PubMed İndeksli Yayın Koleksiyonu
Bu koleksiyon için kalıcı URI
Güncel Gönderiler
Yayın Evaluation of posterior segment changes in pediatric asthma patients with and without inhaled corticosteroid therapy(Springer Nature, 2025) Kıvrak, Ulviye; Çiçek, Fatih; Köle, Mehmet Tolga; Kaya Adaş, Büşra; Kandemir, İbrahimThis study aimed to evaluate and compare changes in the posterior segment of pediatric asthma patients, potentially associated with asthma or inhaled corticosteroids. A retrospective analysis was conducted on children aged 7–17 diagnosed with atopic asthma. The participants were categorized into groups: Group 1 (no inhaled corticosteroids) and Group 2 (inhaled corticosteroid treatment). A control group of healthy children was also included. Demographic data, clinical findings, and laboratory results (e.g., eosinophil count, IgE, CRP levels) were collected. Optical coherence tomography (OCT) and OCT angiography (OCTA) were used to measure posterior segment parameters. Asthma patients demonstrated a statistically significant reduction in subfoveal choroidal thickness, the superficial capillary plexus in the superior and nasal quadrants, the choriocapillaris in the foveal quadrant, and the peripapillary vascular density in the inferior and superior quadrants compared to controls. Inflammation markers such as eosinophil count and CRP showed significant correlations with changes in vascular density. Asthma, as a chronic inflammatory and hypoxic condition, can significantly affect posterior segment parameters, leading to potential visual function impairments in children. Regular monitoring with OCT and OCTA can help detect early microvascular changes, allowing for timely interventions to preserve visual health.Yayın In vivo reflectance confocal microscopy for detecting cutaneous metastasis in breast cancer(Mattioli 1885, 2025) Duman, Nilay; Yaman, Banu; Oraloğlu, Göktürk; Kararaslan, IşılA 45-year-old female with a history of invasive ductal breast carcinoma (IDBC) presented with an asymptomatic erythematous nodule on the right mastectomy scar. Dermos copy revealed erythematous peripheral border, polymor phous and atypical vessels, focal scaling, and multiple white structureless areas appearing as white clods and strands. Reflectance confocal microscopy (RCM) revealed a normal epidermis with a preserved honeycombed pattern, with der mal tumoral clusters of varying sizes consisting of highly polymorphous hyporeflective cells with different sizes and shapes.Yayın Evaluation of enamel surface roughness and volumetric change after resin remnant removal following orthodontic bracket debonding(Quintessence Publishing Deutschland, 2025) Korkut, Bora; Uzun, Kadir Emre; Hacıali, Çiğdem; Ünal, Tuna; Tağtekin, DilekPurpose: To evaluate surface roughness and volumetric change of enamel after using different resin remnant removal (RRR) techniques, following orthodontic bracket debonding. Materials and Methods: Metal orthodontic brackets (Mini Twin Brackets, RMO) were bonded to 60 human (central or lateral) labial mid-third surfaces, and debonded 24 h after by a single orthodontist. The remaining composites were completely removed with the fluorescence light guidance by the D-Light-Pro led curing unit (GC/detection mode). The removal procedures were performed without magnification (n = 30) or with 20× magnification/5500 K illumination by a dental microscope (OMS2000, Zumax) (n = 30). Three RRR techniques were used: 12-bladed carbide bur (Horico), red-banded diamond bur (Horico), SofLex Disc (medium/40 μm, fine/24 μm, and superfine/8 µm; 3M). Surface changes were evaluated visually through microscope photographs by enamel surface index (ESI) and volumetrically by overlapping the three-dimensional images of a laser scanner device (LAS-20, SD-Mechatronik) in the Geomagic Design X (3D Systems) software. The deemed significance was set at 0.050 for the statistical analyses. Results: A positive, strong correlation was found between visual and volumetric change scores (P 0.001). Lesser volumetric loss (P 0.001) and roughness (P = 0.009) were observed for all RRR techniques when the magnification was used. Volumetric loss (mm3) by diamond bur was significantly the highest [1.85(1–3)a], followed by SofLex Disc [1.1(1–1)c] and carbide bur [0.59(0–1)b](P 0.001). Visual surface roughness scores (Ra) were significantly higher for diamond bur [4.5(4–5)b](P 0.001), followed by carbide bur 2(1–3)a and SofLex Disc 1(1–2)a. Conclusion: Surface roughness should always be assessed together with the volumetric enamel loss for the selection of RRR technique. Red-banded diamond bur should not be used for RRR. Even though