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Maternal health experiences on respectful and adequate care of immigrant women: A prospective multicenter study
(Wiley, 2024) Topçu, Elif Göknur; Terzioğlu, Merve; Okumuş, Zihniye Gonca; Şavklı, Ayşe Özge; Demirkıran, Cansu İrem
Objective: Migration of pregnant women can be challenging. Access to adequate and respectful care may not be possible. We aimed to assess the maternity care that im migrant women receive and their satisfaction with the care they experience. Methods: This multicenter prospective study was conducted in a tertiary public hos pital and a private hospital in Istanbul between April 2023 and July 2023. A face-to face questionnaire was completed in the postpartum department by obstetricians and translators. Results: In total, 267 patients participated in this study. A majority of these patients delivered at the public hospital (75%). Approximately 21% of all deliveries in both hos pitals were with foreign mothers. A majority of the patients (82%) in the public hospi tal said they easily reached midwives, nurses, and an obstetrician, while this number rose to 100% in the private hospital. Patients in the private hospital had a higher average number of obstetrician visits compared to those in the public hospital, which was statistically significant (P< 0.05). Patients in the public hospital were significantly less informed about various maternity topics than those in the private hospital group (P< 0.001 for all topics). Most patients said their ideas and thoughts were taken seri ously by the health care providers (80% and 97% in the public and private hospitals, respectively). Almost all patients recommended giving birth in the same hospital (94% vs. 96%, public and private hospitals, respectively), while around 99% recommended giving birth in Turkey. Conclusion: Immigrant women are overall satisfied with the care they receive in both public and private hospitals. They have easier access to obstetricians in private hospi tals, as well as being more informed on maternal health issues. Clinical efforts should focus on patient education in antenatal care.
Quantification of agnuside in human plasma with a novel high-performance liquid chromatographic method and pharmacokinetic study
(Oxford University Press, 2025) Egeli, Derya; Tiris, Gizem; Kepekçi Tekkeli, Şerife Evrim
This study presents a combination of High Performance Liquid Chromatography (HPLC) and ultraviolet (UV) detection that provides the quantification of agnuside in human plasma specimens. Reverse-phase chromatographic separation was carried out with C18 column (150 mm × 4.6 mm × 5 μm), at 25°C with isocratic elution of the mobile phase containing methanol: 0.1% formic acid (35:65 v/v) at 0.6 mL/min flow rate. Experiments were carried out at a wavelength of 258 nm. The retention time of the analyte is 9.70 ± 0.01 min. The developed technique was validated based on the International Conference on Harmonization guideline. The correlation coefficient of the technique was 0.9915, and the calibration range was 5–125 μg/mL. The recovery value of the proposed method was found to be 101.4%, and the precision of the method was calculated as 6.35 with the highest RSD% value. A pharmacokinetic study was performed by administering agnuside to a healthy volunteer.
Toward green and sustainable zinc-ion batteries: The potential of natural solvent-based electrolytes
(Wiley, 2025) Yaman Uzunoğlu, Gülşah; Yüksel, Recep
Zinc-ion batteries (ZIBs) are emerged as a promising alternative for sustainable energy storage, offering advantages such as safety, low cost, and environmental friendliness. However, conventional aqueous electrolytes in ZIBs face significant challenges, including hydrogen evolution reaction (HER) and zinc dendrite formation, compromising their cycling stability and safety. These limitations necessitate innovative electrolyte solutions to enhance ZIB performance while maintaining sustainability. This review explores the potential of natural solvent-based electrolytes derived from renewable and biodegradable resources. Natural deep eutectic solvents (DES), bio-ionic liquids, and biomass-derived organic compounds present unique advantages, including a wider electrochemical stability window, reduced HER activity, and controlled zinc deposition. Examples include DESs based on choline chloride (ChCl), glycerol-based systems, and biomass-derived solvents such as γ-valerolactone (GVL) and aloe vera, demonstrating improved cycling stability and dendrite suppression. Despite their promise, challenges such as high viscosity, cost, and scalability remain critical barriers to commercialization. This review underscores the need for further research to optimize natural solvent formulations, enhance Zn anode compatibility, and integrate these systems into practical applications. By addressing these challenges, natural solvent-based electrolytes can pave the way for safer, high-performance, and environmentally sustainable ZIBs, particularly large-scale energy storage systems.
