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Energy, exergy and exergoeconomic analysis of a CI engine fuelled with waste frying oil biodiesel blended with waste tyre pyrolysis oil and higher alcohols (Heptanol and Octanol): A waste-to-energy approach
(Elsevier, 2025) Gülcan, Halil Erdi; Demirci, Oğuz Kürşat; Erol, Derviş; Tunçer, Erdal
This study evaluates a waste-to-energy diesel concept that co-valorises waste cooking oil and end-of-life tyres by formulating biodiesel–tyre pyrolysis oil blends with small additions of higher alcohols (1-heptanol and n-octa nol). Five fuels (B100, B90T10, B85T10H5, B85T10O5 and B80T10H5O5) were tested in a single-cylinder diesel engine. Engine performance, emissions and combined energy–exergy–exergoeconomic indicators were used to assess thermodynamic and economic viability. The quaternary blend B80T10H5O5 achieved the highest mean energy and exergy efficiencies (26.5 % and 24.6 %) and reduced brake-specific fuel consumption by about 5 % relative to neat biodiesel, owing to improved volatility and fuel oxygenation. This benefit was accompanied by higher NOx emissions and the largest specific exergy cost (≈1430 USD GJ− 1 ) at full load. By contrast, the binary blend B90T10 preserved biodiesel-like efficiency while lowering the specific exergy cost of shaft power by roughly 10 %, emerging as the most cost-effective option. Overall, modest shares of tyre pyrolysis oil (10 %) and long-chain alcohols (≤5 %) in waste-oil biodiesel can provide an attractive compromise between energy effi ciency, emissions and exergy-based cost, supporting circular-economy-oriented diesel combustion.
Gender differences in the distribution of IDL, LDL, and HDL lipoprotein subfractions in MODY compared to type 2 diabetes: Data from the MODY-Ist study
(Elsevier, 2025) Yılmaz Aydoğan, Hülya; Kanca Demirci, Deniz; Gül, Nurdan; Yanar, Fatih; Poyrazoğlu, Şükran; Güleç Yılmaz, Seda; Tüzüner, Mete Bora; İsbir, Turgay; Öztürk, Oğuz; Satman, İlhan
Background: The distribution of intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and high density lipoprotein (HDL) subfractions specific to diabetes types and changes under dyslipidemia conditions have been well characterised. Research into the distribution of lipoprotein subfractions in Maturity-Onset Diabetes of the Young (MODY) has hitherto been confined to certain subtypes, with gender-based differences remaining to be elucidated. The objective of this study was to comparatively evaluate the distribution of lipoprotein subfractions according to gender in MODY, T2DM patients, and control groups. Methods: Lipoprotein subfractions in 119 serum samples of the study groups were analyzed using the Lipoprint System. Results: The midbands of IDL (MID-A to C) in female MODY cases, and the HDL-small fraction in male MODY cases, were found to be lower compared to female and male T2DM cases, respectively. In the T2DM group, age was positively correlated with MID-C and MID-B in both genders, while it was negatively correlated with MID-A in female cases. ROC analysis demonstrated that the decrease in the MID-C fraction in female MODY subjects (AUC:0.809, p = 0.0001) and the decrease in the HDL-small fraction in male MODY subjects (AUC:0.818, p = 0.002) were significantly associated with the likelihood of MODY. Conclusion: Given that a considerable proportion of MODY patients are frequently misdiagnosed as T2DM, low levels of MID-C and HDL-small fractions, both of which are triglyceride-rich, may have potential as a diagnostic value for female and male MODY patients, respectively.
Evaluation of the prevalence and location of second mesiobuccal canals in 2100 upper first and second molar teeth: A cone beam computed tomography study
(Inonu University, 2025) Kaplan, Bahar; Adıgüzel, Özkan; Öner Talmaç, Ayşe Gül; Aslan Öztürk, Elif Meltem
It is essential to undertake thorough preparation, debridement and filling of all root canals in order to achieve a clinically successful treatment outcome. A total of 525 CBCT images of both maxillary first and second molars were analyzed. The observations and measurements were positioned 1 millimeter (mm) apically from the pulp base to standardize the methodology for the detection of the second mesiobuccal canal (MB2). To assess the distances between the canals and the relationship between the presence of MB2 and mesiobuccal (MB) root length, MB root length was quantified in millimeters. IBM SPSS Version 21.0 was employed for statistical analyses, with a type I error level of 5% accepted. MB2 was identified in 36.5% of the first maxillary molar (1MM) and second maxillary molar (2MM) teeth of the patients included in the study. When the frequency of MB2 was evaluated according to gender and right-left side, no statistically significant difference was found (p>0.05). When examining the relationship between the presence of MB2 and the length of the MB root, it was observed that only in the left second molars with MB2 present, the root length was slightly shorter. It is our contention that this study will furnish dentists with crucial data that will enhance the efficacy of root canal therapy for these teeth.
