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Editorial for special issue of deep brain stimulation
(Elsevier, 2026) İşler, Cihan; Değirmenci, Yıldız; Kocabıçak, Ersoy
Dear Colleagues, We are pleased to present the special issue consisting of selected topics that were presented at the fifth Clinical Neuroscience Course held in Atlas University, between 8 and 11 December, 2022. The course was organized by the national Deep Brain Stimulation Society of Turkiye, which is a chapter of the Deep Brain Stimulation Society.
Professional grief and the second victim experience in neurosurgery: An international cross-sectional study on professional sustainability and educational implications
(Elsevier, 2026) Şanlıer, Nafiye; Flora Göy, Defne; Sulaimanov, Umid; Moniri, Ariorad; Akbaş, İbrahim Halil; Ismayilova, Gular; Demir, Hüseyin; Öztürk, Öykü; Nizzola, Mariagrazia; Hatipoğlu Majernik, Gökçe
OBJECTIVE Adverse events are inevitable in neurosurgical practice and may have significant emotional and professional implications for surgeons. While second victim experiences have been increasingly recognized, the role of professional grief remains insufficiently characterized within the field of neurosurgery. This study aimed to examine professional grief as a component of the second victim experience and its associations with distress, support dimensions, educational needs, and professional sustainability. METHODS We conducted an international, cross-sectional, anonymous web-based survey among neurosurgeons and neurosurgical trainees. Professional grief related to a personally impactful adverse event was assessed retrospectively using the Professional Bereavement Scale-Short-term Bereavement Reactions Subscale (PBS-Acute); scores therefore reflect retrospectively recalled acute grief responses rather than contemporaneously measured reactions. Second victim dimensions were evaluated with the Second Victim Experience and Support Tool-Revised (SVEST–R). Associations among grief severity, second victim dimensions, and professional sustainability indicators were analyzed using correlation and multivariable regression. RESULTS Of 465 respondents from 49 countries, 314 completed the survey and were included in the analysis. A total of 240 participants (76.4%) reported a personally impactful adverse event. Professional grief severity was substantial among respondents (PBS-Acute mean 37.9 ± 13.8) and was strongly correlated with psychological distress (ρ = 0.71, p < 0.001). Higher grief severity was independently associated with increased turnover intention (β = 0.026, p < 0.001). Perceived preventability and primary surgeon role were associated with higher grief severity, while event timing and seniority were not. Supervisor support was inversely associated with grief severity. Participants reported substantial unmet educational needs related to medicolegal processes, communication with patient families, and grief coping skills. CONCLUSIONS Among surveyed neurosurgeons who described a personally impactful adverse event, professional grief was frequently reported. Professional grief in this sample was associated with second victim experiences, psychological distress, and indicators of professional vulnerability. These cross-sectional associations suggest that professional grief may warrant consideration in structured educational models and tiered support systems within neurosurgical training and institutional practice. Prospective work is needed to clarify the direction and durability of these relationships and their implications for professional sustainability.
Laparoscopic resection–rectopexy with natural orifice specimen extraction (NOSE): In a male with recurrent internal rectal prolapse—A video vignette
(Wiley, 2026) Arslan, Çiğdem; Yıldırım, Yasemin; Ermeç, Elif Diler; Erenler Bayraktar, İlknur
Laparoscopic sigmoid resection and suture rectopexy (LRR) is a well- established option for overt rectal prolapse; however, evidence for its role in internal rectal prolapse (IRP) and obstructed defecation syn drome (ODS) remains limited, and the potential impact on functional and sexual outcomes—particularly in young males—often prompts caution [1–3].
