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Traumatic fibroma of the gingiva in a child: 4-year follow-up
(Cumhuriyet University Faculty of Dentistry, 2025) Taşdemir, Tülin; Erbaş Ünverdi, Gizem; Çehreli, Zafer Cavit
This case report presents a 3-year-old boy referred to the Department of Pediatric Dentistry with a hyperplastic soft tissue lesion in the maxillary anterior region, present for six months. The lesion began as small and gradually enlarged without pain or bleeding, as reported by the parents. The lesion was treated with surgical excision under local anesthesia. Histopathological analysis confirmed a diagnosis of traumatic fibroma, a benign reactive lesion often associated with chronic irritation. Postoperative recovery was uneventful, but recurrence was observed at one year, presenting as small punctate lesions. Over a subsequent four-year follow-up, no further growth was noted. This case highlights the importance of accurate diagnosis and long-term monitoring of reactive oral lesions in pediatric patients, given their potential for recurrence.
Protective roles of gallic acid and lycopene against 4-nonylphenol induced testicular damage in SD rats
(SAGE Publications, 2026) Güleş, Özay; Kum, Şadiye; Naseer, Zahid; Boyacıoğlu, Murat; Özel Armutoğlu, Emine; Yıldız, Mustafa; Kırıkkulak, Murat; Doğan, Göksel; Bilici, Esra; Türkmen, Aybike; Tuna, Bilginer; Eren, Ülker
4-Nonylphenol (4-NP), an endocrine disruptor, is known to induce mutagenic, toxic, or carcinogenic effects, including testicular toxicity via inducing oxidative stress and apoptosis. The objective of this work was to determine the capacity of lycopene (LC) and gallic acid (GA) to protect testicular histological structure, biochemical responses, and semen parameters in rats exposed to 4-NP. In this 28-day dietary trial, six groups (n= 6 per group) received treatment via oral gavage: a control (corn oil, 2 mL/kg/day), LC (10 mg/kg body weight (BW)/day), GA (50 mg/kg BW/day), 4-NP (125 mg/kg BW/day), LC + 4-NP (LC followed by 4-NP), and GA + 4-NP (GA followed by 4-NP) groups. The results indicated that 4-NP administration adversely affects the final body weight, testicular histology, seminiferous epithelium heights (SEHs) (4-NP: 57.95 ± 0.49, p: 0.000), follicle-stimulating hormone (FSH) level, testis antioxidant capacity, testis malondialdehyde (MDA) level, and sperm viability and morphology. LC and GA supplementation significantly improved SEHs, activities of testis superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), and sperm viability compared to the 4-NP group. Moreover, LC and GA exposures decreased histopathological lesions, including germinal epithelial degeneration, vacuolization, immature germ cells in the tubular lumen, and congestion in the interstitial area. Furthermore, they lowered TUNEL-positive cell counts and tubule percentages, testicular MDA levels, and abnormal sperm percentages. To our knowledge, this study provides one of the first systematic comparisons of lycopene and gallic acid in protecting against 4-NP-induced testicular toxicity under identical experimental conditions. The findings suggest that both compounds preserve testicular structure and function through their antioxidant and anti-apoptotic properties.
Efficacy-oriented approach for medium-sized follicles: A perspective on stimulation, expectation, and triggering strategy in IVF cycles
(Wiley, 2026) Aydın, Gerçek; Ergin, Elif; Araç, Merve; Bülbül, Mehmet; Çalışkan, Eray; Hatırnaz, Şafak; Dahan, Michael; Malvasi, Antonio; Tinelli, Andrea
Objective: To assess the therapeutic significance of routinely aspirating mid-sized fol licles (14.0–16.9 mm) during oocyte pick-up (OPU) by looking at procedural efficiency and embryo usage in cycles with varied follicular cohorts. Methods: In vitro fertilization (IVF) cycles with follicles classified as large (≥17 mm) or mid-sized (14.0–16.9 mm) at the time of OPU were included in this prospective cohort. Each group's oocytes were extracted and treated independently while main taining rigorous traceability. Analysis was performed on embryologic results, opera tive time factors, and embryo transfer utilization across successive transfer attempts. Pregnancy outcomes and the length of the operation were investigated. Laboratory results pertaining to trigger strategies were assessed descriptively. Results: When measured per mature oocyte, oocytes from mid-sized follicles showed comparable fertilization and blastocyst development rates. However, only a small percentage of embryo transfers included embryos from mid-sized follicles, especially in the initial two transfer attempts. Large follicles had a longer total OPU duration, and cycles that resulted in miscarriage had significantly longer operative times among large-follicle-derived embryo transfers. For mid-sized follicles, there were no differ ences in the length of the procedure based on the pregnancy outcome. Conclusion: The contribution of mid-sized follicle-derived oocytes to embryo trans fer selection seems to be restricted in everyday practice, despite their reassuring laboratory competence. Procedural efficiency is a potentially significant factor in customized IVF care, as evidenced by the correlation between longer operating times and worse clinical outcomes. In certain clinical situations, a focused stimula tion and aspiration approach might be suitable without obviously jeopardizing cu mulative results.
