PubMed İndeksli Yayın Koleksiyonu

Bu koleksiyon için kalıcı URI

https://hdl.handle.net/20.500.13055/9

Listeleniyor 1 - 20 / 353

The letrozole use in reproductive medicine: Beyond aromatase inhibition - a comprehensive review
(Galenos Publishing House, 2026) Aydın, Gerçek; Hatırnaz, Şafak; Hatırnaz, Ebru Saynur; Çetinkaya, Mehmet Bilge; Akdeniz, Muhterem; Dokuzeylül Güngör, Nur; Güler, Oğuz; Merdanoğlu, Merdan Ali; Uzun, Asiye; Eroğlu, Semra; Dahan, Michael
Letrozole and other aromatase inhibitors are increasingly recognized as first-line ovulation induction (OI) medications, offering an efficient and physiologic approach to ovarian stimulation that enhances outcomes in reproductive medicine. By selectively inhibiting aromatase and maintaining lower peripheral estrogen levels, letrozole supports mono- or bi-follicular development while reducing the risk of supraphysiologic estradiol exposure seen with traditional gonadotropin regimens. These pharmacological characteristics have contributed to its expanding use not only in OI but also in various assisted reproductive technologies. To evaluate the clinical benefits, effectiveness, and safety of using letrozole in in vitro fertilization (IVF), in vitro maturation (IVM), and OI, with particular attention to reproductive outcomes, ovarian response, endometrial effects, cycle characteristics, and treatment-related adverse events. A comprehensive systematic search covering the period from December 2000 to November 2025 was conducted across major electronic databases including PubMed, Embase, the Cochrane Library, and Google Scholar. The search strategy incorporated predefined keywords related to letrozole, aromatase inhibition, OI, IVF, and IVM. Studies involving randomized controlled trials, observational cohorts, and meta analyses were included, while non-clinical and non-reproductive data were excluded. Relevant outcomes were extracted and synthesized qualitatively. Letrozole demonstrates broad clinical utility in reproductive medicine, spanning assisted reproductive techniques, ovarian stimulation strategies, and the management of ovarian hyperstimulation syndrome risk, ectopic pregnancy, and endometriosis-related infertility. Its targeted estrogen suppression, cost-effectiveness, and favorable safety profile make it a valuable component of individualized treatment protocols. Nonetheless, further high-quality research is required to refine optimal dosing strategies, identify ideal patient populations, and clarify long-term reproductive and obstetric safety.
Survey on the usage and frequency of digital magnification devices in dentistry
(BioMed Central, 2026) Kıtın, Emine; Yazıcıoğlu, Oktay; Pekgöz, Abdullah; Kuzucan, Sera Gülhan
Objective This study aimed to evaluate the awareness, usage frequency, and perceptions of dental magnification devices (DMDs) among academic dental practitioners. Methods A cross-sectional survey was conducted at the Istanbul University Faculty of Dentistry, which targeted academic staff, doctoral candidates, and specialization students. A total of 159 participants completed an 18-item multiple-choice questionnaire. The data were collected via email and QR codes and statistically analyzed via descriptive and inferential methods. Results The results revealed increasing awareness and usage of DMDs, with ergonomic benefits and improved treatment precision being the most commonly cited advantages. Despite these benefits, barriers such as cost and concerns over device dependency have limited broader adoption. The participants indicated that magnification was particularly valuable in endodontics and restorative procedures. Conclusion The findings emphasize the growing recognition of DMDs in academic dental practice and highlight the need to incorporate magnification training into dental education curricula to enhance clinical skills and ergonomic awareness from an early stage.