Long-term microbiome and clinical effects of a microbiome-guided personalized diet versus low-FODMAP diet in irritable bowel syndrome: A 12-month follow-up randomized controlled trial
(Taylor & Francis, 2026) Tunalı, Varol; Arslan, Çiğdem; Derviş Haki̇m, Gözde; Gündoğdu, Aycan; Ermi̇ş, Beyza Hilal; Hora, Mehmet; Nalbantoğlu, Özkan Ufuk
Dietary therapy is central to irritable bowel syndrome (IBS) management, yet the long-term durability of the low-FODMAP diet (LFD), and of microbiome-guided personalization, remains unclear. We assessed the long-term clinical and gut-microbiome effects of a microbiome-guided personalized diet (PD) compared with a standard LFD in adults meeting Rome IV criteria for IBS. In this multicenter, open-label randomized controlled trial with blinded outcome assessment, participants who completed a 6-week dietary intervention (PD or LFD) were followed at 6 and 12 months without further dietary intervention. Outcomes included the IBS Severity Scoring System (IBS-SSS), IBS Quality of Life (IBS-QOL), and the Hospital Anxiety and Depression Scale (HADS); gut microbiota were profiled by 16S rRNA sequencing. Longitudinal changes were evaluated using linear mixed-effects models, responder analyses, PERMANOVA, and PERMDISP. Both diets reduced IBS-SSS at 6 weeks. PD maintained symptom improvement at 6 and 12 months (−82.0 and −78.3 points from baseline), whereas LFD benefits regressed by 12 months (+29.3 points; between-group p = 0.001). At 12 months, IBS-SSS responder rates were higher with PD than LFD (62.5% vs 34.5%; absolute risk difference +28.0%, 95% CI 4.2–47.7; Fisher p = 0.029), and IBS-QOL, HADS-anxiety, and HADS-depression showed more favourable trajectories with PD. PD was associated with sustained Shannon alpha-diversity gains (+0.488 at 6 weeks; +0.205 at 12 months; both p < 0.01). A modest between-group beta-diversity difference at 6 months (R2 = 0.035; p = 0.011) was not significant at 12 months. This hypothesis-generating follow-up suggests more durable benefit with PD; larger trials powered for long-term clinical and microbiome outcomes are warranted.
A clinical mirage: The peril of improving laboratory markers in meningococcal-induced cardiac tamponade
(Elsevier, 2026) Özyüksel, Arda
In this issue of JACC: Case Reports, Pagotan et al describe a compelling case of immune-mediated meningococcal pericarditis progressing to car diac tamponade despite apparent microbiological resolution and improving laboratory parameters.
Robotic eTEP-TAR abdominal wall reconstruction for complex post liver transplant incisional hernia with concomitant inguinal hernia repair: A video vignette
(Springer Nature Link, 2026) Bayrakçeken, Serra; Benlice, Çigdem; Aghayeva, Afag; Kudsi, Omar Yusef; Baca, Bilgi
Introduction Complex incisional hernias after major upper abdominal surgery are technically challenging because of altered anatomical planes, multiple fascial defects, and expected adhesions. Robotic enhanced-view totally extraperitoneal repair with transversus abdominis release may provide a minimally invasive option for selected patients by enabling retromuscular dissection, fascial closure, and wide extraperitoneal mesh reinforcement while limiting intraperitoneal manipulation. Case presentation This video vignette presents an 84-year-old man with multiple incisional hernia defects along a previous Mercedes incision after liver transplantation and a concomitant left direct inguinal hernia. Preoperative imaging demon strated a wide subxiphoid abdominal wall defect and a fat-containing left inguinal hernia. Surgical technique A robotic eTEP-TAR approach was performed. Bilateral retromuscular dissection was completed, the inguinal and incisional hernia contents were reduced, and bilateral transversus abdominis release was performed to facilitate medial fascial advancement and lateral extension of the working space. The fascial and peritoneal defects were closed intra corporeally, and wide mesh reinforcement was achieved using a 30 × 30 cm polypropylene mesh, with additional meshes placed for the inguinal and lower quadrant defects. The postoperative course was uneventful, and the patient was discharged on postoperative day 2. At postoperative day 7 follow-up, he had no complaints, and the wounds were clean. Conclusion This case demonstrates the feasibility of robotic eTEP-TAR abdominal wall reconstruction with concomitant inguinal hernia repair in a selected post-transplant patient with complex abdominal wall defects.
