İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Therapeutic effects of mesenchymal stem cell conditioned medium in rat varicocele model
(Korean Society for Sexual Medicine and Andrology, 2024) Şerefoğlu, Ege Can; Kolbaşı, Bircan; Bülbül, Muhammet Volkan; Karabulut, Seda; Çakıcı, Çağrı; Gündoğdu Özdemir, Reyhan Zeynep; Keskin, İlknur
Purpose: This study aimed to examine the therapeutic effects of injection of conditioned medium of adipose-derived mesen chymal stem cells (ADMSC-CM) in a surgically created varicocele model in comparison with varicocelectomy. Materials and Methods: Twenty-eight male Wistar Albino rats were randomly divided into four groups: sham group, varico cele group, varicocelectomy group, and ADMSC-CM injection group. Sperm parameters were analyzed in samples taken from the epididymis after treatment. Malondialdehyde and superoxide dismutase (SOD) levels in blood samples were exam ined by biochemical analysis. The testicular tissues were stained with hematoxylin-eosin for histological examination (John sen’s Score). Additionally, Western Blot analyzes were performed to detect Claudin-11 levels, the functional protein of the blood-testis barrier, in testicular tissues. Results: Varicocelectomy and ADMSC-CM treatments significantly improved mean sperm parameters (concentration, pro gressive motility, motility, normal sperm morphology) (p≤0.05 for all). Both treatment groups had increased SOD levels along with a decrease in malondialdehyde levels (p≤0.05 for all). No significant difference was observed between the ADMSC CM group and the varicocelectomy group in preserving normal testicular histology according to Johnsen’s Score (p=0.114). Levels of Claudin-11 were significantly higher in the varicocelectomy and ADMSC-CM groups compared to the varicocele group (p≤0.05 for all). Conclusions: The therapeutic effects of ADMSC-CM in varicocele model may involve secretion of anti-inflammatory and re generative factors from ADMSC. ADMSC-CM injection appears to be a promising new strategy in the treatment of varicocel
The Homeostasis-Enrichment-Plasticity (HEP®) approach for premature ınfants with developmental risks: A pre-post feasibility study
(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Balıkçı, Aymen; May-Benson, Teresa A.; Sırma, Gamze Çağla; Kardaş, Ayten; Demirbaş, Duygu; Arıcikul Balıkçı, Ayşe Firdevs; İlbay, Gül; Sözen, Hatice Gülhan; Beaudry-Bellefeuille, Isabelle
Background: The environmental enrichment (EE) framework has inspired several early intervention (EI) approaches. This study evaluated the feasibility, safety, caregiver acceptance, and satisfaction of implementing the HEP Approach intervention, a novel EI model based on the EE paradigm. Outcome measures for motor development, individual functional goals, sensory functions, caregiver-provided environmental affordances, and motivation for movement were examined. Methods: A pre-post-study design examined 18 premature infants (<33 weeks six days gestation) with a corrected age of 4–10 months. A 21-item Likert scale survey assessed the feasibility, safety, acceptability, and satisfaction of implementing the HEP Approach intervention. The Peabody Developmental Motor Scales-2, Test of Sensory Functions in Infants, Affordances in the Home Environment for Motor Development, and Infant Movement Motivation Questionnaire were used for outcomes. The goal attainment scale measured progress toward parent goals. The HEP Approach consisted of 12 one-hour sessions implemented over three months. Results: Most participating parents found the HEP Approach intervention feasible, safe, acceptable, and satisfactory. GAS scores demonstrated significant gains with a mean t-score of 67.75 (SD = 2.00). Results found significant improvement (p ≤ 0.05) in all outcome measures. Conclusions: Results suggest that the HEP Approach intervention is safe, feasible, and acceptable to implement. Outcome measures were meaningful and sensitive in identifying improved motor development, individualized parental goals, sensory functions, caregivers’ use of environmental opportunities, and movement motivation in premature at-risk infants. Results suggest further studies on the HEP Approach are feasible, and highlight the potential of this intervention to inspire and guide future research in this field.
Comparison of different machining strategies and their effects on CNC vertical machining center
(2024) Öztürk, Ömer Faruk; Tanrıver, Kürşat; Ay, Mustafa
In today's world, interest in the aviation sector and developments within it continue to grow at an accelerated pace. With this increase, the demand for the production of components for unmanned aerial vehicles, passenger airplanes, or jet aircraft has risen correspondingly. However, due to the complex structure of aviation parts, the strategy employed during their processing is of significant importance. The distortion issue encountered in the machining of aviation parts, particularly in thin-walled components, leads to unwanted dimensional changes and significantly complicates the production of these parts. This study aims to investigate the effects of different machining techniques on the widely used Al 7075 T7351 aluminum alloy in the aviation sector and to contribute the experimental results to both readers and the literature. In the experiments, samples of Al 7075 T7351 aluminum alloy with thicknesses of 1.00 mm, 1.20 mm, and 1.50 mm were processed using various machining strategies. According to the experimental results, the effect of tool strategy on thickness was observed to vary between a minimum of 0.67% and a maximum of 7.78%. Taking the average of the minimum and maximum values of the three samples, the average effect of the tool path strategy on surface roughness was found to be 55.46%, and its effect on parallelism varied between 37.50% and 112.50%. Furthermore, it is believed that the methods presented in this study will contribute to solving similar problems in other industries, in addition to the aviation sector, in areas such as material selection, determination of processing parameters, and compliance of three-dimensional coordinate measurements (CMM) with standards.
