nazlıkul, Hüseyin
Diaphragmatic dysfunctions are a medical issue whose relevance is often underestimated. They manifest in respiratory and systemic symptoms such as dyspnea, sleep disturbances, chronic fatigue, gastroesophageal reflux, and even heart failure. As the primary respiratory muscle, the diaphragm is pivotal in maintaining trunk stability and regulating intra-abdominal pressure, making its dysfunction capable of exerting profound impacts on overall health. Causes and Pathophysiology of Diaphragmatic Dysfunctions: Diaphragmatic dysfunctions can arise from a variety of factors, including: • Chronic stress, which increases tension in the diaphragm and surrounding fascia, • Myofascial trigger points, which impair muscle contraction and mobility, • Scar tissue, which limits fascial mobility, • Trauma, surgeries, or mechanical stress, which may irritate or impair the function of the phrenic nerve. The phrenic nerve, which innervates the diaphragm, plays a crucial role in the functionality of this muscle. Irritation or damage to the phrenic nerve can significantly impair diaphragmatic movement, leading not only to breathing difficulties but also to dysregulation of the autonomic nervous system and organ functions. Treatment Approaches: The combination of neural therapy and manual medicine has proven to be particularly effective in treating diaphragmatic dysfunctions. Injections targeting myofascial trigger points and segmental therapy can support diaphragmatic function. Manual diagnostics play a critical role in identifying segmental dysfunctions and fascial adhesions.
Histological staining technics for identifying various structures for histological assessment of bone and cartilage healing
(ICBH, 2023) Dikmen, Tayfun
Bone and cartilage regeneration are challenging topics which the scientists are constantly looking for new approaches to eliminate current limitations of the traditional therapeutic methods which are being used. Cellular therapy and use of biomaterials for that purpose is providing encouraging results, especially in cases like osteoarthritis and bone healing. In such studies, the histological assessment of the healing of corresponding tissues are vital to determine to see if the developed method is indeed resulted with positive outcomes or not. Each tissue has some different distinctive structures that must be investigated during the healing process. There are several histological staining technics being used for the evaluation of the healing of bone and cartilage tissues by identifying the structures of interest. Among them, hematoxylin eosin staining comes forward as the most applied technic. However, it is not suitable to identify each and every important histological structure, and some specific staining technics are necessary to identify such structures like new bone formation areas, mineralized bone areas, glycosaminoglycan aggregates, collagen fiber formation, etc; regarding the aim of the research. In this study, bone and articular cartilage samples were taken and stained with Alcian blue staining, Picro-sirius red staining, Masson-Goldner’s trichrome staining, Movat’s pentachrome staining, von Kossa staining technics to identify different structures in bone and cartilage. The outcomes might help researchers to determine the appropriate staining technics to be used in their studies to fully demonstrate their findings.
Toward green and sustainable zinc-ion batteries: The potential of natural solvent-based electrolytes
(Wiley, 2025) Yaman Uzunoğlu, Gülşah; Yüksel, Recep
Zinc-ion batteries (ZIBs) are emerged as a promising alternative for sustainable energy storage, offering advantages such as safety, low cost, and environmental friendliness. However, conventional aqueous electrolytes in ZIBs face significant challenges, including hydrogen evolution reaction (HER) and zinc dendrite formation, compromising their cycling stability and safety. These limitations necessitate innovative electrolyte solutions to enhance ZIB performance while maintaining sustainability. This review explores the potential of natural solvent-based electrolytes derived from renewable and biodegradable resources. Natural deep eutectic solvents (DES), bio-ionic liquids, and biomass-derived organic compounds present unique advantages, including a wider electrochemical stability window, reduced HER activity, and controlled zinc deposition. Examples include DESs based on choline chloride (ChCl), glycerol-based systems, and biomass-derived solvents such as γ-valerolactone (GVL) and aloe vera, demonstrating improved cycling stability and dendrite suppression. Despite their promise, challenges such as high viscosity, cost, and scalability remain critical barriers to commercialization. This review underscores the need for further research to optimize natural solvent formulations, enhance Zn anode compatibility, and integrate these systems into practical applications. By addressing these challenges, natural solvent-based electrolytes can pave the way for safer, high-performance, and environmentally sustainable ZIBs, particularly large-scale energy storage systems.
Viewpoints of nurse auditors regarding the profession: A qualitative study
(Emerald Publishing, 2025) Aydoğdu, Ana Luiza Ferreira
Abstract Purpose – This study aims to understand the experiences of Brazilian nurse auditors in the practice of their profession, exploring the importance, challenges, rewards and strategies related to the occupation. Design/methodology/approach – This is a qualitative descriptive study conducted with 44 nurse auditors. An online, open-ended questionnaire was used. Thematic content analysis was performed. Findings – Five themes were identified: (1) functions of a nurse auditor; (2) skills required for a nurse auditor; (3) learning to be a nurse auditor; (4) advantages of being a nurse auditor and (5) challenges faced by a nurse auditor. Also, a total of 16 subthemes were presented. Research limitations/implications – The study critically examined essential aspects of auditing through the lens of nurse auditors, addressing a relevant topic. However, limitations must be acknowledged, including the use of self-report questionnaires, regional representation disparities, the scarcity of international articles on the topic and potential researcher bias. Practical implications – The study underscores the importance of increasingly integrating nurse auditors into the workforce while emphasizing the need to enhance the capacitation of these professionalsthrough theoretical and practical education. It highlights the significance of educating other multidisciplinary team members about the nurse auditor’s crucial role in fostering teamwork and ensuring the quality of healthcare services. Originality/value – To the best of the author’s knowledge, this is the first study conducted with Brazilian nurse auditors, exploring crucial aspects of auditing from the perspective of these professionals. Understanding the critical role of nurse auditorsinmaintaining and improving healthcare quality can enhance public trust in healthcare systems.