the least surface roughness can be provided by SofLex Disc system, it can provide more intact enamel surface loss than the carbide bur. Magnification was considered useful for the RRR to provide a smoother surface while better preserving the intact enamel tissue.Yayın Biomimetic management of orthodontic white spot lesions(Royal Society of Chemistry, 2025) Tunalı, Esra; Karaçay, Şeniz; Özen, Buğra; Albayrak, ÖnderObjectives: white spot lesions (WSLs) may develop in patients with inadequate oral hygiene during orthodontic treatment. This study aimed to develop a natural remineralization agent by creating artificial WSLs in vitro. Materials/methods: WSLs were created in teeth with orthodontic buttons in vitro. The teeth were divided into the following groups: P11-4 (group 1), Nano-HA solution before sintering (group 2), Nano-HA solution after sintering (group 3), P11-4 and Nano-HA mixture before sintering (group 4), P11-4 and Nano-HA mixture after sintering (group 5), boron-containing Nano-HA mixture before sintering (group 6), boron-containing Nano-HA mixture after sintering (group 7), CPP-ACP (group 8), and artificial saliva (group 9). Measurements were taken before and after demineralization, and at the 7th, 14th, 21st, and 28th days of remineralization. Images were recorded using DIAGNOcam and VistaCamIX, area measurements were made using ImageJ, and SEM was used for remineralization assessment. Results: all groups except group 9 showed a reduction in the WSL area, with statistically significant results. SEM analysis revealed the lowest remineralization in groups 8 and 9, while the other groups exhibited more intense remineralization. Conclusions: the most successful groups for WSL remineralization were those containing pure Nano-HA (groups 2 and 3), with the other groups showing varying levels of remineralization.Yayın Role of ovarian stem cells in postnatal oogenesis and implications in fertility preservation(Springer Nature Link, 2025) Benlioğlu, Can; Turan, Volkan; Öktem, ÖzgürIt is a long-held dogma in reproductive biology that females are born with a set nonrenewable number of oocytes in the ovary. While some animal studies challenged this dogma by demonstrating allegedly postnatal oogenesis and the presence of certain stem cell factor expression germ cell markers, their biological roles are yet to be defined. In this chapter, we revisited this issue revisit this dogma in light of most recent data. The chapter outlines the characteristics of these putative OSCs, including their morphological features, expression of germline markers (e.g., DDX4, DAZL), telomerase activity, and methods for their isolation and culture, acknowledging the ongoing debate and methodological controversies surrounding their identification, particularly the reliability of DDX4-based sorting. We critically evaluate the evidence for their capacity to differentiate into oocyte-like cells in vitro and in vivo, including experiments involving transplantation into animal models. Finally, the chapter explores the profound implications these OSCs hold for fertility preservation, especially for women facing premature ovarian insufficiency, age-related infertility, or gonadotoxic treatments. We discuss potential future applications, such as autologous OSC transplantation to restore ovarian function or in vitro generation of mature oocytes for fertilization. We highlight the significant technical and safety hurdles that must be overcome, including optimizing culture systems, ensuring genomic stability, and validating human functional competency. While the physiological role and definitive existence of functional OSCs in adult human ovaries remain contentious subjects requiring further rigorous investigation using advanced techniques like single-cell analysis and lineage tracing, the potential therapeutic promise continues to drive research in this exciting, albeit controversial, area of reproductive medicine.Yayın Individualized oral hygiene home visits for children with special needs(Wiley, 2025) Tunalı, Esra; Ataş, Cafer; Çağ, Yakup; Orhan, Ahmet Lütfullah; Aydınbelge, Mustafa; Tunalı, Mustafa; Özen, BuğraObjective: This study aims to evaluate the 6-month effects of an applied oral hygiene education program delivered through homevisits for children with special needs in Istanbul. Additionally, the study seeks to establish an individualized oral health monitoringprogram and promote non-cariogenic dietary habits.Methods and Results: The study included 279 children with special needs aged 1–8 years. Participants’ oral hygiene practices,dietary habits, and dental health status were compared before and after the education