Low-cost mobile lidar and RTK GNSS integration for georeferenced HBIM of cultural heritage: A scan-to-BIM workflow based on multi-sensor data fusion for accuracy enhancement
(The Association for Computer-Aided Architectural Design Research in Asia, 2026) Aş Çemrek, Handan; Işıkdağ, Ümit
This study discusses a scan-to-BIM workflow based on the integration of low-cost mobile LiDAR and RTK GNSS, focusing on cultural heritage, and compares the performance of two different portable scanning systems. An 18th-century Sibyan School was selected as a case study, managed by Mimar Sinan Fine Arts University (MSGSU), Istanbul. The study employed a viDoc RTK-enabled iPad Pro (photogrammetry + LiDAR) and a Realsee Galois M2 tripod mounted panoramic 3D LiDAR scanner. Point cloud data obtained from both systems were georeferenced with RTK GNSS control points, and their location accuracies were comparatively assessed. The generated point cloud datasets were combined using a multi-sensor data fusion approach and fed into an HBIM-based modeling process. Component geometries were analyzed for detail, data gaps, and noise. The findings indicate that the RTK-enabled viDoc method offers advantages in terms of location accuracy and level of detail, while the Realsee Galois M2 stands out for its rapid deployment, indoor coverage, and practical field use. In conclusion, the study suggests that low-cost mobile systems should be considered as part of a multi-sensor hybrid cultural heritage documentation and digital twin production strategy rather than completely replacing terrestrial laser scanning and suggests a repeatable workflow for similar projects.
Sex differences in ambulatory blood pressure among patients referred for 24-hour monitoring a retrospective cross-sectional study
(Lippincott Williams and Wilkins Ltd., 2026) Atmaca, Hasan; Gürbüz, Doğaç Çağlar; Erol, Mustafa Kemal; Yetkin, Ertan
Few studies have addressed the differences between hypertensive women and men regarding the diagnosis and control of blood pressure (BP). Accordingly, we aimed to assess the possible discrepancies in BP values between women and men who underwent 24-hour ambulatory blood pressure monitoring. The study population comprised all patients who underwent 24-hour ambulatory blood pressure monitoring, which was retrospectively screened and recorded. Demographic and clinical characteristics of 1204 patients were included in the analysis. Sex-specific analyses of all patients, including those with and without a former diagnosis of hypertension (HT), were performed. Two-thirds of the patients were women. In the general population, both systolic and diastolic BP levels in women were significantly lower than those in men. BP in women was also significantly lower than that in men, both in patients with and without a former diagnosis of HT. Our study demonstrated that women exhibited significantly lower systolic and diastolic BP values than men in this referral cohort, irrespective of a prior diagnosis of HT. While the exact mechanisms remain to be elucidated, this difference highlights the necessity for further research into sex-specific hemodynamic profiles. Consequently, further research is necessary to establish diagnostic thresholds and BP targets to achieve effective and targeted management of BP abnormalities in women.
Multicenter machine learning model using clinical and radiomic features for prediction of postoperative residual status in meningioma
(American Association of Neurological Surgeons, 2026) Şanlıer, Nafiye; Yüce, Murat; Sulaimanov, Umid; Ismayilova, Gular; Hüryol, Çağın; Bozkurt, Hüseyin; Öztürk, Öykü; Öztürk, Fikret; Demir, Hüseyin; Başkaya, Mustafa K.
