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  • Yayın
    The Homeostasis-Enrichment-Plasticity (HEP®) approach for premature infants with developmental risks: A pre-post feasibility study
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024) Balıkçı, Aymen; May-Benson, Teresa A.; Sırma, Gamze Çağla; Kardaş, Ayten; Demirbaş, Duygu; Arıcikul Balıkçı, Ayşe Firdevs; İlbay, Gül; Sözen, Hatice Gülhan; Beaudry-Bellefeuille, Isabelle
    Background: The environmental enrichment (EE) framework has inspired several early intervention (EI) approaches. This study evaluated the feasibility, safety, caregiver acceptance, and satisfaction of implementing the HEP Approach intervention, a novel EI model based on the EE paradigm. Outcome measures for motor development, individual functional goals, sensory functions, caregiver-provided environmental affordances, and motivation for movement were examined. Methods: A pre-post-study design examined 18 premature infants (<33 weeks six days gestation) with a corrected age of 4–10 months. A 21-item Likert scale survey assessed the feasibility, safety, acceptability, and satisfaction of implementing the HEP Approach intervention. The Peabody Developmental Motor Scales-2, Test of Sensory Functions in Infants, Affordances in the Home Environment for Motor Development, and Infant Movement Motivation Questionnaire were used for outcomes. The goal attainment scale measured progress toward parent goals. The HEP Approach consisted of 12 one-hour sessions implemented over three months. Results: Most participating parents found the HEP Approach intervention feasible, safe, acceptable, and satisfactory. GAS scores demonstrated significant gains with a mean t-score of 67.75 (SD = 2.00). Results found significant improvement (p ≤ 0.05) in all outcome measures. Conclusions: Results suggest that the HEP Approach intervention is safe, feasible, and acceptable to implement. Outcome measures were meaningful and sensitive in identifying improved motor development, individualized parental goals, sensory functions, caregivers’ use of environmental opportunities, and movement motivation in premature at-risk infants. Results suggest further studies on the HEP Approach are feasible, and highlight the potential of this intervention to inspire and guide future research in this field.
  • Yayın
    Is there a relationship between the disease duration of migraine and symptoms of depression and anxiety?
    (Sağlık Bilimleri Üniversitesi Kocaeli Derince Eğitim ve Araştırma Hastanesi, 2022) Ur Özçelik, Emel; Özarslan, Melek
    INTRODUCTION: We aimed to investigate the relation between disease duration and severity of anxiety disorder and depression symptoms in migraine patients. METHODS: Two-hundred ninety-one patients with a definitive diagnosis of migraine according to ICHD-3 beta and who did not receive any other treatment for prophylaxis for at least one month were included. Headache diaries, Beck anx iety, and Beck depression inventories were filled. Whether there is a linear relationship between disease duration of migraine and the score s of depression and anxiety inventories was investigated using appropriate statistical methods. The patients were di vided into six groups according to their disease duration as follows: <2 years (Group A), >2-<5 years (Group B), >5-<10 years (Group C), >10- <15 years (Group D), >15-<20 years (Group E), and >20 years (Group F). RESULTS: The mean age of the patients was 35.6±10.2 years, of which 93.1% were female (n=271), and the mean disease duration was 11.84±8.2 years. No significant difference was found between the groups regarding the mean scores of Beck depression and anxiety inventories (p>0.05). There was also no correlation between the duration of migraine and the scores of Beck depression (r(291)=0.007, p=0.970) and anxiety (r (291)=-0.033, p=0.573) inventories. DISCUSSION AND CONCLUSION: No significant difference was determined between the severity of depression a nd anxiety symptoms in patients with a longer disease duration compared with those with shorter duration. The data we obtained may be related to the fact that the co-existence of migraine and the symptoms of depression and anxiety disorder is in the nature of the disease, independent of disease process.
  • Yayın
    Anatomical and functional alterations in juvenile myoclonic epilepsy: voxel-based morphometry and resting-state fMRI study
    (Wiley, 2022) Ur Özçelik, Emel; Ay, Ulaş; Kurt, Erkan; Şirin, Nermin Görkem; Bebek, Nerses; Demiralp, Tuğba; Baykan, Betül
    Purpose: We aimed to investigate the structural and functional brain abnormalities in juvenile myoclonic epilepsy (JME) patients with photosensitivity. Methods: Thirty JME patients, 15 of (50%) who were photosensitive (JME-PS) and 32 healthy controls (HC) were involved in the study. The high-resolution T1-weighted MRI data were acquired for voxel-based morphometry (VBM) analysis, and resting-state functional MRI data were acquired for functional connectivity (FC) analysis. The regions that showed significant differences in VBM analyses, were used as regions of interest in FC analysis for the comparisons between the whole JME group, which consist of PS and non-photosensitive (NPS) JME subgroups, and HCs. Cluster-level significance was set at family-wise error (FWE) corrected p < 0.05. Results: The left postcentral gyrus showed decreased connectivity in the right dominant bilateral middle cingulate gyrus, the right dominant bilateral supplementary motor area, and right superior frontal gyrus whereas left cerebellum crus 1 showed decreased connectivity in right cerebellum lobule IX and dorsal pons in JME-PS compared to the HCs (pFWE-corr = 0.0014, pFWE-corr = 0.0436,respectively).The left middle temporal gyrus showed decreased connectivity with the left dominant bilateral superior frontal gyrus in JME-PS compared to JME-NPS (pFWE-corr = 0.0016). Left precentral gyrus showed; i) increased connectivity with left superior frontal gyrus in JME-NPS compared to HCs (pFWE-corr = 0.0015), ii) decreased connectivity with right dominant bilateral calcarine fissure and occipital pole in JME-PS compared to JME-NPS (pFWE-corr = 0.0103).
