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Yayın Integrative neural therapeutic approach for migraine with aura – A case report(Pubtexto Publishers, 2025) Ural Nazlıkul, Fatma Gülçin; Nazlıkul, Hüseyin; Acarkan, TijenThis case report presents the clinical course of a 37-year-old female patient diagnosed with migraine with aura, who experienced significant and sustained symptom relief following neural therapeutic interventions. The patient had a long-standing history of recurrent, unilateral, pulsating headaches, often preceded by visual aura symptoms such as scintillating scotoma, and accompanied by nausea, photophobia, and phonophobia. Previous pharmacological treatments provided only limited and temporary relief and were associated with side effects. A structured, integrative therapeutic protocol was initiated, comprising neural therapy with 1% procaine administered segmentally at cervical ganglia (C2/C3), the stellate ganglion, tonsillar region, trigeminal pathways, and relevant vegetative-reflex zones. The treatment focused on modulation of the autonomic nervous system and regulation of possible interference fields. After just two sessions, the patient reported a marked reduction in attack frequency and improvement in vegetative symptoms, with further improvement following a total of four sessions. Complementary interventions included a migraine diary to identify individual triggers, nutritional optimization, stress reduction, and patient education to improve early aura recognition and preventive action. Notably, the patient was able to discontinue acute medication use without recurrence of intense episodes, and her quality of life improved substantially. This case underscores the value of neural therapy as a safe, efficient, and individualized approach in managing migraine with aura. The observed therapeutic effects are attributed to autonomic regulation, stabilization of neuroimmunological networks, and treatment of interference fields such as chronic tonsillitis. Importantly, neural therapy allowed for medication sparing and enhanced patient compliance without systemic adverse effects. These findings support the integration of neural therapy into a holistic, patient-centered strategy for chronic migraine conditions. It provides an alternative for patients who seek non-pharmacological treatment options and demonstrates promising potential in reducing migraine burden long-term.Yayın Long-term effects of neural therapy in fibromyalgia – A retrospective multicenter analysis effectiveness of neural therapy in patients with fibromyalgia(Salient Visionary Publications, 2025) Ural Nazlıkul, Fatma Gülçin; Nazlıkul, Hüseyin; Özkan, Neslihan; Acarkan, Tijen; Tamam, Yusuf; Orak, Murat; Bilgin, Mehmet DinçerBackground: Fibromyalgia syndrome (FMS) is a chronic pain condition associated with widespread musculoskeletal discomfort, persistent fatigue, and diminished quality of life. Many patients show limited response to conventional treatments. Neural therapy (NT), a core modality of regulatory medicine, aims to restore autonomic balance and modulate inflammatory reflexes through targeted injections of local anesthetics. Objective: This retrospective multicenter study evaluates the long-term effectiveness of NT in 565 patients with treatment resistant fibromyalgia who previously failed to respond adequately to standard therapies. Methods: Data were collected from five neural therapy clinics between 2017 and 2024. Standardized outcome measures were assessed at baseline, immediately post-treatment, and at 3, 6, and 12 months: Pain intensity: Visual Analog Scale (VAS) Disease burden: Fibromyalgia Impact Questionnaire (FIQ) Quality of life: Short Form-36 (SF-36), including subdomains (physical function, pain, energy/fatique, social function, general health perception) Statistical analysis employed the Friedman test for repeated measures. Results: VAS scores dropped from a mean of 8.5 to 1.9 post-treatment and remained below 3.0 over 12 months. FIQ scores decreased from a baseline mean of 78.1 to 18.6 and remained significantly improved (mean 24.9 at 12 months). SF-36 physical function increased from 33.5 to 82.0, with sustained gains at all follow-ups. Social functioning, general health perception, pain and vitality domains showed similar sustained improvements. The treatment completion rate was 92.9%, indicating high tolerability and patient satisfaction. Conclusion: Neural therapy produced significant and sustained improvements in pain, physical functioning, energy, and social participation in fibromyalgia patients. Its multimodal effects—autonomic modulation, anti-inflammatory action, and improved microcirculation—support its use in integrative and regulatory pain medicine. This study presents strong evidence for neural therapy as an effective, safe, and cost-efficient option in patients with resistant fibromyalgia. Further randomized controlled trials are needed to confirm these findings and establish standard treatment protocols.Yayın Neural therapy as a key modulator in non-specific low back pain(Salient Visionary Publications LLC, 2025) Nazlıkul, Hüseyin; Ural Nazlıkul, Fatma Gülçin; Özkan, Neslihan; Tamam, Yusuf; Acarkan, Tijen; Elmacıoğlu, Mehmet Ali; Bilgin, Mehmet DinçerBackground: Non-specific low back pain (NSLBP) is a widespread musculoskeletal disorder with multifactorial origins, including postural dysfunctions, myofascial