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Dose-dependent effects of boron exposure on locomotor activity and oxidant-antioxidant status in zebrafish
(Wiley, 2025) Özel Korlu, Armağan Begüm; Beler, Mahmut; Eğilmezer, Gizem; Mızrak, Zülal; Akkuş, Efruz İrem; Ünal, İlay Sema
Dose-dependent effects of boron exposure on locomotor activity and oxidant-antioxidant status in zebrafish
Effects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line
(Wiley, 2025) Eronat, Allison Pınar; Ceviz Çubukçuoğlu, Ayşe Begüm; Özkara, Gamze Akın; Yılmaz Aydoğan, Hülya; Öztürk, Özmen
Effects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line.
Comparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line
(Wiley, 2025) Çelik, İrem Nur; Aydoğan, Çağatay; Ceviz Çubukçuoğlu, Ayşe Begüm; Tomaç, Hakan; Öztürk, T.; Yılmaz Aydoğan, Hülya; Öztürk, Özmen
Comparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line.
Cytotoxic effects of polyphenolic cocktail (PFK5120), salicylic acid and indole-3-carbinol combinations on gastric adenocarcinoma cell line
(Wiley, 2025) Yalım, Dikmen; Çelik, İrem Nur; Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; Yılmaz Aydoğan, Hülya; Öztürk, T.; Öztürk, Özmen
Cytotoxic effects of polyphenolic cocktail (PFK5120), salicylic acid and indole-3-carbinol combinations on gastric adenocarcinoma cell line.
Polyphenolic cocktail (PFK5120) treatment of breast cancer cell lines: superior anti-carcinogenic and anti-metastatic effects to doxorubicin
(Wiley, 2025) Özkara, Gamze Akın; Ceviz Çubukçuoğlu, Ayşe Begüm; Çelik, İrem Nur; Korkmaz, Nur Damla; Öztürk, Özmen; Yılmaz Aydoğan, Hülya
Polyphenolic cocktail (PFK5120) treatment of breast cancer cell lines: superior anti-carcinogenic and anti-metastatic effects to doxorubicin
Molecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance
(Wiley, 2025) Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; İbrahimova, Gülnar; Yılmaz Aydoğan, Hülya; Öztürk, Özmen
Molecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance.
Safety monitoring of colistin therapy in critically ıll neonates with late-onset sepsis: A retrospective observational study
(British Pharmacological Society, 2025) Acargök, Baran Cengiz; Yaman, Akan; Rzayev, Turkay; Jalalzada, Nazlı; Kandemir, İbrahim; Memişoğlu, Aslı; Bilgen, Hülya Selva
This study aimed to evaluate the safety of colistin therapy by monitoring renal function and electrolyte levels in critically ill neonates with late-onset sepsis (LOS) hospitalized in the neonatal intensive care unit (NICU) between 2015 and 2021. This ret rospective case–control study included 58 critically ill neonates treated with colistin for late-onset sepsis and 22 control neonates with late-onset sepsis who did not receive colistin. Data were analyzed to compare patient outcomes, microbiological profiles, and side effects of treatment. Statistical analyses were performed using repeated-measures ANOVA and Bayesian calculations to evaluate serum creatinine levels and biochemical parameters over time. Serum creatinine levels showed similar alterations within the first 7days of colistin treatment with moderate evidence. However, serum magnesium and sodium levels were lower on the 7th day in the colistin-treated group compared with the control group. Colistin therapy in critically ill neonates with late-onset sepsis appears to be a viable treatment option with an acceptable short-term safety profile. These findings emphasize the importance of routine monitoring of renal function and electrolyte levels during colistin use in neonatal intensive care to minimize potential complications.