OBJECTIVE Gross-total resection is the primary surgical objective in meningioma management; however, predicting re sectability preoperatively remains challenging, particularly for meningiomas located in the skull base that exhibit complex anatomical relationships. There is a lack of validated reproducible models that integrate known anatomical factors for surgery; similarly, the value of radiomics as a stand-alone predictor is still unclear. The aim of this study was to develop a machine learning model that combines clinical and radiomic features to estimate early postoperative residual menin gioma. METHODS This retrospective multicenter study included 369 patients who underwent meningioma resection from 2020 to 2024 and had available preoperative contrast-enhanced T1-weighted MRI. Patient data from 3 centers (n = 307) were used to develop the model using leave-one-center-out cross-validation, and an independent cohort (n = 62) was used for external validation. Radiomic features were derived from manually segmented meningiomas, filtered for reproducibility, and integrated with 6 predefined clinical variables. The clinical-only, radiomics-only, and combined models were trained using 4 machine learning classifiers. Model performance was assessed through cross-validation, independent external validation, and receiver operating characteristic analysis. Formal incremental benefit analyses were performed on the common overlap external subset, with predictions available for all compared models. RESULTS Residual meningioma occurred in 23.5% of patients in the development cohort and 14.5% in the external cohort. Lesion location and venous sinus involvement were significantly associated with residual status. Following the feature selection, 2 stable radiomic texture features were retained. In external validation, the combined radiomics-clinical k-nearest neighbors model achieved the highest area under the curve (0.821), with sensitivity of 0.889, specificity of 0.706, and accuracy of 0.733. Clinical variables provided most of the predictive value, whereas radiomic features provided only limited incremental value when added to the clinical model. Decision curve analysis revealed net benefit for the combined model within a narrow range of low thresholds. CONCLUSIONS In this multicenter study, which included external validation, clinical variables provided most of the predictive value for postoperative residual meningioma. Radiomic features alone showed limited discrimination and only modest added value beyond clinical predictors. These combined models could serve as decision-support tools for preoperative risk assessment in meningioma surgery but are not yet suitable for routine stand-alone clinical use.
Risk factors for human papillomavirus positivity in a tertiary care center: A case–control study incorporating genotype distribution, co-infection patterns, and quantitative viral load analysis
(MDPI Publishing, 2026) Karalök, Mete Hakan; Dündar, Bağnu; Parmaksız, Ayhan; Gök Yurttaş, Asiye
Background/Objectives: Human papillomavirus (HPV) is the leading cause of cervical cancer and anogenital malignancies, yet its clinical presentation, genotype distribution, co-infection patterns, and viral load are poorly characterised in tertiary-care referrals. This study aimed to identify predictors of HPV positivity and describe genotype, co-infection, and relative viral copy number (Cq values) in this setting. Methods: A retrospective case–control study of 234 patients (97 HPV-positive, 137 HPV-negative) used a 37-genotype qPCR platform at a tertiary-care hospital between January-December 2025. Demographic data, clinical diagnosis categories, genotype profiles, co-infection patterns, and cycle quantification (Cq) values were recorded, and multivariable logistic regression identified independent predictors of HPV positivity. Results: HPV positivity was 41.5% (97/234). Only the clinical diagnosis category independently predicted HPV status. Compared with non-specific presentations, patients with anogenital or viral warts (aOR: 4.25; 95% CI: 1.49–12.14; p = 0.007) and vaginal or vulvar inflammation (aOR: 2.08; 95% CI: 1.19–3.63; p = 0.010) had higher odds of positivity. High-risk genotypes were the second most frequently detected category (40.00% of detections), after low-risk genotypes (48.21%), with HPV-16 leading among high-risk types. Co-infection occurred in 44.3% of HPV-positive patients, mostly involving mixed-risk genotypes. Patients with anogenital warts had lower Cq values than those with urinary tract complaints (p = 0.011), reflecting higher relative viral copy numbers per swab. Conclusions: HPV positivity and relative viral copy number (as approximated by Cq values) tracked more closely with clinical presentation than with demographic background. The dominance of low-risk and high-risk genotypes and the prevalence of mixed-risk co-infections were consistent with the symptomatic profile of the cohort. These findings support interpreting HPV results in light of clinical presentation and extended genotyping with relative viral copy number quantification in tertiary settings.
