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A quality by design study of the use of microfluidic nanoprecipitation for the generation of sub-100 nm drug nanocrystals
(Elsevier, 2026) Pirinçci Tok, Yağmur; Abukhamees, Shorooq; Fitaihi, Rawan; Demiralp, Burcu; Özsoy, Yıldız; Craig, Duncan
Although drug nanocrystals have attracted considerable interest within the pharmaceutical industry, there remain issues with the production of nanocrystals with a size below 100 nm. The aim of the present study is to develop a stable, reproducible Canagliflozin (CFZ) sub-100 nm nanosuspension system using microfluidic nanoprecipitation and Quality by Design (QbD) techniques. By means of the circumscribed central composite design (CCCD), critical parameters of the microfluidic nanoprecipitation process and nanosuspension formula tion components were optimised. Optimal CFZ nanosuspension with Z-average of 89.52 ± 3.30 nm, PDI of 0.12 ± 0.01 and drug content of 92.49 ± 0.03 % was successfully fabricated using Soluplus as a stabiliser. An increase in saturation solubility corresponding to approximately 250 times the value of the pure CFZ in water was noted. The optimised CFZ nanosuspension was solidified by freeze-drying and electrospraying. Overall, the study has demonstrated that by using a combination of microfluidics and QbD it is promising to generate stable sub-100 nm nanocrystals with high yield, and narrow size distribution and favourable stability.
Logistics operations management in the industry 4.0 era: A case study for transition of an automotive company′s operations to fourth-party logistics structure
(Vilnius Gediminas Technical University, 2025) Döner, Hülya; Vayvay, Özalp; Vardarlıer, Pelin; Kalender, Zeynep Tuğçe
In recent years, the understanding of minimum inventory and customer satisfaction in the flow of goods and services from manufacturers to end-users is of great importance among the factors that make businesses more interested in outsourcing logistics activities. Additionally, technological transformation and customer requests for complicated technology and services caused the appearance of new circumstances, which is progressively altering the industry. In this regard, choosing, managing and coordinating between multiple vendors become very difficult and time consuming so, companies outsource more functions while supply chain operations getting more complex. Companies generally preferred 3PL providers for their logistics functions including packaging design and management of company-owned assets. On the other hand, with technological transformation in logistic sector, businesses are looking to outsource 4PL more than ever. 4PL system transitions are difficult processes since it requires comprehensive system integration and should be well understood by the company′s supply chain team. Today, although the importance of 4PL systems is more understood and this structure is becoming more widespread, many companies still face similar adaptation problems. From this point of view, it is believed that this study creates important insights into the business world. In this study, the transition process of an automotive company is examined which successfully completed after a 5-month project period. As a detailed case study, the Transportation Management Module (TTM) is selected since the whole transition process was very comprehensive and included many dimensions. Study revealed that adaptation of the new system, developed by the partnership of the automotive company and 4PL company, provided several benefits. In this sense, with the transition of Transportation Management (TM), TTM is reduced by 2 days, almost 10% savings are reported in the whole company and only in the Turkey branch, 243311 € cost saving is achieved in the 1st year. The study proves that focusing on the core business via outsourcing supply chain activities not only increases efficiency in the selected automotive company but also increases supply chain quality as well.
