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    Long-term effects of neural therapy in fibromyalgia – A retrospective multicenter analysis effectiveness of neural therapy in patients with fibromyalgia
    (Salient Visionary Publications, 2025) Ural Nazlıkul, Fatma Gülçin; Nazlıkul, Hüseyin; Özkan, Neslihan; Acarkan, Tijen; Tamam, Yusuf; Orak, Murat; Bilgin, Mehmet Dinçer
    Background: Fibromyalgia syndrome (FMS) is a chronic pain condition associated with widespread musculoskeletal discomfort, persistent fatigue, and diminished quality of life. Many patients show limited response to conventional treatments. Neural therapy (NT), a core modality of regulatory medicine, aims to restore autonomic balance and modulate inflammatory reflexes through targeted injections of local anesthetics. Objective: This retrospective multicenter study evaluates the long-term effectiveness of NT in 565 patients with treatment resistant fibromyalgia who previously failed to respond adequately to standard therapies. Methods: Data were collected from five neural therapy clinics between 2017 and 2024. Standardized outcome measures were assessed at baseline, immediately post-treatment, and at 3, 6, and 12 months: Pain intensity: Visual Analog Scale (VAS) Disease burden: Fibromyalgia Impact Questionnaire (FIQ) Quality of life: Short Form-36 (SF-36), including subdomains (physical function, pain, energy/fatique, social function, general health perception) Statistical analysis employed the Friedman test for repeated measures. Results: VAS scores dropped from a mean of 8.5 to 1.9 post-treatment and remained below 3.0 over 12 months. FIQ scores decreased from a baseline mean of 78.1 to 18.6 and remained significantly improved (mean 24.9 at 12 months). SF-36 physical function increased from 33.5 to 82.0, with sustained gains at all follow-ups. Social functioning, general health perception, pain and vitality domains showed similar sustained improvements. The treatment completion rate was 92.9%, indicating high tolerability and patient satisfaction. Conclusion: Neural therapy produced significant and sustained improvements in pain, physical functioning, energy, and social participation in fibromyalgia patients. Its multimodal effects—autonomic modulation, anti-inflammatory action, and improved microcirculation—support its use in integrative and regulatory pain medicine. This study presents strong evidence for neural therapy as an effective, safe, and cost-efficient option in patients with resistant fibromyalgia. Further randomized controlled trials are needed to confirm these findings and establish standard treatment protocols.