Can neoadjuvant chemoradiotherapy be omitted in cT2N+ and cT3 mid-rectal cancer: Protocol for a prospective, observational, cohort study (CANO)
(Public Library of Science, 2025) Karakayalı, Feza; Arslan, Çiğdem; Bisgin, Tayfun; Erenler Bayraktar, İlknur; Bayraktar, Onur; Canda, Aras Emre
Background Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME) is the standard treatment for locally advanced rectal cancer. However, nCRT is associ ated with significant morbidity, impacting patients’ quality of life. Recent advancements in MRI-based risk stratification have raised the possibility of omitting nCRT in selected patients without compromising oncologic outcomes. This study aims to evaluate whether upfront TME alone achieves similar 3-year disease-free survival compared to the standard approach of nCRT followed by TME in patients with cT2N+ and cT3Nx mid-rectal cancer without MRI-based high-risk features regarding local recurrence. Methods The CANO trial is a prospective, multicenter, observational cohort study involving 436 patients across Türkiye. Eligible patients will be classified into two groups: those undergoing direct TME and those receiving nCRT followed by TME. The primary endpoint is 3-year disease-free survival (DFS), with secondary outcomes including 5-year DFS, overall survival, local recurrence rates, and quality of life assessments using validated questionnaires. Data will be prospectively collected and monitored by the steering committee with predefined interim analyses. Discussion The CANO trial addresses the ongoing debate regarding selective omission of nCRT in low-risk mid-rectal cancer. By leveraging MRI-based risk stratification and PLOS One | https://doi.org/10.1371/journal.pone.0321819 November 5, 2025 2 / 11 a collaborative national network, the study aims to provide high-quality evidence supporting a more personalized treatment approach. The findings have the potential to reduce treatment-related morbidity without compromising oncologic safety, contrib uting to the refinement of current guidelines.
Gender-specific foot morphology and biomechanical patterns in young adults: A combined photogrammetric and plantar pressure analysis
(Springer Nature Link, 2025) Nteli Chatzioglou, Gkionoul; Govsa, Figen; Bedre, Özden; Pınar, Yelda; Hepgüler, Simin
Purpose Understanding gender-based foot morphological differences is critical for ergonomic footwear design. This study investigated these variations in young adults using photogrammetric and plantar pressure analysis. Methods We analyzed 200 healthy participants (100 males, 100 females; aged 19–21 years) through digital photogrammetry and RSscan Footscan pressure mapping. Key parameters included foot length (FL), ball width (BWF), hallux valgus angle (HVd), lateral foot angle (LdF), and Clarke’s Index for arch classification. Plantar pressure distribution was assessed across 10 anatomical zones. Results We revealed significant gender disparities: males had longer (26.6 vs. 25.2 cm) and wider feet (10.2 vs. 9.1 cm), while 75% of participants exhibited HVd (5.1°–6.3°), with no gender difference. Dynamic Clarke’s Index showed 80% had high arches, correlating with lower BMI (p<0.001). Pressure analysis highlighted higher midfoot loading (37.8–41.2 cm2 ) and medial forefoot pressure in HVd cases. Females predominantly wore smaller shoes (sizes 36–38), whereas 89% of males wore sizes 42–44. BMI influenced midfoot pressure (r=0.3) and arch height, with flat arches linked to higher BMI. Foot asymmetry (38%) and HVd prevalence underscored the need for gender-specific shoe designs. Conclusion It emphasize prioritizing ergonomic footwear to mitigate pressure imbalances, HVd progression, and asym metry, particularly in high-BMI individuals. This dual-method approach provides actionable insights for biomechanical applications and footwear customization.