A green electrochemical sensor based on molecular imprinting for etoposide detection in environmental matrices
(Elsevier, 2026) Al Faysal, Abdullah; Kaya, Beril Sena; Dorreh, Setareh; Erdoğan, Taner; Gölcü, Ayşegül
A semisynthetic form of podophyllotoxin, etoposide (ETO), is frequently used to manage multiple types of cancer, including lung, testicular, bladder, prostate, and gastric malignancies. Having been utilized in clinical settings for over twenty years, it is one of the most frequently prescribed anticancer agents globally. The primary cytotoxic mechanism of ETO involves the inhibition of topoisomerase II. In the present work, an innovative electrochemical detection platform utilizing MIP was successfully established to enable both highly selective and exceptionally sensitive determination of ETO in pharmaceutical injection forms and environmental specimens. An ETO-specific MIP sensor was fabricated through a photopolymerization process and immobilized onto a GCE, where AMPS served as the active monomer, and EGDMA functioned as the cross-linking agent. This study marks the first instance of a MIP-based electrochemical sensor designed explicitly for ETO identification. The AMPS ETO@MIP/GCE sensor was subjected to electrochemical and morphological assessments through FTIR, SEM, CV, and EIS. An indirect measurement approach was employed using a 5.0 mM potassium ferricyanide/ferro cyanide system to ascertain the analytical detection range from 1.0 to 10.0 pM. The sensor demonstrated excellent sensitivity, reproducibility, and selectivity, enabling effective discrimination of ETO from structurally similar compounds while retaining reliable performance in complex matrices such as soil and tap water. Results from validation experiments in pharmaceutical matrices indicated superior recovery, supporting the sensor's practical effectiveness and stability. To further investigate the experimental results and better understand the nature of template–monomer interactions, a series of DFT calculations was performed. Binding energies were evaluated for ETO–AMPS complexes across varying template-to-monomer ratios.
Predictors of re-biopsy in percutaneous musculoskeletal tumor biopsies: A single-center retrospective cohort study
(SAGE Publications, 2026) Yücesan, Ali; Arıkan, Yavuz; Doğukan, Fatih Mert; Mutlu, İlhan Nahit; Toy, Serdar; Atan, Tamer; Özer, Devrim
Purpose: This study aimed to evaluate the diagnostic success of percutaneous biopsies performed for suspected mus culoskeletal tumors and to identify clinical, anatomical, and procedural factors associated with the need for repeat biopsy (re-biopsy). The secondary objective was to assess the impact of multidisciplinary team (MDT) evaluation on reducing unnecessary re-biopsy procedures. Methods: A total of 565 patients (331 bone, 234 soft tissue lesions) who underwent percutaneous biopsy for suspected musculoskeletal tumors between 2020 and 2024 were retrospectively analyzed. Diagnostic success was defined as a biopsy yielding a definitive histopathological diagnosis sufficient to guide treatment planning without additional tissue sampling. Predictive factors including lesion size, depth, location, and performing specialty were evaluated using univariate and multivariate logistic regression analyses. Results: The initial diagnostic yield was 65.5%. Multivariate analysis revealed that lesion width <2 cm (OR = 2.01; 95% CI, 1.19–3.39; p = 0.009) and biopsy performed by an interventional radiologist (compared to an orthopedic surgeon) (OR = 5.25; 95% CI, 2.83–9.74; p < 0.001) were independent predictors of re-biopsy recommendation. Among 72 patients recommended for re-biopsy, MDT evaluation averted the need for a second procedure in 38 cases (52.8%). Conclusion: Smaller lesion size (<2 cm) and the medical specialty performing the biopsy were independent predictors of re-biopsy recommendation, with the latter likely reflecting systematic differences in case complexity and procedural environment rather than operator skill. Structured MDT evaluation significantly reduced unnecessary repeat procedures.