Anatomic safety profile of a novel mini external fixator for proximal crescentic osteotomy in hallux valgus correction: A cadaveric study
(Springer Nature Link, 2026) Coşkun, Osman; Nteli Chatzioglou, Gkionoul; Gürses, İlke Ali; Ok, Fatma; Gayretli, Özcan; Erdil, Mehmet
Purpose The proximal crescentic osteotomy is an effective procedure for hallux valgus correction, but stable fixation remains challenging. Our previous biomechanical study suggested that the MEF may offer comparable or greater stability than a specific cannulated screw fixation construct in a cadaveric model. This study aims to evaluate the anatomical safety of the MEF by investigating its relationship with critical neurovascular structures and tendons. Methods An anatomical dissection study was performed on ten foot cadaveric specimens. The MEF was applied using five mini-Schanz pins inserted in predefined positions. Following fixation, a layer-by-layer dissection was conducted to expose the dorsalis pedis artery, superficial cutanous branches of the foot, the superficial venous arch, and the extensor hallucis lon gus and brevis tendons. The distance from each pin to these structures and any iatrogenic injuries were recorded. Results The superficial venous arch was injured at low rates by the medial distal pin (20%), the medial proximal pin (10%), and the lateral distal pin (20%). Tendon injury was more frequent, with the extensor hallucis longus tendon being injured by 20–30% of pins, and the extensor hallucis brevis tendon by the lateral intermediate and distal pins (20% each). Conclusion The application of the MEF for first metatarsal fixation appears anatomically safe with respect to major arteries and nerves. The consistent avoidance of the dorsalis pedis artery and key sensory nerves is a significant advantage over some established techniques. However, surgeons should be aware of the potential risk to the superficial venous arch and extensor tendons during pin placement. These findings support further investigation of the MEF for proximal crescentic osteotomy f ixation.
Anatomical study of the superficial and deep circumflex iliac arteries: Morphology, variability, and surgical relevance
(Springer Nature Link, 2026) Ok, Fatma; Nteli Chatzioglou, Gkionoul; Karip, Burak; Önal, Vildan; Yıldız, Nilay; Tatar, Burak Ergün; Gayretli, Özcan
Purpose The vascular anatomy of the groin region plays an important role in reconstructive surgery and regional anesthesia, yet data on the precise morphology and topography of the superficial and deep circumflex iliac arteries remain limited. Methods 28 lower extremities of fourteen formalin-fixed male cadavers were dissected to examine the superficial and deep circumflex iliac arteries. Their origins, branching patterns, diameters, and spatial relationships to the inguinal ligament and femoral triangle were recorded. Morphometric distances were measured with a digital caliper, and correlations between parameters were analyzed statistically. Results The superficial circumflex iliac artery arose exclusively from the femoral artery in all cases and was consistently located within the femoral triangle. Its mean origin diameter was 1.83±0.46 mm. The deep circumflex iliac artery showed greater variability, originating from the external iliac artery in half of the cases and from the femoral artery in the other half. Its mean origin diameter was 2.25±0.40 mm, and it was located outside the femoral triangle in 71.4% of cases. Multiple significant correlations were identified between vessel diameters, bifurcation points, and their spatial relationships with the inguinal ligament. Conclusion The superficial circumflex iliac artery displays consistent anatomy, whereas the deep circumflex iliac artery demonstrates notable variability in origin and topography, though with stable vessel caliber. These findings provide detailed morphometric insights that may support safer flap design and improve surgical and anesthetic planning in the groin region.
Energy production from gas hydrates
(Elsevier, 2025) Çifci, Günay; Parlaktuna, Mahmut; Çelebi, Serdar Suut; Okay Günaydın, Seda
Gas hydrates are a type of natural formation that contains large amounts of mostly methane, which is also known as natural gas, and water, in the form of ice. Methane hydrates are cages of water molecules that surround and trap methane molecules. Gas hydrate is geophysical, geologically and economically important for several reasons: Gas hydrates are good cap rocks for oil and natural gas. The methane hydrate itself is an important energy source. A volume of gas hydrate can store up to 164 times per volume of gas as zipped gas, and the fact that gas hydrate occurs almost all around the world. Methane seepage may indicate the existence of a deeper hydrocarbon reservoir, and the methane production and migration in the slope sediments may cause massive slope failure. Last but not least Methane gas has a minimum 22 times more global warm absorption capacity compared to carbon dioxide if it is released into the atmosphere. In other words, greenhouse gas is due to its contribution to climate change. Gas hydrates have drawn significant interest as a potential near future energy resource. Research in the production field of gas hydrates has focused on several key areas, including the feasibility of commercial production, the environmental impacts, and the technological improvements associated with the safe recovery of gas.