The effects of light and vibration on the correction of lower incisor crowding with aligners
(Galenos Publishing House, 2025) Özcan, Mustafa; Nalbantgil, Didem
Objective: To compare the effects of low-frequency vibration (LFV), photobiomodulation (PBM), and their combination (HOT) on the rate of mandibular incisor alignment during clear aligner therapy. Methods: This retrospective study included 89 patients treated with a single clear aligner system for mild-to-moderate mandibular anterior crowding. Patients were assigned to four groups: control (n=19), LFV (n=26), PBM (n=21), and HOT (n=23). LFV [30 Hz, 0.25 N (≈25 g)] and PBM (850 nm, 16×5 mm LEDs, ≈9.5 J/cm2 ) devices were used daily for 20 minutes in relevant groups. The primary outcome was the change in Little’s Irregularity Index at baseline (T0), 28 days (T1), 48 days (T2), and 62 days (T3). Statistical analyses included one-way ANOVA, repeated measures ANOVA, and Pearson’s correlation. Results: The HOT group showed significantly greater crowding reduction compared to all other groups (p<0.05). LFV and PBM alone were not significantly different from the control. Within-group analysis revealed significant reductions in all groups over time, with the HOT group showing consistent improvements at each interval. Correlation analyses revealed no significant associations between device usage or aligner wear time and crowding reduction. Conclusion: Combining LFV and PBM during clear aligner therapy produced greater short-term acceleration of mandibular incisor alignment than either modality alone. Further randomized controlled trials are warranted to confirm long-term efficacy and safety.
Synthesis and supramolecular architectures of novel hydrazine derivative homometallic schiff base complexes and their spectroscopic and thermal chacterization
(Springer Nature Link, 2025) Temizkan Özdamar, Kevser
In this study, a hydrazine-containing Schiff base (ScB) and its metal complexes with five different metals—Co (ScB Co), Cu (ScB-Cu), Pb (ScB-Pb), Mn (ScB-Mn), and Zn (ScB-Zn)-were synthesized and subsequently characterized both structurally and thermally. The ScB was synthesized via an elimination reaction between vanillin and phenylhydrazine in ethanol. Hexadentate homometallic complexes (HMCs) were then obtained by reacting the ScB with five different metal salts in tetrahydrofuran. The structural architecture of the synthesized ScB and its HMCs was elucidated using Fourier Transform Infrared (FT-IR) spectroscopy, as well as proton (1 H) and carbon (13C) Nuclear Magnetic Resonance (NMR) spectroscopy. Optical, thermal, and surface characterizations of the structurally confirmed ScB and HMCs were performed using UV-Visible spectroscopy (UV-Vis), thermogravimetric and differential thermogravimetric analyses (TG-DTG), and scanning electron microscopy (SEM), respectively. According to thermogravimetric analysis, the char yield of ScB was 28.2%, while the char yields of its metal complexes—ScB-Co, ScB-Cu, ScB-Pb, ScB-Zn, and ScB-Mn—were 5.4%, 27%, 16%, 19%, and 7.1%, respectively. These results indicate that the incorporation of metal ions into the structure reduced its thermal stability, as evidenced by the decreased residue amounts at 1000 °C.
Senior nursing students' perspectives on nursing management: A qualitative study
(SAGE Publications, 2025) Aydoğdu, Ana Luiza Ferreira; Dişbudak, Büşra
Background Theoretical and practical classes in nursing management are part of nursing programmes; however, students often state a need for more preparation to apply leadership and management skills in clinical settings, highlighting the need for innovative educational approaches. This gap between theoretical preparation and the practical application of leadership and management skills underscores the importance of understanding students’ views on what constitutes effective nurse management. Aim This study aimed to explore final-year nursing students’ perspectives on the essential skills, practice and attitudes that nurse managers should demonstrate. Methods This is a descriptive qualitative study. It comprises written narratives of 35 senior undergraduate nursing students. Data were collected between 23 November 2023, and 4 December 2023. Descriptive thematic analysis was undertaken. Results Five themes were identified: (1) What makes a successful nurse manager, (2) Perspectives on effective leadership in nursing, (3) Fostering empowerment in the nursing team, (4) Building and strengthening team cohesion in nursing and (5) Effective care delivery models. Students believe nurse managers should take on a more effective leadership role. Conclusions Nursing students’ reflections can be utilised to update nursing curricula, to improve student leadership and managerial knowledge and skills as they enter the workforce.
