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Artificial intelligence in predicting macular hole surgery outcomes: A focus on optical coherence tomography parameters
(Springer Nature, 2025) Öztürk, Yücel; Ağın, Abdullah; Yelmi, Burcu; Zorlutuna Kaymak, Nilufer
Purpose To evaluate the predictive performance of optical coherence tomography (OCT)-based indices and artificial intelligence (AI) using a Generative Pre-Trained Transformer (GPT) model and compare them with traditional logistic regression in forecasting anatomical success following macular hole (MH) surgery. Methods This retrospective observational study included 51 eyes of 51 patients who underwent pars plana vitrectomy for idiopathic MH. Preoperative OCT measurements of macular hole index (MHI), traction hole index (THI), hole form factor (HFF), basal hole diameter (BHD), and minimum hole diameter (MHD) were recorded. GPT-based AI predictions were generated using masked input data. A logistic regression model was developed with the same variables. Predictive performance was assessed using accuracy, area under the curve (AUC), positive predictive value (POPV), negative predictive value (NPV), and Kappa statistics. Results Anatomical success was achieved in 72.5% of cases. MHI, THI, and HFF were significantly higher in the successful group (p<0.0001). GPT achieved an accuracy of 77.0% and AUC of 0.770, with perfect POPV (1.000) but low NPV (0.452). Logistic regression outperformed GPT, achieving an accuracy of 84.3%, an AUC of 0.759, a higher NPV (0.800), and better agreement (Kappa 0.568 vs. 0.392). BHD and MHD showed poor predictive power (AUC 0.291). Conclusion OCT-derived indices, especially MHI, THI, and HFF, effectively predict MH surgery outcomes. Logistic regression based on actual patient data demonstrated superior predictive performance compared to GPT. AI models hold potential but require further development, integration of multimodal data, and validation before clinical application.
Examination of anatomical features of zygomaticofacial foramen in children: A 3d reconstruction study
(Springer Nature Link, 2025) Ay, Tuğba; Kervancıoğlu, Piraye; Adanır, Saliha Seda; Yalçın, Eda Didem
Background Considering the implications of surgical fixation techniques such as plating, screwing, or wiring in pediatric zygomatic fractures, a detailed understanding of the zygomaticofacial foramen (ZFF) anatomy in children may help reduce intraoperative complications particularly injury to the zygomaticofacial nerve, which passes through the ZFF. Objective The aim of the present study is to examine the morphometric and morphological features of the ZFF in the pediatric population. Methods Before the study commenced, approval was obtained from Gaziantep University Clinical Research Ethics Committee (Approval number: 2024/177). Cone-beam computed tomography (CBCT) images of 119 patients who applied to Gaziantep University Faculty of Dentistry, Department of Oral and Maxillofacial Radiology for any reason were retrospectively examined with Radiant DICOM Viewer program. The presence, number, localization and distances to certain anatomical points of ZFF were measured. The ZFF was classified based on the number of foramina. To determine the localization of the foramen, the lateral surface of zygomatic bone was divided into four quadrants using two reference lines. These quadrants were designated as a, b, c, and d in a clockwise direction from the inferomedial to the superomedial region. Statistical analyses were performed with SPSS 24.0 package program and p < 0.05 was considered statistically significant. Results A total of 119 children (male: 65, female: 54; mean age: 13.14 ± 3.24) CBCT images (238 sides) were examined. In the classification based on the number of foramina, the absence of any foramen was defined as Type 0 (106, 44.5%); the presence of one, two, and three foramina was classified as Type I (91, 38.2%), Type II (35, 14.7%), and Type III (6, 2.5%), respectively. The mean distance between ZFF-orbit and ZFF-temporozygomatic suture was greater in male than in female (p = 0.006, p = 0.009, respectively). The mean distance between ZFF-frontozygomatic suture was greater in female (p = 0.032). The distances between ZFF-zygomaticomaxillary suture and lowest point of zygomatic bone were significantly different between age groups (p = 0.026, p = 0.004, respectively). Conclusion The findings of the present study indicate that the zygomaticofacial foramen (ZFF) is most frequently located in region c and rarely in region b. Based on this observation, region b may represent a safer zone for surgical interventions in this area. The findings of the present study may help to minimize complications in surgeries and invasive procedures involving the zygoma region in children.