Viewpoints of nurse auditors regarding the profession: A qualitative study
(Emerald Publishing, 2025) Aydoğdu, Ana Luiza Ferreira
Abstract Purpose – This study aims to understand the experiences of Brazilian nurse auditors in the practice of their profession, exploring the importance, challenges, rewards and strategies related to the occupation. Design/methodology/approach – This is a qualitative descriptive study conducted with 44 nurse auditors. An online, open-ended questionnaire was used. Thematic content analysis was performed. Findings – Five themes were identified: (1) functions of a nurse auditor; (2) skills required for a nurse auditor; (3) learning to be a nurse auditor; (4) advantages of being a nurse auditor and (5) challenges faced by a nurse auditor. Also, a total of 16 subthemes were presented. Research limitations/implications – The study critically examined essential aspects of auditing through the lens of nurse auditors, addressing a relevant topic. However, limitations must be acknowledged, including the use of self-report questionnaires, regional representation disparities, the scarcity of international articles on the topic and potential researcher bias. Practical implications – The study underscores the importance of increasingly integrating nurse auditors into the workforce while emphasizing the need to enhance the capacitation of these professionalsthrough theoretical and practical education. It highlights the significance of educating other multidisciplinary team members about the nurse auditor’s crucial role in fostering teamwork and ensuring the quality of healthcare services. Originality/value – To the best of the author’s knowledge, this is the first study conducted with Brazilian nurse auditors, exploring crucial aspects of auditing from the perspective of these professionals. Understanding the critical role of nurse auditorsinmaintaining and improving healthcare quality can enhance public trust in healthcare systems.
The impact of domestic violence and sexual assault on family dynamics and child development: A comprehensive review
(AVES, 2025) Brockstedt, Matthias; Uğur Baysal, Serpil; Daştan, Kadir
This review synthesizes current research on domestic violence and sexual assault, focusing on their short-term and long-term effects on family dynamics, particularly on the development and well-being of children and adolescents. The article employs a curated body of literature, including surveys, reviews, program evaluations, and international health reports, to elucidate the direct and collateral damage caused by such trauma within families. The review critically examines the intersecting consequences of abuse, including immediate psychological distress and long-term socio-economic and educational disruptions for affected youths. Additionally, the review examines structural impediments and cultural intricacies that shape reporting prac tices and access to support services. The role of civil legal aid and victim advocacy in promoting survivor safety and justice is discussed, supported by findings from service evaluation studies. The review also addresses the exacerbating effects of the Coronavirus pandemic on domes tic violence rates and service provision, noting increased occurrences of domestic abuse and decreased pursuit of urgent care and support, highlighting research conducted from the pan demic’s start through 2023. Emergent studies reveal a rise in domestic abuse occurrences and a decline in urgent care and support pursuit, emphasizing the need for adapted intervention strategies. The review offers evidence-based recommendations for policymakers, healthcare providers, and community organizations, stressing the necessity of persistent and collaborative efforts to address and prevent domestic violence. The ultimate goal is to advocate for a stron ger international response to repair harm and prevent future occurrences, ensuring a safer environment for all family members, particularly children and adolescents.
Effect of biphenyl derivative of coumarin compounds photodynamic therapy on the expression of carcinoma-associated genes
(Slovensko Kemijsko Drustvo, 2024) Gök Yurttaş, Asiye; Elgün, Tuğba; Erkal Çam, Burçin; Kefeli, Melike; Çınar, Kamil
Photodynamic Therapy (PDT) is a cancer treatment. Singlet oxygen is produced as a result of the photochemical reaction between light, photosensitizer (PS), and molecular oxygen, which kills cells. Colon cancer, affecting 1.23 million people worldwide, often requires surgery but has high recurrence and metastasis rates. Photodynamic therapy (PDT) repre-sents an alternative treatment for colon cancer. This study used MTT assays to evaluate cell viability and applied Zinc (II) Phthalocyanine (ZnPc) photosensitizers to the colorectal adenocarcinoma (HT-29) cell line to investigate cancer pathways via flow cytometry and q-PCR. The results showed that PDT with ZnPc significantly reduced cell viability in HT-29 cells and induced apoptosis at a rate of 53%. According to q-PCR results, CT values of ten out of thirty genes were significant, and their association with cancer was evaluated.