Green extraction of lycopene and volatile compounds from solanum lycopersicum (tomato) peel and products
(Elsevier, 2026) Özdemir Olgun, Fatoş Ayça; Özel, Mustafa Zafer
The primary aim of this study is the quantitative determination of lycopene and volatile composition in tomato peel and commercial tomato products using subcritical ethanol extraction. Box- Behnken Response Surface Methodology was conducted in order to evaluate the key operational parameters of the extraction process. The priority of the current study was to determine the lycopene efficiency; however, antioxidant activity and total volatile analysis of the extracts were also further evaluated using spectroscopic and chromatographic assays. AGREE-Analytical greenness metric software was applied to evaluate the greenness of the proposed extraction process. These findings demonstrate the efficiency of the proposed procedure in achieving the highest extraction yield (6.51 mg g⁻¹) from tomato peel in the literature. The study emphasises the significance of advanced extraction technologies in converting agricultural raw material or waste into value-added products, thereby promoting the advancement of a green circular economy.
Long-term seizure outcomes in patients with drug-resistant mesial temporal lobe epilepsy due to hippocampal sclerosis
(Elsevier, 2026) Gül, Günay; Eren, Fulya; Kandemir Yılmaz, Melek; Yandım Kuşcu, Demet; Keskinkılıç, Cahit; Tuğcu, Bekir
Objective: Resective surgery is a significant therapeutic option for patients with drug-resistant mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis (HS). Numerous studies have demonstrated the efficacy of epilepsy surgery in the short to median term. However, studies on long-term outcomes are limited in number. The objective of this study was to document the long-term prognosis and associated factors of patients under going resective surgery for MTLE. Methods: A retrospective analysis was conducted on the data of patients with drug-resistant MTLE due to HS who underwent resective surgery between 2001 and 2013 at our epilepsy centre. The demographics and clinical variables of the patients were documented and analysed in order to ascertain their long-term prognosis. The postoperative outcomes were evaluated in accordance with the Engel classification system. Results: Of the 45 patients (mean age: 44.64 ± 8.96, range: 31–67), 31 (68.89%) were male. The age at onset of epilepsy, age at surgery, and the duration of epilepsy at the time of surgery ranged from 0.25 to 26 years (11.51 ± 7.07), from 12 to 47 years (26.82 ± 8.14), and from 2 to 33 years (16.03 ± 7.85), respectively. The patients were followed up for 10–23 years (17.73 ± 2.96). HS was identified in 23 (51.11%) of the patients on the right side and 22 (48.89%) on the left. The pre-operative EEG recordings revealed temporal discharges in 40 (88.89%) patients unilaterally. 22 patients (48.89%) underwent amygdalohippocampectomy with a temporal lobectomy (AH+ATL), while 23 patients (51.11%) underwent selective amygdalohippocampectomy (SAH). 28 (62.22%) patients were classified as Engel I. The patients did not have any statistically significant difference in terms of gender, age at epilepsy onset, age at surgery, duration of epilepsy at surgery, side of HS, and surgical procedure according to Engel classification (p = 0.64, 0.08, 0.60, 0.25, 0.67, 0.10, respectively). Executive and memory functions were improved after surgery at 5th year. Conclusion: 62% of the patients were classified as Engel I. Although previous studies have suggested that certain factors may influence prognosis, our findings did not yield any statistically significant results in this regard. It is crucial that patients undergo surgical evaluation without delay to achieve seizure control and improve cognitive function.