Effectiveness of fissure sealants following different silver fluoride application protocols in MIH-affected molars: Randomized clinical study
(Springer Nature Link, 2026) Çayıroğlu, Nagihan; Ballıkaya, Elif; Erbaş Ünverdi, Gizem; Çehreli, Zafer Cavit
Objectives To compare the clinical efficacy of glass ionomer sealants (GIS) and resin-based sealants (RBS) applied imme diately or one week after silver fluoride (SF) application to permanent molars affected by molar incisor hypomineralization (MIH) in children at high risk for caries. Methods A total of 216 MIH-affected molars (ICDAS 1–2) from 102 children aged 6–14 years were randomly allocated to six groups: Resin- or glass ionomer–based fissure sealants were placed either one week after the application of silver fluoride or during the same clinical session. In the same-visit protocols, sealants were applied immediately after silver fluoride treatment, either following gentle blot drying with cotton or after immediate rinsing. Hypersensitivity, caries progression, and sealant retention were assessed at 1, 6, and 12 months. Hypersensitivity was evaluated using the Schiff Cold Sensitivity Scale (SCASS). Sealant performance was analyzed using modified USPHS criteria. Statistical analyses included Fisher’s Exact Test and the Friedman test. Results Full retention was achieved in all resin-based sealant groups, while the lowest retention rate (88.9%) was recorded in the glass ionomer sealant group applied one week after silver fluoride. Caries occurred in 2.8% of teeth and was confined to three groups: glass ionomer sealants placed one week after silver fluoride, resin-based sealants applied immediately following blot drying, and glass ionomer sealants applied immediately after rinsing. All other groups showed complete clinical success. No statistically significant differences were found among groups regarding caries prevention (p=1.000) or sealant retention (p=0.062). Hypersensitivity decreased significantly over time in all groups. Conclusion Resin-based and glass ionomer fissure sealants placed either one week after silver fluoride application or immediately following treatment, using rinsing or blot-drying protocols, showed similar outcomes over a 12-month follow-up period in terms of caries prevention and reduction of hypersensitivity. Nonetheless, within the limitations of this study, sealants placed immediately following silver fluoride application demonstrated a greater frequency of discoloration. Clinical significance Both glass ionomer and resin-based fissure sealants can be successfully applied either immediately or one week following silver fluoride treatment to provide protection for MIH-affected permanent molars. Clinical trials registration number NCT06641011.
Functional and surgical outcomes of ventral mesh rectopexy in male patients with rectal prolapse: A nationwide multicenter retrospective cohort study by the pelvic floor working group of the Turkish society of colon and rectal surgery (TSCRS)
(Springer Nature Link, 2026) Gültekin, Fatma Ayça; Balcı, Bengi; Kuzeyli Yıldırım, Yasemin; Arslan, Çiǧdem; Yaşar, Necdet Fatih; Bisgin, Tayfun; Bayraktar, Adem; Zenger, Serkan; Şengül, Neriman; Bulut, Türker Mehmet
Background The indications and outcomes of ventral mesh rectopexy (VMR) in the treatment of rectal prolapse in males have been minimally addressed in the literature. This study aimed to evaluate the demographics, clinical characteristics, and surgical outcomes associated with VMR in male patients. Methods This nationwide retrospective cohort study included male patients who underwent VMR at centers performing pelvic floor surgery across Turkey. Clinical and surgical characteristics were obtained, and functional outcomes were evalu ated using Cleveland Clinic Incontinence score (CCIS) and Altomare Obstructed Defecation Syndrome (ODS) scores at the pre- and postoperative periods. Results Forty-one male patients (mean age, 45.4 years; mean BMI, 25.6 kg/m2 ) underwent VMR (2 open, 5 robotic, and 34 laparoscopic). The cohort comprised 11 patients with internal rectal prolapse (IRP) and 30 with external rectal prolapse (ERP). The overall complication rate was 17.1% (2.4% related to mesh), with a 12% recurrence rate. The median follow-up was 33 (6–127) months. The recurrence rate was 36.4% for IRP patients and 3.3% for ERP patients (p=0.014). Significant improvements were observed in the CCIS (preoperative: 6.1±4.8; postoperative: 2.8±3.3, p=0.005) and Altomare ODS (preoperative: 11.9±4.6; postoperative: 7.26±5.8, p<0.001). Conclusions In this nationwide retrospective cohort study, VMR was associated with favorable functional outcomes in males. Recurrence rates were significantly higher in those with internal rectal prolapse. As sexual function was not systematically assessed, prospective studies with standardized patient-reported outcomes are warranted.