  • Yayın
    The evaluation of videos about branched-chain amino acids supplements on YouTube™: A multi-approach study
    (Multidisciplinary Digital Publishing Institute (MDPI), 2022) Günalan, Elif; Turhan, Saadet; Yıldırım Çavak, Betül; Kaya Cebioğlu, İrem; Çonak, Özge
    Branched-chain amino acids (BCAAs) are one of the most controversial ergogenic aids in terms of effectiveness and safety. This study aimed to evaluate the quality and reliability of BCAA supplements related to English videos on YouTube™ and to synthesize with the sentiment–emotion analysis of comments on videos. The content analysis of the information on videos was evaluated with the use of DISCERN, Journal of American Medical Association (JAMA) benchmark criteria, and Global Quality Score (GQS). In addition, word cloud and sentiment and emotional analysis of comments in videos were performed with the R package. As a result, the mean ± standard error values of DISCERN, JAMA, and GQS scores of all videos were 29.27 ± 1.97, 1.95 ± 0.12, and 2.13 ± 0.17, respectively. It was found that advertisement-free videos have a significantly higher DISCERN and GQS score than advertisement-included videos (p < 0.05). A moderately significant positive correlation was determined between DISCERN score of video content and the positive sentiment of video comments (rs: 0.400, p = 0.002). In conclusion, it was determined that BCAA-related YouTube™ videos have mostly very poor quality in terms of content and that videos with higher quality may receive positive comments from viewers according to the DISCERN instrument.
  • Yayın
    Pretreatment electroencephalographic features in patients with childhood absence epilepsy
    (Elsevier, 2022) Ur Özçelik, Emel; Çokar, Özlem; Demirbilek, Veysi
    Objective To analyze the ictal and interictal electroencephalographic (EEG) features in newly diagnosed childhood absence epilepsy (CAE) and determine the association between seizure onset topography, interictal focal spike-wave discharges (FSWDs) and accompanying clinical features of absence seizures. Methods The authors searched the EEG database for a definite diagnosis of CAE according to ILAE 2017 criteria. Video-EEGs of untreated pediatric patients during sleep and wakefulness were evaluated retrospectively. Results The study included 47 patients (25 males, 22 females). Interictal FSWDs were observed in 49% of patients with CAE during wakefulness and in 85.1% during sleep (p = 0.001). Interictal FSWDs were most frequently observed in the frontal regions (awake: 34%; asleep: 74.5%), followed by the posterior temporoparietooccipital region (awake: 21.2%; asleep: 36.1%), and the centrotemporal region (awake: 6.4%; asleep: 8.5%). Eleven patients (23.4%) had polyspikes during sleep. Both bilateral symmetric and asymmetric seizure onset were noted in 32%, whereas focal seizure onset was observed in 14.9% of the patients. Absence seizures with and without motor components were seen in 72.3% and 61.7% of patients, respectively, and in 33% of patients both occurred. There were no associations between the existence of interictal FSWDs, focal/asymmetric seizure onset, and absence seizures with and/or without motor components. Conclusion Asymmetric and/or focal seizure onset, interictal FSWDs, and absence seizures with motor components are commonly observed in drug-naive CAE. This study found no association between seizure onset topography, interictal FSWDs, and semiological features of absence seizures.