Trends and regional differences for fertil ity preservation procedures in women with breast cancer
(Elsevier, 2024) Turan, Volkan; Bedoschi, Giuliano; Lee, Dong-Yun; Barbosa, Caio Parente; Oliveira, Renato de; Saçıntı, Koray Görkem; Sönmezer, Murat; Lambertini, Matteo; Massarotti, Claudia; Schaub, Amelia; Wang, Erica; Gayete-Lafuente, Sonia; Dunlop, Cheryl; Anderson, Richard A.; Bang, Heejung; Oktay, Kutluk H.
Introduction : Breast cancer is the most common malignancy in women of reproductive age and chemotherapy protocols impair fertility, frequently necessitating fertility preservation (FP) referral. Embryo, oocyte, or ovarian tissue cryopreservation are established FP modalities in women with breast cancer but there are few data on their uptake over time. In this study our aim was to determine the regional time trends and utility differences for fertility preservation methods of reproductive tissue cryopreservation. Methods : This multicenter study included 1,623 women diagnosed with breast cancer from seven tertiary centers in six countries (Brazil, Italy, Scotland, South Korea, Turkey, USA). Participant centers provided the details of FP cryopreservation approaches broken down annually from 2012 to 2021. Women with newly diagnosed breast cancer, aged 18-45 years who were referred for FP at participating centers and had normal ovarian function at the time were included. Results : We found a mean increase of 7% per year (p=0.002, adjusting for centers) in the number of women referred for FP. Of those who were referred (n=1623), a mean 38.7% underwent FP (n=629), with a range of 12% in South Korea) to 95% in Brazil. The number of women undergoing ovarian stimulation for FP continually increased until 2021, with oocyte cryopreservation being the most common procedure throughout the study period (p=0.014 for time trend). The proportion of random start ovarian stimulation cycles increased each year from 58.3% in 2012 to 86.8% in 2021, (p=0.005 for time trend, and p=0.04 for 2012 vs. 2021). Conclusions : The utility of FP has steadily increased for young women with breast cancer over the last decade, although regional differences significantly influence FP practices. The findings of our study could have value for policy making in FP care for young women with breast cancer at the local, regional, or global level. Micro abstract Breast cancer is the most common malignancy in women of reproductive age and chemotherapy protocols impair fertility, frequently necessitating fertility preservation referral. The utility of fertility preservation has steadily increased for young women with breast cancer over the last decade, although regional differences significantly influence fertility preservation practices.
Farklı dental tarayıcı teknolojilerinin doğruluklarının değerlendirilmesi: In-Vitro çalışma
(7tepe Klinik, 2024) Ayvalıoğlu Şamiloğlu, Demet Çağıl; Beydili, Serra Nur
GİRİŞ ve AMAÇ: Diş hekimliğinde dijital teknolojinin kullanımı CAD/ CAM sistemlerinin hayatımıza girmesiyle son yıllarda oldukça artmıştır. CAD/CAM sistemleri ile bir iş akışı ağız içi tarayıcılarla direkt veya masaüstü tarayıcılarla indirekt yöntem ile başlayarak takip edilebilir. Bu çalışmanın amacı, tam ark dişli çenelerde masaüstü tarayıcı ve ağız içi tarayıcıların doğruluklarının değerlendirilmesidir. YÖNTEM ve GEREÇLER: Tam ark dişli çene modelinde yer alan kanin ve molar dişleri üzerinde, ISO standartları çerçevesinde, dört adet 6 mm çapında negatif küre oluşturulmuştur. Standart ışıksız ortamda, model, Dijital Şerit Projeksiyon Teknolojisi, Aktif Triangulasyon ve Konfokal Mikroskopi teknolojilerine sahip tarayıcılar ile firmanın önerdiği tarama protokolleriyle 20 kez taranarak dijitalize edilmiştir. Kontrol grubu, referans dijital data, endüstriyel tarayıcı (Solutionix C500, MEDIT) ile elde edilmiştir. Elde edilen tüm dijital data, 3 boyutlu (3B) analiz yazılım programı ile değerlendirilmiştir (Geomagic studio 2015; 3D Systems Inc., Almanya). Normal dağılan veriler için tek yönlü ANOVA ve post hoc Bonferroni testi, normal dağılmayan veriler için Bonferroni, Kruskal-Wallis testi ile değerlendirilmiştir (α=0,05). BULGULAR: Tam ark dişli model taramalarının doğruluğu, masaüstü tarayıcı ve ağız içi tarayıcıların tipine bağlı olarak anlamlı farklılık göstermiştir (p˂0,05). Her iki ağız içi tarayıcı arasında tarama doğruluğu bakımından istatistiksel olarak anlamlı fark bulunmuştur (p˂0,05). TARTIŞMA ve SONUÇ: Tam ark taramalarda dijital sistemlerin kullanılması klinik olarak kabul edilebilir sonuçlar göstermektedir.