Safety, feasibility and indications of transabdominal oocyte pick-up: Initial experience
(World Scientific, 2026) Turan, Volkan; Öktem, Özgür
Although the transvaginal route is the preferred method for the oocyte retrieval procedure, the transabdominal (TA) route may be preferred in certain conditions. In this opinion we presented our experience with TA oocyte pick-up in 101 patients across several different indications and assessed the safety of the procedure.
Evaluation of changes in oral and dental health and deleterious oral habits after adenoidectomy or adenotonsillectomy in children
(Korean Association of Orthodontists, 2026) Arat Maden, Eda; Yoğurucu Değerli, Gizem; Kurt Dizdar, Senem; Turgut, Suat
Objective: This study aimed to evaluate changes in oral health status and related oral habits in children undergoing adenoidectomy or adenotonsillectomy, focusing on dental indices and mouth breathing-associated symptoms. Methods: This prospective observational study included 52 children (mean age: 7.4 ± 2.1 years) who underwent adenoidectomy or adenotonsillectomy. Clinical evaluations included decayed, missing, and filled teeth for primary dentition/ decayed, missing, and filled teeth for permanent dentition (dmft/DMFT) scores, plaque index (Silness and Löe), gingival index (Löe and Silness), and unstimulated salivary flow rate. Parents completed structured questionnaires assessing their children’s medical and dental history, oral health-related behaviors, and symptoms. Oral health-related quality of life was evaluated using the Early Childhood Oral Health Impact Scale. Results: Statistically significant improvements were found in salivary flow rate (from 0.43 ± 0.21 mL/min to 0.75 ± 0.19 mL/min), plaque index (1.58 ± 0.48 to 1.06 ± 0.33), and gingival index (1.28 ± 0.55 to 0.70 ± 0.39) (all P = 0.001). Several mouth breathing related symptoms, such as snoring, dry mouth, daytime sleepiness, and halitosis, also showed a significant postoperative reduction (P < 0.05). Conclusions: Adenoidectomy or adenotonsillectomy significantly improved periodontal parameters and reduced mouth breathing-associated symptoms in children. These findings highlight the importance of interdisciplinary management involving otolaryngologists, pediatric dentists, and orthodontists.
Meta-learning analysis of deep neural network architectures on diverse numeric datasets via geometric complexity descriptors
(Wiley, 2026) Bulut, Faruk; Dönmez, İknur
Meta-learning techniques aim to predict the most suitable learning algorithm for a given dataset based on its intrinsic structural characteristics. These techniques provide a robust framework for understanding algorithmic behavior across diverse data dis tributions and attributes. Although these state-of-the-art models (CNNs and transformers) are widely applied in various machine learning tasks, their use on numerical datasets remains underexplored due to the complexity of their internal structures. This study aims not only to predict the performance of two black-box deep learning models on static datasets but also to conduct a behavioral analysis in order to identify which meta-features most strongly infuence their outcomes. It seems unclear which specifc attributes of a dataset positively or negatively afect the performance of these deep learning models. To bridge this gap, we constructed a meta dataset consisting of 296 datasets, each characterized by 20 meta-features describing the dataset’s statistical, geometric, and structural properties. The analysis identifes which intrinsic dataset properties infuence model accuracy, without relying on raw data or hyperparameter tuning. Results show that both models perform best on datasets with high feature discriminability, as captured by meta-features such as maximum feature efciency, collective feature efciency, and directional separability. In contrast, performance declines with increasing class boundary complexity and nonlinearity, refected in features like class separability measures and the linear classifer nonlinearity metric. While CNNs are more sensitive to local geometric complexity, transformers respond more strongly to global statistical measures such as mutual information and entropy, highlighting their distinct inductive biases. The proposed meta-model accurately predicts the performance of both architectures on unseen datasets (0.96 correlation coefcient, 0.019 MAE, and 0.025 RMSE for CNNs; 0.92 correlation coefcient, 0.027 MAE, and 0.036 RMSE for transformers), enabling performance estimation without costly training. These fndings emphasize the importance of aligning model architecture with dataset geometry and structure. Additionally, the framework supports more interpretable, efcient, and sustainable deep learning model selection in structured data settings.