Investigation of effects of hybrid hyrax-mentoplate treatment in high-angle class III patients: A three-dimensional, retrospective study
(Wiley, 2026) Yıldırım, Gamze; Önem Özbilen, Elvan; Özdemir, Fulya
Objective: This retrospective study evaluated three-dimensional effects of hybrid hyrax-mentoplate (HH-M) orthopaedic treat-ment in high-angle Class III individuals using Cone Beam Computed Tomography (CBCT) images.Materials and Methods: Pre-treatment (T0) and post-treatment (T1) CBCTs of 17 fully compliant high-angle Class III patients(7 males, 10 females, age: 11.7 ± 1.32 years, treatment duration: 12.62 ± 1.7 months) treated with HH-M were analysed. T0 andT1 CBCTs were superimposed from the cranial base using artificial intelligence-based AMASSS module of the 3D Slicer version5.8.1 software (www.slicer.org). Linear and angular changes were analysed in the sagittal, vertical and transverse planes, along-side three-dimensional landmark displacements and volumetric airway measurements. Significance level was set at p < 0.05.Results: Significant increases occurred in SNA, ANB and Occlusal Plane (OP) to Mandibular Plane (MP) angle (p < 0.001,p < 0.001, p = 0.001, respectively), while Sella-Nasion to OP and Palatal Plane (PP) to OP decreased (p = 0.008, p = 0.008, re-spectively). Vertical linear measurements remained stable (p > 0.05). All transverse linear measurements increased (p < 0.05).Upper Molar (UM) to PP, Upper Incisor to PP, Lower Incisor to MP and overjet have significantly increased (p < 0.001, p = 0.018,p = 0.048, p < 0.001, respectively). Overbite remained unchanged (p > 0.05). Nasopharynx (p = 0.008) and Middle Pharynx(p = 0.003) volumes significantly increased.Conclusion: Despite the significant alterations observed in OP and UM-PP, this technique effectively managed to maintain over-all vertical skeletal dimensions without inducing a significant change in other facial height parameters and enhanced the airwayvolume. Significant expansion occurred across maxillary, nasal and zygomatic levels. HH-M represents an effective orthopaedictreatment approach for high-angle Class III patients.
DNA methylation of ANKRD23 as a novel biomarker for early diagnosis of ovarian cancer
(Women's Health and Action Research Centre, 2026) Alizada, Aydan; Şükrüoğlu Erdoğan, Özge; Kılıç Erciyas, Seda; Çelik Demirbaş, Betül; Pasin, Özge; Dinç, Ahmet; Saip, Pınar; Yazıcı, Hülya; Tuncer, Şeref Buğra
Ovarian cancer (OC) is a leading cause of gynecologic cancer-related mortality and is frequently diagnosed at advanced stages due to the absence of effective early detection tools. Epigenetic alterations, particularly DNA methylation, play a critical role in tumorigenesis and represent promising non-invasive biomarkers. This study investigated the methylation status of the ANKRD23 gene in OC and evaluated its diagnostic potential using peripheral blood samples. A total of 385 serous OC patients, 50 individuals with benign ovarian conditions, and 99 healthy controls were included. DNA methylation was assessed using methylation-sensitive restriction enzymes followed by real-time PCR. ANKRD23 methylation was significantly associated with clinical stage (p = 0.029), histological grade (p = 0.009), and ethnicity (p = 0.024). Moreover, methylation levels differed significantly among OC patients, benign cases, and healthy controls (p = 0.026). These findings support blood-based ANKRD23 methylation as a promising biomarker for non-invasive ovarian cancer diagnosis and risk stratification. (Afr J Reprod Health 2026; 30 [15] 16-25).
Is d-dimer associated with disease severity and contralateral slip risk in slipped capital femoral epiphysis?
(Wolters Kluwer, 2026) Kürk, Muhammed Bilal; Albayrak, Kutalmış; Aydın, Abdurrahman; Kayış, Görkem; Akpınar, Evren
Background: To evaluate D-dimer levels in patients with slipped capital femoral epiphysis (SCFE), to investigate their associa tion with disease severity and the development of contralateral slip, and to assess their contribution to existing predictive models. Methods: In this single-center retrospective cohort study, 25 patients with unilateral SCFE diagnosed between January 2020 and April 2024 were included. The control group con sisted of age- and sex-matched obese individuals and healthy subjects with normal body mass index (BMI). Clinical varia bles (age, sex, BMI, stability according to the Loder classi fication, and chronicity); laboratory parameters [complete blood count, neutrophil-to-lymphocyte ratio (NLR), in flammatory markers including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and coagulation pa rameters including prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer]; and radiographic measurements [Southwick angle, interhip angle difference, posterior sloping angle (PSA), and modified Oxford bone score (MOBS)] were analyzed. Subgroup analyses based on stability and chronicity were performed, and correlations between D-dimer levels and clinical, laboratory, and radio graphic parameters were assessed. Multivariable logistic re gression models were constructed to predict contralateral slip, and model performance was evaluated using receiver operating characteristic (ROC) curve analysis. Results: D-dimer levels were significantly higher in the SCFE group compared with both obese and healthy control groups (P < 0.001). D-dimer showed positive correlations with CRP and NLR and negative correlations with the MOBS and the interhip Southwick angle difference. Higher D-dimer levels were ob served in unstable and acute-on-chronic cases (P < 0.001). During a mean follow-up of 24 months, patients who developed contralateral slip had significantly higher D-dimer levels (P = 0.002). The addition of Southwick angle difference to a baseline model including age and MOBS increased the AUC from 0.73 to 0.80, while further inclusion of D-dimer improved the AUC to 0.87. However, the increase in AUC after addition of D-dimer was not statistically significant according to the paired DeLong test (P = 0.18). Conclusion: D-dimer levels are associated with disease severity and the risk of contralateral slip in SCFE. Incorporation of D-dimer into established clinical and radiographic parameters improved predictive model performance. These findings support the role of inflammatory and microvascular processes in the pathogenesis of SCFE and suggest that D-dimer may serve as a useful adjunct biomarker for risk stratification.