Ozone treatment attenuates neuroinflammation and alters miRNA expression in a rat model of post-traumatic epilepsy
(Springer Nature Link, 2026) Demir, Hüseyin; Demirtaş, Cumaali; Yıldırım, Hava; Demir, Ecem; Kıroğlu Uzun, Sezin; Şevgin, Kübra; Beyaztaş, Hakan; Güler, Eray Metin; Hekimoğlu, Gulam; Çoşkunpınar, Ender Mehmet; Şanlıer, Nafiye; Yıldırım, Mehmet
The aim of this study was to investigate the effects of intraperitoneal ozone therapy in a post-traumatic epilepsy (PTE) model. An in vivo PTE model was established in male Sprague–Dawley rats, which were randomised to control (n=8), PTE (n=10), and PTE+Ozone (n=10) groups. 0.7 mg/kg ozone was administered intraperitoneally for 3 consecutive days. Seizure activity was video recorded for 120 min and evaluated for latency, frequency, duration, and severity. Behav ioral assessments of locomotor activity, anxiety, and spatial memory were conducted using open field, elevated plus, and radial arm maze tests on days 4–6 after the first ozone application. Blood and brain tissues were collected for biochemical assays (SUR1, TRPM4, IL-1β, IL-6, TNF-α, TAS, TOS, OSI, thiol–disulfide homeostasis), histological analyses (H&E, Cresyl Violet, and 8-OHdG immunostaining), and qRT-PCR of epilepsy-related miRNAs. Significant differences were observed among the groups for all serum and brain biomarkers (p<0.001). The PTE group showed marked increases in SUR1, TRPM4, IL-1β, IL-6, TNF-α, TOS, OSI, TT, NT, and DIS levels, accompanied by a decrease in TAS. Ozone treatment partially reversed these changes by reducing cytokine and oxidative stress markers, improving thiol–disulfide balance, and restoring TAS levels. Behavioural testing revealed beneficial effects of ozone, including reduced immobil ity, fewer errors in the radial arm maze, and increased open-arm exploration. Although seizure severity, latency, and duration were not significantly altered, seizure frequency showed a decreasing trend (p=0.067). Immunofluorescence for 8-OHdG revealed increased hippocampal oxidative DNA damage in the PTE group, which was attenuated following ozone treatment. Analysis of miRNA expression revealed downregulation in the PTE group, whereas ozone treatment resulted in overall upregulation. There was no statistically significant difference between miRNA expression results and the PTE+Ozone group (p=0.056–0.076). Ozone therapy mitigated oxidative stress and inflammation, improved redox homeostasis, enhanced cognitive and locomotor performance, and reduced hippocampal DNA damage in the PTE model. Furthermore, the observed upregulation of specific miRNAs following ozone treatment highlights a potential molecular mechanism contributing to its neuroprotective effects.
Clinical and molecular features of ovarian stimulation in peripubertal girls with mosaic turner’s syndrome
(Oxford University Press, 2026) Öktem, Özgür; Kalajahi, Hesam Ghafouri; Esmaeilian, Yashar; Benlioğlu, Can; Hela, Francesko; Yusufoğlu, Sevgi; Kalkan, Üzeyir; Turan, Volkan; Ata, Barış
STUDY QUESTION: Do peripubertal girls with mosaic Turner’s syndrome (TS) respond to ovarian stimulation (OS) for oocyte freezing as adult women with normal ovarian reserve? SUMMARY ANSWER: Clinical and molecular reproductive/endocrine features of OS in these patients are similar to those of adult females. WHAT IS KNOWN ALREADY: OS for oocyte freezing is quite a new concept in peripubertal and young adolescent girls with TS be cause ovarian tissue cryopreservation (OTC) does not have proven efficacy, likely due to already diminished ovarian reserve and ac celerated follicle atresia. No data are available in the literature regarding the molecular IVF characteristics of these cycles in this group of patients. We aimed to address this issue in the current study by analyzing gonadotropin receptor expression, response to gonadotropins, and steroidogenic function at the molecular level in four peripubertal patients aged 9, 12, 13, and 15 in comparison to control adult females with normal ovarian reserve undergoing OS for male factor infertility. STUDY DESIGN, SIZE, DURATION: This is a clinical and research study that simultaneously analyzes the clinical and molecular characteristics of OS in peripubertal young girls with TS between 2021 and 2023 at a university hospital and translational re search center. PARTICIPANTS/MATERIALS, SETTING, METHODS: All participants underwent OS using a progestin-primed protocol with recombi nant forms of FSH and LH, and final maturation was induced with recombinant hCG. Control patients who had normal ovarian re serve and underwent OS for male factor infertility were randomly recruited during the study period to simultaneously compare and analyze the clinical and molecular OS characteristics of the peripubertal TS cases. Luteinized mural granulosa cells obtained during oocyte retrieval procedures were used for the experiments. Cell culture, quantitative real-time PCR, immunoblotting, confocal time lapse live-cell imaging, and hormone assays were used. MAIN RESULTS AND THE ROLE OF CHANCE: All TS cases responded to gonadotropin stimulation. Nine mature oocytes were re trieved and vitrified in the 9-year-old prepubertal mosaic TS case after four cycles of OS with r-FSH (300 IU) and r-LH (150 IU)/day after a mean stimulation period of 9.72 ± 2.1 days. Eight mature oocytes were retrieved in the case aged 13 after three rounds of OS. The other cases, aged 12 and 15, underwent only one cycle of OS, and two mature oocytes from each were retrieved. The expression of FSH/LH receptors and steroidogenic enzymes, basal and gonadotropin-induced up-regulation in the expression of the steroidogenic enzymes, and estradiol and progesterone productions of the GCs of the TS patients were similar to those of adult control patients. Confocal immunofluorescence microscopy and live imaging revealed no differences in cholesterol uptake/trafficking or in staining patterns of the steroidogenic enzymes and their co-localization with mitochondria and cholesterol-laden lipid droplets. LIMITATIONS, REASONS FOR CAUTION: Findings were obtained from a limited number of mosaic TS patients. It is unclear if these findings are reproducible in non-mosaic peripubertal cases. Furthermore, no data are available yet regarding the post-thaw survival, fertilization, embryo development competency, euploidy status, and obstetrical outcomes of the vitrified oocytes of these patients. WIDER IMPLICATIONS OF THE FINDINGS: This study provides reassuring clinical and molecular evidence that OS for oocyte freez ing can be an option in young girls with mosaic TS who are not ideal candidates for OTC due to diminished ovarian reserve. STUDY FUNDING/COMPETING INTEREST(S): This study was supported by the School of Medicine, the Graduate School of Health Sciences, and the Research Center for Translational Medicine (KUTTAM) at Koc¸ University. The authors declare no competing interests. TRIAL REGISTRATION NUMBER: Not applicable.