Impact of bruxism on the mandibular angle and condylar structures: A panoramic radiographic assessment
(Springer Nature Link, 2025) Artaş, Aslıhan; Aslan Öztürk, Elif Meltem
Objectives The aim of this study is to comparatively evaluate morphologic changes in the mandibular angle and condylar region, assess the mandibular cortical index (MCI), and analyze the relationships between these parameters in bruxers and non-bruxers using panoramic radiographs. Methods A total of 182 patients (364 mandibular condyle and angle), 91 bruxers and 91 non-bruxers (controls), aged between 18 and 35, were participated in this study. Three hundred sixty four mandibular angles were classifed as G0, G1, G2, G3 in terms of bone apposition and direction change. In addition, osseous changes in the mandibular condyle were determined and the endoestal edge of the basal cortex was evaluated according to the MCI classifcation. Parameters were analyzed using the Pearson’s Chi-Square test and Fisher's Exact test. A p value<0.05 was considered signifcant. Result MCI class C1, G0 class, and normal condyle type were found to be signifcantly more common in the non-bruxist group than in the bruxist group (p<0.001, p=0.025, p=0.006, respectively). It was determined that deformity and MCI-C2 class were more common in the bruxist group (p=0.006, p<0.001). Morphologic changes in the endosteal margin of the cortex and in the condylar region were observed more frequently in bruxist individuals. Conclusion For a general overview of the probable presence of bruxism, osseous changes in the mandibular condyle, and MCI can be used as auxiliary diagnostic markers.
Surgical anatomy of the distal part of the dorsal scapular nerve with a focus on the triple-tendon transfer
(Wiley, 2025) Çelikgün, Beyza; Gayretli, Özcan; Gürses, İlke Ali; Coşkun, Osman; Kale, Aysin
Introduction: A review of the literature shows that most studies of the dorsal scapular nerve (DSN) have focused on morphological evaluation of the proximal part of the nerve. Morphometric studies contributing to clinical applications are limited. Therefore, we aimed to investigate the topographic and morphometric anatomy of the distal part of the DSN. Methods: 13 cadavers in the Department of Anatomy, Istanbul Faculty of Medicine, were examined bilaterally. DSN dissection was performed on the anterior surface of the levator scapulae and rhomboids, and the distance to the medial border of the scapula (MBS) was recorded at different levels. The insertion lengths of the levator scapulae and rhomboids were also measured. Results: Two types of DSN were observed according to the level of termination in the muscle. Contrary to its classical course, the nerve ran laterally to the MBS on the four sides. The shortest distance between the nerve and the MBS was at the level of the superior border of the rhomboid minor (4.46 ± 9.88 mm). The insertion lengths of the levator scapulae and rhomboids according to gender and the insertion length of the rhomboid minor according to the level of termination in the muscle were significant. Discussion: We have obtained results that may be useful during Eden–Lange tendon transfer. The DSN is not always located medial to the MBS, it may be located lateral to it. To avoid nerve damage, we believe it is important to identify the nerve on the anterior surface of the muscles for a successful surgery.
Anatomical features of the superior vesical artery and its relationship with neighboring arteries
(Springer Nature Link, 2025) Toklu, Elif; Gayretli, Özcan; Sağlam, Latif; Şahan, Orhun; Kara, Erdoğan; Coşkun, Osman
Background The superior vesical artery (SVA) is one of the important arteries that supply the urinary bladder. This study aimed to investigate anatomical features of the SVA, its morphometric relationships with neighboring arteries. Methods Totally, 102 (52 male and 50 female) fresh cadavers were dissected. The lengths of the common iliac artery (LCIA) and the internal iliac artery (LIIA) were measured. The distances between the umbilical and the frst superior vesical arteries (UmbA-First SVA), and the umbilical and the last superior vesical arteries (UmbA-Last SVA) were calculated. The distance between the uterine and the frst superior vesical arteries (UA-First SVA) was measured. The measurements were conducted in millimeters using the ImageJ software program. Results The mean LCIA was 60.75±15.03 mm on the right and 61.96±16.17 mm on the left. The mean LIIA was 34.19±14.33 mm on the right and 32.02±14.58 mm on the left. The number of SVA ranged from 1 to 4. The mean UmbA First SVA and UmbA-Last SVA were 14.59±13.80 mm and 31.12±17.47 mm for the right, respectively. Additionally, the mean UmbA-First SVA and UmbA-Last SVA were 13.87±13.06 mm and 35.90±18.26 mm for the left, respectively. A statistically signifcant diference was found for UmbA-First SVA according to gender and for UmbA-Last SVA according to sides. Lastly, the mean UA-First SVA was 18.05±9.26 mm on the right and 23.39±13.47 mm on the left. Conclusion The results of the study may guide clinicians in bladder-focused pelvic surgeries, oncological treatments, endo vascular operations, and interventional radiologic treatments.