The thermogenic roles of bioactive compounds: A comprehensive bibliometric review
(Elsevier, 2026) Karakaya, Zeynep Ercan; Turgut, Rana; Günalan, Elif
The current review aims to describe the physiological mechanisms of thermogenic bioactive substances at the molecular level and to analyze the publications in the Scopus database using VOSviewer. The stimulation of thermogenesis by external factors, such as diet, is a multifaceted approach with significant potential to combat obesity and its associated metabolic complications. This understanding has led to numerous studies that have defined the thermogenic role of various bioactive compounds in metabolic health. Bibliometric analysis of these studies highlights the activation of brown adipose tissue (BAT), mitochondrial biogenesis, and stimulation of browning, which are the cornerstone mechanisms underlying the action of these compounds. However, each bioactive compound regulates distinct genes and signaling pathways, resulting in varied physiological responses. The findings provide a strong basis for the anti-obesity effects of thermogenic bioactive compounds. Many clinical studies can be designed using various doses, pharmaceutical routes, and forms of thermogenic compounds to treat obesity. However, phytochemical treatment interventions that include BAT activation must be closely monitored and managed due to the cardiovascular risks.
Gray zone of hypertension thresholds values can be overcome by individualized symptom-oriented approaches
(Lippincott Williams and Wilkins Ltd., 2026) Yetkin, Ertan; Atmaca, Hasan; Gürbüz, Dogaç Çağlar; Yalta, Kenan; Erol, Mustafa Kemal
Dear Editor, We have read with great interest the recently published article of Chung et al. [1]. Briefly, they reassessed the sensitivity, specificity and diagnostic accuracy of home blood pressure monitoring (HBPM) by changing threshold values for the diagnosis of hypertension from 135/85 to 130/80 mmHg in 646 participants who were suspected of having hypertension (office blood pressure ≥140/90 mmHg). Eventually, they have found that lowering the diagnostic threshold of home hypertension from 135/85–130/80 mmHg significantly enhances the diagnostic sensitivity of HMBP.
Does thermoforming setup affect thickness in thermoplastic orthodontic appliances? A comparison of single vs. dual-model fabrication
(MDPI Publishing, 2026) Allaf, Ferdi; Arslan, Meriç; Özcan, Mustafa; Erdem, Buket
Thermoforming remains the predominant fabrication route for clear thermoplastic orthodontic appliances, yet it reduces and redistributes sheet thickness, which governs force delivered to teeth. Simultaneous thermoforming of two models may reduce fabrication time and material waste; however, its effect on final appliance thickness has not been evaluated. This in vitro study compared appliance thickness after thermoforming over a single model or two models simultaneously, using ten commercial aligner brands with different polymer composition and initial thickness. Thickness was measured with a digital caliper at anterior, canine and posterior sites, and analyzed using three-way ANOVA with Tukey post hoc tests. A significant three-way interaction (measurement point × number of models × brand; p < 0.001) was found. Significant single- versus dual-model differences emerged in some brand–region combinations; in most, dual-model appliances were thicker than single-model appliances. Four brands showed no significant difference at any site. Within the limits of this study, simultaneous fabrication of two appliances in a single thermoforming cycle produced appliances with thicknesses comparable to, and often slightly greater than, those fabricated over a single model. Simultaneous thermoforming maintained comparable appliance thickness and may improve manufacturing efficiency.