Association of body mass index with orbital fat volume in lower eyelid blepharoplasty
(Springer Nature, 2025) Solmaz, İskender Alkın; Ertan, Elif
Purpose To investigate the relationship between body mass index (BMI) and the volume of orbital fat excised during lower eyelid blepharoplasty. Methods This retrospective cross-sectional study included 58 patients who underwent bilateral transconjunctival lower eyelid blepharoplasty between January and December 2024. Total orbital fat volume was measured intraoperatively using a graduated cylinder. BMI was calculated from preoperative height and weight and classified according to World Health Organization criteria. Statistical analyses included Pearson correlation, one-way ANOVA with Tukey’s post-hoc test, and univariate and multivariable linear regression. Results The mean age of the patients was 49.2±11.6 years, and the mean BMI was 24.5±3.8 kg/m². The mean total orbital fat volume excised was 2.08 ± 0.94 cc. Fat volume differed significantly across BMI categories (p<0.001), with obese and overweight patients having greater excised fat than normal-weight individuals. Pearson correlation demonstrated a strong positive association between BMI and fat volume (r=0.592, p<0.001). In regression analysis, BMI was the only significant predictor of orbital fat volume, explaining 35.1% of the variance (R²=0.351). Conclusion BMI is strongly associated with orbital fat volume excised during lower eyelid blepharoplasty. These findings suggest that systemic adiposity extends to the periorbital region and highlight the relevance of considering BMI in preoperative planning to optimize surgical outcomes.
Investigation of the association between nitric oxide synthase gene variants and NAFLD in adolescents with obesity
(De Gruyter, 2025) Hasanoğlu Sayın, Sevde; Kandemir, İbrahim; Oyacı, Yasemin; Khudiyeva, Shahri; Şahin, Memduh; Yetim Şahin, Aylin; Pehlivan, Sacide
Objectives: The present study aimed to investigate whether nitric oxide synthase (NOS) enzyme gene variants (iNOS rs1060826, eNOS rs1799983, eNOS 27-bp VNTR) play a role in the etiopathogenesis of nonalcoholic fatty liver (NAFLD) in adolescents. Methods: This cross-sectional study was conducted with obese adolescents [body mass index (BMI) standard devia tion score (SDS) ≥2] aged 10–19 years (104 individuals) and age- and sex-matched healthy individuals (64 individuals) whose presence of NAFLD was determined by ultrasound. The iNOS rs1060826 and eNOS rs1799983 variants were performed by Polymerase Chain Reaction-Restriction Frag ment Length Polymorphism (PCR-RFLP) method, and the eNOS 27-bp VNTR variant was analyzed using the PCR method. The genotypes detected were compared between the patient group and the healthy controls and with the clinical parameters of the patients. Results: iNOS rs1060826 and eNOS rs1799983 were inde pendent of obesity, whereas eNOS 27-bp VNTR was inde pendent of NAFLD. However, in the obese group, especially in those with NAFLD (+), the iNOS rs1060826 GG genotype was found to be associated with lower diastolic blood pres sure (DBP) (p=0.011). Compared with the clinical parameters, insulin resistance (HOMA-IR) was higher in those carrying the eNOS rs1799983 gene variant-TT genotype in the NAFLD (+) group (p=0.051). Conclusions: While the three functional gene variants of the NOS enzyme did not show a significant difference in terms of genotype between patients and healthy controls, it was determined that both the iNOS rs1060826 gene variant GG allele was associated with low DBP and HOMA-IR may be higher in those carrying the eNOS rs1799983 gene variant TT genotype in NAFLD (+) patients. The iNOS rs1060826 poly morphism is a potentially important genetic variant that may influence DBP regulation through its effects on nitric oxide production.