Evaluating a pathogen-specific IgG binding assay for rapid detection of healthcare-associated infections
(Nature Portfolio, 2026) Karakullukçu, Asiye; Akker, Mustafa; Kuşkucu, Mert Ahmet; Aygün, Gökhan; Dikmen, Yalım
Rapid and accurate diagnosis of healthcare-associated infections (HAIs) is an unmet need for improving outcomes in intensive care units (ICUs). Traditional culture-based methods, while the gold standard, are time-consuming and can delay therapeutic interventions. In this study, we evaluated the diagnostic utility of pathogen-specific immunoglobulin G (IgG) binding levels using an enzyme-linked immunosorbent assay (ELISA). We measured IgG binding against pathogens including Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Enterococcus faecium, and Staphylococcus aureus. Diagnostic performance was evaluated through receiver operating characteristic (ROC) curve analysis, with culture results as the reference. The assay demonstrated an overall diagnostic accuracy of 83.2%, with a sensitivity of 85.4%, a specificity of 81.4%, and an area under the curve (AUC) of 0.910. Pathogen-specific cutoff values ranged from 0.918 to 1.534. Especially, A. baumannii showed the highest performance metrics, achieving a sensitivity of 94.7%, a specificity of 93.6%, and an AUC of 0.975. The pathogen-specific IgG binding levels can offer a novel and effective diagnostic tool for the initial assessment of HAIs, enhancing early detection and improving patient management across healthcare settings.
Does lip change following premolar extraction differ in patients with high and normal vertical growth patterns?
(Galenos Publishing House, 2026) Erdem, Buket; Başal, Ece; Emir, Büşra
Objective: To evaluate the relationship between incisor retraction and upper and lower lip repositioning in patients with high and normal vertical growth patterns (NVP), and to assess whether vertical growth pattern influences soft tissue changes following extraction treatments. Methods: Pre- and post-treatment lateral cephalograms of 79 patients who underwent extraction of two or four first premolars were analyzed. Patients were divided into a [high vertical pattern (HVP); Frankfort-mandibular plane angle (FMA) >30°, n=49] and a NVP; 22< FMA ≤30°, n=30) group. Horizontal and vertical changes in the lips, labiomental fold, and lip strain were measured, and correlations between these changes and incisor movements were assessed. Results: Upper lip retraction was greater in the HVP group (2.86 mm, p<0.05) than in the NVP group (1.97 mm, not significant). Upper lip height decreased significantly in both groups, with a slightly greater decrease in the NVP group (p<0.001). Upper lip strain decreased in both groups, especially in the HVP group (p<0.001). Incisor retraction was strongly correlated with upper-lip changes in both groups, and with lower-lip and labiomental-fold repositioning in the NVP group. Conclusion: Soft tissue response to incisor retraction varies with vertical growth pattern, with greater upper lip retraction in HVP patients. Vertical growth patterns should be considered for optimal soft tissue outcomes.