Comparison of short- and long-term outcomes of diode laser vs. crystallized phenol treatment for pilonidal sinus disease: A propensity score-matched multicentre study
(Wiley, 2025) Bilgin, İsmail Ahmet; Ramoğlu, Nur; Saylık, Onur; Benlice, Çigdem; Erkaya, Metincan; Kurtul, İnci; Aghayeva, Afag; Turan, Ersin; Maden, Abdullah Sami; Acar, Fahrettin; Karahasanoğlu, Tayfun; Hamzaoğlu, İsmail; Baca, Bilgi; Doğru, Osman
Aim: Pilonidal sinus disease (PSD) primarily affects young adults; rapid recovery is essential and yet lacks a standardized treatment approach. While excisional techniques delay recovery, minimally invasive options like laser ablation and phenol application are gaining interest, yet comparative long-term evidence is scarce. This study compared short- and long-term outcomes of laser versus phenol treatment in PSD. Method: In this multicentre retrospective cohort study (Nov. 2017–Sep. 2024), patients treated with laser or phenol were included. 1:3 propensity score matching using the nearest neighbour algorithm was performed based on age, gender, prior surgical history and year of operation. Categorical variables were analysed using chi-squared or Fisher's exact tests, whereas continuous variables were compared using Student's t-test or Mann– Whitney U test depending on distribution normality. Results: Out of 897 eligible patients, 644 were included (median age: 26 years, body mass index [BMI]: 26.2 kg/m2 , male-to-female ratio: 4:1). The number of sinuses/pits was 2–3 in both groups. Operating time was significantly longer in the laser group. Complications occurred in 6.8% of laser patients, whereas none were reported in the phenol group. Pain scores were higher in the laser group (2 [1–3] vs. 1 [0–2]). Median follow-up was 45 months (laser) and 40 months (phenol). Return to daily activities was delayed in the laser group, whereas complete healing was slower in the phenol group. Readmission, recurrence and recovery rates were comparable (85%–86%). Conclusion: Both treatments demonstrated low complication and recurrence rates with high recovery rates. Laser favoured faster healing and fewer sessions, whereas phenol allowed for shorter procedures and earlier return to daily life.
Investigation of the effects of melatonin on granulosa cell proliferation and DNA methylation
(Proceedings of the Bulgarian Academy of Sciences, 2025) Türkmen, Ervanur; Gündoğan, Gül İpek; Arslan, Halil İbrahim; Gök Yurttaş, Asiye; Elgün, Tuğba
Melatonin, a pineal hormone with antioxidant and regulatory functions, has emerged as a key modulator of ovarian physiology. Its presence in fol licular fluid suggests important roles in granulosa cell function, follicle devel opment, and reproductive outcomes. However, its effects on granulosa cell tumour (GCT) biology and epigenetic regulation remain insufficiently defined. This study aimed to investigate the effects of melatonin on proliferation and global DNA methylation in human granulosa tumour cells (COV434) com pared with healthy endothelial controls (HUVECs). COV434 and HUVEC cells were treated with melatonin at 1, 10, 100, and 1000 µM. Cell viabil ity and proliferation were assessed using the MTT [3-(4.5-dimethylthiazol-2- yl)-diphenyl tetrazolium bromide] (Cambridge, UK) assay and xCELLigence RTCA system (Roche), while DNA methylation was quantified with a 5-mC ELISA kit (Epigentek Group Inc, USA). Experimental groups included nega tive, sham, melatonin-treated, and positive controls. Melatonin showed a cell type-dependent effect. In COV434 cells, proliferation was significantly inhib ited, with an IC50 of 10.55 µM, whereas HUVECs displayed increased prolifer ation at higher doses. DNA methylation levels decreased in both cell types in a dose-dependent manner, reaching the highest significance in COV434 cells at 1000 µM (p < 0.001). In conclusion, melatonin demonstrated a dose-dependent inhibitory effect on COV434 cell proliferation while simultaneously reducing global DNA methylation levels.
