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Yayın Regenerative dentistry: Applications of bioactive materials in dentin-pulp complex(Springer Nature Link, 2025) Şişmanoğlu, Soner; Işık, Vasfiye; Erçal, PınarTissue engineering in dentistry is revolutionizing the regeneration of dental pulp. The dental pulp is a specialized connective tissue that plays an important role in maintaining tooth health and supporting healing processes. However, exposure of the pulp to harmful factors, such as infections or trauma, can negatively impact its function, leading to inflammation, tissue necrosis, and ultimately pulp loss. As a solution to these challenges, tissue-engineered vital pulp therapies (VPTs) are emerging as an alternative to conventional root canal treatments. These therapies aim to preserve the vitality of the pulp, stimulate natural healing processes, and restore the dentin-pulp structure. Regenerative dentistry is also exploring tissue repair through innovations such as three-dimensional (3D) bioprinting, exosome-based therapies, and novel scaffold structures.This chapter explores the potential of tissue engineering in dental pulp regeneration, focusing on the role of stem cells, growth factors, scaffolds, and bioactive materials. In particular, stem cells derived from dental pulp are critical to this process due to their ability to differentiate into odontoblast-like cells and promote dentin production. The combination of these stem cells with bioactive scaffolds that release growth factors can significantly enhance the healing of pulp tissue. Furthermore, innovative materials, such as calcium silicate-based materials and bioactive glasses, have shown promising results in pulp regeneration and restorative dentin formation. While the future of these therapies is promising, challenges such as clinical application, long-term efficacy, and cost-effectiveness remain. As research advances, the importance of interdisciplinary collaboration and clinical trials will grow in overcoming these barriers.Yayın Regenerative strategies in pediatric dentistry: A comprehensive overview of tissue engineering from past to future(Springer Nature Link, 2025) Şirinoğlu Çapan, Belen; Birant, Sinem; Gümüştaş, Burak; Erçal, Pınar; Şişmanoğlu, SonerTissue engineering in pediatric dentistry focuses on regenerating damaged dental tissues in children, aiming to restore their natural functions and address challenges associated with immature teeth. This field applies interdisciplinary biological principles to repair and regenerate tissues, using biomaterials, stem cells, and growth factors. Current advancements emphasize the regeneration of the dentin-pulp complex and tooth development through the use of biomaterials such as collagen, which offers structural support for cell growth and favorable interactions in tissue engineering. Additionally, various growth factors like FGF, TGF-β, BMP, and VEGF play vital roles in tissue regeneration by regulating signaling mechanisms in the dentin-pulp complex. Stem cells, particularly dental-derived ones such as DPSCs, SHEDs, and PDLSCs, have shown great potential in regenerating dental tissues in pediatric patients. These multipotent cells are capable of differentiating into various lineages, including odontoblasts, and are essential for the regeneration of both soft and hard dental tissues. While gene therapy, scaffolding techniques, and advanced technologies like three-dimensional (3D) bioprinting hold promise for tissue engineering, challenges remain in clinical implementation due to high costs and the need for further research. However, tissue engineering has already begun revolutionizing pediatric dental treatments, particularly in regenerative endodontics, and offers a minimally invasive alternative to traditional procedures like root canal treatments for young immature teeth. The future of regenerative dentistry in pediatric care lies in improving the application of stem cell–based therapies and bioactive materials to achieve complete tissue regeneration and provide more effective, personalized care for young patients.Yayın Principles and applications of computeraided design (cad) and computeraided manufacturing (cam) in maxillofacial surgery(Turkiye Klinikleri Yayınevi, 2025) Koçyiğit Daştan, Hayrunisa; Sağlam, ReyhanMaxillofacial surgery requires precise repair and treatment of complex anatomical structures. Accord ingly, computeraided design and manufacturing (CAD/CAM) systems provide significant advantages in designing patientspecific implants, producing surgical