Comparison of quadro‑iliac plane block and erector spinae plane block for postoperative analgesia management after single level lumbar discectomy surgery: A randomized, double‑blind, controlled, prospective, multicenter study
(Springer Nature Link, 2025) Turan, Engin İhsan; Otlu Bıyıkoğlu, Büşra; Özen, Volkan; Alver, Selçuk; Umutoğlu, Tarık; Cücü, Oğuzhan; Çevik, Serdar; Çiftçi, Bahadır; Şahin, Ayça Sultan
Purpose Effective postoperative analgesia management is critical for optimizing recovery and patient satisfaction following lumbar discectomy. Erector Spinae Plane Block (ESPB) is an established regional anesthesia technique with proven efficacy, while the novel Quadro-Iliac Plane Block (QIPB) has shown promise as an alternative approach. This study compares the analgesic efficacy, opioid-sparing potential, and safety of ESPB and QIPB in single-level lumbar discectomies. Method This multicenter, prospective, randomized, double-blind study included 60 patients aged 18–65 years undergoing single-level lumbar discectomy. Patients were randomized into ESPB (n=30) and QIPB (n=30) groups. Both blocks were performed at the end of surgery, before the extubation under ultrasound guidance using 40 ml (0.25%) bupivacaine bilater ally. The primary outcome was postoperative pain assessed by the Numeric Rating Scale (NRS) at 12 h. Secondary outcomes included tramadol consumption, rescue analgesia requirements, hemodynamic parameters, and adverse events. Results The primary outcome, 12-h NRS scores, did not differ significantly between groups (p>0.05), indicating similar anal gesic efficacy. Secondary outcomes—including total tramadol consumption (54.00±49.03 mg for ESPB vs. 44.67±44.16 mg for QIPB, p=0.476), need for rescue analgesia, and incidence of nausea and vomiting—were also comparable. No motor block was observed in either group. Conclusion Although QIPB did not demonstrate superiority over ESPB, it was found to be not inferior in analgesic effect and safety outcomes. These findings suggest that QIPB may be a reliable alternative to ESPB in lumbar discectomy procedures.
Impulsivity in parkinson’s disease
(Wolters Kluwer, 2026) Değirmenci, Yıldız; Altınbaş, Kürşat; Keçeci, Hulusi; Bougea, Anastasia; İsmayılov, Rashad; Gourzis, Philippos
Introduction/Aims: Parkinson’s disease (PD) is a neurodegenerative disease characterized by cardinal motor and nonmotor symptoms. Impulse control disorders are common neuropsychiatric manifestations in patients with PD (pwPD) under dopaminergic therapy. However, impulsivity is an underestimated symptom. Hence, the present study aimed to evaluate the impulsivity in pwPD. Methods: Forty‑seven adults who were diagnosed with having PD according to the Queen Square Brain Bank criteria for PD diagnosis and 30 age‑matched healthy controls were enrolled in the study. The sociodemographic data of the study participants and disease characteristics of the patients were recorded. All participants completed the Barratt impulsiveness scale (BIS). BIS scores were statistically analyzed between the groups. Results: The results revealed no significant differences between the patients and controls in terms of age (P > 0.05) or sex (P > 0.05). The total BIS scores were higher in the PD group than in the healthy controls (t = 2.1, P = 0.038). The items of BIS and attentional impulsivity scores were higher in the pwPD than in the controls (t = 2.8, P = 0.005), but there were no statistically significant differences between the groups in terms of motor and nonplanning impulsivity (z = 1.8, P = 0.07; and t = 1.1, P = 0.31, respectively). Discussion: Our results indicate that attentional impulsivity is an important clinical characteristic of pwPD, even in the absence of impulse control disorders. Conclusion: Further studies are required to confirm these findings in view of personalized PD treatment.