A randomised clinical trial to evaluate a digital therapeutic (TH-001) for improving glycaemic control in adults with prediabetes
(SAGE Publications, 2025) Çakmak, Ramazan; Tosun, İlker; Avcu, Hasan; Birer, Gürkan Caner; Akgül, Özer; Saini, Kamal S.; Carnell, Jonathan; Kutlu, Orkide
Background and Aims: Prediabetes, characterized by elevated blood glucose levels below diabetes diagnostic thresh olds, presents a significant global health challenge due to high prevalence and associated risks for developing type 2 dia betes. Traditional diabetes prevention programs (DPPs) often face challenges in scalability and accessibility, particularly in underserved communities. Digital therapeutics (DTx), like TH-001, offer potential scalable solutions requiring clinical val idation. This randomized, open-label, controlled, parallel-group clinical trial aimed to evaluate the efficacy and safety of TH-001, a digital therapeutic application, reducing hemoglobin A1c (HbA1c) among adults with prediabetes over a 90-day intervention period. Methods: 68 eligible adults were randomly assigned to either standard care alone or standard care plus the TH-001 intervention. Primary outcomes measured were glycaemic parameters including HbA1c, fasting glucose, 2-h post-load glucose from an oral glucose tolerance test, and insulin levels, while secondary outcomes included anthropometric mea sures. User engagement metrics were also assessed. Results: The intervention significantly reduced HbA1c levels (mean difference −0.22%, p = .023) and body weight (−2.53 kg, p < .001) compared to the control group. Although fasting glucose and insulin levels showed positive trends, differences were not statistically significant. User engagement was high, correlating strongly with HbA1c reduction (r = .95, p < .001), demonstrating the critical role of sustained interaction with TH-001. Conclusions: TH-001 demonstrates significant effectiveness in HbA1c reduction and body weight, with strong user engagement suggesting it may effectively overcome traditional barriers of DPPs. Long-term studies are needed to confirm sustained benefits.
Sex specific knee joint soft tissue mineralization with fibrillin-1 mutation in male tight skin mice
(Forum Multimedia Publishing, 2025) Keenan, Craig; Wang, Xia; Dikmen, Tayfun; Wen, Y.; Ramos-Mucci, Lorenzo; Shorter, Emily; Abraham, David; Bou-Gharios, George; Poulet, Blandine
Articular soft tissue mineralization and ossification are clear pathological signs of osteoarthritis (OA) joints. However their molecular and cellular aetiologies remain largely unknown. Transforming growth factor beta (TGF-β) family members are known contributors to both pathological ossification and osteoarthritis development. In this study, we used a fibrillin-1 (Fbn1) mutant mouse, the tight skin (TSK) mouse, to define the detrimental effects of abnormal Fbn1 in TSK mice and known high TGF-β activity in joint pathology such as articular soft tissue mineralization and ossification. Methods: Knee joints of male and female TSK and wild-type (WT) littermates were analysed by micro-computed tomography (micro-CT) imaging and histology for articular soft tissue pathologies, as well as OA severity. Both aged (10, 26, 35 and 52 weeks) and following in vivo non-invasive repetitive joint overloading were used. Results: We find that male TSK mice develop spontaneous soft tissue ossification from 26 weeks of age, followed by increased osteoarthritis at 1 year-old. In addition, knee joint overloading induced ligament and meniscal mineralisation and ossification in both WT and TSK male mice, but were significantly more severe in TSK knees, including ossification of the patella ligament and synovial lining. In contrast, female TSK knees did not develop more severe soft tissue mineralisation compared to littermate WT mice in neither aged nor overloaded knees. Conclusions: We conclude that Fbn1 mutation, and possibly overactive TGF-β activity in TSK mice, induce articular soft tissue ossification and osteoarthritis in a sex-specific manner. Further studies are needed to confirm the specific signalling involved and the relative protection from female mice from such pathologies.