program. Plaque levels were assessed usingthe Silness-Löe Plaque Index, and Streptococcus mutans (S. mutans) levels were measured using the Saliva-Check Mutans test kit.After the intervention, the proportion of children brushing twice daily increased from 13.8% to 33% (p < 0.05), while the percentageof children with moderate plaque levels decreased from 40.1% to 26.5%. Additionally, the proportion of children with S. mutanslevels exceeding 105 CFU/mL decreased significantly from 91.3% to 68.0% (p < 0.005).Conclusion: Individualized oral hygiene education was found to be effective in improving oral health in children with specialneeds. Significant reductions in plaque levels and S. mutans concentrations were observed, along with increased parentalawareness. Future multidimensional educational programs incorporating home visits may play a crucial role in maintaininglong-term oral hygiene habits in children with special needs.Yayın Artificial intelligence in predicting macular hole surgery outcomes: A focus on optical coherence tomography parameters(Springer Nature, 2025) Öztürk, Yücel; Ağın, Abdullah; Yelmi, Burcu; Zorlutuna Kaymak, NiluferPurpose To evaluate the predictive performance of optical coherence tomography (OCT)-based indices and artificial intelligence (AI) using a Generative Pre-Trained Transformer (GPT) model and compare them with traditional logistic regression in forecasting anatomical success following macular hole (MH) surgery. Methods This retrospective observational study included 51 eyes of 51 patients who underwent pars plana vitrectomy for idiopathic MH. Preoperative OCT measurements of macular hole index (MHI), traction hole index (THI), hole form factor (HFF), basal hole diameter (BHD), and minimum hole diameter (MHD) were recorded. GPT-based AI predictions were generated using masked input data. A logistic regression model was developed with the same variables. Predictive performance was assessed using accuracy, area under the curve (AUC), positive predictive value (POPV), negative predictive value (NPV), and Kappa statistics. Results Anatomical success was achieved in 72.5% of cases. MHI, THI, and HFF were significantly higher in the successful group (p<0.0001). GPT achieved an accuracy of 77.0% and AUC of 0.770, with perfect POPV (1.000) but low NPV (0.452). Logistic regression outperformed GPT, achieving an accuracy of 84.3%, an AUC of 0.759, a higher NPV (0.800), and better agreement (Kappa 0.568 vs. 0.392). BHD and MHD showed poor predictive power (AUC 0.291). Conclusion OCT-derived indices, especially MHI, THI, and HFF, effectively predict MH surgery outcomes. Logistic regression based on actual patient data demonstrated superior predictive performance compared to GPT. AI models hold potential but require further development, integration of multimodal data, and validation before clinical application.Yayın Impact of bruxism on the mandibular angle and condylar structures: A panoramic radiographic assessment(Springer Nature Link, 2025) Artaş, Aslıhan; Aslan Öztürk, Elif MeltemObjectives The aim of this study is to comparatively evaluate morphologic changes in the mandibular angle and condylar region, assess the mandibular cortical index (MCI), and analyze the relationships between these parameters in bruxers and non-bruxers using panoramic radiographs. Methods A total of 182 patients (364 mandibular condyle and angle), 91 bruxers and 91 non-bruxers (controls), aged between 18 and 35, were participated in this study. Three hundred sixty four mandibular angles were classifed as G0, G1, G2, G3 in terms of bone apposition and direction change. In addition, osseous changes in the mandibular condyle were determined and the endoestal edge of the basal cortex was evaluated according to the MCI classifcation. Parameters were analyzed using the Pearson’s Chi-Square test and Fisher's Exact test. A p value<0.05 was considered signifcant. Result MCI class C1, G0 class, and normal condyle type were found to be signifcantly more common in the non-bruxist group than in the bruxist group (p<0.001, p=0.025, p=0.006, respectively). It was determined that deformity and MCI-C2 class were more common in the bruxist group (p=0.006, p<0.001). Morphologic changes in the endosteal margin of the cortex and in the condylar region were observed more frequently in bruxist individuals. Conclusion For a general overview of the probable presence of bruxism, osseous changes in the mandibular condyle, and MCI can be used as auxiliary diagnostic markers.Yayın Surgical anatomy of the distal part of the dorsal scapular nerve with a focus on the triple-tendon transfer(Wiley, 