Incidence and prognostic factors of isolated para-aortic lymph node metastasis in endometrial cancer: A single-center study
(Minerva Medica, 2025) İbrahimov, Akbar; Boyraz, Gökhan
Para-aortic lymph node metastasis (PALNM) is a key prognostic factor in endometrial cancer (EC). This study aimed to de- termine the incidence and prognostic factors of lymph node metastasis (LNM) and isolated PALNM in endometrioid-type EC patients. METHODS: EC patients treated surgically between 2000 and 2015, staged by FIGO 2009 criteria, were retrospectively analyzed. Included were patients with endometrioid histology grades I-III who underwent pelvic and PALN dissection. Excluded were those without lymph node dissec tion or with non-endometrioid histology. RESULTS: A total of 417 patients met the criteria. Of these, 246 (59%) were grade I, 117 (28.1%) grade II, and 46 (11%) grade III. Pelvic LNM (PLNM) was found in 43 (10.3%), and PALNM in 22 (5.3%). Five patients (1.19%) had isolated PALNM. PALNM was more frequent in patients with stage III, tumors >2 cm, cervical glandular/stromal involvement, deep myometrial invasion, positive peritoneal cytology, adnexal involvement, PLNM, and LVSI. Isolated PALNM was notably higher with adnexal involvement. Independent predictors of PALNM were cer vical glandular involvement and LVSI. Deep myometrial invasion, LNM, PLNM, LVSI, and adnexal involvement were linked to disease-free survival (DFS), while peritoneal cytology, PLNM, and LVSI were linked to recurrence. There was no significant difference in recurrence and DFS between PALNM and isolated PALNM. CONCLUSIONS: Isolated PALNM without PLNM is rare in EC patients but should be assessed for optimal staging and treatment.
Association of health-promoting behaviors with oral health status among Turkish dental students: A cross-sectional study
(Springer Nature Link, 2026) Ballı Akgöl, Beyza; Bayram, Merve; Üstün, Nilüfer; Aksaka, Nurcan
Background: Oral health is an essential component of overall well-being, and dentistry students are expected to model healthy behaviors. However, their lifestyle habits may not always reflect this role. This study explores the relationship between oral health status and health-promoting behaviors among fourth-year dental students. While the Health-Promoting Lifestyle Profile II (HPLP II) has been widely applied, its use alongside objective oral health indices in this population remains limited. Methods: This cross-sectional study assessed health-promoting behaviors using the Health-Promoting Lifestyle Profile II (HPLP II) and evaluated oral health status using clinical indices, including Decayed, Missing, and Filled Teeth (DMFT) index, Gingival Index (GI), and Plaque Index (PI), among fourth-year dental students. Results: Students with better gingival health exhibited higher overall health-promoting lifestyle scores, particularly in the domains of nutrition and health responsibility. Similarly, participants with better plaque control demonstrated more favorable stress management behaviors. In addition, weak inverse associations were observed between dental caries experience and spiritual growth, as well as between plaque accumulation and overall health-promoting lifestyle behaviors. Conclusion: This study revealed significant links between key health promoting lifestyle domains—nutrition, stress management, and health responsibility—and oral health indicators. These findings underscore the need to integrate structured health promotion modules into dental curricula to improve students’ well-being and clinical competence.
Addressing spirituality in counseling: Turkish mental health professionals’ views on a training program for professional competencies
(Springer Nature Link, 2026) Ekşi, Halil; Turgut, Ebru Talibe; Karalı, Fatma Betül; Şen, Hale; Akyol, Havvanur; Aydın, Neslihan; Koç, Yusuf Ziya
The integration of spirituality into counseling has gained increased attention due to its significant impact on psychological well-being. However, mental health profes sionals often face challenges with incorporating spiritual dimensions into therapy, primarily due to inadequate training, conceptual ambiguity, and ethical concerns. This qualitative phenomenological study aims to explore mental health profession als’ perspectives on addressing spirituality in counseling and to assess the necessity of a specialized training program to enhance competencies in this area. We used cri terion sampling to select 11 experienced psychologists, counselors, and academics to, conduct semi-structured interviews, and analyze the data using descriptive analy sis to identify the key themes related to integrating spirituality into counseling. The findings reveal that the current training curricula does not adequately cover spir ituality, which has led to a lack of confidence among mental health professionals. The participants highlighted several barriers, including professional hesitancy, ethi cal concerns, clients’ misunderstandings, and the dominance of secular educational models. Additionally, the study identified the specific competencies needed for inte grating spirituality into counseling and categorized them into knowledge, skills, and attitudes. The professionals emphasized the need for a structured training program that includes conceptual knowledge about spirituality, evidence-based intervention techniques, ethical considerations, and culturally sensitive approaches. Furthermore, recommendations were made regarding the content, format, and evaluation methods for such a training module. The study underscores the urgent need for standardized training to equip mental health professionals with the skills required to address spir ituality in an ethical and culturally competent manner.