Differential expression of erythrocyte proteins in patients with alcohol use disorder
(MDPI Publishing, 2025) Boşgelmez, İffet İpek; Güvendik, Gülin; Dilbaz, Nesrin; Esen, Metin
Alcohol Use Disorder (AUD) poses global health challenges, and causes hematological alterations such as macrocytosis and oxidative stress. Disruption of protein structures by alcohol and/or its metabolites may exacerbate AUDs; proteomics can elucidate the underlying biological mechanisms. This study examined the proteins differentially ex pressed in the cytosol and membrane fractions of erythrocytes obtained from 30 male patients with AUD, comparing them to samples from 15 age- and BMI-matched social drinkers (SDs) and 15 non-drinkers (control). The analysis aimed to identify the molecular differences related to alcohol consumption. The AUD patient subgrouping was based on mean corpuscular volume (MCV), with 16 individuals classified as having a normal MCV and 14 having a high MCV. Proteins were separated via two-dimensional(2D)-gel electrophoresis, digested with trypsin, and identified via Matrix-Assisted Laser Desorp tion/Ionization Time-of-Flight (TOF) mass spectrometry (MALDI-TOF/TOF). Additionally, levels of malondialdehyde and 4-hydroxyalkenals (MDA + HAE), reduced glutathione (GSH), oxidized glutathione (GSSG), serum carbohydrate-deficient transferrin (%CDT), disialotransferrin (%DST), and sialic acid (SA) were analyzed. The results showed increased MDA + HAE and decreased total thiols in AUD patients, with GSSG elevated and the GSH/GSSG ratio reduced in the AUD MCV-high subgroup. Serum %CDT, %DST, and SA were significantly higher in AUD. Compared to the control profiles, the AUD group exhibited differential protein expression. Few proteins, such as bisphosphoglycerate mu tase, were downregulated in AUD versus control and SD, as well as in the MCV-high AUD subgroup. Conversely, endoplasmin and gelsolin were upregulated in AUD relative to control. Cytoskeletal proteins, including spectrin-alpha chain, actin cytoplasmic 2, were overexpressed in the AUD group and MCV-high AUD subgroup. Several proteins, such as 14-3-3 isoforms, alpha-synuclein, translation initiation factors, heat shock proteins, and others, were upregulated in the MCV-high AUD subgroup. Under-expressed proteins in this subgroup include band 3 anion transport protein, bisphosphoglycerate mutase, tropomyosin alpha-3 chain, uroporphyrinogen decarboxylase, and WD repeat-containing protein 1. Our findings highlight the specific changes in protein expression associated with oxidative stress, cytoskeletal alterations, and metabolic dysregulation, specifically in AUD patients with an elevated MCV. Understanding these mechanisms is crucial for developing targeted interventions and identifying biomarkers of alcohol-induced cellular damage. The complex interplay between oxidative stress, membrane composition, and cellular function illustrates how chronic alcohol exposure affects cellular physiology.
Evaluation of pediatric dentists’ knowledge, attitudes, and practices regarding the use of lasers
(Springer Nature Link, 2025) Arat Maden, Eda; Tırnaksız Müftüoğlu, Mine; Özen, Buğra; Altun, Ceyhan
This study aims to evaluate pediatric dentists’ knowledge, attitudes, and clinical practices regarding the use of laser tech nology. Additionally, it seeks to identify educational needs to support the accurate and effective implementation of laser applications in pediatric dentistry. The study received ethical approval from the Non-Interventional Research Ethics Com mittee of ………….University. Data were collected through an online questionnaire distributed via email and social media. A total of 233 volunteer pediatric dentists participated in the survey, which included 26 questions across five sections: sociodemographic data, knowledge, attitudes, clinical practices regarding laser use in pediatric dentistry, and laser-related training. Participation was voluntary, and informed consent was obtained at the beginning of the survey. The results of the study showed that 85.8% of pediatric dentists were knowledgeable about the use of lasers in pediatric dentistry. How ever, this knowledge was not fully reflected in clinical practice. It was found that only 35.2% of pediatric dentists had performed laser-assisted procedures. Among these, the most frequently performed procedures were frenectomy (73.2%) and the exposure of unerupted teeth (64.6%). Knowledge and attitude scores were significantly higher among dentists aged 41–50 and those with more than 20 years of professional experience (p<0.05). 73.8% of the participants stated that laser education should be integrated into pediatric dentistry training programs.There are variations in pediatric dentists’ knowledge and clinical practices regarding the use of lasers. To ensure the safe and effective use of this technology, edu cational opportunities need to be improved.