Machine learning assisted mechanical design: Multi objective optimization of welding parameters for robotic gripper joint
(Taylor & Francis, 2026) Tanrıver, Kürşat
This study presents a data driven, mechanically grounded optimization framework to improve the tensile performance of TIG welded AISI 304 stainless steel joints used in load bearing robotic gripper applications. Unlike prior machine learning–assisted welding optimization studies that emphasize metallurgical characteristics or isolated statistical metrics, the proposed approach explicitly links welding parameters to structural per formance and mechanical design requirements of robotic systems. A Taguchi based experimental design consisting of ten orthogonally arranged welding trials was employed to generate the training dataset. Gaussian Process Regression (GPR) and Support Vector Regression (SVR) models were developed to predict ultimate tensile strength (UTS) and eval uated using cross validation metrics. The GPR model demonstrated super ior accuracy, achieving a coefficient of determination exceeding 0.97 with low prediction error. Feature importance analysis identified welding volt age and material thickness as dominant parameters, consistent with their influence on arc stability, heat distribution, weld pool geometry and load bearing cross sectional integrity. Multi objective optimization was performed using a Multi Objective Genetic Algorithm (MOGA), where UTS was treated as the primary mechan ical objective, while heat input and a distortion related surrogate response were included as competing process related objectives. The resulting Pareto optimal solutions yielded UTS values of approximately 554–580 MPa within feasible parameter limits. Model robustness was assessed through Monte Carlo–based uncertainty quantification using ±5% stochastic variation in welding parameters. Two confirmation experiments conducted outside the training dataset demon strated agreement between predicted and experimental UTS values, with total prediction errors below 1.3%. Overall, the proposed ML-MOGA frame work offers a practical optimization strategy for reliable decision making under limited experimental data conditions.
A mixture of potent polyphenolic anticarcinogens: Microarray analysis of their efficacy in MCF-7 and MCF-10A cell lines
(ACG Publications, 2026) Seyhan, Mehmet Fatih; Eronat, Allison Pınar; Diren, Ayça; Tüzüner, Mete Bora; Ceviz, Ayşe Begüm; Yılmaz Aydoğan, Hülya; Öztürk, Tülin; Öztürk, Oğuz
Polyphenols are abundantly available through diet and show great promise with their safe use against cancer. In our previous studies, we have shown cytotoxic effects of more than 30 polyphenols in breast cancer. In this study, we have aimed to investigate the effects of various polyphenols upon MCF-7 breast cancer and MCF-10A normal epithelial cells. To this end, we have designed a polyphenolic mixture based on the most effective concentrations of seven compounds, which is a first according to literature in terms of polyphenolic combi nation studies. Cell proliferation experiments were executed utilizing WST-1 and apoptotic status by Annexin V-PI. After determining most effective concentrations, we operated whole genome microarray analysis. Based on microarray data, the best effective concentration for both cell lines is 75% of polyphenolic mixture. In MCF-7 cell line, this dosage induced in down regulation of cell cycle, cell division, DNA repair and some genes linked to breast cancer. In contrast, no remarkable effect was observed in MCF-10A cell line. The designed polyphenolic mixture was demonstrated to inhibit breast cell division in multiple pathways. Our findings on cell division in MCF-7 cell line were found similarly with the study based on polyphenol rich propolis which inhibited cell division remarkably in SK-BR-3 cells. This mixture, which is shown to have highly effective anticarcinogenic effects, can be considered as a prototype of natural prescription design for our future research.