Origin-order classification of axillary third-part branching: Donor-based dissection–CTA correlation for surgical planning
(Springer Nature Link, 2025) Temizsoy Korkmaz, Fulya; Coşkun, Osman; Gürses, İlke Ali; Gayretli, Özcan; Özdemir, Sevim; Öztürk, Adnan; Kale, Ayşin
Purpose Variations in the branching of the subscapular artery (SSA), anterior circumflex humeral artery (ACHA), and posterior circumflex humeral artery (PCHA) are directly relevant to reconstructive planning with subscapular-system flaps and to humeral-head perfusion in shoulder surgery. Evidence organized around an origin-order–based framework remains limited. We aimed to address this gap by comparing body-donor dissections and computed tomography angiography (CTA) to provide a clinically useful classification and morphometric reference. Methods We performed a two-arm cross-sectional morphometric study: body-donor dissection (28 donors; bilateral, 56 sides) and CTA (25 patients; bilateral, 50 sides). In total, 104 sides were evaluated; 96 were classifiable. Classification used the sequential SSA–ACHA–PCHA origin order and common-trunk presence. Ostial diameters and SSA → CSA distances were measured; the radial nerve (NR)–SSA relationship was assessed in donors. origin_order__five_type_classif… Results In donors, Type-1, -2, -3, and -4 accounted for 36.5%, 32.7%, 23.1%, and 7.7%, respectively; Type-5 was absent. In CTA, Type-1, -4, and -5 comprised 93.2%, 2.3%, and 4.5% (one bilateral case); Types-2/-3 were not observed. Inter-modality comparison showed a longer SSA → CSA distance and smaller TDA/CSA diameters in CTA (all p < 0.001), while the SSA ostial diameter was similar. A posterior NR course relative to the SSA was associated with a longer SSA → CSA distance (p = 0.026). Conclusion An origin-order–based classification, corroborated across dissection and CTA, yields a practical map for (i) single-pedicle harvesting within the subscapular system and chimeric flap design, and (ii) avoiding iatrogenic compromise of humeral-head vascularity during shoulder procedures. Incorporating presurgical CTA mapping of the SSA and its branches may enhance safety where variants (e.g., short/combined trunks, rare Type-5) are suspected.
Braindetective: An advanced deep learning application for early detection, segmentation and classification of brain tumours using MRI images
(Springer Nature Link, 2025) Tokatlı, Nazlı; Bayram, Mücahit; Ogur, Hatice; Kılıç, Yusuf; Han, Vesile; Batur, Kutay Can; Altun, Halis
This study aims to create deep learning models for the early identification and classification of brain tumours. Models like U-Net, DAU-Net, DAU-Net 3D, and SGANet have been used to evaluate brain MRI images accurately. Magnetic resonance imaging (MRI) is the most commonly used method in brain tumour diag nosis, but it is a complicated procedure due to the brain’s complex structure. This study looked into the ability of deep learning architectures to increase the accuracy of brain tumour diagnosis. We used the BraTS 2020 dataset to segment and classify brain tumours. The U-Net model designed for the project achieved an accuracy rate of 97% with a loss of 47%, DAU-Net reached 90% accuracy with a loss of 33%, DAU-Net 3D achieved 99% accuracy with a loss of 35%, and SGANet achieved 99% accuracy with a loss of 20%, all demonstrating effective outcomes. These find ings aim to improve patient care quality by speeding up medical diagnosis processes using computer-aided technology. Doctors can detect 3D tumours from MRI pictures using software developed as part of the research. The work packages correctly han dled project management throughout the study’s data collection, model creation, and evaluation stages. Regarding brain tumour segmentation, 3D U-Net architecture with multi-head attention mechanisms provides doctors with the best tools for planning surgery and giving each patient the best treatment options. The user-friendly Turkish interface enables simple MRI picture uploads and quick, understandable findings.
Diffuse alveolar hemorrhage induced by epileptic seizure
(Wiley, 2025) Talibov, Tural; İnci, Meltem; Ismayilov, Rashad; Bebek, Nerses
Diffuse alveolar hemorrhage (DAH) is a rare but life-threatening complication of generalized tonic–clonic seizures. We describe a 28-year-old woman with no prior seizure history who experienced three consecutive generalized tonic–clonic seizures, followed by acute hemoptysis and dyspnea. Imaging confirmed diffuse alveolar hemorrhage, which responded rapidly to corticosteroid therapy. Seizure-induced DAH is an uncommon and underrecognized condition. This case underscores the importance of considering DAH in patients presenting with respiratory symptoms following seizures, even in the absence of underlying systemic disease.
Testing the performance of cross-correlation techniques to search for molecular features in JWST NIRSpec G395H observations of transiting exoplanets
(Oxford University Press, 2025) Esparza-Borges, Emma; Lopez-Morales, Mercedes; Palle, Enric; Makhnev, Vladimir; Gordon, Iouli; Hargreaves, Robert; Kirk, James; Caceres, Claudio; Solmaz, Arif; Redfield, Seth
Cross-correlations techniques offer an alternative method to search for molecular species in James Webb Space Telescope (JWST) observations of exoplanet atmospheres. In a previous article, we applied cross-correlation functions for the first time to JWST NIRSpec/G395H observations of exoplanet atmospheres, resulting in a detection of CO in the transmission spectrum of WASP-39b and a tentative detection of CO isotopologues. Here, we present an improved version of our cross-correlation technique and an investigation into how efficient the technique is when searching for other molecules in JWST NIRSpec/G395H data. Our search results in the detection of more molecules via cross-correlations in the atmosphere of WASP-39b, including H2O and CO2, and confirms the CO detection. This result proves that cross-correlations are a robust and computationally cheap alternative method to search for molecular species in transmission spectra observed with JWST. We also searched for other molecules (CH4, NH3, SO2, N2O, H2S, PH3, O3, and C2H2) that were not detected, for which we provide the definition of their cross-correlation baselines for future searches of those molecules in other targets. We find that that the cross-correlation search of each molecule is more efficient over limited wavelength regions of the spectrum, where the signal for that molecule dominates over other molecules, than over broad wavelength ranges. In general, we also find that Gaussian normalization is the most efficient normalization mode for the generation of the molecular templates.