Unleashing the hidden potential: The transformative influence of occupational health and safety education on chemical engineers
(Sakarya University, 2025) Dilek, Sümeyye; Özdemir Olgun, Fatoş Ayça
Occupational Health and Safety (OHS) education plays a crucial role in shaping the professional development of chemical engineers, equipping them with the necessary knowledge and skills to ensure workplace safety and prevent occupational hazards. This manuscript presents a comprehensive review of the impacts of OHS education on chemical engineers, focusing on its role in enhancing awareness, knowledge acquisition, and practical application. The study explores the influence of OHS education on promoting a safety culture, improving risk assessment and management practices, and fostering a proactive approach towards identifying and mitigating occupational hazards. It also investigates the effects of OHS education on job satisfaction, professional growth, and career opportunities within the chemical engineering field. By analyzing relevant literature and case studies, this review provides valuable insights into the positive outcomes resulting from integrating OHS education into the curriculum at universities. The findings emphasize the significance of OHS education in cultivating competent and safety-conscious chemical engineers who contribute to sustainable and responsible industrial practices.
Utilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: A meta-analysis
(Elsevier, 2025) Turan, Volkan; Öktem, Özgür; Bang, Heejung; Oktay, Kutluk Han
Our aim was to assess fertility preservation (the proportion of women who had at least 1 live birth) and utilization rates (the proportion of women who utilized their cryopreserved embryos) rates among women who cryopreserved their embryos before breast cancer treatments. PubMed and Cochrane library database were searched until December 2024. We included all studies that reported pregnancy outcomes, the number of women who returned for frozen embryo transfer, and the number of women who preserved their fertility. The primary outcome measures were the utilization and fertility preservation rates. Secondary outcome measures were implantation, clinical pregnancy, and live birth rates. Of the 12 studies, 9 met the criteria, encompassing >2126 women with breast cancer who cryopreserved their embryos for fertility preservation. In 9 studies that reported the total number of attempts, 424 women underwent 863 embryo transfers. Based on those studies, the clinical pregnancy and live birth rates were 50% (95% CI: 35-65, I 2: 80%) and 33% (95% CI: 22-46, I 2: 76%), respectively. The utilization and fertility preservation rates were 18% (95% CI: 9-32, I 2: 95%) and 39% (95% CI: 29-51, I 2: 48%), respectively, all from random-effects models. Fertility preservation success with embryos cryopreserved before breast cancer treatments seems to be promising. However, the utilization rate of cryopreserved embryos is low. Additional studies with larger sample size and longer follow up are required to evaluate the long-term utility rates.
Child and adolescent psychiatry consultations during the COVID-19 pandemic
(Springer Nature Link, 2025) Vatansever Pınar, Zeynep; Çimen, İrem Damla; Küçük, Elif; Köle, Mehmet Tolga; Kandemir, İbrahim
This study aimed to identify the biopsychosocial stressors influencing child and adolescent mental health during periods when facetoface education was suspended and to evaluate the psychological sequelae of school closures and related restrictions. We conducted a retrospective observational study at Kartal Dr. Lütfi Kırdar City Hospital, a tertiary care center in İstanbul, reviewing all patients referred to the child and adolescent consultation-liaison psychiatry (CLP) unit between March 2020 and March 2022. We assessed associations between psychiatric diagnoses and health-related stressors, school closure status, age, and sex using both frequentist and Bayesian methods. During the study period, 264,013 pediatric admissions were recorded, of whom 270 (0.10%) required psychiatric consultation. The proportions of suicide attempts and anxiety diagnoses did not differ between periods of open and closed schools (BF10 = 0.21 and 0.138, respectively; moderate evidence for the null). Multivariate analysis showed that the odds of suicide attempts were higher in patients exposed to family or schoolrelated stressors (OR = 6.63, 95% CI 2.72–16.19), in females (OR = 8.10, 95% CI 4.16–15.77), and with increasing age (OR = 1.32 per year, 95% CI 1.16–1.50). Female sex (OR = 4.17, 95% CI 2.03–8.55) and older age (OR = 1.30 per year, 95% CI 1.12–1.50) were also associated with depression. Anxiety was more likely in those facing isolation or healthrelated stressors (OR = 3.91, 95% CI 1.66–9.22). These findings highlight the differential impact of stressor type on internalizing symptoms and may inform resource allocation and crisisresponse planning in child mental health services.