Double materiality and SWOT analysis: A practical framework for environmental impact and sustainability assessment
(Inderscience, 2026) Yurtsever, Özlem; Çelik, Mustafa Cem; Uyar, Tanay Sıdkı
Double materiality is becoming a necessity in sustainability reporting, as it is essential for aligning organisational strategies with ESG priorities. This study proposes a framework to embed SWOT analysis within sustainability reporting, focusing on double materiality. By positioning SWOT as a bridge, the framework enables a holistic evaluation of internal capabilities and external ESG-related risks and opportunities. It encourages periodic updates to question sets, supporting an evolving, stakeholder-inclusive process aligned with annual reporting cycles. This approach offers organisations a practical reference to develop transparent, credible, and adaptable sustainability disclosures, reinforcing their strategic decision-making and compliance with increasingly complex reporting standards.
Anxiety levels and associated sociodemographic factors in mothers of children with first febrile seizures: A case-control study
(Elsevier, 2026) Küçük, Elif; Köle, Mehmet Tolga; Erkin, Gökşen; Kandemir, İbrahim; Hüsrevoğlu Esen, Feyza; Güven, Deniz; Uysal, Feride; Akın, Yasemin
Objective: The prognosis of febrile seizures (FS) is generally favorable; however, a child's first febrile seizure can be distressing for parents. The aim of this study was to assess the anxiety levels of mothers whose children present to the pediatric emergency department with FS for the first time and to examine the relationship between these anxiety levels and the sociodemographic characteristics of the mothers. Methods: This case-control study included mothers presenting for the first time to the pediatric emergency department of our hospital with children aged 6 months to 6 years, either for simple FS or for fever without seizures. Maternal anxiety levels were assessed using the State–Trait Anxiety Inventory (STAI) approximately 12 h after the initial seizure. Sociodemographic characteristics were also collected, and the relationship between these characteristics and anxiety levels was analyzed. Results: A total of 103 participants (52 in the FS group, 51 controls) were included. Higher maternal education and family income were associated with lower STAI-S and STAI-T scores. The FS group had significantly higher mean STAI-S (p < 0.001) and STAI-T (p = 0.007) scores, by 14.6 and 3.6 points, respectively. Multivariate analyses revealed that income was a significant confounder for both STAI-T and STAI-S. Conclusion: Mothers of children with FS report higher levels of anxiety. Sociodemographic factors, such as income and maternal education level, play a significant role in maternal anxiety levels. Targeted educational and support programs addressing income inequalities in healthcare could help reduce maternal anxiety and improve the management of FS.
Assessment of antioxidant performance of silybum marianum extract as a natural antioxidant additive in polyethylene by time-dependent melt rheology tests
(Springer Nature Link, 2026) Alanalp, Mine Begüm; Şıdım, Gizem; Mirmahmutoğulları, Esra; Pınar, Özlem; Durmuş, Ali
In this study, Silybum marianum (SM) extract as a natural primary antioxidant (PAO) additive was introduced into low density polyethylene. This primary antioxi dant was supported by a commercial grade secondary antioxidant (SAO, Irgafos® 168). The effect of compositional variations, mainly amount of SM and the weight ratio of PAO: SAO in the composition, on the thermooxidative stability of low density polyethylene (LDPE) was characterized by determining the thermal param eters, oxygen induction time (OIT) and oxidation onset temperature (OOT) using conventional thermal analysis methods performed in a DSC in air atmosphere. Fur thermore, time-dependent rheology test procedures were suggested for monitoring the thermooxidative degradation behavior of antioxidant-loaded compounds. It was found that SM loading of 0.2 or 0.5 wt% provided sufficient oxidation stability in polyethylene, at least 5 min at 240 °C under air when supported by introducing two- or three-fold of SAO. It can be concluded that these SM-Irgafos® 168 antioxi dant packages can be successfully used in polyethylenes processed in conventional melt processing windows that can be varied in 180–240 °C, in processing devices (e.g., compounder, kneader, extruders, injection molding, rotomolding) because the obtained thermorheooxidative stability times are longer than the residence time of polymer melts, approximately in the range of 1–4 min from the melting zone to die during the extrusion process.