Evaluation of muscle oxygenation by functional near-infrared spectroscopy in patients with myasthenia gravis during rest and exercise
(Turkish Neuropsychiatric Society, 2026) Coşkun Semiz, Ebru; Alökten, Merve; Karakulak, Ece Zeynep; Aysal, Fikret; Hanoğlu, Lütfü
Introduction: Myasthenia gravis (MG) is an autoimmune disease that is caused by autoantibodies targeting the neuromuscular junction. A few studies in the literature show that MG may negatively affect muscle metabolism. However, no current study investigates MG pathophysiology’s effect on muscle oxygenation. In this study, we aimed to investigate the difference in muscle oxygenation in MG disease and to evaluate its clinical Pathophysiological implications. Methods: 19 MG patients and 19 age, gender and body mass index (BMI) matched healthy controls participated in the study. Functional near-infrared spectroscopy (fNIRS) recordings were recorded from six channels over the biceps brachii muscles during the rhythmic elbow flexion-extension task. Results: It was observed that oxygenated-hemoglobin (HbO) (p = 0.008) and total hemoglobin (HbT) (p = 0.017) values during exercise were significantly lower in MG patients in the motor point of the biceps brachii muscle. In addition, at rest, deoxygenated-hemoglobin (HbR) levels were significantly lower in patients (p<0.05) in the motor point and the lateral region of the biceps brachii muscles. Additionally, a difference is observed in fNIRS values between the moderate-severe MG group and healthy controls. Also, a negative correlation was observed between exercise-state HbO and rest-state HbR values and disease severity (p<0.05). Conclusion: MG patients show deterioration in muscle oxygenation values during exercise and rest. Oxygenation values show significant differences in disease severity and negatively correlate with disease severity. Based on these findings, MG disease may affect muscle oxygenation and can be monitored by fNIRS.
Sharps injuries among nursing staff: A qualitative study
(SAGE Publications, 2026) Aydoğdu, Ana Luiza Ferreira
Background: Injuries involving members of the nursing team are not uncommon, with sharps-related incidents being among the most frequent. Previous studies have focused on quantitative outcomes or on healthcare professionals in general, leaving a gap in understanding the subjective experiences and perspectives of nursing staff. This study aimed to explore the opinions and experiences of nursing staff regarding sharps injuries, with the goal of identifying contributing factors, gaps in current prevention strategies, and opportunities to improve occupational safety and injury-prevention practices within healthcare settings. Methods: This qualitative study used a descriptive phenomenological approach and included 38 nursing staff from various regions of Brazil. Participants responded to open-ended online questions between July 26 and September 11, 2025. Findings: Themes emerged: (1) the moment when the injuries occur, (2) factors that trigger the injuries, (3) the period following the injuries, and (4) strategies adopted to prevent new injuries. Twelve subthemes were identified.Conclusions/Applications to Practice:The study addresses a highly relevant issue in healthcare, as nursing staff need to prioritize their own health while caring for others. Although it does not present findings different from previous research regarding the occurrence of such injuries, its importance may lie precisely in highlighting results that remain unchanged. The study also shows that nurses often internalize blame for occupational injuries, viewing them as personal failures rather than system issues. It highlights the need for rigorous monitoring, ongoing training, consistent safety materials, and encouragement of incident reporting to strengthen collective safety and promote a positive safety culture.
Beyond organ-specific therapies: A unified approach to multi-organ fibrosis
(Dove Medical Press Ltd, 2026) Pan, Ziyan; Zerehpoosh, Shadi; Wang, Shu-Chi; Örmeci, Necati; Kim, Won; Eslam, Mohammed
Organ fibrosis, characterized by excessive scarring of tissues in the liver, kidney, lung, and heart, poses a significant and growing global health challenge, resulting in considerable morbidity and mortality, with a lack of effective treatment options. Most research and drug development efforts have traditionally focused on individual organs in isolation. This review aims to provide a comprehensive perspective on multi-organ fibrosis, highlighting recent advances that clarify the complex cellular and molecular mechanisms involved in the liver, kidney, lung, and heart. It examines both common and organ-specific factors that drive fibrogenesis. Additionally, the review discusses the current and future landscape of antifibrotic therapies, including innovative approaches to developing pan-organ antifibrotic drugs. Challenges and future directions in the design of clinical trials are also addressed.
