Yazar "Bisgin, Tayfun" seçeneğine göre listele

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    Can neoadjuvant chemoradiotherapy be omitted in cT2N+ and cT3 mid-rectal cancer: Protocol for a prospective, observational, cohort study (CANO)
    (Public Library of Science, 2025) Karakayalı, Feza; Arslan, Çiğdem; Bisgin, Tayfun; Erenler Bayraktar, İlknur; Bayraktar, Onur; Canda, Aras Emre
    Background Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME) is the standard treatment for locally advanced rectal cancer. However, nCRT is associ ated with significant morbidity, impacting patients’ quality of life. Recent advancements in MRI-based risk stratification have raised the possibility of omitting nCRT in selected patients without compromising oncologic outcomes. This study aims to evaluate whether upfront TME alone achieves similar 3-year disease-free survival compared to the standard approach of nCRT followed by TME in patients with cT2N+ and cT3Nx mid-rectal cancer without MRI-based high-risk features regarding local recurrence. Methods The CANO trial is a prospective, multicenter, observational cohort study involving 436 patients across Türkiye. Eligible patients will be classified into two groups: those undergoing direct TME and those receiving nCRT followed by TME. The primary endpoint is 3-year disease-free survival (DFS), with secondary outcomes including 5-year DFS, overall survival, local recurrence rates, and quality of life assessments using validated questionnaires. Data will be prospectively collected and monitored by the steering committee with predefined interim analyses. Discussion The CANO trial addresses the ongoing debate regarding selective omission of nCRT in low-risk mid-rectal cancer. By leveraging MRI-based risk stratification and PLOS One | https://doi.org/10.1371/journal.pone.0321819 November 5, 2025 2 / 11 a collaborative national network, the study aims to provide high-quality evidence supporting a more personalized treatment approach. The findings have the potential to reduce treatment-related morbidity without compromising oncologic safety, contrib uting to the refinement of current guidelines.
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    Complex ventral hernia repair using botulinum toxin with combination of Fasciotens® after colorectal surgery: A video vignette
    (Wiley, 2026) Demirli Atıcı, Semra; Yıldırım, Yasemin; Canda, Aras Emre; Terzi, Mustafa Cem; Arslan, Çiğdem; Erenler Bayraktar, İlknur; Bayraktar, Onur; Bisgin, Tayfun
    Complex ventral hernia repair using botulinum toxin with combination of Fasciotens® after colorectal surgery: A video vignette
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    Functional and surgical outcomes of ventral mesh rectopexy in male patients with rectal prolapse: A nationwide multicenter retrospective cohort study by the pelvic floor working group of the Turkish society of colon and rectal surgery (TSCRS)
    (Springer Nature Link, 2026) Gültekin, Fatma Ayça; Balcı, Bengi; Kuzeyli Yıldırım, Yasemin; Arslan, Çiǧdem; Yaşar, Necdet Fatih; Bisgin, Tayfun; Bayraktar, Adem; Zenger, Serkan; Şengül, Neriman; Bulut, Türker Mehmet
    Background The indications and outcomes of ventral mesh rectopexy (VMR) in the treatment of rectal prolapse in males have been minimally addressed in the literature. This study aimed to evaluate the demographics, clinical characteristics, and surgical outcomes associated with VMR in male patients. Methods This nationwide retrospective cohort study included male patients who underwent VMR at centers performing pelvic floor surgery across Turkey. Clinical and surgical characteristics were obtained, and functional outcomes were evalu ated using Cleveland Clinic Incontinence score (CCIS) and Altomare Obstructed Defecation Syndrome (ODS) scores at the pre- and postoperative periods. Results Forty-one male patients (mean age, 45.4 years; mean BMI, 25.6 kg/m2 ) underwent VMR (2 open, 5 robotic, and 34 laparoscopic). The cohort comprised 11 patients with internal rectal prolapse (IRP) and 30 with external rectal prolapse (ERP). The overall complication rate was 17.1% (2.4% related to mesh), with a 12% recurrence rate. The median follow-up was 33 (6–127) months. The recurrence rate was 36.4% for IRP patients and 3.3% for ERP patients (p=0.014). Significant improvements were observed in the CCIS (preoperative: 6.1±4.8; postoperative: 2.8±3.3, p=0.005) and Altomare ODS (preoperative: 11.9±4.6; postoperative: 7.26±5.8, p<0.001). Conclusions In this nationwide retrospective cohort study, VMR was associated with favorable functional outcomes in males. Recurrence rates were significantly higher in those with internal rectal prolapse. As sexual function was not systematically assessed, prospective studies with standardized patient-reported outcomes are warranted.