imbalances, autonomic dysregulation, and psychosocial influences. Differentiating between functional and degenerative causes is crucial for treatment planning. Conventional therapies often fall short, particularly in chronic cases. This study evaluate the efficacy of neural therapy as a regulatory, minimally invasive treatment option for NSLBP. Methods: This retrospective analysis includes 1,242 patients treated at the Natural Health Clinic between 2017 and 2024. Patients underwent neural therapy targeting modulation of the autonomic nervous system (ANS), resolving interference fields, and treating myofascial trigger points. Treatment duration, symptom severity (VAS, ODI), and functional improvement were assessed, with stratification by age and chronicity. Results: Neural therapy led to complete symptom resolution in 29% of cases and marked improvement in 35%, with only 2% reporting worsening symptoms. Most patients required between 2 and 4 sessions; fewer than 10% needed over 12 sessions. Age and symptom duration correlated with treatment intensity—older and long-term chronic patients often needed more sessions. Combined with manual medicine, neural therapy enhanced outcomes by addressing vegetative dysfunctions, neurogenic inflammation, and segmental restrictions. Conclusion: Neural therapy offers a compelling integrative approach for both functional and degenerative NSLBP. Its ability to regulate autonomic dysfunctions, reduce chronic inflammation, and address underlying interference fields positions it as a practical component of multimodal pain management. The retrospective data from over 1,200 patients underscores its clinical relevance, especially for middle-aged and older adults with chronic symptoms.Yayın Neural therapy in migraine: Clinical evidence for a holistic therapeutic approach - analysis of 464 cases(Salient Visionary Publications LLC, 2025) Nazlıkul, Hüseyin; Ural Nazlıkul, Fatma Gülçin; Bilgin, Mehmet Dinçer; Acarkan, Tijen; Özkan, Neslihan; Tamam, YusufBackground: Migraine is one of the most common neurological disorders and significantly impairs quality of life. While conventional therapies may alleviate symptoms, they often fail to address the underlying causes. Neural therapy is a therapeutic approach in which local anesthetics such as procaine or lidocaine are not primarily used for analgesia but rather to modulate the autonomic nervous system, particularly its sympathetic branch. This method aims to restore functional balance and stabilize dysregulated networks through segmental and systemic reflex pathways, thereby supporting a holistic regulatory effect. Objective: This retrospective study aims to evaluate the effectiveness of neural therapy in 464 migraine patients using a holistic, regulatory medical approach. Methods: Patient history forms were analyzed for hormonal dysregulation, intestinal dysbiosis, temporomandibular dysfunction, C2 vertebral blockage, hydration status, and interference fields. Additionally, clinical treatment progressions were statistically assessed. Results: Over 91% of patients demonstrated clinical improvement, and 60% became symptom-free. The most frequently observed contributing factors were intestinal dysbiosis (89%), hormonal imbalance (71%), and temporomandibular/C2 dysfunctions (43% each). Conclusion: Neural therapy is an effective and regulatory therapeutic option for migraines, particularly in chronic, multifactorial cases. Its integration into a holistic treatment strategy may yield substantial clinical benefits.Yayın The significance of thoracic blockages for the autonomic nervous system – neural therapy and its clinical relevance(Sci Vision Publishers, 2025) Nazlıkul, Hüseyin; Ural Nazlıkul, Fatma Gülçin; Tamam, Yusuf; Oettmeier, Ralf; Acarkan, Tijen; Reuter, Uwe Rudolf MaxBackground: Thoracic blockages not only present as mechanical movement restrictions but also influence a wide range of physiological processes due to their close connection with the autonomic nervous system, particularly the sympathetic nervous system. Persistent sympathetic activation can lead to autonomic dysfunctions, organ disorders, hormonal imbalances, metabolic diseases, myofascial pain syndromes, and circulatory disturbances. Methods: This study analyzes the pathophysiological mechanisms of thoracic blockages and their impact on the spinal and autonomic nervous systems. The primary focus is on the interplay between sympathetic hyperactivity, impaired microcirculation, and the formation of myofascial trigger points. Results: Chronic thoracic blockages can induce reflexive hypertonia of the paravertebral musculature, leading to pain, organ dysfunction, and central nervous system sensitization. This exacerbates muscular imbalances and contributes to the chronicity of pain syndromes. Therapy: Combining neural therapy and manual medicine offers an integrative approach to restoring disrupted physiological balance. While neural therapy targets sympathetic dysregulation and modulates interference fields, manual medicine helps restore mobility and reduce muscular dysfunction. Conclusion: Effective treatment of thoracic blockages requires an interdisciplinary approach that addresses both neurovegetative and mechanical aspects. The combination of neural therapy and manual medicine is an effective method for sustainably regulating structural and functional imbalances while reducing healthcare costs.