A quality by design study of the use of microfluidic nanoprecipitation for the generation of sub-100 nm drug nanocrystals
(Elsevier, 2026) Pirinçci Tok, Yağmur; Abukhamees, Shorooq; Fitaihi, Rawan; Demiralp, Burcu; Özsoy, Yıldız; Craig, Duncan
Although drug nanocrystals have attracted considerable interest within the pharmaceutical industry, there remain issues with the production of nanocrystals with a size below 100 nm. The aim of the present study is to develop a stable, reproducible Canagliflozin (CFZ) sub-100 nm nanosuspension system using microfluidic nanoprecipitation and Quality by Design (QbD) techniques. By means of the circumscribed central composite design (CCCD), critical parameters of the microfluidic nanoprecipitation process and nanosuspension formula tion components were optimised. Optimal CFZ nanosuspension with Z-average of 89.52 ± 3.30 nm, PDI of 0.12 ± 0.01 and drug content of 92.49 ± 0.03 % was successfully fabricated using Soluplus as a stabiliser. An increase in saturation solubility corresponding to approximately 250 times the value of the pure CFZ in water was noted. The optimised CFZ nanosuspension was solidified by freeze-drying and electrospraying. Overall, the study has demonstrated that by using a combination of microfluidics and QbD it is promising to generate stable sub-100 nm nanocrystals with high yield, and narrow size distribution and favourable stability.
Anatomic safety profile of a novel mini external fixator for proximal crescentic osteotomy in hallux valgus correction: A cadaveric study
(Springer Nature Link, 2026) Coşkun, Osman; Nteli Chatzioglou, Gkionoul; Gürses, İlke Ali; Ok, Fatma; Gayretli, Özcan; Erdil, Mehmet
Purpose The proximal crescentic osteotomy is an effective procedure for hallux valgus correction, but stable fixation remains challenging. Our previous biomechanical study suggested that the MEF may offer comparable or greater stability than a specific cannulated screw fixation construct in a cadaveric model. This study aims to evaluate the anatomical safety of the MEF by investigating its relationship with critical neurovascular structures and tendons. Methods An anatomical dissection study was performed on ten foot cadaveric specimens. The MEF was applied using five mini-Schanz pins inserted in predefined positions. Following fixation, a layer-by-layer dissection was conducted to expose the dorsalis pedis artery, superficial cutanous branches of the foot, the superficial venous arch, and the extensor hallucis lon gus and brevis tendons. The distance from each pin to these structures and any iatrogenic injuries were recorded. Results The superficial venous arch was injured at low rates by the medial distal pin (20%), the medial proximal pin (10%), and the lateral distal pin (20%). Tendon injury was more frequent, with the extensor hallucis longus tendon being injured by 20–30% of pins, and the extensor hallucis brevis tendon by the lateral intermediate and distal pins (20% each). Conclusion The application of the MEF for first metatarsal fixation appears anatomically safe with respect to major arteries and nerves. The consistent avoidance of the dorsalis pedis artery and key sensory nerves is a significant advantage over some established techniques. However, surgeons should be aware of the potential risk to the superficial venous arch and extensor tendons during pin placement. These findings support further investigation of the MEF for proximal crescentic osteotomy f ixation.
Anatomical study of the superficial and deep circumflex iliac arteries: Morphology, variability, and surgical relevance
(Springer Nature Link, 2026) Ok, Fatma; Nteli Chatzioglou, Gkionoul; Karip, Burak; Önal, Vildan; Yıldız, Nilay; Tatar, Burak Ergün; Gayretli, Özcan
Purpose The vascular anatomy of the groin region plays an important role in reconstructive surgery and regional anesthesia, yet data on the precise morphology and topography of the superficial and deep circumflex iliac arteries remain limited. Methods 28 lower extremities of fourteen formalin-fixed male cadavers were dissected to examine the superficial and deep circumflex iliac arteries. Their origins, branching patterns, diameters, and spatial relationships to the inguinal ligament and femoral triangle were recorded. Morphometric distances were measured with a digital caliper, and correlations between parameters were analyzed statistically. Results The superficial circumflex iliac artery arose exclusively from the femoral artery in all cases and was consistently located within the femoral triangle. Its mean origin diameter was 1.83±0.46 mm. The deep circumflex iliac artery showed greater variability, originating from the external iliac artery in half of the cases and from the femoral artery in the other half. Its mean origin diameter was 2.25±0.40 mm, and it was located outside the femoral triangle in 71.4% of cases. Multiple significant correlations were identified between vessel diameters, bifurcation points, and their spatial relationships with the inguinal ligament. Conclusion The superficial circumflex iliac artery displays consistent anatomy, whereas the deep circumflex iliac artery demonstrates notable variability in origin and topography, though with stable vessel caliber. These findings provide detailed morphometric insights that may support safer flap design and improve surgical and anesthetic planning in the groin region.