Complex ventral hernia repair using botulinum toxin with combination of Fasciotens® after colorectal surgery: A video vignette
(Wiley, 2026) Demirli Atıcı, Semra; Yıldırım, Yasemin; Canda, Aras Emre; Terzi, Mustafa Cem; Arslan, Çigdem; Erenler Bayraktar, İlknur; Bayraktar, Onur; Bisgin, Tayfun
Complex ventral hernia repair using botulinum toxin with combination of Fasciotens® after colorectal surgery: A video vignette
Interfacial bond strength of CAD/CAM resin composites on dentin vs. composite substrates: Influence of dual-cure and self-adhesive resin cements
(MDPI Publishing, 2026) Batgerel, Oyun Erdene; Yazıcıoğlu, Oktay; Kıtın, Emine; Gençel, Burç İhsan; Yamak, Fatih; Ergün Bozdağ, Süreyya; Sasany, Rafat
This in vitro study evaluated the shear bond strength (SBS) of four CAD/CAM (Computer aided design/Computer aided manufacturing) polymer-based indirect composites bonded to dentin and microhybrid composite substrates using two resin cements. Gradia Plus (GP), Ceramage (Ce), Tescera ATL (TA), and Lava Ultimate (LA) were fabricated into cylindrical specimens (3 × 3 mm). Dentin substrates were obtained from extracted molars, while composite substrates were prepared from Filtek Z250 (4 mm × 2 mm). Bonding was performed using either a self-adhesive resin cement (RelyX U200; RU200) or a dual-cure adhesive resin cement (RelyX Ultimate; RU), resulting in 16 experimental groups (n = 12 per group). SBS was measured using a universal testing machine (1 mm/min), and failure modes were assessed under stereomicroscopy. Bond strength was significantly higher on composite substrates than on dentin (p < 0.001), primarily due to favorable polymer– polymer compatibility and matrix interdiffusion, which improved stress accommodation at the adhesive interface. TA and Ce showed superior adhesion when combined with RU, while LA exhibited the lowest values, particularly on dentin bonded with RU200. Overall, the dual-cure adhesive system provided stronger bonding than the self-adhesive system (p < 0.05). These findings highlight the influence of substrate type, composite architecture, and cement chemistry on interfacial performance in indirect polymer-based restorations.
Long-Term endocrine outcomes with special emphasis on the gonadal impact of acute lymphoblastic leukemia treatment in females
(Springer Nature Link, 2026) Karakaş, Hasan; Tarçın, Gürkan; Bayramoğlu, Elvan; Turan, Hande; Ocak, Süheyla; Turan, Volkan; Evliyaoğlu, Olcay; Tiraje, Tiraje; Apak, Hilmi; Ercan, Oya
This study aims to explore the long-term endocrine and gonadal effects of chemotherapy and radiotherapy in female acute lymphoblastic leukemia (ALL) patients. A cohort study included girls diagnosed with ALL and treated between 2000 and 2020. Patients with at least 2 years elapsed since treatment completion were included. Endocrinological evalua tions included anthropometric measures and pubertal status, as well as fasting insulin, glucose, lipid levels, and hormone assessments for adrenal, and thyroid functions. Reproductive functions were evaluated based on gonadotropin, estradiol, and anti-Müllerian hormone (AMH) levels. A total of 51 female patients were included. At the time of study participa tion, the mean age was 14.7 years, and the mean time since treatment completion was 9.4 years. At least one endocrine disorder was present in 39.2% of participants, with dyslipidemia, insulin resistance, and obesity being the most common. Low AMH levels (<1.1 ng/dL) were found in 41.6%, particularly in those who underwent bone marrow transplantation. A significant positive correlation was found between the time elapsed since treatment and AMH levels (p<0.001, r=0.612), while age at diagnosis, risk group (standard, intermediate or high risk), and cranial radiotherapy showed no significant associations. A substantial proportion of ALL survivors developed endocrine complications, with ovarian reserve compro mised in over 40% of cases. Notably, this is the first cohort study to demonstrate a significant positive correlation between AMH levels and the time elapsed since treatment, suggesting a potential for gonadal recovery except in those exposed to intensive chemotherapy or transplantation.