  • Yayın
    Dietary supplement use of Turkish footballers: differences by sex and competition level
    (Multidisciplinary Digital Publishing Institute (MDPI), 2022) Günalan, Elif; Yıldırım Çavak, Betül; Turhan, Saadet; Kaya Cebioğlu, İrem; Domínguez, Raúl; Sánchez-Oliver, Antonio Jesús
    Abstract This study aimed to evaluate the consumption of dietary supplements (DS) and to determine related topics in Turkish football players of different sexes and competition levels. A total of 117 footballers (79 males and 38 females) completed a specific survey regarding DS consumption in athletes. The type of DS ingested was classified based on the level of scientific evidence by the Australian Institute of Sport (AIS): group A (high level of scientific evidence), group B (DS that could have a positive effect, but require more evidence), group C (evidence is against their use), and group D (prohibited substances). After a Kolmogorov–Smirnov test, a t-test or Mann–Whitney U test was performed for quantitative variables, while Pearson’s chi-square and odds ratio (with the confidence interval) were performed for qualitative variables. Of the sample, 87.2% reported having consumed DS, with a higher consumption rate in males (males: 93.7%, females: 73.7%; p = 0.006; OR = 5.3 [1.7–16.8]) and professional players (professional: 98.2%, non-professional: 77.4%; p < 0.001; OR = 7.9 [1.2–52.3]). Males and professional players consume more sports foods (p < 0.001), performance supplements (p < 0.001), and total group A supplements (p < 0.001) compared to females and non-professionals. In addition, males consume more medical supplements (p = 0.012) and total group C supplements (p < 0.001) than female footballers. The most consumed DS were sports drinks (63.2%), magnesium (52.1%), vitamin C (51.3%), vitamin D (46.2%), caffeine (38.5%), sports bars (37.6%), whey protein (28.2%), meat protein (25.6%), vitamin E (24.8%), and omega-3 fatty acids (24.8%). The supplement consumption was higher in male and professional footballers. According to the AIS classification, there were significant differences in the consumption of sports foods, medical supplements, performance supplements, and the total number of group A and group C supplements according to sex, and there were significant differences in the consumption of sports foods, performance supplements, and the total number of group A supplements according to competition level.
  • Yayın
    Use of dietary supplements in Turkish professional soccer players: Preliminary data
    (Instituto Politécnico de Setúbal, 2022) Günalan, Elif; Yıldırım Çavak, Betül; Turhan, Saadet; Kaya Cebioğlu, İrem; Domínguez, Raúl; Sanchez-Oliver, Antonio Jesús
    The usage of dietary supplements (DS) is a potential strategy to achieve success for professional soccer players who have a very challenging schedule with national and international competitions. The aim of this study is to evaluation the DS consumption and related issues of Turkish soccer players. 117 professional soccer players (79 male and 38 female) participated to the study. All the participants completed DS consumption related spesific questionnaire which including parts of demographic properties, sports/ training and consumption of DS. According to results, 87.2% (n=102) of participants declared consuming at least one supplement. Consumption of DS was determined a higher amount in males than females (93.7% vs. 73.6%). The average number of consumed DS (plus the std. dev.) by the participants was calculated as 7.4 ± 7.0 (10.1 ± 7.5 in males vs. in females 4.0 ± 4.3). The mostly consumed DS were sports drinks (63.2%), magnesium (52.1%), vitamin C (51.3%), vitamin D (46.2%), caffein (38.5%), sports bar (28.2%), whey protein (28.2%), meat protein (25.6%), vitamin E (24.7%), omega 3 fatty acids (24.8%), zinc (23.1%), electrolites (22.2%) and iron (22.2%). The major reason for consumption of DS was to increase the sport performance (65.8%). Most common sites of purchase were soccer club (38.5%), pharmacy (25.6%) and internet (18.8%). Main sources of DS consuming motivation were dietitian (39.3%) and physical trainer (35%). Consumption of DS was widely common behaviour among Turkish professional soccer players. However, it has been observed that there were majör differences in consumption awareness of DS among soccer players who were different sexes. In the further analysis and studies, the investigation of the consumption of DS within the framework of legality, effectiveness and reliability will be important in terms of protection and improvement the health of soccer players.
  • Yayın
    Quality and reliability analysis of youtube videos about branched-chain amino acids supplements: a pilot study
    (ICBH, 2022) Günalan, Elif; Turhan, Saadet; Yıldırım Çavak, Betül; Kaya Cebioğlu, İrem; Çonak, Özge; Acaröz, Ulaş
    Abstract: The branched-chain amino acids (i.e. leucine, isoleucine and valine) (BCAA) play role in stimulating protein synthesis, recovery processes from exercise and protection of mental health after prolonged exercise. However, unconscious intake of BCAA supplements may contribute to the progression of pathological conditions such as renal failure and cancer, especially in unhealthy people. Social media tools such as YouTube and etc. are effective platforms to promote the use of such supplements. The aim of the study was to determine quality and reliability of branched-chain amino acids supplements related English videos on YouTube. “BCAA” and “BCAA supplements” terms were searched as key words and the mostly viewed 100 videos were obtained for each term. Unrelated to BCAA, non-Turkish and duplicated videos were excluded from study. Following the exclusion criteria, 9 videos were selected from 200 videos. The duration of videos, the number of like, the number of views and job of the person in the video were recorded. The quality and reliability of information on videos were evaluated using DISCERN, Journal of American Medical Association (JAMA) benchmark criteria and global quality score. The job of the person in videos was mostly fitness trainer (%88). The mean of DISCERN score was 41.5 ± 13.2, the mean of JAMA score was 1.2 ± 0.4 and the mean of global quality score was 2.6 ± 1.1. There was significantly positive correlation between JAMA score and video duration (r=0.8, p<0.05). According to findings, mostly viewed Turkish videos about BCAA were mostly low and average quality. Sports supplements are products consumed globally, and large-scale studies with much more videos are needed to identify the potential risk.