İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Effects of yoga-based and conventional physiotherapy programs on functional, respiratory, and psychosocial outcomes in stage II sarcoidosis: A randomized controlled trial
(Mattioli 1885, 2026) Yıldız, Şeyda; Kavas, Murat; Takinacı, Zuhal Didem; Aydoğan Eroğlu, Selma
Background and aim: Sarcoidosis, a multisystemic granulomatous disease, presents with various clinical symp toms such as deterioration in respiratory functions, decreased exercise capacity, fatigue, sleep disorders, anxiety depression, and consequently reduced quality of life. A standard rehabilitation protocol has not been defined for sarcoidosis, and due to the nature of the disease, holistic approaches are crucial in this group, which is known to have multisystem involvement. Therefore, this study aims to contribute to the development of future rehabilitation protocols by comparing the effectiveness of yoga and conventional physiotherapy programs delivered via telereha bilitation, in addition to standard aerobic training, in sarcoidosis patients with pulmonary involvement. Methods: Thirty-four Stage II sarcoidosis patients were included in this study, and the participants were randomly divided into two groups (conventional physiotherapy, n=16, yoga, n=18). Before and after the 8-week programs, participants completed the following questionnaires: Fatigue Assessment Scale (FAS), Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index (PSQI), and St. George Respiratory Questionnaire (SGRQ). Furthermore, the 6MWT, Body Oxygen Level Test (BOLT), spirometric measurements, DLCO, Maximum inspiratory pressure (MIP), and dyspnea (mMRC score) measurements. Results: Programs significantly improved exercise capacity, inspiratory muscle strength, fatigue (FAS), dyspnea, PSQI scores, anxiety-depression levels, quality of life (SGRQ), and BOLT time in both groups. While similar improvements were observed overall in intergroup comparisons, the increase in MIP and BOLT time was more pronounced in the conven tional physiotherapy group. Neither program resulted in significant changes in spirometric parameters or DLCO values. Conclusions: This study found that both 8-week telerehabilitation-based yoga and conventional physiotherapy programs were effective for patients with Stage II sarcoidosis. The similar effects observed between yoga and con ventional physiotherapy suggest that yoga, a holistic mind-body approach, may be an effective alternative in the treatment of sarcoidosis.
Awareness of forensic odontology and child abuse recognition among desntists
(Sociedade Portuguesa de Estomatologia e Medicina Dentária (SPEMD), 2026) Gürcan, Aliye Tuğçe; Tatlı, Ezgi; Özen, Buğra
Objectives: This study assessed the awareness of dental students and practicing dentists in Turkey regarding forensic odontology and the recognition and reporting of child abuse. Methods: A questionnaire-based cross-sectional study included 406 participants. The 31-item questionnaire covered forensic odontology, child abuse recognition, legal responsibilities, and reporting procedures. A certainty score was calculated from the objectively structured True/False/“I don’t know” items (Q18-Q28), while the remaining items were analyzed descriptively. Descriptive and subgroup analyses evaluated associations between participant characteristics and certainty scores. Internal consistency was assessed using Cronbach’s alpha. Results: The mean certainty score was 5.08 ± 2.74 (range: 0-11), with no significant gender differences (p > 0.05). Cronbach’s alpha indicated acceptable internal consistency (α = 0.74). Many participants were uncertain about medico-legal aspects and reporting procedures. Reporting preferences varied across workplace settings, suggesting inconsistent knowledge of reporting pathways. Conclusions: Although participants demonstrated a general awareness of forensic odontology and child abuse recognition, important uncertainties remained regarding medico-legal responsibilities and reporting procedures. These findings highlight the need to strengthen undergraduate and postgraduate education in forensic odontology and child abuse reporting within dental curricula. However, the findings should be interpreted in light of the study’s exploratory nature and methodological limitations. (Rev Port Estomatol Med Dent Cir Maxilofac. 2026;67(x):1-10)
Protein fermentation in the gastrointestinal system and health effects of its metabolites
(Dünya Kongre, 2025) Demir, Kübra; Mutlu, Hayrettin
Protein fermentation results in the production of short-chain fatty acids, branched-chain fatty acids, ammonia, phenolic and indolic compounds, biogenic amines, hydrogen sulfide, nitric oxide, and other protein-derived intestinal microbial metabolites. These metabolites have beneficial and detrimental effects on host health. Metabolites have beneficial effects, such as controlling energy homeostasis, improving intestinal barrier function, regulating immunity, and exhibiting anti-inflammatory and antioxidant properties. However, high levels of some protein metabolites may reduce colonocyte lifespan, have procarcinogenic, genotoxic, and cytotoxic effects. The number of studies addressing protein metabolites and their health effects in the literature is quite limited. This review aims to comprehensively examine the health effects of these metabolites, which can be considered targets for health research due to their therapeutic potential. For this purpose, keywords were searched in databases using various combinations, and the information obtained was compiled. In conclusion, various studies have reported both beneficial and harmful effects of metabolites on health. However, more studies are needed to better understand the interaction of these metabolites with nutrients and their effects on various cells.
