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Characterization of bovine bone marrow derived mesenchymal stem cells and immunostaining of differentiated neurospheres
(Hellenic Veterinary Medical Society, 2023) Dikmen, Tayfun; Özden Akkaya, Özlem; Nawaz, Shah; Erdoğan, Metin
Stem cell differentiation has been a key element for the therapeutical applications for various disorders. The novel anti-inflammatory and angiogenic findings and potential applications for both autologous and allogenic studies have emphasized about the usage of mesenchymal stem cells in the clinical trials. The neurosphere differentia-tion studies and their role for peripheral nerve injuries have gained momentum recently. Following study emphasized on the isolation of stem cells from bovine bone marrow and characterization of their mesenchymal potential by PCR followed by their differentiation into mesodermal lineages and into neurospheres under specific induction media. The generated neurospheres were further investigated for their potential expressions of neuroprogenitor markers Sox2, Nestin and neurofilament protein β-III Tubulin by immunofluorescence staining. The results of following study high-light the unique potential of bone marrow derived mesenchymal stem cells for translational research and regenerative therapy in nervous tissue injuries.