Preconcentration of bismuth using nickel hydroxide nanoflower from water samples and determination by FAAS
(Springer, 2025) Yıldız, Barış; Durukan, İlknur; Şaylan, Meltem; Zaman, Buse Tuğba; Bakırdere, Sezgin
In this study, a preconcentration strategy based on Ni(OH)2 nanofowers (NFs) was developed for the extraction/separation of bismuth ions from environmental water samples before the determination by fame atomic absorption spectrometry (FAAS). The homogeneous coprecipitation method was employed for the synthesis of the fower-shaped Ni(OH)2 and used as an adsorbent for the preconcentration of bismuth. The extraction variables were determined by a univariate optimization strategy to obtain maximum extraction performance. The optimal parameters of the method were as follows: 15 min mechanical shaking at 120 rpm, pH 6.0 bufer solution (1.0 mL), 20 mg of sorbent, and 250 µL of 6.0 M nitric acid for the elution. Under the optimized instrumental and extraction conditions, LOD (limit of detection), LOQ (limit of quantitation), and linear dynamic range were determined as 2.8 µg/L, 9.4 µg/L, and 0.010–0.30 mg/L, respectively. The enhancement factor of the sorbent-based method was calculated as 139.1-folds by comparing the slopes of calibration plots obtained from FAAS and the preconcentration method. To assess the feasibility and reliability of the developed method, tap water and spring water samples were analyzed under optimized conditions. The satisfactory %recoveries were obtained close to 100% using the direct comparison method. The obtained results show that the presented method is a promising candidate for efcient extraction and trace determination of bismuth in several sample mediums.
Green synthesis of zinc oxide nanoparticles including Rosehip (Rosa canina L.) seed extract: Evaluation of its characterization and bioactivity properties
(Wiley, 2024) Bozkurt, Rabia Nur; Şahin, Selin
The use of bioactive compounds in plants as reducing, stabilizing, and capping agents in nanoparticle manufacturing is an exceptionally eco-friendly approach. This work used rosehip seed extract, acquired by automatic solvent extraction, in the microwave-assisted green production of zinc oxide nanoparticles (ZnO NPs). The total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity of the extracted materials and nanoparticles were assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The ideal synthesis parameters were established as 25 mL of extract, pH 12, 360 W of microwave power, and a metal salt concentration of 0.05 M for a duration of 7 minutes. The characterization of the ZnO NPs synthesized under these conditions was performed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy with energy dispersive X-ray analysis (SEM-EDX), dynamic light scattering (DLS), zeta potential measurements, and UV-Vis spectrophotometry. High-purity, nano-sized, antioxidant ZnO NPs were manufactured using an ecologically friendly, sustainable, and ecological technique.
CXCR1 gene SNP variability that affects mastitis resistance in Holstein cows in Türkiye
(Kafkas Üniversitesi, 2025) Avanus, Kozet; Yılmaz, Alper; Güneş, Halil; Altınel, Ahmet; Ekiz, Bülent; Yalçıntan, Hülya; Keçici, Dilara; Doğan, Nurşen
Genotyping 16 SNPs of C-X-C motif chemokine receptor 1 (CXCR1) gene region which affects host resistance against mastitis disease was carried out in Holstein cows raised in Türkiye. In this study, the frequency of the undesirable C allele in the CXCR1 c.771C>G polymorphic region, associated with an incomplete response, was found to be high. Additionally, the genotypes c.1016AA and c.1016GG, which contribute to mastitis resistance, were observed at low frequencies. Several SNP loci in the CXCR1 gene, including c.606G>A, c.678G>A, c.1104G>A, c.1119+6C, c.1119+7A, and c.1119+10, significantly deviated from Hardy-Weinberg equilibrium (HWE) (P<0.0001), indicating violations of HWE assumptions such as random mating and absence of selection. The deviations at c.606G>A, c.678G>A, and c.1104G>A suggest strong selection pressures, likely due to artificial selection in Holstein cattle. These variants are synonymous mutations that do not alter the amino acid sequence but may influence protein synthesis through effects on mRNA stability, splicing, or translation efficiency. Furthermore, the absence of heterozygotes at loci c.1119+6C, c.1119+7A, and c.1119+10, which are located on untranslated regions (UTRs), potentially affecting gene expression by regulating mRNA stability, localization, or translation initiation, points to genetic drift or population substructure. These findings are important for understanding genetic variability and can inform marker-assisted selection programs to enhance breeding strategies while preserving genetic diversity for traits like disease resistance and milk production.