guides and optimizing preoperative planning processes. In particular, 3D printing technology offers a revolutionary innovation in the production of personalized implants and surgical guides. In maxillofacial surgery, biocompatible materials such as titanium, PEEK (polyetheretherketone), bioceramics and biological graft materials are frequently preferred for their tissue compatibility, mechanical durability and aesthetic advantages. CAD/CAM systems have advantages such as surgical precision, shorter operative times and patient satisfaction. However, there are challenges such as limitations of the technology and high cost. CAD/CAM systems are expected to develop further in the future. The potential offered by nextgeneration technologies in the field of maxillofacial surgery is demonstrated, and it is expected that these innovations will be increasingly used in clinical practice.Yayın The effect of implant position, thread design and tilting on marginal bone resorption in tilted implant system(Ağız ve Çene Yüz Cerrahisi Birliği Derneği, 2024) Aktürk, Hüsna; Çapkat, Ulviye; Bilgi Özyetim, Esra; Dayan, Süleyman Çağatay; Geçkili, Onur; Ramazanoğlu, MustafaThe all-on-four system utilizes 2 parallel anterior implants and 2 distally tilted posterior implants between mental foramina on mandible, between maxillar sinuses on maxilla with an immediately loaded temporary fixed prosthesis. Purpose of this study is evaluating the effect of implant position, thread design and tilting on marginal bone resorption after tilted implant surgery similar to the all-on-four system. 17 patient recieved 92 implants with 2 different forms (level, rapid). Radiographic assessment of marginal bone level change was performed at 1 year follow-up period. The differences between marginal bone resorption for implant position, thread design and tilting degree were analyzed with the Mann Whitney U test. The value p = 0.05 was considered as the level of significance. Total marginal bone level was, on average, 0.2994mm (SD=0.80026) for mandible, 0.3992mm (SD=0.43636) for maxilla, 0.4377mm (SD=0.82100) for tilted implants, 0.2682mm (SD=0.41187) for axial implants, 0.3785mm (SD=0.70581) for level form implants, 0.2789mm (SD=0.46179) for rapid form implants. Mean bone loss was significantly higher in the tilted implants. There is no significant difference found in marginal bone loss between the maxilla-mandible and different threaded implant forms.Yayın Evaluation of the intraoperative and postoperative complications of orthognathic surgery(Atatürk University, 2024) Tokuç, Berkay; Memiş, Sadi; Ankaralı, Deniz Akın; Hoşgör, Hatice; Coşkunses, Fatih MehmetObjective: The aim of this study was to evaluate the incidence of preoperative and postoperative complications in patients undergoing orthognathic surgery. Methods: The clinical records and radiographs of 112 patients who undergone orthognathic surgery between 2014 and 2021 were retrospectively analyzed. Patients’ demographics, follow-up period, type of malocclusion and operation were recorded. All surgical complications were evaluated into two groups as intraoperative or postoperative complications. Results: The mean age of 112 patients (69 female, 43 male) was 24.4 ± 5.5 (ranging from 16 to 47). The most frequent intraoperative complication was the bad split (5 cases, 4.5%), followed by severe hemorrhage due to rupture of facial artery (1 case, 0.9%), dissection of inferior alveolar nerve (1 case, 0.9%), and dental damage (1 case, 0.9%). The most common postoperative complication was the neurosensorial deficit (29 cases, 25.9%), followed by infection (6 cases, 5.4%), extraoral scar formation (5 cases, 4.5%), fracture of fixation material (2 cases, 1.8%), maxillary non-union (2 cases, 1.8%), postoperative nasal hemorrhage (1 case, 0.9%), and failure of fixation material (1 case, 0.9%). There were no fatal complications. Conclusion: Although the wide range of complications related to orthognathic surgery is reported both in our study and the literature, the frequency of these appears to be uncommon. However, in order to manage the complications of the operation properly, through knowledge and experience are essential.Yayın The influence of health behavior on immediate loading implant success and patient satisfaction in the complete edentulous treatment(PNG Publications, 2023) Aslan, MuzafferObjective: The cases of edentulous treatment are increasing in Turkey. The patients are less satisfied with the health care facilities of the public sector health institutes. The government of Turkey is