Dermoscopy-guided surveillance in xeroderma pigmentosum: A retrospective analysis
(Galenos Publishing House, 2025) Oraloğlu, Göktürk; Duman, Nilay; Yaman, Banu; Akalın, Taner; Karaarslan, Işıl
Aim: Xeroderma pigmentosum (XP) is a life-threatening disease characterized by high rates of skin cancers. Therefore, it is important to establish key guidelines for the follow-up of these patients to detect skin cancers, particularly melanoma, at an early stage. Materials and Methods: This is a retrospective study that includes the analysis of the follow-up findings and medical records of XP patients who were followed up with whole-body skin examination, dermoscopic examination, and whole-body photographing between 2003 and 2021 in the Dermato Oncology unit of Ege University Department of Dermatology. Results: Of the 19 patients, 10 were male and 9 were female. The youngest patient was 5 years old, while the oldest patient was 64 years old. A total of 234 lesions were excised from these patients. Seventeen melanomas were excised, including 11 in situ, with a Breslow thickness of less than 1 mm. The highest Breslow scores belong to patients who missed their appointments or did not receive follow-up care previously. Conclusion: It was observed that regular full-body skin examinations, whole-body photography, and dermoscopic monitoring performed at 3-month intervals in XP patients are helpful in detecting skin malignancies at an early stage and preventing unnecessary excisions.
Red cell distribution width-to-platelet ratio and other hematological markers as early predictors of bronchopulmonary dysplasia in preterm infants
(MDPI Publishing, 2025) Arcagök, Baran Cengiz; Kandemir, İbrahim
Background/Objectives: Bronchopulmonary dysplasia (BPD) frequently affects preterm infants and is associated with lasting morbidity. Early prediction remains challenging. The present study investigated whether hematological inflammatory markers—platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), and red cell distribution width-to-platelet ratio (RPR)—can predict the development of BPD in preterm neonates. Methods: We performed a retrospective cohort study involving 100 infants born at less than 32 weeks’ gestation. Complete blood count (CBC) parameters were collected at birth, 72 h, 1 week, and 2 weeks of life. Associations between PLR, RDW, RPR, and BPD development were analyzed. Multivariate regression and receiver operating characteristic (ROC) curve analyses were carried out to evaluate the predictive performance of the markers. Results: Forty-nine percent of infants developed BPD. Those with BPD had significantly higher RDW, PLR, and RPR values, and lower lymphocyte and platelet counts at various time points. Gestational age, respiratory distress syndrome, and hematological indices independently predicted BPD. ROC analysis showed that RDW ≥ 67.2 and PLR ≥ 98.13 at 72 h, and RPR ≥ 0.3 at 7 and 14 days had good predictive performance. A combined scoring system, including clinical and hematological markers, achieved high sensitivity and specificity. Conclusions: Hematological inflammatory markers, especially RPR, PLR, and RDW, derived from routine CBC tests may serve as accessible, cost-effective tools for early BPD risk stratification in preterm infants. Additional studies are needed to confirm these results and better define their relevance in clinical practice.