Hemimyelomeningocele: A systematic review and meta‑analysis of the literature
(Springer Nature Link, 2026) Adıyaman, Ali Ekrem; Karakaş, Furkan; Hamzaoğlu, Can; Saban, Şevval; Kılınç, Tunahan; Acar, Burak; Nabili, Tabriz; Ekşi, Murat Şakir
Hemimyelomeningocele (HMM) is a rare split cord malformation where only one hemicord forms a myelomeningocele-like sac, and the opposite hemicord undergoes normal neurulation. We aimed to compile all published HMM cases to concisely summarize embryology, presentation, imaging, associated anomalies, management, and outcomes of the disorder. Following PRISMA 2020, we searched PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar (1968–Feb 2025) for studies with confirmed human HMM, extracting clinical, radiological, surgical, and follow-up data. Of 688 records screened, 25 articles met inclusion criteria, encompassing 67 patients. Most publications were single-patient case reports. Presentation occurred predominantly in newborns or early infancy. The dysraphic sac was lumbosacral in most cases, and type I split cord malformation with a bony spur outnumbered type II. Hemivertebrae and congenital scoliosis were the common vertebrae anomalies. Nearly all patients underwent surgery combining sac excision, detethering, and bony spur removal. Postopera tive neurological outcomes were favorable: the majority improved, and the other ones remained stable; no surgery-related mortality was reported. HMM can be recognized as a distinct clinic radiological entity within the split-cord spectrum. Early, ideally prenatal diagnosis, timely microsurgical repair, and coordinated multidisciplinary care yield favorable functional outcomes in most patients. This first systematic review compiles the available evidence and provides a practical basis for future diagnostic and treatment decisions.
Rare but critical: Indomethacin-responsive headache with long-lasting autonomic symptoms
(Galenos Publishing House, 2026) Talibov, Tural; İnci, Meltem; Ekizoğlu, Esme; Baykan, Betül
Hemicrania with long-lasting autonomic symptoms (LASH), first described in by Rozen1 , is an extremely rare headache disorder thought to be part of the trigeminal autonomic cephalalgia (TAC) spectrum. However, it is not included in the current International Classification of Headache Disorders, 3rd Edition (ICHD-3).2 Notably, patients with LASH typically respond well to indomethacin.
Redox-responsive and mucoadhesive nanoparticles: An overlooked synergy in modern drug delivery
(Elsevier, 2026) Küçükertuğrul Çelik, Sibel; Şentürk, Sema; Bal, Kevser; Kaplan, Özlem; Gök, Mehmet Koray
The continuous advancement of therapeutic technologies has intensified the pursuit of drug delivery systems that respond intelligently to physiological and pathological stimuli, thereby enabling precise, localized, and sustained therapeutic outcomes. Among redox-based approaches, systems responsive to intracellular glutathione (GSH) have attracted particular attention due to their ability to trigger disulfide bond cleavage and controlled release within diseased tissues. Mucoadhesive systems, on the other hand, prolong residence time on mucosal surfaces through non-covalent interactions and covalent bond formation, thereby facilitating increased absorption and decreased clearance. Despite their individual successes, the integration of these two mechanisms remains underexplored. This review critically examines the coupling of redox sensitivity and mucoadhesion, highlighting how disulfide-based bonds can simultaneously function as both redox-cleavable and mucoadhesive moieties.