2025) Çelikgün, Beyza; Gayretli, Özcan; Gürses, İlke Ali; Coşkun, Osman; Kale, AysinIntroduction: A review of the literature shows that most studies of the dorsal scapular nerve (DSN) have focused on morphological evaluation of the proximal part of the nerve. Morphometric studies contributing to clinical applications are limited. Therefore, we aimed to investigate the topographic and morphometric anatomy of the distal part of the DSN. Methods: 13 cadavers in the Department of Anatomy, Istanbul Faculty of Medicine, were examined bilaterally. DSN dissection was performed on the anterior surface of the levator scapulae and rhomboids, and the distance to the medial border of the scapula (MBS) was recorded at different levels. The insertion lengths of the levator scapulae and rhomboids were also measured. Results: Two types of DSN were observed according to the level of termination in the muscle. Contrary to its classical course, the nerve ran laterally to the MBS on the four sides. The shortest distance between the nerve and the MBS was at the level of the superior border of the rhomboid minor (4.46 ± 9.88 mm). The insertion lengths of the levator scapulae and rhomboids according to gender and the insertion length of the rhomboid minor according to the level of termination in the muscle were significant. Discussion: We have obtained results that may be useful during Eden–Lange tendon transfer. The DSN is not always located medial to the MBS, it may be located lateral to it. To avoid nerve damage, we believe it is important to identify the nerve on the anterior surface of the muscles for a successful surgery.Yayın Pilonidal disease: Gaps in the guidelines and future perspectives(Galenos Publishing House, 2025) Arslan, ÇiğdemPilonidal disease (PD) is an increasingly common condition that predominantly affects the young population. The variety of treatment modalities described in the literature makes it nearly impossible to design a study capable of definitively identifying the optimal method. As a result, treatment strategies are broadly categorized into minimally invasive and excisional approaches, with the choice often tailored to the severity and complexity of the disease on an individual basis. Currently, four major guidelines and consensus reports have been published on PD: The American (1), German (2), and Italian (3) guidelines, as well as the most recent guideline from the European Society of Coloproctology (ESCP) (4) in 2024. While these guidelines share certain points of agreement, they also diverge on several issues, and most of their recommendations are based on expert opinion or very low levels of evidence. Furthermore, many questions frequently encountered by surgeons in daily practice are either not addressed or remain unanswered in these guidelines.Yayın Utilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: A meta-analysis(Elsevier, 2025) Turan, Volkan; Öktem, Özgür; Bang, Heejung; Oktay, Kutluk HanOur aim was to assess fertility preservation (the proportion of women who had at least 1 live birth) and utilization rates (the proportion of women who utilized their cryopreserved embryos) rates among women who cryopreserved their embryos before breast cancer treatments. PubMed and Cochrane library database were searched until December 2024. We included all studies that reported pregnancy outcomes, the number of women who returned for frozen embryo transfer, and the number of women who preserved their fertility. The primary outcome measures were the utilization and fertility preservation rates. Secondary outcome measures were implantation, clinical pregnancy, and live birth rates. Of the 12 studies, 9 met the criteria, encompassing >2126 women with breast cancer who cryopreserved their embryos for fertility preservation. In 9 studies that reported the total number of attempts, 424 women underwent 863 embryo transfers. Based on those studies, the clinical pregnancy and live birth rates were 50% (95% CI: 35-65, I 2: 80%) and 33% (95% CI: 22-46, I 2: 76%), respectively. The utilization and fertility preservation rates were 18% (95% CI: 9-32, I 2: 95%) and 39% (95% CI: 29-51, I 2: 48%), respectively, all from random-effects models. Fertility preservation success with embryos cryopreserved before breast cancer treatments seems to be promising. However, the utilization rate of cryopreserved embryos is low. Additional studies with larger sample size and longer follow up are required to evaluate the long-term utility rates.Yayın Child and adolescent psychiatry consultations during the COVID-19 pandemic(Springer Nature Link, 2025) Vatansever Pınar, Zeynep; Çimen, İrem Damla; Küçük, Elif; Köle, Mehmet