Comparing the effects of halloysite nanotubes and precipitated calcium carbonate nanoparticles on the environmental stress cracking resistance and mechanical properties of polycarbonate
(Wiley, 2025) Aktaş, Deniz; Taşdemir, Hacı Abdullah; Alanalp, Mine Begüm; Durmuş, Ali
Polycarbonate (PC) is a versatile and amorphous engineering thermoplastic used in various areas due to its exceptional me-chanical and thermal properties. However, its susceptibility to environmental stress cracking limits its industrial application inchemically aggressive environments. This study investigates the effects of incorporating surface-modified halloysite nanotubes(HNTs) and precipitated calcium carbonate (PCC) as nanofillers on the mechanical properties and environmental stress cracking(ESC) resistance of PC. PC nanocomposites were prepared with varying filler concentrations (1%, 3%, and 5% by weight) usingtwin-screw extruder and injection molding devices. Comprehensive mechanical characterization, including three-point bending,Charpy impact toughness, and Shore D hardness tests, revealed that introducing 1 wt% of HNT optimally balances stiffness,toughness, and ESC resistance. PCC, on the other hand, significantly improved processability but demonstrated poor ESC perfor-mance, with samples failing within an hour in methanol immersion tests. ESC resistance testing in methanol and sodium laurylether sulfate (SLES) solutions confirmed the superior performance of HNT-reinforced PC nanocomposites. Scanning electronmicroscopy (SEM) analyses provided insights into filler-matrix interactions and crack propagation mechanisms. These findingsoffer valuable guidance for the development of PC nanocomposites tailored for automotive, electronics, and chemical processingindustries.
Comprehensive classification of variations of the anterior part of the circle of willis in fresh cadavers anterior communicating artery
(Galenos Publishing House, 2025) Nteli Chatzioglou, Gkionoul; Nas, Emine; Kale, Ayşin; Aktaş, Kardelen; Coşkun, Osman; Gayretli, Özcan
Objective: The goal of our study is to evaluate and classify the variations of the anterior communicating artery (AComA) on fresh cadavers from the Türkiye population. Methods: In this study, 182 fresh cadavers were analysed and classified according to the number, shape and course of the AcomA. Results: In our study, typical AcomA was the most common with a rate of 86 (47.25%), while variations of the AcomA were found in the remaining 96 (52.75%) cases. Among these variations, in 11.46% (11/96) of cases, AcomA variations were identified as distal and proximal duplications according to the number of branches they represented; 68.75% (66/96) of cases were identified by their shape (X-shaped, single/double fenestration, hypoplasia, or aplasia); and, in 19 cases, it was characterized by course (median artery or oblique course). The rate of variations was 65% (26/40) in females and 49.29% (70/142) in males. In our study, the X-shaped and single fenestration variations were recorded as the most common. Conclusions: The results of the study are important for cerebrovascular surgery and radiological interventions. It emphasises the importance of recognising and considering variations. The study will contribute to the understanding of cerebrovascular diseases and the development of treatment strategies.
Psychological impact of the February 6 earthquake on displaced individuals with proximal loss residing in temporary shelters
(Routledge, 2025) Filazoğlu Çokluk, Gülşen; Bal, Fatih; Savaş, Esra
The present study examines the psychological effects of the earthquake that occurred in Turkey on 6 February 2023 on individuals residing in temporary shelters who have experienced losses in their immediate surroundings. The objective of the present research is to elucidate the relationships between post-traumatic stress disorder (PTSD), depression, anxiety, and the subjective impact of the traumatic event. Nine months following the disaster, a survey was conducted among 923 adults aged 25 to 60 residing in temporary shelters in Antakya. Participants completed a series of validated and reliable measurement tools, including the DSM-5 Post-Traumatic Stress Disorder Checklist (PCL-5), the Beck Anxiety Inventory (BAI), the Beck Depression Inventory (BDI), and the Impact of Events Scale (IES). The findings indicate significant and positive correlations between PTSD and all other variables, including the impact of the event, depression and anxiety. The multiple regression analysis revealed that these three variables significantly predicted PTSD symptoms and collectively explained 41% of the variance in PTSD levels. This study emphasizes the cumulative psychological impact of forced displacement and close losses on individuals and underscores the pressing need for culturally sensitive and trauma-informed mental health services in post-disaster intervention processes. The findings contribute to the understanding of trauma dynamics in post-disaster communities and guide the development of targeted mental health policies and psychosocial support programs.