facing critical challenges for medical reforms in the public sector to improve the living standards of the public. The objective of current research is to determine the influence of health behavior on immediate loading implant success and patient satisfaction in complete edentulous treatment. Method: A Likert scale questionnaire is employed and the response rate of this research is 71%. The population of this research is the patients visiting different clinics for edentulous treatment and loading implant success. Results: The research findings demonstrate the satisfaction of the patients and implant success is influenced by the health behavior of patients. Conclusion: The model of this research is enrichment in the knowledge of the edentulous treatment of the patients. The practical implications of this research are outstanding to influence the satisfaction of the edentulous treatment patients who are getting the treatment of loading implant success. The research has certain limitations that are straightforwardly presented with future directions to enrich the knowledge of edentulous treatment by the research work of scholars in health care.Yayın Psychological and social effects of tooth loss(2022) Aslan, MuzafferA beautiful smile is a window to society and an important factor for a healthy life. It also creates a positive self-image for the personality. Tooth loss is a very traumatic and distressing experience psychologically. This situation is accepted as a serious event that creates important psychological problems in human life. Patients experience both physical and emotional deprivation following the loss of one or more teeth, which reduces their quality of life. The aim of this study was to investigate the patient's desire, necessity and awareness for the restoration of missing teeth. In the study, a questionnaire including questions about the physical, emotional and aesthetic effects of edentulism was applied to 200 patients of both sexes. The collected data were interpreted together with their reasons. In our analysis, there were physical and emotional complaints related to missing teeth in most of our patients. However, those with missing teeth in the anterior region showed higher psychological and social disability scores, while those with missing teeth in the posterior region showed higher physical complaints and functional deficit scores. As a result, anterior tooth loss has a far-reaching impact on both emotional and overall dental health. Anterior tooth restoration should be given priority when planning treatment. Therefore, when evaluating the restoration of missing teeth during the examination, the position of these missing teeth in the mouth should also be taken into account.Yayın Transoral robotik cerrahi(Ekin Yayınevi, 2022) Aslan, MuzafferGeleneksel agresif cerrahi yaklaşımlara kıyasla minimal invaziv yaklaşımlar cerrahi pratikte en son teknolojidir ve tıp alanında giderek daha fazla kullanım alanı bulmaktadır. Son yirmi yılda dokuların korunması ve fonksiyonel / estetik sonuçların iyileştirilmesi amacıyla minimal invazyon sürekli olarak geliştirilmiştir. Yaygın olarak kullanılan laporoskopik tekniklerin yanı sıra minimal invazyon alanındaki son gelişmeler arasında, lazer mikrocerrahi ve robotik cerrahi yer almaktadır. Robotik cerrahi, sadece karın cerrahisi, üroloji, ortopedi, radyocerrahi, girişimsel radyoterapi, kalp cerrahisi ve beyin cerrahisinde değil, aynı zamanda ağız yoluyla bazı farklı bölgelere ulaşarak (hipofarenks, orofarenks ve nazofarenks, parafaringeal boşluk, gırtlak ve kafa tabanı) bu bölgelerdeki çeşitli tümörlerin tedavisi için onkolojide popüler hale gelmiştir.Yayın Zigomatik implantlar(Ekin Yayınevi, 2022) Aslan, MuzafferZigomatik implantlar atrofik maksillada immediat yükleme imkanı veren, tedavi süresini kısaltan, maliyetleri düşüren ve hasta memnuniyetini arttıran öngörülebilir bir tedavi seçeneğidir. Ancak olası komplikasyonları önlemek ve gelişirse çözebilmek için yüksek seviyede cerrahi beceri ve tecrübe gerektirir.Yayın Dental implantlarda hemen yükleme(Ekin Yayınevi, 2022) Aslan, MuzafferDental implantlar, tamamen yada kısmen dişsiz hastaların tedavisinde kullanılan yapay diş kökleridir. Dental implant tedavisinin başarısında ve bu başarının devamında koşul osseointegrasyonun sağlanmasıdır. Osseointegrasyonun gerçekleşmesinde; uygun materyal seçimi, atravmatik cerrahi, yeterli hacim ve yoğunlukta kemik, aseptik operasyon ve protezin yükleme zamanı gibi faktörler rol oynar (Buser et al. 1997; Becker et al. 1997; Astrand et al. 1996; Albrektsson et al. 