Tolga; Kandemir, İbrahimThis study aimed to identify the biopsychosocial stressors influencing child and adolescent mental health during periods when facetoface education was suspended and to evaluate the psychological sequelae of school closures and related restrictions. We conducted a retrospective observational study at Kartal Dr. Lütfi Kırdar City Hospital, a tertiary care center in İstanbul, reviewing all patients referred to the child and adolescent consultation-liaison psychiatry (CLP) unit between March 2020 and March 2022. We assessed associations between psychiatric diagnoses and health-related stressors, school closure status, age, and sex using both frequentist and Bayesian methods. During the study period, 264,013 pediatric admissions were recorded, of whom 270 (0.10%) required psychiatric consultation. The proportions of suicide attempts and anxiety diagnoses did not differ between periods of open and closed schools (BF10 = 0.21 and 0.138, respectively; moderate evidence for the null). Multivariate analysis showed that the odds of suicide attempts were higher in patients exposed to family or schoolrelated stressors (OR = 6.63, 95% CI 2.72–16.19), in females (OR = 8.10, 95% CI 4.16–15.77), and with increasing age (OR = 1.32 per year, 95% CI 1.16–1.50). Female sex (OR = 4.17, 95% CI 2.03–8.55) and older age (OR = 1.30 per year, 95% CI 1.12–1.50) were also associated with depression. Anxiety was more likely in those facing isolation or healthrelated stressors (OR = 3.91, 95% CI 1.66–9.22). These findings highlight the differential impact of stressor type on internalizing symptoms and may inform resource allocation and crisisresponse planning in child mental health services.Yayın Early fibrinogen replacement based on shock index and lactate levels in massive postpartum hemorrhage: A retrospective cohort study(SIMTI, 2025) Küçükbaş, Mehmet; Güner Özen, Eda; Özen, Süleyman; Selçuk, Selçuk; Polat, Mesut; Karateke, AteşBackground - Massive postpartum hemorrhage (PPH) remains a major cause of maternal morbidity and mortality worldwide. Timely fibrinogen replacement is critical in hemostatic resuscitation, yet laboratory delays may hinder early intervention. This study evaluates the clinical outcomes of early fibrinogen concentrate administration in massive PPH using a protocol based on shock index and serum lactate levels rather than laboratory-confirmed hypofibrinogenemia. Materials and methods - This retrospective cohort study included 103 PPH patients treated at a tertiary hospital in Istanbul, Turkey, between 2016 and 2020. Patients were divided into four groups based on fibrinogen dose: Group I (<2 g), Group II (2–4 g), Group III (>4 g), and Group IV (non-massive PPH, no fibrinogen). A predefined protocol guided early fibrinogen administration based on clinical indicators. Fibrinogen was administered without awaiting lab confirmation. Results - Group III had the highest estimated blood loss (2,600±500 mL) and Group IV the lowest (600±150 mL; p<0.001). ICU admission was significantly lower in Group III (23.8%) than in Group I (62.1%; p=0.020). Group III patients also had fewer secondary surgical interventions and reduced transfusion requirements compared to Groups I and II. No thromboembolic events or mortality were observed in any group. Discussion - Early fibrinogen replacement based on shock index and lactate levels appears feasible and beneficial in managing massive PPH. This approach was associated with improved hemostatic control, reduced ICU admissions, and fewer surgical interventions. Prospective studies are warranted to further assess this strategy’s safety, efficacy, and cost-effectiveness.Yayın Comprehensive classification of variations of the anterior part of the circle of willis in fresh cadavers anterior communicating artery(Galenos Publishing House, 2025) Nteli Chatzioglou, Gkionoul; Nas, Emine; Kale, Ayşin; Aktaş, Kardelen; Coşkun, Osman; Gayretli, ÖzcanObjective: The goal of our study is to evaluate and classify the variations of the anterior communicating artery (AComA) on fresh cadavers from the Türkiye population. Methods: In this study, 182 fresh cadavers were analysed and classified according to the number, shape and course of the AcomA. Results: In our study, typical AcomA was the most common with a rate of 86 (47.25%), while variations of the AcomA were found in the remaining 96 (52.75%) cases. Among these variations, in 11.46% (11/96) of cases, AcomA variations were identified as distal and proximal duplications according to the number of branches they represented; 68.75% (66/96) of cases were identified by their shape (X-shaped, single/double