Determinants of foreign direct investment in the textile sector: A research with IT2 Fuzzy TOPSIS methodology
(Institute National Cercetare-Dezvoltare Textiles Pielarie, 2025) Şahin, Recep Uğurcan; Nalbant, Kemal Gökhan; Keskin, Abdulkadir; Özdemir, Yavuz; Keskin, Abdurrahman
This study aims to identify the determinants of foreign direct investment (FDI) in the textile sectors in Poland, Romania, Hungary, Slovakia, Czechia and Türkiye. The study assesses these criteria through paired comparisons conducted by experts who have a minimum of 10 years of professional experience in the field and analyses them using the IT2 Fuzzy Technique for Order of Preference by Similarity to the Ideal Solution (TOPSIS) technique. According to the findings, the criteria with the highest degree of importance are national security, inflation rate, patent and trademark protection, transportation networks and market size. On a country-by-country basis, Poland has a higher investment attraction potential compared to other countries according to the criteria of openness, corruption, legal regulations and privatization policies, import and export quotas, education and professional status, renewable energy resources, sustainability, intellectual property protection, patent and trademark protection and national security. Hungary scores highest on import and export quotas and tax rates, while Slovakia stands out on import and export quotas and waste management/environmental regulations. Romania scores highest on profitability and debt financing, labour costs and import and export quotas. Czechia scores highest on inflation rate, political stability, legal regulations and privatization policies, economic incentives, general trade policies, import and export quotas and cultural situation and lifestyle. Türkiye scores the highest in terms of market size, GDP growth rate, access to raw materials and markets, technological infrastructure and innovation, transport networks, production sites, energy production, import and export quotas and business-friendly approaches.
Development of an HPLC method for the determination of fampridine (dalfampridine) in human plasma by fluorimetric derivatization and application to a prototype pharmacokinetic study
(Editions de l'Academie Republique Populaire, 2025) Ceylan, Burhan; Önal, Cem; Önal, Armağan
Fampridine (dalfampridine) is used to improve walking in people who have multiple sclerosis. In this study, a new, fast and sensitive HPLC method with fluorometric detection was developed for the determination of fampridine in human plasma and applied to a pharmacokinetic study. Fampridine was precolumn derivatized with 7-chloro-4-nitrobenzofurazan (NBD-Cl) and the fluorescent derivative was separated on a C18 (150 × 4.6 mm × 2.6 μm) analytical column at 30 ºC using a mobile phase composed of acetonitrile – 0.1% o-phosphoric acid in water (80:20, v/v) by isocratic elution with flow rate of 1.0 mL min–1 . The method was based on the measurement of the derivative using fluorescence detection (λex= 310 nm, λem = 365 nm). The retention time of fampridine is 4.10 ± 0.02 min. This currently developed method was validated according to EMA criteria by evaluating the specificity, linearity, precision, accuracy and robustness. The method was determined to be linear in a concentration range of 0.01–20 ng mL–1 with the correlation coefficient of 0.9996. LOD and LOQ were found to be 0.003 and 0.01 ng mL–1 , respectively. Intraday and interday RSD values were less than 2.45%. The plasma concentration-time profile and pharmacokinetic parameters such as AUC0–t, AUC0–∞, Cmax, tmax, t1/2, were calculated according to the assays. The presented method can certainly be used for bioequivalence and bioavailability investigations and routine analysis of the drug in plasma.
Fluorimetric derivatization-based HPLC-FL method for the prototype pharmacokinetic analysis of selexipag in human plasma
(Taras Shevchenko National University, 2025) Ceylan, Burhan; Çayci, Meltem; Önal, Cem; Önal, Armağan
A simple and cost-effective HPLC-FL method has been developed for measuring selexipag in human plasma, showcasing its suitability for pharmacokinetic research. Selexipag was precolumn derivatized with 7-chloro-4-nitrobenzofurazan (NBD-Cl) and the fluorescent derivative was separated on a C18 (150 mm × 4.6 mm × 2.6 μm) analytical column at 30 ºC using a mobile phase composed of acetonitrile – 0.1% o-phosphoric acid in water (70:30, v/v) by isocratic elution with flow rate of 1.0 mL min-1. The method was based on measuring the derivative using fluorescence detection (λex = 380 nm, λem = 420 nm). The retention time of selexipag is 6.40 ± 0.01 min. This currently developed method was validated according to EMA criteria by evaluating the specificity, linearity, precision, accuracy, and robustness. The method was determined to be linear in a concentration range of 0.01-20 ng mL-1 with a correlation coefficient of 0.9998. LOD and LOQ were found to be 0.003 and 0.01 ng mL-1, respectively. Intraday and interday RSD values were less than 1.75%. The plasma concentration-time profile and pharmacokinetic parameters such as AUC0–t, AUC0–∞, Cmax, tmax, t1/2, were calculated according to the assays. The presented method can be effectively used for bioequivalence and bioavailability investigations, as well as for routine analysis of the drug in plasma.