Is digital anesthesia a viable alternative for pain and anxiety control in pediatric dentistry?
(Wiley, 2025) Ateşçi, Alp Abidin; Korkut Işık, Buse; Yılmaz, Dilek Özge; Gergit, Berk; Çoruh Kılıç, Münevver; Önçağ, Rüştü Özant
Background: Pain and anxiety during dental procedures remain major challenges in pediatric dentistry, particularly during local anesthesia administration. Aim: This study compared the effectiveness of digital anesthesia systems versus conventional infiltration and mandibular block techniques in managing pain, anxiety, and behavioral responses in pediatric dental patients. Design: Seventy-nine children aged 6–12 were randomly assigned to receive anesthesia via digital anesthesia system (DAS), infiltration, or mandibular block. Pain was assessed using the Wong-Baker Faces Pain Rating Scale (WBFRPS), anxiety via the Modified Child Dental Anxiety Scale (MCDAS), and behavioral responses through the FLACC scale. Statistical analyses included ANOVA, Kruskal–Wallis, and chi-square tests (p<0.05). Results: Children in the DAS group reported significantly lower pain scores during needle insertion, anesthetic delivery, and treatment. Post-treatment MCDAS scores decreased significantly in the DAS group, especially for items related to “tooth exami nation,” “filling,” and “gingival injection.” FLACC results also indicated more favorable behavioral responses—such as relaxed facial expressions and absence of crying—in the digital group (p<0.05). Conclusion: Digital anesthesia appears to be a highly effective alternative to conventional techniques for minimizing pain, reducing dental anxiety, and improving behavioral cooperation in pediatric patients, supporting its broader implementation in clinical practice.
A novel model for early prediction of in hospital mortality in seawater drowning: The SNOP score
(Springer Nature Link, 2025) Öncü, Kıvanç; Özcan, Özhan; Şi̇mşi̇rgi̇l Kara, Şeyma; Parmaksız, Ayhan; Erşen, Teoman
Background Drowning is a leading cause of preventable mortality worldwide; however, early in-hospital risk stratification remains limited. Although tools such as the Szpilman score assist in early severity assessment, they may not fully capture the evolving clinical status after admission. This study aimed to develop a simplified and objective model based on readily available parameters to predict in-hospital mortality following seawater drowning. Methods This retrospective study was conducted at a referral emergency department (ED) in northern Turkey between July 1, 2011, and December 31, 2024. Of 190 patients initially included, 166 with complete clinical and laboratory data were analyzed. Data were obtained from institutional and national health information systems. Clinical, physiological, and biochemical variables were assessed. Predictors of in-hospital mortality were identified using receiver operating characteristic (ROC) analysis and multivariable logistic regression. Variables with near-perfect discrimination (e.g., GCS, pH, Szpilman score) were excluded to avoid overfitting. Results Among the 166 patients, 34 (20.5%) died during hospitalization. CPR and endotracheal intubation rates were significantly higher among non-survivors (CPR: 97.1% vs. 0%; intubation: 97.1% vs. 2.3%; both p<0.001). Non survivors also presented with lower GCS (median 3 vs. 15), lower arterial pH, and higher Szpilman scores (all p<0.001). ROC analysis identified four potential predictors with AUC values between 0.90 and 0.95—pCO₂, lactate, SpO₂, and sodium—all showing significant discriminatory capacity (p<0.001). These variables were entered into a binary logistic regression model, from which serum sodium (OR=2.110; 95% CI: 1.310–3.401; p=0.002) and SpO₂ (OR=0.902; 95% CI: 0.847–0.961; p=0.001) emerged as independent predictors. These formed the basis of the SNOP score (Saturation and Natremia-based Outcome Predictor), a two-parameter logistic model demonstrating excellent performance: AUC=0.996, sensitivity=99.0%, specificity=96.2%, and overall accuracy=98.4%. Conclusion: The SNOP score is a simple, ED-specific tool for early prediction of in-hospital mortality in seawater drowning. It complements existing assessment systems by incorporating objective, admission-based parameters. Prospective multicenter validation is warranted to confirm its clinical applicability and support broader implementation.