fenestration, hypoplasia, or aplasia); and, in 19 cases, it was characterized by course (median artery or oblique course). The rate of variations was 65% (26/40) in females and 49.29% (70/142) in males. In our study, the X-shaped and single fenestration variations were recorded as the most common. Conclusions: The results of the study are important for cerebrovascular surgery and radiological interventions. It emphasises the importance of recognising and considering variations. The study will contribute to the understanding of cerebrovascular diseases and the development of treatment strategies.Yayın Psychological impact of the February 6 earthquake on displaced individuals with proximal loss residing in temporary shelters(Routledge, 2025) Filazoğlu Çokluk, Gülşen; Bal, Fatih; Savaş, EsraThe present study examines the psychological effects of the earthquake that occurred in Turkey on 6 February 2023 on individuals residing in temporary shelters who have experienced losses in their immediate surroundings. The objective of the present research is to elucidate the relationships between post-traumatic stress disorder (PTSD), depression, anxiety, and the subjective impact of the traumatic event. Nine months following the disaster, a survey was conducted among 923 adults aged 25 to 60 residing in temporary shelters in Antakya. Participants completed a series of validated and reliable measurement tools, including the DSM-5 Post-Traumatic Stress Disorder Checklist (PCL-5), the Beck Anxiety Inventory (BAI), the Beck Depression Inventory (BDI), and the Impact of Events Scale (IES). The findings indicate significant and positive correlations between PTSD and all other variables, including the impact of the event, depression and anxiety. The multiple regression analysis revealed that these three variables significantly predicted PTSD symptoms and collectively explained 41% of the variance in PTSD levels. This study emphasizes the cumulative psychological impact of forced displacement and close losses on individuals and underscores the pressing need for culturally sensitive and trauma-informed mental health services in post-disaster intervention processes. The findings contribute to the understanding of trauma dynamics in post-disaster communities and guide the development of targeted mental health policies and psychosocial support programs.Yayın Predicting risk of lymph node metastasis in papillary thyroid cancer using miRNAs and clinicopathological features(Springer Nature Link, 2025) Ergün, Penbe Gül; Aydoğan, Çağatay; Ceviz, Ayşe Begüm; Candan, Gonca; Batur, Şebnem; Yılmaz Aydoğan, Hülya; Öztürk, Oğuz; Öztürk, TülinThis study investigates potential prognostic values in models created with clinico pathological features and expression profles of miRNAs known for their critical roles in papillary thyroid carcinoma (PTC) for lymph node metastasis (LNM) in PTC cases. Forty-seven lymph node-metastatic PTC patients and 46 non-metastatic patients were included. Using RT-PCR, miR-21, miR-146b, miR-221, and miR-222 expression was analyzed in carcinoma tissues and metastatic lymph nodes of the same PTC patients and carcinoma tissues of non-metastatic PTC patients. MiR 146b (p<0.001) and miR-221 (p=0.009) were overexpressed in metastatic PTCs compared to non-metastatic PTCs. The miRNA expression profles were similar in the lymph nodes and primary cancer of metastatic PTCs. In the presence of larger tumors (>1 cm) in metastatic PTCs, miR-146b and miR221 were overexpressed in the tumor tissue (p=0.036), while miR-222 was overexpressed in metastatic lymph nodes (p=0.035). miR-146b was also upregulated in lack of peritumoral lympho cyte infltration (p=0.006). In conclusion, our fndings suggest that the overexpres sion of miR-146b and miR-221 in PTC tissues may be associated with lymph node metastasis and a poorer prognosis. Furthermore, the presence of larger tumors and increased levels of intratumoral fbrosis in non-metastatic PTC patients could indi cate a poor prognosis.Yayın Antihypertensive treatment of a patient with normal blood pressure: Case report and call for paying attention(Wolters Kluwer, 2025) Atmaca, Hasan; Erol, Mustafa Kemal; Yetkin, ErtanThe current 2024 European Society of Cardiology (ESC) guideline for the management of elevated blood pressure and hypertension defines blood pressure less than 115/65 mmHg by ambulatory blood pressure monitoring (ABPM) as nonelevated, blood pressures in-between 115–129 and 65–79 mmHg as elevated blood pressure, and hypertension as ≥130/80 mmHg. There, might be patients seeking medical attention for the symptoms, apparently nonspecific but suggestive of hypertension