University-industry collaboration and sustainable organizational resilience: The mediating role of relationship quality and the moderating effect of institutional alignment
(MDPI Publishing, 2026) Gemici, Evrim
As firms increasingly rely on external partnerships to navigate complex and volatile envi ronments, understanding the distinct pathways through which such collaborations may relate to resilience has become essential. However, despite growing interest in interorgani zational collaboration, limited research has explicitly examined how university–industry collaboration relates to organizational resilience, as prior studies have predominantly fo cused on innovation and performance-related consequences. This study examines whether university–industry collaboration is associated with organizational resilience, conceptu alized as a micro-foundation of sustainable development. Specifically, it investigates the mediating role of relationship quality within the university–industry collaboration and re silience nexus and the moderating effect of institutional alignment. The proposed research model and hypotheses were tested using survey data collected from 220 firms operating in science and technology parks (STPs) in Türkiye through partial least squares structural equation modeling (PLS-SEM) with SmartPLS. The results indicate that university-industry collaboration exhibits a significant association with organizational resilience, which is also linked to long-term sustainability at both firm and systemic levels. Furthermore, relationship quality serves as a distinct mediating pathway linking university–industry collaboration with organizational resilience. In addition, institutional alignment shows a significant moderating role in this relationship, such that higher alignment between university and industry partners strengthens the collaboration–resilience linkage. This study offers an early empirical attempt to conceptualize university–industry collaboration as an external driver associated with organizational resilience while delineating the distinct processes of mediation and moderation. Drawing on institutional theory and relational coordination theory, the findings elucidate the distinct institutional and relational pathways through which collaborations are associated with organizational resilience. For managers and policymakers, the study underscores the importance of investing in high-quality re lationships and institutional congruence to better leverage collaborative partnerships for sustainable organizational resilience.
Experimental sciatic nerve neuropathy caused by diclofenac sodium in rats
(Kare Publishing, 2026) Aykut, Ali Maksut; Kaya, Mustafa Emrah; Oral, Şükrü; Serarslan, Yurdal; Aras, Mustafa; Yılmaz, Atilla; Özgür, Tümay; Doğan, Serdar
OBJECTIVE: Our aim in this study is to investigate the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values of diclofenac sodium, which is a non-steroidal anti-inflammatory analgesic, after sciatic nerve injury, to examine the histopathological changes in the sciatic nerve, and to examine the results and enable important changes in treatment. It is one of the rare studies conducted histopathologically on post-injection sciatic nerve damage of diclofenac sodium, and the parameters of our biochemical approach have not been evaluated before in the literature. METHODS: study was divided into 5 main groups as control, sham, trauma, isotonic fluid, and diclofenac sodium. Sham, trauma, isotonic fluid, and diclofenac sodium groups were divided into four subgroups as early stage (day 1, day 3) and late stage (day 7 and day 14). Subjects in each group were evaluated daily by neurological examination according to the Tarlov scale. In all groups except the control group, the sciatic nerve was exposed through appropriate surgical procedures. TAS, TOS, and OSI were run on blood samples biochemically. Nerve tissue samples were evaluated histopathologically and immunohistochemically. RESULTS: There was a significant difference in pairwise comparison of the groups in terms of CASPASE-3 values. A statis tically significant difference was found between the groups in terms of myelin thickness and axon diameter. A statistically significant difference was found between the groups in terms of nerve diameter values. CONCLUSION: Our study demonstrates that intramuscular injections of diclofenac sodium have potential harmful ef fects. We recommend that alternative methods of using diclofenac sodium intramuscularly be preferred whenever possi ble due to the potential complications associated with this drug, that healthcare professionals receive necessary training on intramuscular administration, that the procedures be performed more carefully, and that patients be informed about these complications.

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