Comparison of ocular posterior segment parameters in the pediatric population with migraine without aura and tension-type headache
(Hacettepe University Institute of Child Health, 2024) Kıvrak, Ulviye; Köle, Mehmet Tolga; Kandemir, İbrahim; Kaytan, İsmail
Background. This study aims to compare the posterior ocular structure parameters in children with migraine without aura (MWA), tension-type headache (TTH), and a healthy control group. Methods. The study included 31 patients with MWA, 29 patients with TTH, and 38 healthy controls between 6 and 18 years of age. For all participants, the detailed eye examination and measurements including peripapillary retinal nerve fiber layer (pRNFL) thickness, central macular thickness (CMT), subfoveal choroidal thickness (SCT), macular vessel densities and foveal avascular zone (FAZ) parameters measured by optical coherence tomography (OCT) and OCT-angiography (OCTA), were obtained from the patient files. Results. The mean age was 12.1±3.3 years in MWA patients, 12.4±2.8 years in TTH patients, and 11.9±3.8 years in the healthy controls (p=0.844). Among the groups, the mean pRNFL thickness, CMT, and SCT values were lowest in the MWA group. However, this difference was not statistically significant (p=0.621, p=0.854 and p=0.201, respectively). The mean and four-quadrant (superior, inferior, temporal, nasal) pRNFL thicknesses, the CMT, and the SCT were not statistically significant between the groups (p=0.621, p=0.500, p=0.186, p=0.565, p=0.744, p=0.854 and p=0.201, respectively). The macular vascular densities were lower in MWA patients than in the other two groups, and there was a statistically significant difference between the groups only in the nasal quadrant of the deep retinal capillary plexus (p = 0.014). There were also no statistically significant differences between the groups in the superficial and deep FAZ area parameters (p=0.652 and p=0.985). Conclusion. This study suggested that differential diagnosis between MWA and TTH can be difficult in childhood, as these conditions, which can present with ocular symptoms, may also be characterized by changes in posterior segment parameters. Long-term studies incorporating OCT-A in larger patient populations may provide valuable insights into retinal changes associated with these two distinct headache spectrums.
Colorectal cancers and microsatellite instability
(Türk Radyasyon Onkolojisi Derneği, 2025) Esmkhani, Sahra; Emrem, Mustafa; Şahin, Ali; Babayev, Hüseyn; Zeyneloğlu, Can; Ardıçlı, Sena; Yazıcı, Hilal; Yazıcı, Hülya
Colorectal cancer (CRC) is a multifactorial disease arising from the complex interplay between genetic predisposition and environmental influences. Despite its widespread incidence globally, CRC demon strates favorable prognostic outcomes when detected at an early stage. Microsatellite instability (MSI) is a common molecular abnormality associated with colorectal tumorigenesis. This review provides a comprehensive analysis of the molecular mechanisms, clinical implications, therapeutic approaches, and immune system interactions in MSI-associated CRC (MSI-CRC). Molecular changes include DNA slippage, dysfunction in the DNA mismatch repair (dMMR) system, and genetic/epigenetic factors that contribute to MSI. Clinically, MSI-CRC is characterized by distinct phenotypic features, including associations with Lynch syndrome, specific diagnostic methodologies, and prognostic relevance. The therapeutic landscape highlights the promising efficacy of immunotherapies and targeted treatments, particularly in dMMR–MSI-H-CRC. Immune dynamics within the tumor microenvironment (TME) reveal patterns of immune infiltration, immune evasion strategies, and opportunities to enhance the effectiveness of immunotherapy. Understanding these interrelated aspects is critical for developing tai lored therapeutic strategies and improving patient outcomes in MSI-CRC
