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    Assessment of nutritional composition of Turkish Red crescent menus after the M7.8 and M7.6 earthquakes in Kahramanmaraş, Türkiye
    (Cambridge University Press, 2024) Günalan, Elif; Yoldaş, Tuba; Turgut, Rana; Yenigün, Ayça; Yıldırım Çavak, Betül; Parmaksız, Ayhan
    Objective: This study aims to evaluate the nutritional content and quality of the Turkish Red Crescent (TRC) menus delivered to earthquake victims after the 2023 earthquakes in Kahramanmaraş, Türkiye. Methods: The menus of general, search-rescue, diabetes, and celiac were obtained from the TRC following the magnitudes of 7.8 and 7.6 Kahramanmaraş earthquakes. The nutrient content of the menus was evaluated with the Nutrient Rich Food (NRF20.3) score. In addition, the menus’ energy, macronutrient, and micronutrient contents were compared with the dietary reference intake values of the Türkiye Dietary Guideline—2022, European Food Safety Authority, and Food and Drug Administration. Results: The general menu was insufficient to meet the daily requirements of vitamin D, vitamin K, vitamin C, calcium, and potassium for earthquake victims. The sodium, phosphorous, and omega-6/omega-3 ratios were much higher than the recommended intakes. The NRF20.3 score of the diabetes menu was significantly higher than the search-rescue and celiac menus (P < 0.05). The energy content of the search-rescue menu was significantly higher than that of other menus (P < 0.05). Conclusion: The several nutritional risks were determined in TRC menus for earthquake victims who suffered from the Kahramanmaraş earthquakes. Several supplementation programs can be applied to the earthquake regions to obtain strength immunity and effectively challenge posttraumatic stress symptoms.
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    Depremzedelerin optimal sağlığı için besinsel takviyelerin önemi
    (Özgür Yayınları, 2023) Turgut, Rana; Yenigün, Ayça; Mutlu, Hayrettin; Günalan, Elif; Öztürk, Musa; Kırca, Mustafa
    (Dünya Sağlık Orgütü, doğal afeti "dış yardım gerektirecek kadar büyük ve ani ekolojik fenomen" olarak tammlamaktadır. Yer kabuğunda ani olarak ortaya çıkan enerjinin dalgalar halinde yer yüzeyini sarsmasıyla görülen dep-remler, can kapplarmın yanı sıra ciddi ekonomik kayıplara da neden olan önemli doğal afetlerdendir (Bao ve ark, 2021). Afet hazırlığı içerisinde yer alan "afet beslenmesi" kavramı 2000'li yıllarda geliştirilen yeni bir kavramdır (Koenig ve Schultz, 2010). Doğal afet sırasında gıda ve beslenme yönetimi ise afetin evresine göre farklılık göstermektedir ("Euboyama-Kasaoka ve Pur-ba, 2014).
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    The therapeutic effects of bioactive compounds on colorectal cancer via PI3K/Akt/mTOR signaling pathway: A critical review
    (Wiley, 2024) Demir, Kübra; Turgut, Rana; Şentürk, Selcen; Işıklar, Handan; Günalan, Elif
    Understanding the molecular signaling pathways of colorectal cancer (CRC) can be accepted as the first step in treatment strategy. Permanent mTOR signaling activation stimulates the CRC process via various biological processes. It supplies the survival of CRC stem cells, tumorigenesis, morbidity, and decreased response to drugs in CRC pathogenesis. Therefore, inhibition of the mTOR signaling by numerous bioactive components may be effective against CRC. The study aims to discuss the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. The potential molecular effects of bioactive compounds on the mTOR pathway's upstream and downstream targets are examined. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration, and suppression of glycolysis through mTOR signaling inhibition. As a result, carcinogenesis is inhibited by inducing apoptosis and autophagy. However, it should be noted that studies are primarily in vitro dose-dependent treatment researchers. This study raises awareness about the role of phenolic compounds in treating CRC, contributing to their future use as anticancer agents. These bioactive compounds have the potential to be developed into food supplementation to prevent and treat various cancer types including CRC. This review has the potential to lead to further development of clinical studies. In the future, mTOR inhibition by applying several bioactive agents using advanced drug delivery systems may contribute to CRC treatment with 3D cell culture and in vivo clinical studies.