Anatomical investigation of levator palpebrae superioris muscle and the distribution pattern of oculomotor nerve
(Springer Nature Link, 2025) Nteli Chatzioglou, Gkionoul; Gayretli, Özcan; Özbilen, Kemal Turgay; Önal, Vildan; Coşkun, Osman; Kale, Ayşin
Purpose This study aims to evaluate the morphological features of the levator palpebrae superioris muscle (LPS) and the variations in the distribution of the oculomotor nerve in the muscle. Methods 100 bilateral orbits from 50 cadavers were included in our study. In our study, the medial, lateral, and middle length, width, and thickness of the LPS were measured from 3 different points and recorded. In addition, the number of branches of the oculomotor nerve entering the LPS muscle was calculated. Results The medial, lateral, and middle length of LPS were 34.85±5.30 mm, 34.62±5.67 mm, 35.77±5.31 mm on the right side and 33.66±4.74 mm, 33.81±4.83 mm, 34.54±5.14 mm on the left side, respectively. The width of the muscle was seen to expand from proximally to distally. It was noted that the middle 1/3 thickness of the LPS was the thickest part of the muscle compared to the other parts. A total of 239 oculomotor branches entered the LPS. The middle 1/3 of the LPS was reached by 151 oculomotor nerve branches. It was noted that the largest number of oculomotor nerves entered the middle 1/3 part of LPS. Conclusion The morphometric and morphological findings of LPS and branches of the oculomotor nerve may be useful in surgical planning for the LPS and levator aponeurosis and in preventing complications during surgical interventions.
Diagnostic value of leukocyte count, c-reactive protein, and procalcitonin in pediatric liver transplant patients during the first week postoperative: A longitudinal study from a tertiary center and a new diagnostic method for predicting systemic infection
(MDPI Publishing, 2025) Önal, Zerrin; Türkmen, Elif; Demirkol, Demet; Leblebici, Uğur Can; Kandemir, İbrahim; Yılmaz, Tuğçe Göksu; Torun, Selda Hançerli; Ekiz, Feza; Özden, Ilgın; Durmaz, Özlem
Background/Objectives: Infection is a major complication during the early postoperative period following pediatric liver transplantation (LT). Prompt diagnosis and treatment are essential to prevent death. We aimed to assess the diagnostic value of procalcitonin (PCT), white blood cell count (WBC), and C-reactive protein (CRP) levels for detecting bacterial infection and SIRS within the first week after LT. Methods: Demographic data, vital signs, laboratory results (PCT, CRP, WBC), and culture findings on the 1st, 4th, and 7th days between January 2010 and 2024 were collected retrospectively. Results: The study included 88 patients. Seventy-two percent had cirrhotic liver disease. SIRS was present in 17% (n = 15), and bacterial growth was detected in 20% (n = 18). Bacterial growth was found in 80% of patients with SIRS (n = 12/15) and in 8% of SIRS-negative patients (n = 6/73). PCT levels were significantly elevated on days 1, 4, and 7, and CRP lev els on days 4 and 7 in patients with SIRS. PCT elevation was significant on days 1, 4, and 7, while WBC increase was noted on day 7 in patients with bacterial growth. Body temperature ≥ 37.1 ◦C and PCT ≥ 5.1 ng/dL on the first day together showed a sensitivity of 72.2% and specificity of 84.3% for bacterial growth. Similarly, body temperature ≥ 37.1 ◦C and PCT ≥ 9.2 ng/dL on the first day yielded 73% sensitivity and 95% specificity for diagnosing SIRS. Cirrhotic patients exhibited limited or no WBC response to bacterial growth. Conclusions: PCT, CRP, and WBC alone are insufficient for diagnosing infection. Combined assessment of body temperature changes and PCT elevation may serve as more accurate indicators. Nonetheless, close monitoring of culture results and clinical signs, with serial physical exams, can aid timely infection management or prevent unnecessary antibiotic adjustments.

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