1986). İlk olarak Branemark ve arkadaşları tarafından önerilen osseointegrasyonun en önemli şartı; implantın iyileşme döneminde stressiz, üzerine yük gelmeden beklenmesidir (Brånemark et al. 1977). Brånemark’ın geleneksel protokolü iki aşamalıdır. Buna göre birinci aşamada doku açılır, implanta yerleştirilir ve kapatılır. Alt çene için 3 ay, üst çene için 6 ay bekledikten sonra doku açılır ve ancak o zaman yükleme yapılabilir. Bu yaklaşımın arkasındaki mantığa göre fonksiyonel kuvvetler nedeniyle erken iyileşme döneminde implant-kemik arayüzünde fibröz doku oluşmakta ve bu da osseointegrasyona engel olmakta dolayısıyla da başarısızlığa neden olmaktadır. Bu yükleme koşulu, günümüzde de sıklıkla kullanılan ”geleneksel yükleme” olarak adlandırılır (Babbush CA 1986).Yayın Sofortbelastung von zygoma-implantaten in fällen von amelogenesis imperfecta mit kronenresorption multipler retinierter zähne(Quintessenz Verlags GmbH, 2022) Aslan, MuzafferDie implantatgestützte Rekonstruktion stark resorbierter Oberkiefer ist insofern besonders anspruchsvoll, als das vorhandene Knochenvolumen keine idealen Implantatpositionen unterstützt. Daher sind in der Regel Knochen- und Sinusbodenaugmentationen mit Knochentransplantaten erforderlich. Diese Techniken sind gut dokumentiert und zeigen hohe Erfolgsraten, sind aber zeitaufwendig, erfordern gegebenenfalls einen zweiten Eingriff an der Spenderstelle und schließen eine Sofortbelastung aus. In entsprechenden Fällen findet daher ein neues Konzept, bei dem im Jochbein platzierte Implantate (Zygoma-Implantate) zum Einsatz kommen und das beachtliche Erfolgsraten vorweisen kann, zunehmend Beachtung. Dieser Fallbericht zeigt die Behandlung von zwei Patienten mit Amelogenesis imperfecta in Verbindung mit fortgeschrittenen Kronenresorptionen und Durchbruchstörungen sowie Zahnnichtanlagen unter Verwendung von sofortbelasteten Standard- und Zygoma-Implantaten.Yayın Retrospective analysis of neurosensory disturbances related to dental implant placement in mandibular interforaminal region(Erciyes University, 2021) Kütük, Nükhet; Topan, Cihan; Demirbaş, Ahmet Emin; Alkan, AlperThe aim of this study is to evaluate the risk of neurosensory disturbances resulting from the injury of the anterior loop of the inferior alveolar nerve (IAN) in dental implant surgery with panoramic radiography. Panoramic radiographs of 1614 consecutive patients treated with dental implants were examined, and patients with implants located at a distance less than 5 mm to the mental foramen were recorded. Paresthesia, anesthesia, neuropathic pain was investigated retrospectively. In 405 patients, the implants were located in a distance less than 5 mm to the mental foramen. A range of 0.6 mm to 5 mm distance was detected between the mental foramen and these dental implants. No patient complained of bilateral paresthesia. In five (2.06%) of the 242 regions, it was found that patients had permanent unilateral paresthesia in their lower lips. In conclusion, panoramic radiography is not an entirely reliable imaging method for dental implant planning in the interforaminal region. Methods that are more sophisticated may be required to assess the risk of neurosensory disorder before treatment.Yayın The comparison of axial and tilted implants for immediate loading(Tobacco Regulatory Science Group, 2021) Aslan, MuzafferBackground: The success and sustainability of osseointegration in implant treatment is considered an important factor and therefore the value of Marginal Bone Loss (MBL) is an important consideration. Method: Thirty eight patients (17 females and 21 males) were included in the study. Immediately loaded fixed prosthesis supported by two axial and two tilted implants were performed for each patient. 36 axial implants and 36 tilted implants were placed in maxilla, and 40 axial and 40 tilted implants were placed in mandible. Loading was performed 24 hours after the operation and final prosthesis was performed after 6 months. Patients were followed up at 6, 12, 24 and 36 months. Results: According the results of the MBL measurements, there was a statistically significant difference between all results (p = 0.000 <0.05). The value of MBL increased with time and MBL measurements are similar in both tilted and axial implants in maxilla and mandible. In this method, there is no graft cost and augmentation is not required. Discussion: In our study, it is seen that routine control of the patients and early detection of the problem are important in order to prevent problems related to the implant and prosthesis.