Safety management system and risk-based approach in aviation maintenance: A systematic literature review
(Elsevier, 2025) Kıvanç, Ercan; Tuzkaya, Gülfem; Vayvay, Özalp
Safety within aviation is defined by the effective management and mitigation of risks associated with aviation activities, encompassing direct aircraft operations and supporting functions. The safety management system (SMS), a holistic approach to proactively managing safety risks, is central to this endeavor. Comprising four integral components—safety policy and objectives, safety risk management, safety assurance, and safety pro motion—the SMS hinges on a systematic risk management process. This study aims to understand the founda tional principles for framing and executing organizational systems harmonized with the SMS and a risk-based approach within the realm of aviation maintenance organizations. Through a detailed literature review, this research discloses a concentrated focus on organizational factors, human factors, and managerial aspects within existing scholarship. Findings underscore the multifaceted nature of ensuring safety in aviation maintenance operations, clarifying the complicated bonds between organizational factors, human factors, and managerial aspects within this specialized context. Finally, we presented the essential characteristics of an SMS-integrated aviation maintenance organization, as derived from our comprehensive literature review.
Microwave-assisted synthesis of antimony oxide nanoparticles for the determination of trace cadmium in mulberry leaf tea matrices by flame atomic absorption spectrophotometry
(Springer, 2024) İnce, Merve Nur; Serbest, Hakan; Bakırdere, Sezgin
In this study, a rapid, sensitive and accurate analytical method was optimized for the determination of trace levels of cadmium (Cd) by fame atomic absorption spectrophotometry (FAAS) after antimony oxide nanoparticles (AO NPs)-based dispersive solid-phase extraction (DSPE). The AO-NPs were synthesized with a specifc microwave tem perature program, and they exhibited high purity and good surface morphology, making them appropriate sorbent material for the preconcentration/separation of a heavy metal. All experimental parameters afecting the extraction efciency were optimized univariately. Under the optimum operational conditions (35 mL sample volume, 0.75 mL of pH 8.0 bufer, 15 mg of sorbent, 5 s vortex and 100 µL of 1.0 M of HNO3), the limit of detection (LOD) and the limit of quantitation (LOQ) values were determined as 0.27 and 0.89 µg L−1, respectively. Thanks to the developed method, a 164.8-fold improvement in the sensitivity of the conventional FAAS system was achieved. Reusability tests showed that the AO-NPs can be employed 5 times. The feasibility of the method was confrmed by recovery tests with mul berry leaf tea matrices, and good recovery results between 77.6 and 115.8% were obtained using the matrix matching calibration method.
Evaluation of the extraction methods prior to ICP-MS determination of metal levels in kinetic (magic) sand samples used for children’s play
(Taylor & Francis, 2024) Özdemir Olgun, Fatoş Ayça
Kinetic (magic) sand is widely used in preschool activities in order toimprove the children’s creative abilities. Despite its popularity, thisstudy will be the first in literature to assess the heavy metal contentof kinetic sand samples. Focusing on the determination of metalcontent (Hg, Cd, Sb, Sn, Al, Ni, Co, Cu, Pb) of 10 different brands ofkinetic sand samples sold in Turkish markets, the significance ofsample preparation step was further discussed with the applicationof wet digestion and microwave digestion methods, prior to analy-sis by ICP-MS. Based on the acute toxicity classes defined byEuropean Union (EU) As, Cd, Hg belongs to Class 1; Ni, CrVI, Pbbelongs to Class 2, whereas Zn and Cu belongs to Class 3. Amongthe potential toxic elements studied, the Al content of samplesattracts attention with its high level exceeding the limits ofdirectives.