Survival at stake: Surgical decision-making in metastatic femoral
(Acta Medica Belgica, 2025) Yücesan, Ali; Arıkan, Yavuz; Toy, Serdar; Karaduman, Volkan; Özer, Devrim
Pathological femoral fractures resulting from primary or metastatic tumors represent a complex clinical challenge for orthopedic surgeons, often requiring individualized treatment strategies. This retrospective study aimed to evaluate and compare the outcomes of different surgical approaches used in the management of pathological femoral fractures secondary to metastatic disease. A total of 46 patients (52 femoral fractures) who underwent surgical treatment between 2020 and 2023 were included in the study. Data collected encompassed demographic characteristics, tumor histology, surgical techniques employed, and clinical outcomes. Statistical analysis was conducted using appropriate parametric and non-parametric tests, depending on data distribution. Of the patients included, 51% underwent tumor resection followed by endoprosthetic reconstruction, 40% were treated with intramedullary nailing, and 9.4% underwent plate osteosynthesis. The highest postoperative mortality rate was observed among patients with lung cancer metastases. Blood transfusions were necessary in 66% of cases. The overall mean survival time following surgery was 4.5 months, with significant variation according to tumor type and metastatic burden. The findings of this study underscore the importance of a multidisciplinary approach in the surgical management of pathological femoral fractures caused by metastatic tumors. Surgical interventions such as intramedullary nailing, plate fixation, and endoprosthetic reconstruction can effectively restore mechanical stability and contribute to improved patient quality of life. Selection of the optimal surgical technique should be guided by tumor histopathology, anatomical location and extent of bone involvement, number of metastatic lesions, and overall patient prognosis. Timely and appropriate surgical intervention remains critical to minimizing complications and enhancing survival outcomes in this patient population.
Microwave assisted hydrothermal synthesis of flower shaped bismuth sulfide nanomaterial and its usage for copper removal from spiked tap water samples
(Springer Nature Link, 2026) Tezgin, Emine; Dalgıç Bozyiğit, Gamze; Zaman, Buse Tuğba; Serbest, Hakan; Turak, Fatma; Bakırdere, Sezgin
This study was designed to enhance the removal efficiency of copper ions from tap water samples by developing an adsorptive treatment method employing bismuth sulfide based nanoflowers (Bi2S3 NFs) and evaluating with the flame atomic absorption spectrophotometry (FAAS) system. A fast, and easy microwave assisted hydrothermal method was developed to synthesize Bi2S3 NFs for this application. The equilibrium adsorption investigations were conducted in tap water samples following the full optimization of all experimental parameters through univariate optimization research. As the result of optimization studies, the removal process was conducted in the conditions of 30 mg of Bi2S3 NFs for 40 mL of aqueous copper solution which was adjusted to pH 7.0 with 2.0 mL of buffer solution. The adsorption process was enhanced utilizing a sonication bath for 2.0 min before the effluent separation. The removal efficiency values, expressed as percentages, were found to be between 83.8 and 98.9% for various concentrations of copper ions in the tap water samples. Langmuir adsorption isotherm was used to model the equilibrium data. Equilibrium constant of Langmuir was calculated as 5.887 L/mg. The results obtained indicate that the adsorption mechanism of Bi2S3 NFs, when used as adsorbents, is effective to remove copper from tap water samples.
The multifaceted effects of rosmarinic acid on breast cancer, regulating autophagy and increasing apoptosis
(Taylor & Francis, 2026) Erol Kutucu, Deniz; Erkısa Genel, Merve; Üvez, Ayça; Armutak, Elif İlkay; Yılmazer, Nadim; Demirci, Huri; Soluk Tekkesin, Merva; Ulukaya, Engin; Gürel Gürevin, Ebru
Cancer remains a complex and formidable disease that necessitates the development of diverse therapeutic strategies, including the investigation of natural products as complementary agents. Rosmarinic acid (RA), a phenolic compound, has demonstrated promising anticancer activity across various malignancies. Combining RA with conventional chemotherapeutic agents may represent a novel therapeutic approach. In the present study, the efficacy of these combinations was evaluated in vitro through the assessment of cell viability, apoptosis, autophagy, and proliferation, and in vivo by examining their effects on tumor growth in an Ehrlich Ascites Carcinoma (EAC) model. Among the tested combinations, RA and Paclitaxel (PTX) exhibited enhanced cytotoxicity and synergistic activity compared with individual treatments, whereas other combinations demonstrated limited efficacy. Morphological and moleculer analyses indicated induction of apoptosis, evidenced by increased expression of FAS, FADD, and cleaved caspases detected by Western blotting. Moreover, the RA+PTX (Rosmarinic acid+Paclitaxel) combination was associated with impaired autophagic flux, as reflected by elevated LC3 and p62 levels. Although the combined treatment reduced tumor volume in vivo, its antitumor efficacy was comparable to that of RA monotherapy. Collectively, these findings indicate that while the RA+PTX combination enhanced cytotoxicity activity against triple-negative breast cancer in vitro, its therapeutic advantage in vivo requires further investigation.