with optimal, or not elevated, or elevated blood pressure values. A female patient with complaints of headache and dizziness lasting for 2 months has been evaluated in cardiology outpatient clinic and assessed by ABPM. It has been told that she had previously blood pressure of 90–100/50–60 mmHg and was suffering from headache when systolic blood pressure exceeds 110 mmHg. Her 24-h ABPM revealed systolic and diastolic blood pressure as 106/63 mmHg showing nighttime decrease compared with daytime pressures (98/59 mmHg and 108/68 mmHg, respectively). Thereafter, she was instructed to keep continuing the life-style modification and given to beta-blocker (bisoprolol 5 mg) as an antihypertensive treatment. At the end of the 2 weeks of follow-up period, she was headache-free and was feeling comfortable and well with a mean home blood pressure of 98/56 mmHg. We have presented prosperous antihypertensive treatment of a female patient suffering from headache and dizziness with a numerically normal or nonelevated blood pressure. In the presence of symptoms and having not elevated or elevated blood pressure levels, patients’ history on previous measure of blood pressure might facilitate our decision-making process.Yayın Comprehensive analysis of brewed tea: Boron content, total antioxidant and oxidant capacity, oxidative stress, and ph value(Springer Nature Link, 2025) Cihan, Aslıhan; Özel Korlu, Armağan Begüm; Tüzüner, Burcin Alev; Yarat, AyşenTea is widely recognized as the most consumed beverage in the world after water. In recent years, the connection between tea and health has gained growing attention as a signifcant research topic. In this study, we evaluated the relationship between tea and health by analyzing the boron content, total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), and pH levels of teas commonly consumed in Türkiye. A total of 42 samples were created from various tea brands and diferent tea types that are widely consumed in Türkiye. The determination of boron in pulverized and brewed tea samples was carried out using the carminic acid method. Additionally, boron transfer was determined in brewed teas. Brewed tea samples were also examined in terms of pH, TAC, TOC, and OSI. It was determined that all teas contained an average of 11.73 mg/L boron, the amount of boron in domestic teas was lower than in imported teas. It was determined that boron transfer into brewed tea was approximately 30%. The pH values ranged between 4–5. No diferences were detected in terms of TAC, TOC, and OSI. Our research shows that tea consumption is safe in terms of boron levels and helps meet daily needs. The OSI of teas is less than 1, so their antioxidant efects can be considered quite good. However, it should be noted that excessive tea consumption can lead to the demineralization of tooth enamel due to low pH levels.Yayın Advances in parkinson's disease research: Exploring biomarkers and therapeutic strategies for halting disease progression(Frontiers Media S. A., 2025) Bougea, Anastasia; Değirmenci, YıldızParkinson's disease (PD) is a multifactorial neurodegenerative disorder, characterized by loss of dopaminergic neurons of substantia nigra (SN) in 1% of people aged above 65 years (Ben-Shlomo et al., 2024). Its complex clinical picture includes motor symptoms such as tremor, bradykinesia, and gait instability, as well as non-motor symptoms (depression, psychosis, cognitive decline) (Schilder et al., 2017;Titova and Chaudhuri, 2017). Current symptomatic therapies have limited long-term efficacy (Aldaajani and Khalil, 2024). A deep analysis of neural network after PD onset could deepen our understanding of the molecular crosstalk and biological processes underlying PD pathogenesis (Tomkins and Manzoni, 2021). However, there is a lack of reliable biomarkers for early diagnosis, presenting barriers to monitoring and developing disease-modifying therapies. There are several different types of biomarkers for PD , such as clinical, neurochemical and genetic (Bougea, 2020). Ten studies provided novel insights into the early detection and monitoring of PD.in the occipital region of the PD group can be usedtilized as a rapid and objective test indicator to screen for depressive symptoms in PD.Zhang et al. identified circadian rhythm genesAK3, RTN3, and LEPR as biomarkers in the progression of PD by regulating NK cells, however, the exact mechanism is not clear.Wang et al. confirmed that authenticated GPR78, CADM3, and CACNA1E were as the biomarkers that mostly mainly participated in pathways, such as the 'cell cycle' and 'hydrogen peroxide catabolic process', and They also found; five types of