Effect of test parameters on the recovery of underground after a Thermal Response Test and optimum waiting time between tests
(Elsevier, 2025) Aydın, Murat; Gültekin, Ahmet
Thermal Response Test (TRT) is an important method to determine the thermal properties of underground. These tests can be interrupted by unexpected reasons and a new test must be started in the same borehole, or the test must be repeated because of various reasons. In this paper, optimum waiting duration for a second test after a completed TRT is investigated through analyzing thermal behavior of a borehole during and after the test. A computational model is built, and it is verified with an experimental test. After the verification, the numerical model is used further parametric investigations. Different cases are considered and the results are discussed. The effect of thermal conductivity and test duration on the minimum waiting times are also investigated. It is shown that optimum waiting duration depends highly on the test conditions, however it varies between 10 and 23 days.
Labiaplasty revision surgery with using clitoral hood flap: A case-cohort study
(Springer, 2024) Şahin, Eda Adeviye; Ağlamış, Özgür; Şahin, Hanifi; Ozan Şahin, Elif; Yılmaz Ergani, Seval
Background: The demand for labia minora reduction surgery has increased due to aesthetic preferences and discomfort caused by labial hypertrophy. This study aims to share experiences with labial reconstruction using clitoral hood flaps in patients who underwent aggressive trim labiaplasty. Methods: Twenty-eight patients who had previously undergone only labiaplasty surgery were included in this study. Surgical techniques focused on preserving blood supply and achieving symmetry. Postoperative care included hospitalization, wound care training, and regular follow-up visits. Complications were monitored and managed as needed. Results: All 28 patients, comprising 23 bilateral and 5 unilateral labiaplasty cases, underwent revision surgery using 49 clitoral hood flaps. Complications occurred in 6 cases, including suture dehiscence, flap necrosis, and infection, all of which were effectively managed. All flaps maintained their viability, and high patient satisfaction was reported. Conclusion: Clitoral hood flap reconstruction following aggressive trim labiaplasty is a viable technique with minimal complications and high patient satisfaction. Further multicenter, long-term studies are necessary to validate these findings and improve surgical outcomes. Level of evidence iii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Distribution of branches of anterior choroidal artery in the uncus: An anatomical study
(Springer, 2024) Kaçur, İdil; Nteli Chatzioglou, Gkionoul; Nas, Emine; Şahan, Orhun; Kale, Ayşin; Çakır, Halit; Coşkun, Osman; Gayretli, Özcan
The aim of our study was to examine the relationship between uncus and uncal branches of anterior choroidal artery (AChA) and to observe the morphological and morphometric features of these branches. 124 hemispheres from 62 fresh cadavers were included in the study. Measurement of the length of AChA and the distances of the uncal branches to the origin of AChA were measured by ImageJ software. Morphological variations of uncal branches originating from AChA were observed. The length of AChA was found as mean 26.24 ± 4.34 mm. It was determined that the average distance of these uncal branches arising from the AChA was 13.48 ± 7.31 mm. In 4 out of 124 AChAs, no branches were observed. 594 branches originating from 120 were detected. 130/594 branches appeared to be terminal branches. AChAs of 80/120 hemispheres have been reported to have uncal branches. Thirty of 130 uncal branches were observed to originate as the first branch of AChA. It was found that uncal branches may originate from AChA with a variability between 1 and 4. When evaluated according to the origin of each branch from the AChA, it was observed that the uncal branches originated from the midpoint of the AChA on average. Also, in 64 hemispheres, morophological variations were detected regarding the origin of uncal branches. We believe that the morphological and morphometric data we obtained from the uncal branches of the AChA are of clinical importance in terms of understanding this complex region and minimizing errors in surgical procedures.