Predicting risk of lymph node metastasis in papillary thyroid cancer using miRNAs and clinicopathological features
(Springer Nature Link, 2025) Ergün, Penbe Gül; Aydoğan, Çağatay; Ceviz, Ayşe Begüm; Candan, Gonca; Batur, Şebnem; Yılmaz Aydoğan, Hülya; Öztürk, Oğuz; Öztürk, Tülin
This study investigates potential prognostic values in models created with clinico pathological features and expression profles of miRNAs known for their critical roles in papillary thyroid carcinoma (PTC) for lymph node metastasis (LNM) in PTC cases. Forty-seven lymph node-metastatic PTC patients and 46 non-metastatic patients were included. Using RT-PCR, miR-21, miR-146b, miR-221, and miR-222 expression was analyzed in carcinoma tissues and metastatic lymph nodes of the same PTC patients and carcinoma tissues of non-metastatic PTC patients. MiR 146b (p<0.001) and miR-221 (p=0.009) were overexpressed in metastatic PTCs compared to non-metastatic PTCs. The miRNA expression profles were similar in the lymph nodes and primary cancer of metastatic PTCs. In the presence of larger tumors (>1 cm) in metastatic PTCs, miR-146b and miR221 were overexpressed in the tumor tissue (p=0.036), while miR-222 was overexpressed in metastatic lymph nodes (p=0.035). miR-146b was also upregulated in lack of peritumoral lympho cyte infltration (p=0.006). In conclusion, our fndings suggest that the overexpres sion of miR-146b and miR-221 in PTC tissues may be associated with lymph node metastasis and a poorer prognosis. Furthermore, the presence of larger tumors and increased levels of intratumoral fbrosis in non-metastatic PTC patients could indi cate a poor prognosis.
Antihypertensive treatment of a patient with normal blood pressure: Case report and call for paying attention
(Wolters Kluwer, 2025) Atmaca, Hasan; Erol, Mustafa Kemal; Yetkin, Ertan
The current 2024 European Society of Cardiology (ESC) guideline for the management of elevated blood pressure and hypertension defines blood pressure less than 115/65 mmHg by ambulatory blood pressure monitoring (ABPM) as nonelevated, blood pressures in-between 115–129 and 65–79 mmHg as elevated blood pressure, and hypertension as ≥130/80 mmHg. There, might be patients seeking medical attention for the symptoms, apparently nonspecific but suggestive of hypertension with optimal, or not elevated, or elevated blood pressure values. A female patient with complaints of headache and dizziness lasting for 2 months has been evaluated in cardiology outpatient clinic and assessed by ABPM. It has been told that she had previously blood pressure of 90–100/50–60 mmHg and was suffering from headache when systolic blood pressure exceeds 110 mmHg. Her 24-h ABPM revealed systolic and diastolic blood pressure as 106/63 mmHg showing nighttime decrease compared with daytime pressures (98/59 mmHg and 108/68 mmHg, respectively). Thereafter, she was instructed to keep continuing the life-style modification and given to beta-blocker (bisoprolol 5 mg) as an antihypertensive treatment. At the end of the 2 weeks of follow-up period, she was headache-free and was feeling comfortable and well with a mean home blood pressure of 98/56 mmHg. We have presented prosperous antihypertensive treatment of a female patient suffering from headache and dizziness with a numerically normal or nonelevated blood pressure. In the presence of symptoms and having not elevated or elevated blood pressure levels, patients’ history on previous measure of blood pressure might facilitate our decision-making process.