Comparison of quadro‑iliac plane block and erector spinae plane block for postoperative analgesia management after single level lumbar discectomy surgery: A randomized, double‑blind, controlled, prospective, multicenter study
(Springer Nature Link, 2025) Turan, Engin İhsan; Otlu Bıyıkoğlu, Büşra; Özen, Volkan; Alver, Selçuk; Umutoğlu, Tarık; Cücü, Oğuzhan; Çevik, Serdar; Çiftçi, Bahadır; Şahin, Ayça Sultan
Purpose Effective postoperative analgesia management is critical for optimizing recovery and patient satisfaction following lumbar discectomy. Erector Spinae Plane Block (ESPB) is an established regional anesthesia technique with proven efficacy, while the novel Quadro-Iliac Plane Block (QIPB) has shown promise as an alternative approach. This study compares the analgesic efficacy, opioid-sparing potential, and safety of ESPB and QIPB in single-level lumbar discectomies. Method This multicenter, prospective, randomized, double-blind study included 60 patients aged 18–65 years undergoing single-level lumbar discectomy. Patients were randomized into ESPB (n=30) and QIPB (n=30) groups. Both blocks were performed at the end of surgery, before the extubation under ultrasound guidance using 40 ml (0.25%) bupivacaine bilater ally. The primary outcome was postoperative pain assessed by the Numeric Rating Scale (NRS) at 12 h. Secondary outcomes included tramadol consumption, rescue analgesia requirements, hemodynamic parameters, and adverse events. Results The primary outcome, 12-h NRS scores, did not differ significantly between groups (p>0.05), indicating similar anal gesic efficacy. Secondary outcomes—including total tramadol consumption (54.00±49.03 mg for ESPB vs. 44.67±44.16 mg for QIPB, p=0.476), need for rescue analgesia, and incidence of nausea and vomiting—were also comparable. No motor block was observed in either group. Conclusion Although QIPB did not demonstrate superiority over ESPB, it was found to be not inferior in analgesic effect and safety outcomes. These findings suggest that QIPB may be a reliable alternative to ESPB in lumbar discectomy procedures.
Association of health-promoting behaviors with oral health status among Turkish dental students: A cross-sectional study
(Springer Nature Link, 2026) Ballı Akgöl, Beyza; Bayram, Merve; Üstün, Nilüfer; Aksaka, Nurcan
Background: Oral health is an essential component of overall well-being, and dentistry students are expected to model healthy behaviors. However, their lifestyle habits may not always reflect this role. This study explores the relationship between oral health status and health-promoting behaviors among fourth-year dental students. While the Health-Promoting Lifestyle Profile II (HPLP II) has been widely applied, its use alongside objective oral health indices in this population remains limited. Methods: This cross-sectional study assessed health-promoting behaviors using the Health-Promoting Lifestyle Profile II (HPLP II) and evaluated oral health status using clinical indices, including Decayed, Missing, and Filled Teeth (DMFT) index, Gingival Index (GI), and Plaque Index (PI), among fourth-year dental students. Results: Students with better gingival health exhibited higher overall health-promoting lifestyle scores, particularly in the domains of nutrition and health responsibility. Similarly, participants with better plaque control demonstrated more favorable stress management behaviors. In addition, weak inverse associations were observed between dental caries experience and spiritual growth, as well as between plaque accumulation and overall health-promoting lifestyle behaviors. Conclusion: This study revealed significant links between key health promoting lifestyle domains—nutrition, stress management, and health responsibility—and oral health indicators. These findings underscore the need to integrate structured health promotion modules into dental curricula to improve students’ well-being and clinical competence.
Addressing spirituality in counseling: Turkish mental health professionals’ views on a training program for professional competencies
(Springer Nature Link, 2026) Ekşi, Halil; Turgut, Ebru Talibe; Karalı, Fatma Betül; Şen, Hale; Akyol, Havvanur; Aydın, Neslihan; Koç, Yusuf Ziya
The integration of spirituality into counseling has gained increased attention due to its significant impact on psychological well-being. However, mental health profes sionals often face challenges with incorporating spiritual dimensions into therapy, primarily due to inadequate training, conceptual ambiguity, and ethical concerns. This qualitative phenomenological study aims to explore mental health profession als’ perspectives on addressing spirituality in counseling and to assess the necessity of a specialized training program to enhance competencies in this area. We used cri terion sampling to select 11 experienced psychologists, counselors, and academics to, conduct semi-structured interviews, and analyze the data using descriptive analy sis to identify the key themes related to integrating spirituality into counseling. The findings reveal that the current training curricula does not adequately cover spir ituality, which has led to a lack of confidence among mental health professionals. The participants highlighted several barriers, including professional hesitancy, ethi cal concerns, clients’ misunderstandings, and the dominance of secular educational models. Additionally, the study identified the specific competencies needed for inte grating spirituality into counseling and categorized them into knowledge, skills, and attitudes. The professionals emphasized the need for a structured training program that includes conceptual knowledge about spirituality, evidence-based intervention techniques, ethical considerations, and culturally sensitive approaches. Furthermore, recommendations were made regarding the content, format, and evaluation methods for such a training module. The study underscores the urgent need for standardized training to equip mental health professionals with the skills required to address spir ituality in an ethical and culturally competent manner.