Integrated use of finite element analysis and gaussian process regression in the structural analysis of AISI 316 stainless steel chimney systems
(Nature Portfolio, 2025) Tanrıver, Kürşat; Etyemez, Ayhan; Ay, Mustafa
This study aimed to conduct a comprehensive structural analysis and machine learning-assisted predictive modelling of a chimney system manufactured from 2 mm thick AISI 316 stainless steel with a diameter of Ø500 mm. The primary motivation of this work was to examine, in detail, the structural behavior of chimney modules under various force and pressure conditions using conventional methods, and to develop a reliable model capable of performing parametric predictions for new scenarios based on the acquired data. The scope of the study encompassed finite element analyses of both the entire chimney system and 3-meter-long intermediate modules, field tests, and the application of the Gaussian Process Regression (GPR) machine learning model. In the analysis of the entire chimney system under an applied force of 22,000 N, a maximum stress of 28 MPa and a safety factor of 8.39 were observed in the chimney clamps. The total deformation was found to be 0.58 mm, which is within acceptable limits. In the structural analysis of the intermediate chimney modules under a force of 1000 N and an internal pressure of 5 MPa, a maximum stress of 11,984 MPa, a safety factor of 1.71, and a total deformation of 0.46 mm were determined, all of which are consistent with the literature. The accuracy of these analyses was validated through pressure and leakage tests conducted in accordance with the EN 1859 standard. The developed GPR machine learning model demonstrated exceptionally high accuracy (R² > 0.999) in predicting Von Mises stress values, providing reliable forecasts with an error rate of less than 3% when compared to ANSYS simulation outputs. However, in predicting total deformation values, error rates exceeded 70%, indicating that the model was less sensitive in low-amplitude deformation cases. These findings suggest that the GPR model can generate reliable predictions for Von Mises stress a more critical parameter than total deformation in chimney design. By integrating conventional structural analysis methods with advanced machine learning techniques, this study demonstrates the potential of predictive modeling as an efficient and reliable tool in engineering design processes, making a significant contribution to the field’s body of knowledge.
Patterns of nutritional supplement use in Turkish handball players: Influence of sex and competition level based on the ais classification system
(MDPI Publishing, 2025) Mor, Ömer; Sanchez-Oliver, Antonio Jesus; Bayraktar, Bülent; Günalan, Elif
Handball is a sport that demands explosive movements and unique skills, and its popu larity has been rising in recent years. This study evaluated elite handball players’ nutri tional supplement (NS) use profiles and the differences in sex, competition level, and com petition type based on the Australian Institute of Sport (AIS) criteria. The data collection form contains questions about participants’ sociodemographic characteristics, training de tails, use of supplements, and related factors. Supplements were classified into A, B, C, and D classes according to the scientific evidence level of the AIS. The study involved 92 elite handball athletes, comprising 48 professionals and 44 amateurs, and included 37 fe males and 55 males. The most frequently used supplements among participants were magnesium (37.0%) (Group C—AIS), vitamin C (20.7%) (Group B—AIS), whey protein (19.6%), sports bars (19.6%), and vitamin D (19.6%) (Group A—AIS). Regarding sex dif ferences, a significant difference was observed only in Group C supplements, with male players using them more frequently than female players (p < 0.05). Professional athletes exhibited a significantly higher prevalence of supplement use, covering total, Group A, sports foods, performance supplements, and Groups B and C, relative to amateur players (p < 0.05). The results reveal that handball players have limited awareness of NS, empha sizing the need for training and consulting services.