The effect of phosphoric acid on the development of neural tube defects in chick embryos
(International Scientific Information, Inc., 2026) Yücel, Murat; Çetin, Eyüp; Canbaz, Halime Tuba; Karip, Betül Zehra; Demir, Emine; Kocaoğlu, Sarper; Demir, Hüseyin
Introduction: Neural tube defects (NTDs) are among the most common congenital malformations and arise from disruption of early neurulation. Phosphoric acid is a widely used food additive; however, its potential effects on early neu ral tube development have not previously been evaluated in experimental neurulation models. This proof-of concept study aimed to investigate the embryotoxic and teratogenic effects of phosphoric acid on neural tube development in a chick-embryo model of neurulation, at a single tested concentration. Material/Methods: Fertilized pathogen-free chicken eggs (n=30) were randomly allocated into 2 groups. Control embryos (n=15) received no injection, whereas embryos in the experimental group (n=15) were injected beneath the embryon ic disc with 0.25 mM phosphoric acid, at Hamburger-Hamilton stage 9. Embryos were incubated for 72 hours, after which survival was recorded and neural tube development was evaluated macroscopically and histopath ologically. Statistical comparisons were performed using Fisher’s exact test. Results: All control embryos survived (15/15, 100%) and exhibited normal neural tube closure. In the phosphoric acid–treat ed group, survival was significantly reduced (10/15, 66.7%; P=0.0421). Among surviving treated embryos, 80% (8/10) demonstrated NTDs, including cranial and caudal closure abnormalities (P<0.001). Histopathological ex amination confirmed incomplete neural fold closure, irregular notochord morphology, and disrupted somite or ganization in affected embryos. Conclusions: Phosphoric acid exposure at the tested concentration and developmental stage markedly reduced embryo sur vival and induced a high incidence of neural tube closure defects in a chick-embryo model. These findings pro vide the first experimental proof-of-concept evidence that phosphoric acid can directly disrupt early neurula tion in a vertebrate neurulation model. However, vehicle-controlled replication, dose–response analyses, and exposure-bridging studies are required to distinguish teratogenic specificity from general embryotoxicity and to assess potential relevance to human embryogenesis.
Effect of plaque-disclosing agents on biofilm removal: Single-center randomized trial in fourth-year dental students
(BioMed Central, 2026) Ballı Akgöl, Beyza; Bayram, Merve; Üstün, Nilüfer; Aksaka, Nurcan
Background To assess whether plaque-disclosing agents (PDA) improve self-performed mechanical plaque removal and gingival health compared with standard instruction alone in dental students. Design/Setting Single-center, parallel-group randomized controlled trial (1:1), Istanbul Medipol University (Oct 2023–Jan 2024). Participants 124 fourth-year dental students (age 20–30 years) randomized to test (n=62) or control (n=62). Interventions Both groups received standardized oral-hygiene instruction (Modified Bass; interdental cleaning guidance). The test group additionally received PDA before brushing as a visual aid; all outcomes were measured after triple rinsing. Primary outcome (prespecified) Between-group difference in change (Δ) in Plaque Index (PI) from baseline to week 1. Secondary outcomes ΔPI baseline→post-brushing and baseline→month 1; ΔGingival Index (GI) baseline→week 1 and baseline→month 1. Masking Outcome assessor blinded at the time of measurement (after rinsing). Results All 124 randomized participants completed follow-up and were analyzed. Both groups showed short-term improvement (immediate reduction in PI post-brushing; GI improvement at week 1). The primary outcome showed no significant between-group difference in ΔPI from baseline to week 1. Secondary analyses similarly found no significant between-group differences in ΔPI or ΔGI at month 1. Conclusions In a population with high baseline oral-hygiene proficiency, adding PDA did not confer a measurable advantage over standardized instruction alone on PI or GI change. PDA may be more informative in lay populations with lower oral-health literacy. Trial registration ClinicalTrials.gov, NCT06080672, registered on October 12, 2023.

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