Comprehensive analysis of brewed tea: Boron content, total antioxidant and oxidant capacity, oxidative stress, and ph value
(Springer Nature Link, 2025) Cihan, Aslıhan; Özel Korlu, Armağan Begüm; Tüzüner, Burcin Alev; Yarat, Ayşen
Tea is widely recognized as the most consumed beverage in the world after water. In recent years, the connection between tea and health has gained growing attention as a signifcant research topic. In this study, we evaluated the relationship between tea and health by analyzing the boron content, total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), and pH levels of teas commonly consumed in Türkiye. A total of 42 samples were created from various tea brands and diferent tea types that are widely consumed in Türkiye. The determination of boron in pulverized and brewed tea samples was carried out using the carminic acid method. Additionally, boron transfer was determined in brewed teas. Brewed tea samples were also examined in terms of pH, TAC, TOC, and OSI. It was determined that all teas contained an average of 11.73 mg/L boron, the amount of boron in domestic teas was lower than in imported teas. It was determined that boron transfer into brewed tea was approximately 30%. The pH values ranged between 4–5. No diferences were detected in terms of TAC, TOC, and OSI. Our research shows that tea consumption is safe in terms of boron levels and helps meet daily needs. The OSI of teas is less than 1, so their antioxidant efects can be considered quite good. However, it should be noted that excessive tea consumption can lead to the demineralization of tooth enamel due to low pH levels.
Advances in parkinson's disease research: Exploring biomarkers and therapeutic strategies for halting disease progression
(Frontiers Media S. A., 2025) Bougea, Anastasia; Değirmenci, Yıldız
Parkinson's disease (PD) is a multifactorial neurodegenerative disorder, characterized by loss of dopaminergic neurons of substantia nigra (SN) in 1% of people aged above 65 years (Ben-Shlomo et al., 2024). Its complex clinical picture includes motor symptoms such as tremor, bradykinesia, and gait instability, as well as non-motor symptoms (depression, psychosis, cognitive decline) (Schilder et al., 2017;Titova and Chaudhuri, 2017). Current symptomatic therapies have limited long-term efficacy (Aldaajani and Khalil, 2024). A deep analysis of neural network after PD onset could deepen our understanding of the molecular crosstalk and biological processes underlying PD pathogenesis (Tomkins and Manzoni, 2021). However, there is a lack of reliable biomarkers for early diagnosis, presenting barriers to monitoring and developing disease-modifying therapies. There are several different types of biomarkers for PD , such as clinical, neurochemical and genetic (Bougea, 2020). Ten studies provided novel insights into the early detection and monitoring of PD.in the occipital region of the PD group can be usedtilized as a rapid and objective test indicator to screen for depressive symptoms in PD.Zhang et al. identified circadian rhythm genesAK3, RTN3, and LEPR as biomarkers in the progression of PD by regulating NK cells, however, the exact mechanism is not clear.Wang et al. confirmed that authenticated GPR78, CADM3, and CACNA1E were as the biomarkers that mostly mainly participated in pathways, such as the 'cell cycle' and 'hydrogen peroxide catabolic process', and They also found; five types of differential immune cells that differed between PD and control groups were identified. Together, these studies highlight the importance of combination of biomarkers and risk variables into predictive models , improving early diagnosis and monitoring of PD. Sme of them may serve as diagnostics (lncRNAs, P1 amplitude) or predictive (NVU, cathepsin B, APA2, circadian rhythm genesAK3) may shed novel light on the pathogenesis of PD.Both pharmaceutical and non-pharmacological (cognitive training, physical activity, and dietary changes) treatments are used to treat PD symptoms (Degirmenci et al., 2023;Ernst et al., 2024). Seven promising approaches were also highlighted by this showed that acupuncture, cognitive behavioral therapy, exercise and repetitive transcranial magnetic stimulation significantly improved sleep, depression, anxiety, cognition, constipation, and quality of life of PD patients.Studies suggest personalized pharmaceutical and non-pharmacological therapies for PD, with nicotine, Golexanolone, taVNS, acupuncture, and FMT showing promising antiparkinsonian properties, by modulating brain activity. Further research is needed to validate their sustainability, safety, and effectiveness.Bibliometric analysis is a systematic approach to evaluating scientific literature and detecting patterns, and effects by using quantitative tools to filter data from relevant sources (Passas, 2024). This research topic includes two bibliometric studies that significantly expand their respective fields. This research topic combines important studies on the risk factors, treatments, biomarkers and bibliometric analysis. The results of these studies provide a useful guide for clinicians in their practice and to suggest targets for researchers in developing new diagnostics and therapeutic strategies. We conclude that the results of these studies are a useful tool that help clinicians in their practice and motivate researchers to look for new developments.