Complex ventral hernia repair using botulinum toxin with combination of Fasciotens® after colorectal surgery: A video vignette
(Wiley, 2026) Demirli Atıcı, Semra; Yıldırım, Yasemin; Canda, Aras Emre; Terzi, Mustafa Cem; Arslan, Çigdem; Erenler Bayraktar, İlknur; Bayraktar, Onur; Bisgin, Tayfun
Complex ventral hernia repair using botulinum toxin with combination of Fasciotens® after colorectal surgery: A video vignette
Interfacial bond strength of CAD/CAM resin composites on dentin vs. composite substrates: Influence of dual-cure and self-adhesive resin cements
(MDPI Publishing, 2026) Batgerel, Oyun Erdene; Yazıcıoğlu, Oktay; Kıtın, Emine; Gençel, Burç İhsan; Yamak, Fatih; Ergün Bozdağ, Süreyya; Sasany, Rafat
This in vitro study evaluated the shear bond strength (SBS) of four CAD/CAM (Computer aided design/Computer aided manufacturing) polymer-based indirect composites bonded to dentin and microhybrid composite substrates using two resin cements. Gradia Plus (GP), Ceramage (Ce), Tescera ATL (TA), and Lava Ultimate (LA) were fabricated into cylindrical specimens (3 × 3 mm). Dentin substrates were obtained from extracted molars, while composite substrates were prepared from Filtek Z250 (4 mm × 2 mm). Bonding was performed using either a self-adhesive resin cement (RelyX U200; RU200) or a dual-cure adhesive resin cement (RelyX Ultimate; RU), resulting in 16 experimental groups (n = 12 per group). SBS was measured using a universal testing machine (1 mm/min), and failure modes were assessed under stereomicroscopy. Bond strength was significantly higher on composite substrates than on dentin (p < 0.001), primarily due to favorable polymer– polymer compatibility and matrix interdiffusion, which improved stress accommodation at the adhesive interface. TA and Ce showed superior adhesion when combined with RU, while LA exhibited the lowest values, particularly on dentin bonded with RU200. Overall, the dual-cure adhesive system provided stronger bonding than the self-adhesive system (p < 0.05). These findings highlight the influence of substrate type, composite architecture, and cement chemistry on interfacial performance in indirect polymer-based restorations.
Long-Term endocrine outcomes with special emphasis on the gonadal impact of acute lymphoblastic leukemia treatment in females
(Springer Nature Link, 2026) Karakaş, Hasan; Tarçın, Gürkan; Bayramoğlu, Elvan; Turan, Hande; Ocak, Süheyla; Turan, Volkan; Evliyaoğlu, Olcay; Tiraje, Tiraje; Apak, Hilmi; Ercan, Oya
This study aims to explore the long-term endocrine and gonadal effects of chemotherapy and radiotherapy in female acute lymphoblastic leukemia (ALL) patients. A cohort study included girls diagnosed with ALL and treated between 2000 and 2020. Patients with at least 2 years elapsed since treatment completion were included. Endocrinological evalua tions included anthropometric measures and pubertal status, as well as fasting insulin, glucose, lipid levels, and hormone assessments for adrenal, and thyroid functions. Reproductive functions were evaluated based on gonadotropin, estradiol, and anti-Müllerian hormone (AMH) levels. A total of 51 female patients were included. At the time of study participa tion, the mean age was 14.7 years, and the mean time since treatment completion was 9.4 years. At least one endocrine disorder was present in 39.2% of participants, with dyslipidemia, insulin resistance, and obesity being the most common. Low AMH levels (<1.1 ng/dL) were found in 41.6%, particularly in those who underwent bone marrow transplantation. A significant positive correlation was found between the time elapsed since treatment and AMH levels (p<0.001, r=0.612), while age at diagnosis, risk group (standard, intermediate or high risk), and cranial radiotherapy showed no significant associations. A substantial proportion of ALL survivors developed endocrine complications, with ovarian reserve compro mised in over 40% of cases. Notably, this is the first cohort study to demonstrate a significant positive correlation between AMH levels and the time elapsed since treatment, suggesting a potential for gonadal recovery except in those exposed to intensive chemotherapy or transplantation.