A randomized controlled trial of internet-based cognitive behavioral therapy (iCBT) and EMDR-flash technique (iEMDR-FT) for improving mental health in breast cancer patients
(Springer Nature Link, 2025) Savaş, Esra; Gündoğmuş, İbrahim; Kınık, Çiğdem; Kubilay, Derin; Kavakçı, Önder; Yaşar, Alişan Burak
This study aims to compare the effectiveness of internet-based Cognitive Behavioral Therapy (iCBT) and internet-based Eye Movement Desensitization and Reprocessing (EMDR) Flash Technique (iEMDR-FT) in reducing fear of cancer recur rence, traumatic stress, anxiety, depression, and increasing the quality of life among patients diagnosed with breast cancer. A randomized controlled trial was conducted with a sample of patients, equally divided into two treatment groups. The iCBT program was administered over 7 weeks, while the iEMDR-FT was delivered in three sessions in three days. The participants were given a sociodemographic data form, Posttraumatic Stress Disorder Control List DSM-5 (PCL-5), Fear of Cancer Recurrence Scale, Depression-Anxiety-Stress 21 scale (DASS-21), and World Health Organization Quality of Life Scale Short Form. Participants were assessed before, immediately after, and three months post-intervention. The mean age of the participants was 43.79 (7.45) years. In comparing the two groups, a statistical difference was found only in the age variable (p=0.025). As a result, there was no significant difference between the two groups when sociodemographic and cancer-related ratings were compared (p>0.05). It was determined that the change in iEMDR-FT scores in all scales was not statistically significantly different compared to the iCBT group (p>0.05). Initial analysis indicates that both iCBT and iEMDR-FT resulted in notable decreases in traumatic stress, fear of cancer recurrence, anxiety, and depression among breast cancer patients. However, this therapeutic improvement is similar in both applications. This result supports the argu ment that two methods with similar effectiveness can be used as alternatives to each other in treatment.
ThermoMicrowave-sonication improves the stability and digestive bioaccessibility of phenolic compounds in parsley juice
(Elsevier, 2026) Yıkmış, Seydi; Tokatlı Demirok, Nazan; Duman Altan, Aylin; Paçal, İshak; Türkol, Melikenur; Tokatlı, Nazlı; Paçal, Nurettin; Abdi, Gholamreza; Aadil, Rana Muhammad
These are indications of the effects of ThermoMicrowave Sonication (TMS) on the bioactive compounds of parsley (Petroselinum crispum) juice and their bioaccessibility during in vitro digestion. Total phenolic content (TPC), iron-reducing antioxidant power (FRAP), chlorophyll, and ascorbic acid levels were measured in TMS treated and pasteurized samples. TMS minimized the loss of heat-sensitive proteins and significantly increased the phenolic content and antioxidant structure (p < 0.05). By following simulated oral, gastric, and intestinal digestion, TPC, chlorophyll, and FRAP levels were better in TMS samples than in controls or pasteurized samples. The highest recoverable levels were observed in the intestinal phase, highlighting the role of TMS in supporting functional quality after digestion. Prediction models using linear regression and LASSO showed strong accuracy (R2 > 0.99) for antioxidant capacity. Overall, TMS offers a promising, environmentally friendly, and industrially applicable tool for preserving and ensuring bioaccessibility of bioactive images in parsley juice and valuable information for functional electrical development. Chemical compounds: Gallic acid (PubChem CID:370); flovone (PubChem CID: 10680); vanillic acid (PubChem CID: 8468); rutin (PubChem CID: 5280805); naringin (PubChem CID: 442428); p- coumaric acid (PubChem CID: 637542); o- coumaric acid (PubChem CID: 637540); quercetin (PubChem CD: 5280459); alizarin (PubChem CD: 6293).