The understanding of the importance of oxidant/antioxidant status in hemophilia patients with arthropathy
(Springer Nature Link, 2025) Bingül, İlknur; Koç Şenol, Başak; Hanikoğlu, Ayşegül; Delen, Elif; Ömer, Beyhan; Genç, Nilgün Sema; Zülfikar, Bülent
This study aimed to investigate the roles of pro-inflammatory cytokine [interleukin-1β (IL-1β)], receptor activator of nuclear factor-kappa B ligand (RANKL), prooxidant [reactive oxygen species (ROS), thiobarbituric acid reactive sub stances (TBARS), advanced oxidation protein products (AOPP), advanced glycation end-products (AGEs)], and antioxi dant markers [ferric reducing antioxidant power (FRAP), total-thiol content (t-SH)] in the pathogenesis of arthropathy in patients with hemophilia (PwH) with/without arthropathy, and to identify potential therapeutic targets for preventing arthropathy and improving quality of life. The study included 18 PwH without arthropathy [31.0 years; (13–65)] and 39 PwH with arthropathy [10 years; (3–36)]. Among PwH with arthropathy, 6% were inhibitor positive, and 26.3% had involvement of more than two joints. Serum ROS and AGE were measured by fluorometric method, while TBARS, AOPP, FRAP, and t-SH were assessed via spectrophotometrically. IL-1β and RANKL concentrations were determined using ELISA. AGE and RANKL concentrations were significantly higher in PwH with arthropathy compared to those without (p=0.002 and p=0.010, respectively), and differences remained significant after age adjustment. FRAP and t-SH levels were initially elevated in PwH with arthropathy (p=0.030 and p=0.007, respectively), but differences lost significance after age adjustment. No significant differences were observed in ROS, TBARS, AOPP, or IL-1β levels between groups. Elevated AGE and RANKL levels in PwH with arthropathy suggest their potential involvement in joint damage and highlight the importance of maintaining oxidant/antioxidant balance. Therefore, monitoring these biomarkers may provide supportive information for early detection and inform future research on preventive strategies to reduce joint complications and preserve long-term quality of life in hemophilia.
Phase-selective synthesis of nanoshell hollow V2O3 and V3O5 microspheres as high-performance cathodes for aqueous Zn-ion batteries
(Elsevier, 2025) Aydın Şahin, Selay; Aydoğdu, Büşra; Yaman Uzunoğlu, Gülşah; Yüksel, Recep
Divanadium trioxide (V2O3) microspheres having nano-sized shells were produced by a facile and cost-efficient solvothermal method. Thermal treatment of V2O3 yielded trivanadium pentoxide (V3O5) microspheres. After the synthesis, the structural and electrochemical characterizations were performed in detail. Cathodes produced with the V2O3 and V3O5 materials reached specific capacities of 388 and 320 mAh g− 1 , respectively, at a current density of 0.1 A g− 1 . Aqueous zinc-ion batteries (ZIBs) fabricated with V2O3 and V3O5 cathodes demonstrated high-rate capability and capacity retention. The V2O3 microspheres, which possess a rhombohedral corundum type structure, showed outstanding rate capability (412 mAh g− 1 at 0.1 A g− 1 ; 149 mAh g− 1 at 20 A g− 1 ) and notable cycling stability (95.6 % capacity retention after 1200 cycles at 2 A g− 1 ; 80 % retention at the 2400th cycle at 5 A g− 1 ). Conversely, monoclinic V3O5 provided a comparable initial capacity (374 mAh g− 1 at 0.1 A g− 1 ) but faced rapid capacity decline at high current (26 % retention after 6000 cycles at 5 A g− 1 ). These results emphasize the significance of crystal structure in achieving stable and high-rate Zn2+ storage. In summary, the rhombohedral V2O3 phase exhibits superior Zn2+ transport kinetics and mechanical strength compared to the monoclinic V3O5, which accounts for the differences observed in their electrochemical performance.
Lowered phase transition temperature of VO2(m) via molybdenum doping toward efficient aqueous zinc-ion batteries
(Wiley, 2025) Aydın Şahin, Selay; Aydoğdu, Büşra; Yaman Uzunoğlu, Gülşah; Yüksel, Recep
Rechargeable aqueous zinc-ion batteries have attracted considerable attention as large-scale energy storage systems owing to their safety, sustainability, and cost-effectiveness. However, their practical application has been hindered by limited energy density, primarily determined by cathode performance. Among transition metal oxides, vanadium dioxide (VO2) is particularly appealing due to its layered structure, rich polymorphism, and ability to host Zn2+ ions reversibly. The thermally driven transition from insulating VO2(M) to conductive VO2(R) enhances charge transport through the metal–insulator transition (MIT). In this work, molybdenum doping is employed to lower the MIT temperature of VO2(M). Doping reduces the MIT temperature of the VO2(M) phase to 56.7 °C, resulting in the VO2(R) phase. Electrochemical measurements reveal that Mo-VO2(R) cathodes deliver up to ten times higher capacity than the pristine VO2(M), with 3Mo-VO2(R) reaching 404.8 mAh g–1 at 0.1 A g–1. These findings demonstrate that Mo doping serves as a practical approach to modify VO2(M) and decrease the MIT temperature, while improving electrochemical performance. Moreover, the heteroatom doping strategy suggests a promising pathway for developing other VO2 cathodes for efficient rechargeable batteries, which can leverage the heat dissipated in energy storage systems.
