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  • Küçük Resim
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    Phthalocyanines bearing silazane group for colorectal cancer
    (Elsevier, 2021) Özdemir, Mücahit; Artuç, Gamze Özgül; Guler, Eray Metin; Yalçın, Bahattin; Salan, Ümit; Bozali, Kübra; Görgülü, Ahmet Orhan; Bulut, Mustafa
    The synthesis of bis(trimethylsilyl)amine substituted zinc(II), and indium(III) chloride phthalocyanine complexes have been performed. The obtained compounds were characterized by spectroscopic methods. All synthesized phthalocyanine derivatives were evaluated for cytotoxic, genotoxic, and apoptotic activities on LoVo cell lines which are the standard colorectal cancer cell lines derived from metastatic site: left supraclavicular region. Nonperipheral silazane substituted zinc phthalocyanine (5) showed quite different behavior from all the other compounds analyzed and found to be the best cytotoxic, genotoxic, and apoptotic compound. All derivatives showed no proliferative effect at all doses. All phthalocyanine compounds increased cytotoxicity, DNA damage, apoptosis, and intracellular ROS dose-dependent manner. To explain and verify in vitro tests, phthalocyanine compound structures were optimized using density functional theory, and in silico molecular docking studies on B-DNA dodecamer were performed. Both the experimental and theoretical findings comply with each other.
  • Küçük Resim
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    Preparation and characterization of an acrylated-coumarin-containing photo-crosslinked thiol-ene network: Investigation of the free-volume, thermal, UV, and photoluminescence properties
    (Wiley, 2025) Uyumaz, Fatmanur; Artuç, Gamze Özgül; Pehlivan, Gamze; Akdoğan, Ayça; Yahşi, Uğur; Tav, Cumali; Bulut, Mustafa; Kahraman, Memet Vezir
    Coumarin, a versatile compound, has attracted great interest in polymer science due to its unique properties and diverse applications. The use of coumarins in polymer research opens avenues for the development of materials with improved functionalities. In this study, an acrylated coumarin (a-coumarin) compound containing polymeric films was obtained via UV curing through a thiol-ene click reaction with a free radical mechanism. The obtained a-coumarin-containing polymeric films were subjected to functional characterization using FTIR and NMR analyses and thermal characterization via DSC and TGA. UV–vis and PL analyses were performed to determine the optical properties. Using positron anni hilation lifetime spectroscopy (PALS), the free volume and proportional free volume fraction of the films were analyzed both below and above the glass transi tion temperature (Tg). The Tg values obtained from PALS were several degrees lower than those obtained via DSC. A-coumarin additives inhibit segmental mobility, hence reducing the proportional free volume fraction and increasing the Tg. This study is the first in the literature to investigate the free volume properties of coumarin-containing polymeric films. The study reveals the impact of a-coumarin on thermal, optical, and free volume properties, paving the way for the design of advanced functional materials.