Temporal trends and regional variations in hepatocellular carcinoma etiology: A multinational study across Asia
(Springer Nature Link, 2026) Takeuchi, Yasuto; Tateishi, Ryosuke; Obi, Shuntaro; Otsuka, Motoyuki; Mochizuki, Hitoshi; Jazag, Amarsanaa; Yokosuka, Osamu; Ogasawara, Sadahisa; Örmeci, Necati; Sarin, Shiv Kumar; Omata, Masao
Background Hepatocellular carcinoma (HCC) remains a major health burden in Asia. Advances in antiviral therapies are reshaping the etiological landscape of HCC. This study evaluated temporal shifts in HCC etiology across Asian countries and their clinical implications. Methods This multinational study analyzed 6,261 newly diagnosed HCC patients registered in the APASL Hepatology/ Oncology Consortium (A-HOC) from 19 centers across seven Asian countries and regions between 2013 and 2023. Data on demographics, tumor characteristics, etiology, and treatment patterns were collected. Etiologies included hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholic liver disease (ALD), metabolic dysfunction-associated fatty liver disease (MAFLD), MAFLD plus excess alcoholic intake (MAFLD +eAL), autoimmune liver disease, cryptogenic, and others. Temporal trends and regional variations were assessed. Results In many countries, HBV remained predominant (43.3%–69.5%) and relatively stable throughout the period, while HCV showed only modest reductions. In Japan, HCV was the leading cause of HCC (33.1%), with a significant decline over time, accompanied by a rise in MAFLD-related HCC. ALD-related HCC increased in South Korea, and MAFLD-related HCC rose in Turkey. Tumor size and stage at diagnosis varied by etiology and region, affecting treatment strategies. Early stage diagnosis was more frequent in Japan and Taiwan, whereas advanced-stage HCC was common in China and Indonesia. Conclusions Distinct regional patterns and temporal changes in HCC etiology across Asia highlight the need for tailored prevention and surveillance measures. The growing burden of MAFLD-related HCC emphasizes its emerging role in liver cancer development, particularly in regions with declining viral hepatitis.
Novel 1-benzyl-2-indolinone indole hybrids as tyrosine kinase inhibitors: Design, synthesis, and biological activity evaluation
(Elsevier, 2026) Cihan Üstündağ, Gökçe; Cinek, Tuğçe; Sancar, Serap; Yıldırım, Merve; Genç Akar, Öyküm; Özen Eroğlu, Güneş; Erol Bozkurt, Ayşe; Öztay, Füsun; Soylu Eter, Özge; Bolkent, Şehnaz; Kuruca, Serap; Karalı, Nilgün
In the present study, new 1-benzyl-2-indolinone indole hybrids (4a-s) were synthesized and their cytotoxic ef fects were determined against human breast (MCF-7 and MDA-MB 231), lung (A549), kidney (CAKI-1 and A498), colon (HT-29 and HCT-116), and pancreas (MIA PaCa-2) cancer cells by MTT assay. Some of the tested com pounds showed significantly better inhibitory effects and safety profiles than sunitinib malate against A498 and MIA PaCa-2 cells. Compound 4s showed a selective and significant cytotoxic effect on MIA PaCa-2 cells (IC50 = 0.15 μM; SI > 666.7). Compound 4b displayed significant cytotoxic effects on both A498 (IC50 = 0.87 μM; SI > 58.3) and MIA PaCa-2 (IC50 = 0.13 μM; SI = 390.0) cells. Compound 4b in A498 cells and compounds 4a-c, 4h, and 4s in MIA PaCa-2 cells significantly decreased general tyrosine kinase activity and induced apoptosis, accompanied by reduced ERK signalings. The inhibitory activities of compounds 4a–c, 4h, and 4s against SRC, PDGFR-β, and c-MET kinases were assessed in MIA PaCa-2 cells. Compounds 4a, 4b, 4h, and 4s inhibited PDGFR β, with 4h and 4s additionally targeting c-MET, while 4a, 4b, and 4h also demonstrated SRC inhibition. In this study, lead compounds 4b and 4s were identified as selective cytotoxic agents against human pancreatic car cinoma cells through induction of apoptosis and inhibition of SRC/PDGFR-β/c-MET signaling. Notably, com pounds 4b and 4s demonstrated a significantly better safety profile than sunitinib malate against noncancerous cells, underscoring their broader therapeutic potential. To understand their potential binding modes, molecular modeling studies were performed at the ATP-binding domains of SRC, PDGFR, and c-MET kinases.

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