Polyherbal ointment with bromelain for chronic diabetic wounds: Insights from a clinical case series
(Springer Nature Link, 2025) Bostanabad, Saber Yari; Özdemir, Samet; Saadati, Mahrokh; Karaca, Banu; Şener, Alper
Purpose Chronic diabetic wounds are characterized by prolonged inflammation and impaired healing. This study evaluates a novel polyherbal ointment, W Cura D Plus®, which contains Azadirachta indica oil, Hypericum perforatum oil, and bro melain from Ananas comosus. After initial debridement with W Cura D Plus®, treatment continued with W Cura G Plus®. To our knowledge, this is the first clinical report examining this specific combination in the treatment of chronic diabetic wounds. Methods A single-center clinical case series was conducted in 13 diabetic patients with Wagner grade 2–3 diabetic foot ulcers of at least 4 weeks’ duration. All patients were on standard type 2 diabetes therapy (oral agents and/or insulin) and routine wound care prior to enrollment. W Cura D Plus® was applied daily for 7 days to promote debridement, followed by W Cura G Plus® until complete closure or no further reduction in ulcer size for two consecutive weeks. Clinical endpoints included wound area, closure percentage, and recovery time. White blood cell (WBC) and C-reactive protein (CRP) levels were monitored. Results Fourteen wound observations were analyzed. Mean wound area decreased from 25.07±24.56 cm² at baseline to 7.38±5.15 cm² (p=0.0103), and mean closure rate was 64.15±0.23% (p=0.0108), surpassing the 50% benchmark for clini cally meaningful improvement. Recovery time averaged 97.7 days compared to baseline (initial status prior to treatment). WBC and CRP significantly declined (p<0.0001). No adverse events were reported. Conclusion This polyherbal formulation may represent a safe adjunct to standard care, but larger controlled trials are needed to confirm efficacy.
Unveiling the interplay of EBV, HSV-1, and ınflammatory biomarkers in psychiatric disorders
(MDPI Publishing, 2025) Akgül, Özer; Demirel, Ömer Faruk; Tosun, İlker; Kavla, Yasin; Kırkpınar, Mehmet Murat; Sapmaz, Burcu; Şenyiğit, Gülçin; Çalışkan, Reyhan; Öner, Yaşar Ali
Background/Objectives: Schizophrenia (SCH), bipolar disorder (BPD), and major depres sive disorder (MDD) are increasingly viewed as neuroimmune disorders shaped by viral exposure and inflammation. Disorder-specific immunovirological profiles, however, re main poorly defined. Methods: In this cross-sectional study, we assessed Epstein–Barr Virus (EBV) and Herpes Simplex Virus type 1 (HSV-1) seropositivity and measured serum CRP, IL-6, and IL-1β in 708 participants: 110 with SCH, 121 with BPD, 135 with MDD, and 342 healthy controls (HC). Statistical analyses included Shapiro–Wilk tests for nor mality; Kruskal–Wallis with Bonferroni-adjusted Dunn post hoc comparisons; and logistic regression adjusted for age, sex, and marital status. Results: EBV seropositivity was higher in SCH (90.9%) than in HC (78.9%) (OR = 3.46, 95% CI: 1.68–7.12; p = 0.001) but not in BPD or MDD. HSV-1 seropositivity was elevated in BPD (83.5%) versus HC (67.0%) (OR = 2.29, 95% CI: 1.34–3.92; p = 0.003), with no differences in SCH or MDD. Inflammatory biomarkers were significantly increased in SCH and MDD compared to HC (p < 0.001), while BPD showed no differences. Conclusions: The findings delineate distinct immunovi rological patterns across major psychiatric disorders. Schizophrenia was characterized by EBV seropositivity accompanied by systemic inflammatory activation, bipolar disorder by HSV-1 seropositivity in the absence of inflammatory changes, and major depressive disor der by inflammatory dysregulation independent of viral exposure. These disorder-specific profiles highlight heterogeneity in neuroimmune pathways and underscore the potential relevance of biomarker-based stratification for generating hypotheses regarding targeted antiviral or anti-inflammatory interventions in psychiatric populations.

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