Investigation of the relationship between cancer and the homologous recombination repair (HRR) mechanism
(Acıbadem University, 2026) İntaş, Adar; Muslubaş, Berke; Yılmazer Aktar, Berin; Aysan, Arzu; Aksu, Soner
Background/Aim: A strong correlation exists between Double-strand breaks (DSBs), genomic instability, and cancer development. Homologous Recombination Repair (HRR) is the primary repair mechanism for highly accurate DSB repair. This study aimed to investigate the relationship between cancer and selected 12 genes involved in the HRR mechanism. Materials and Methods: Using the RT-qPCR analysis differences in the expression levels of the Ataxia Telangiectasia Mutated (ATM), BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1), Fanconi Anemia Complementation Group D2 (FANCD2), Tumor Protein p53 Binding Protein 1 (TP53BP1), DNA Polymerase Theta (POLQ), RAD54 Like (RAD54L), AT-Rich Interaction Domain 1A (ARID1A), RAD52 DNA Repair Protein (RAD52), Bloom Syndrome Protein (BLM), SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin Subfamily A Containing DEAD/H Box 1 (SMARCAD1), Werner Syndrome ATPDependent, Helicase (WRN) and RecQ Like Helicase 4 (RECQL4) genes between cancer and normal cell lines were investigated. Frequently used 10 cancer and 2 normal cell lines were used in this study. Results: It was determined that RAD52 was significantly up-regulated only in colon cancer cell lines. ARID1A was significantly down-regulated, particularly in breast and lung cancer. BLM, WRN, TP53BP1, ATM and RAD54L were down-regulated in all cancer types. RECQL4 was down-regulated in breast and lung cancer, but up-regulated in liver and brain cancer. BRIP1 was down-regulated in breast, brain, and lung cancer, but up-regulated in liver and colon cancer cell lines. FANCD2 was up-regulated only in lung cancer, and significantly down-regulated in all other cancer types. POLQ was significantly down regulated especially in lung cancer. Conclusion: This study has provided preliminary results suggesting that the expression differences observed in the interested genes could be used as a molecular indicator for the carcinogenesis. Meaningful results have also been obtained indicating that diagnostic panels based on gene expression levels can be developed for monitoring cancer progression.
Knowledge and practices of students receiving cooking education about food safety: The example of Istanbul province
(İstanbul Aydın Üniversitesi, 2026) Mutlu, Hayrettin; Tokay, Murat Mutlu; Ercan Karakaya, Zeynep
Nutrition is the most basic need for a healthy life. Healthy food consumption depends on ensuring food safety. Food safety encompasses processes that protect food from physical, biological, and chemical hazards and prevent loss of nutritional value at all stages, from production to the table. In this cross-sectional study, a face-to-face survey was administered to 348 students (male: 183; female: 165) enrolled in three high schools of tourism and hotel management in Istanbul. The overall knowledge level about food safety was higher among female students (14.553.44) than among male students (13.57±3.55) (p < <0.05). The total food safety knowledge level scores for the classes were 13.37±3.50, 14.64±3.60, and 14.22±3.70 in the 10th, 11th, and 12th grades, respectively. A significant increase was detected from the 10th to the 11th grade, whereas the 12th-grade scores remained comparable to those of the 11th grade (p<0.05). The results indicate the need to expand and sustain food safety education. In conclusion, the findings demonstrate that food safety education is a crucial tool for supporting access to healthy, safe food.