Early period survival and neurologic prognosis in newborns with perinatal asphyxia: A tertiary center experience and a mortality chart
(Brieflands, 2025) Yaman, Akan; Kandemir, İbrahim; Alp Ünkar, Zeynep
Background: Clinicians require more data regarding mortality and brain damage risk factors in perinatal asphyxia. Objectives: To assess early term outcomes and identify mortality risk factors in perinatal asphyxia. Methods: This study was conducted in a referral-center tertiary intensive care unit in Istanbul, Turkey, between 2016 and 2023. We included all patients who underwent therapeutic hypothermia treatment due to perinatal asphyxia. We recorded laboratory follow-up data, magnetic resonance imaging (MRI) findings, amplitude-integrated electroencephalograms (aEEG) results, mortality, and clinical outcomes. Both conventional frequentist statistical methods and Bayesian methods were used for analysis. Results: A total of 164 patients were included in the study, with an overall mortality rate of 9.8%. Risk factors for mortality included LDH, troponin I, INR, lactate, 2nd day creatinine, voltage anomalies, seizures, and male gender, as well as APGAR scores. A basic chart for mortality prediction was developed. The Sarnat score showed strong evidence, and APGAR 1 showed anecdotal evidence for association with brain damage, although brain damage was independent of laboratory results and other clinical findings, based on moderate and anecdotal evidence from Bayesian calculations. Cranial MRI findings revealed profound damage in 14.8% of Sarnat 1, 21.8% of Sarnat 2, and 50% of Sarnat 3 patients. Conclusions: This study presents prognostic factors for survival and brain damage in perinatal asphyxia. We recommend obtaining cranial MRI for all patients diagnosed with asphyxia, as most laboratory tests were independent of brain damage. Given that profound brain damage can occur even in Sarnat stage I patients, we emphasize the importance of therapeutic hypothermia for these patients.
Process parameter optimization of laser beam machining for AISI -P20 mold steel using ANFIS method
(Elsevier, 2025) Eaysin, Abdullah; Kabir, Sarower; Günister, Ebru; Jahan, Nur; Hamza, Amir; Zinnah, Muhammad Ali; Bin Rashid, Adib
AISI P20 mold steel is commonly used for injection molds to produce plastic materials, car accessories, and electronic equipment molds. This study employed a fiber laser beam for precise machining of AISI P20 mold steel. The experimental design, based on the Taguchi 27 model, was carried out using Minitab software to optimize machining parameters, including cutting speed, gas pressure, and laser power. Surface roughness (Ra) and kerf width were the response parameters investigated. The ANFIS model, developed and analyzed using MATLAB, successfully predicted response parameters and was experimentally validated, showing improved predictions over actual measurements. The Brute Force algorithm identified the minimum combination for an optimal parameter set. The Taguchi method determined the best process parameters, indicating that cutting speed had the most significant impact. The optimum Ra was achieved with 1 m/min cutting speed, 2 bar gas pressure, and 1.8 kW laser power, while the lowest kerf width was obtained with 2 bar gas pressure, 1 m/min cutting speed, and 1.9 kW laser power. Based on the Brute Force algorithm, the minimum combination resulted in a kerf width of 0.84 mm and a surface roughness of 4.48175 μm. Microstructural analysis was performed on samples with high and low surface roughness to assess the machining surface quality.
RNA splicing aberrations in hereditary cancer: Insights from Turkish patients
(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Kılıç, Seda; Şükrüoğlu Erdoğan, Özge; Tuncer, Şeref Buğra; Çelik Demirbaş, Betül; Yalnız Kayım, Zübeyde; Yazıcı, Hülya
The process of RNA splicing is fundamental in contributing to proteomic diversity and regulating gene expression. Dysregulation of splicing is associated with various human disorders, including cancer. Through functional studies, this study sought to examine the potential impact of seven variants within six inherited cancer-related genes on RNA splicing patterns in Turkish cancer patients. Upon detecting variants using Next-Generation Sequencing (NGS), we used Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) and Sanger sequencing to elucidate the effects of these variants on splicing. Three of the seven variants demonstrated no discernible effect on RNA, while four exhibited pathogenic characteristics. Specifically, the variants APC c.532-1G>A rs1554072547, BRCA1c.4358-3A>G rs1567779966, BRCA2c.7436-1G>C rs81002830 and MSH3c.1897- 1G>A rs1744149615 were identified as pathogenic, while the variants BLMc.4076+4T>G rs183176301, RB1c.2489+2T>C rs1555294636 and RB1c.1050-2A>G rs? were found to be benign from a splicing perspective. These findings highlight the importance of verifying the precise consequences of splice site variants through experimental analysis, given their potential implications for genetic disorders and cancer predisposition. This research contributes to the understanding of splice-site variants in inherited cancer predisposition, particularly among Turkish cancer patients. It emphasizes the necessity for further exploration into the mechanisms and functional consequences of alternative splicing for potential therapeutic interventions in cancer.

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