In-depth analysis of the demographic landscape and clinical outcomes of assisted reproductive technologies in Türkiye: A comprehensive survey for the years 2020 and 2021
(Galenos Publishing House, 2025) Benlioğlu, Can; Aydın, Yunus; Bostancı, Mehmet Sühha; Bozdağ, Gürkan; Bulgurcuoğlu, Sibel; Demir, Ahmet; Dilbaz, Serdar; Dirican, Enver Kerem; Turan, Volkan; Balaban, Başak
Objective: To investigate patient characteristics and outcomes of assisted reproductive technology (ART) cycles conducted in Türkiye during the coronavirus disease-2019 (COVID-19) pandemic (2020-2021). Material and methods: ART centers in Türkiye were invited to participate in this survey. The questionnaire focused on patient demographics and performance outcomes and was sent to center directors via anonymous Qualtrics™ links. Results: The survey was sent to 167 centers and data were collected from 15 centers in 2020 and 24 centers in 2021. The clinical pregnancy rate from intrauterine insemination (IUI) procedures remained similar, with 15.1% in 2020 (1,245 IUI cycles) and 14.5% in 2021 (2,023 IUI cycles), while successful delivery rates were 12.5% and 11.5%, respectively. For ART treatments, the clinical pregnancy rate from fresh embryo transfers increased from 45.1% in 2020 (3,119 transfers) to 50.4% in 2021 (8832 transfers), with similar live birth rates, 34.2% vs. 34.4%. Frozen embryo transfers resulted in clinical pregnancy rates of 47.8% in 2020 (2,498 transfers) and 51.9% in 2021 (12,015 transfers), with live birth rates rising from 39.8% to 42.7%. Preimplantation genetic testing cycles resulted in clinical pregnancy rates of 64.2% in 2020 (271 transfers) and 60.8% in 2021 (2,102 transfers), with live birth rates of 53.5% and 48.2%, respectively. Regarding techniques for fertility preservation in females, 11 prepubertal and 61 postpubertal ovarian tissue cryopreservation procedures were reported, alongside 1,346 cycles performed within the same period. In males, 144 post-pubertal testicular tissue, 871 epididymal and 2,480 ejaculated sperm cryopreservations were reported. During the two years, six ovarian tissue transplantations followed by ART were performed, with 96 women using cryopreserved oocytes. In addition, 40 testicular tissue, 298 epididymal, and 238 ejaculated sperm samples were used for ART purposes. Conclusion: This survey provides a comprehensive overview of ART practices in Türkiye for 2020 and 2021, establishing a long-term, nationallevel analysis while highlighting the challenges posed by the COVID-19 pandemic. The longitudinal analysis established a foundation for future annual reports and offers critical insights into emerging trends over these two years.
Eosin-5′-maleimide (EMA)-binding assay as a diagnostic method of hereditary spherocytosis
(De Gruyter, 2025) Pepeler, Mehmet Sezgin; Falay, Mesude; Aydın, Mürüvvet Seda; Parmaksız, Ayhan; Yılmaz Keskin, Ebru; Alanoğlu, Güçhan; Fettah, Ali; Özet, Gülsüm
Objectives Erythrocyte membrane disorders are caused by a deficiency of structural proteins in the erythrocyte membrane. Accurate differential diagnosis within this group of disorders (is essential for appropriate management. The eosin-5′-maleimide (EMA) binding assay is a novel test that is used for the differential diagnosis of erythrocyte membrane disorders. In this study, we have examined and reported blood counts, reticulocyte indices, and the EMA binding assay results with clinical findings of cases admitted to our laboratory for suspected red blood cell (RBC) membrane disorder. Methods We performed the EMA binding assay on the blood samples of 103 patients who were screened for hereditary erythrocyte membrane disorders at the Flow Cytometry Laboratory of Ankara Numune Training and Research Hospital. The total cohort was grouped as patients with hereditary spherocytosis (HS) (n=36) and control group (patients without erythrocyte membrane disorders (n=60), and non-HS patients with a preliminary diagnosis of hemolytic anemia (n=7). The control group included during data collection, the results of the EMA binding assay were recorded along with demographic features, clinical information, morphologic features, blood count parameters, RBC and reticulocyte indices, and a conventional osmotic fragility (OF) test. Receiver Operating Characteristics (ROC) analyses were performed to evaluate the diagnostic accuracy of the EMA binding assay and reticulocyte parameters. Results Both EMA testing and flow cytometric (FC) OF test were significantly lower in overall (n=36), ≤10-year-old (n=12), and >10-year-old (n=24) patients with HS than in healthy controls (p<0.001). The EMA binding assay had 100 % sensitivity and specificity in screening HS. Conclusions Combined with conventional blood tests, clinical findings, and medical history, the EMA binding assay is a reliable and convenient tool for screening for HS and differentiating hereditary erythrocyte membrane disorders.

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