Evaluation of seropositivity developed against specific antigens of helicobacter pylori in neurodegenerative diseases
(Turkish Neuropsychiatric Society, 2026) Akçin, Rüveyda; Tütüncü, Melih; Karagöz Sakallı, Nazan; Apaydın, Hülya; Bozluolçay, Melda; Can, Günay; Soysal, Aysun; Sirekbasan, Serhat; Dinç, Harika Öykü; Sarıbaş, Suat; Kocazeybek, Bekir
Introduction: It is suggested that Helicobacter pylori (Hp) can reach the brain via the oral-nasal-olfactory route, through Hp-infected monocytes in the disrupted blood-brain barrier (BBB), or through a rapid retrograde neural network leading to neurodegeneration from the gastrointestinal tract (GIS) and may lead to neurodegenerative diseases such as Alzheimer’s (AD), Parkinson’s (PD) and Multiple sclerosis (MS). In this study, we aimed to evaluate the possible immunopathogenesis relationship between Hp-specific antigens and neurodegenerative diseases by determining the frequency of seropositivity against different specific antigens of Hp in diseases such as AD, PD and MS. Methods: In our cross-sectional, retrospective case-control study, the immunoreactivity frequencies of Hp-specific and non-specific CagA (p120), VacA (p95), p75, FSH (p67), UreB (p66), HSP homolog (p57), flagellin (p54), p50, p41, p33, OMP (p30), UreA (p29), p26, OMP (p19), p17 antigens were determined by Western Blot method in 36 AD, 35 PD, 91 MS cases with Hp-IgG reactivity, and 55 controls without a neurodegenerative/demyelinating by ELISA method. Results: No significant difference was found between the immunoreactivity frequencies of Hp antigens between AD and control groups (p>0.05). In the multivariate logistic analysis performed for PD cases, age ≥ 50 and immunoreactivity frequency of p19 were found to be independent risk factors (OR: 36.752, p<0.05) (OR: 5.570, p<0.05). In MS cases, immunoreactivity frequency of p17 antigen was found to be a risk factor (OR: 2.646, p<0.05). In addition, the mean level of Hp-IgG reactivity was found to be negatively associated with MS development (indicating an inverse correlation) in the control group compared to the MS group (OR: 0.585, p < 0.05). Furthermore, logistic regression analysis in the total study group revealed that the immunoreactivity frequency of the p17 antigen was identified as a risk factor for MS (OR: 2.438, p<0.05). Conclusion: Our data on AD cases are insufficient. In PD cases, the significantly higher frequency of immunoreactivity to the Hp-p19 antigen in individuals aged ≥50 years (OR=5.570) is noteworthy. In the MS group, the significantly high detection of Hp p17 antigen and its presence as a risk factor (OR=2.646), and the significantly high detection of p26 antigen suggest the relationship between these antigens and the MS development process. However, it is a fact that new and many prospective cohort-based case-control studies are needed to reveal this more clearly.
Hemimyelomeningocele: A systematic review and meta‑analysis of the literature
(Springer Nature Link, 2026) Adıyaman, Ali Ekrem; Karakaş, Furkan; Hamzaoğlu, Can; Saban, Şevval; Kılınç, Tunahan; Acar, Burak; Nabili, Tabriz; Ekşi, Murat Şakir
Hemimyelomeningocele (HMM) is a rare split cord malformation where only one hemicord forms a myelomeningocele-like sac, and the opposite hemicord undergoes normal neurulation. We aimed to compile all published HMM cases to concisely summarize embryology, presentation, imaging, associated anomalies, management, and outcomes of the disorder. Following PRISMA 2020, we searched PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar (1968–Feb 2025) for studies with confirmed human HMM, extracting clinical, radiological, surgical, and follow-up data. Of 688 records screened, 25 articles met inclusion criteria, encompassing 67 patients. Most publications were single-patient case reports. Presentation occurred predominantly in newborns or early infancy. The dysraphic sac was lumbosacral in most cases, and type I split cord malformation with a bony spur outnumbered type II. Hemivertebrae and congenital scoliosis were the common vertebrae anomalies. Nearly all patients underwent surgery combining sac excision, detethering, and bony spur removal. Postopera tive neurological outcomes were favorable: the majority improved, and the other ones remained stable; no surgery-related mortality was reported. HMM can be recognized as a distinct clinic radiological entity within the split-cord spectrum. Early, ideally prenatal diagnosis, timely microsurgical repair, and coordinated multidisciplinary care yield favorable functional outcomes in most patients. This first systematic review compiles the available evidence and provides a practical basis for future diagnostic and treatment decisions.

Güncel Gönderiler