differential immune cells that differed between PD and control groups were identified. Together, these studies highlight the importance of combination of biomarkers and risk variables into predictive models , improving early diagnosis and monitoring of PD. Sme of them may serve as diagnostics (lncRNAs, P1 amplitude) or predictive (NVU, cathepsin B, APA2, circadian rhythm genesAK3) may shed novel light on the pathogenesis of PD.Both pharmaceutical and non-pharmacological (cognitive training, physical activity, and dietary changes) treatments are used to treat PD symptoms (Degirmenci et al., 2023;Ernst et al., 2024). Seven promising approaches were also highlighted by this showed that acupuncture, cognitive behavioral therapy, exercise and repetitive transcranial magnetic stimulation significantly improved sleep, depression, anxiety, cognition, constipation, and quality of life of PD patients.Studies suggest personalized pharmaceutical and non-pharmacological therapies for PD, with nicotine, Golexanolone, taVNS, acupuncture, and FMT showing promising antiparkinsonian properties, by modulating brain activity. Further research is needed to validate their sustainability, safety, and effectiveness.Bibliometric analysis is a systematic approach to evaluating scientific literature and detecting patterns, and effects by using quantitative tools to filter data from relevant sources (Passas, 2024). This research topic includes two bibliometric studies that significantly expand their respective fields. This research topic combines important studies on the risk factors, treatments, biomarkers and bibliometric analysis. The results of these studies provide a useful guide for clinicians in their practice and to suggest targets for researchers in developing new diagnostics and therapeutic strategies. We conclude that the results of these studies are a useful tool that help clinicians in their practice and motivate researchers to look for new developments.Yayın In-depth analysis of the demographic landscape and clinical outcomes of assisted reproductive technologies in Türkiye: A comprehensive survey for the years 2020 and 2021(Galenos Publishing House, 2025) Benlioğlu, Can; Aydın, Yunus; Bostancı, Mehmet Sühha; Bozdağ, Gürkan; Bulgurcuoğlu, Sibel; Demir, Ahmet; Dilbaz, Serdar; Dirican, Enver Kerem; Turan, Volkan; Balaban, BaşakObjective: To investigate patient characteristics and outcomes of assisted reproductive technology (ART) cycles conducted in Türkiye during the coronavirus disease-2019 (COVID-19) pandemic (2020-2021). Material and methods: ART centers in Türkiye were invited to participate in this survey. The questionnaire focused on patient demographics and performance outcomes and was sent to center directors via anonymous Qualtrics™ links. Results: The survey was sent to 167 centers and data were collected from 15 centers in 2020 and 24 centers in 2021. The clinical pregnancy rate from intrauterine insemination (IUI) procedures remained similar, with 15.1% in 2020 (1,245 IUI cycles) and 14.5% in 2021 (2,023 IUI cycles), while successful delivery rates were 12.5% and 11.5%, respectively. For ART treatments, the clinical pregnancy rate from fresh embryo transfers increased from 45.1% in 2020 (3,119 transfers) to 50.4% in 2021 (8832 transfers), with similar live birth rates, 34.2% vs. 34.4%. Frozen embryo transfers resulted in clinical pregnancy rates of 47.8% in 2020 (2,498 transfers) and 51.9% in 2021 (12,015 transfers), with live birth rates rising from 39.8% to 42.7%. Preimplantation genetic testing cycles resulted in clinical pregnancy rates of 64.2% in 2020 (271 transfers) and 60.8% in 2021 (2,102 transfers), with live birth rates of 53.5% and 48.2%, respectively. Regarding techniques for fertility preservation in females, 11 prepubertal and 61 postpubertal ovarian tissue cryopreservation procedures were reported, alongside 1,346 cycles performed within the same period. In males, 144 post-pubertal testicular tissue, 871 epididymal and 2,480 ejaculated sperm cryopreservations were reported. During the two years, six ovarian tissue transplantations followed by ART were performed, with 96 women using cryopreserved oocytes. In addition, 40 testicular tissue, 298 epididymal, and 238 ejaculated sperm samples were used for ART purposes. Conclusion: This survey provides a comprehensive overview of ART practices in Türkiye for 2020 and 2021, establishing a long-term, nationallevel analysis while highlighting the challenges posed by the COVID-19 pandemic. The longitudinal analysis established a foundation for future annual reports and offers critical insights into emerging trends over these two years.
