Influence of drying methods on redispersibility and dissolution of canagliflozin nanocrystals: A comparative approach

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dc.authorid0000-0001-6915-0283
dc.authorid0000-0003-2838-1688
dc.authorid0000-0002-8199-3010
dc.authorid0000-0001-5658-1797
dc.authorid0009-0007-7952-5406
dc.authorid0000-0003-3660-1951
dc.authorid0000-0002-9110-3704
dc.contributor.authorPirinçci Tok, Yağmur
dc.contributor.authorDemiralp, Burcu
dc.contributor.authorGüngör, Sevgi
dc.contributor.authorSarıkaya, Ali Osman
dc.contributor.authorAldeniz, Emre Erol
dc.contributor.authorDude, Udaya Kumar
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2026-02-12T14:03:14Z
dc.date.available2026-02-12T14:03:14Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractBackground/Objectives: Canagliflozin (CFZ) is the first sodium glucose co-transporter 2 (SGLT-2) inhibitor and is characterized by poor water solubility and permeability, resulting in low oral bioavailability. In this study, a CFZ nanosuspension (CFZ-NS) was converted into a solid form to improve the physical stability of CFZ nanocrystals (CFZ-NCs) and to enable formulation as a tablet dosage form. Methods: To achieve adequate redispersibility of dried CFZ-NCs, fluid bed granulation and spray-drying methods were employed, and the effects of critical process parameters were investigated. The stability of spray dried nanocrystal tablets (NCs-SD-TAB) was evaluated over a three-month period under storage conditions of 25 ± 2 ◦C with 60 ± 5% relative humidity (RH) and 40 ± 2 ◦C with 75 ± 5% RH. Results: The highest redispersibility index (94%) was obtained using the spray-drying method. Tablets prepared with spray-dried NCs-SD-TAB exhibited a significantly higher in vitro dissolution rate under non-sink conditions compared with control tablets prepared using unprocessed CFZ with the same excipients, as well as the marketed product. NCs-SD-TAB showed an approximately three-fold increase in drug release at 15 min in 0.1 N HCl, with a pH 4.5 acetate buffer and pH 6.8 phosphate buffer, which simulate gastrointestinal pH conditions, relative to the marketed product. Conclusions: Overall, these results indicate that nanocrystal technology represents a promising approach for CFZ as an improved oral drug-delivery system, primarily due to its solubility enhancement capabilities.
dc.description.sponsorshipThis research was supported by Abdi ˙Ibrahim Pharmaceuticals within the scope of the Scientific and Technological Research Council of Türkiye (TUBITAK)-2244 Industrial PhD Fellowship Program, grant number 118C081. Bu araştırma, Türkiye Bilim ve Teknolojik Araştırma Konseyi (TÜBİTAK)-2244 Endüstriyel Doktora Bursu Programı kapsamında, 118C081 numaralı hibe ile Abdi İbrahim İlaç tarafından desteklenmiştir.
dc.identifier.citationPirinçci Tok, Y., Demiralp, B., Güngör, S., Sarıkaya, A. O., Aldeniz, E. E., Dude, U. K., & Özsoy, Y. (2026). Influence of drying methods on redispersibility and dissolution of canagliflozin nanocrystals: A comparative approach. Pharmaceuticals, 19(2), pp. 1-24. https://doi.org/10.3390/ph19020240
dc.identifier.doi10.3390/ph19020240
dc.identifier.endpage26
dc.identifier.issn1424-8247
dc.identifier.issue2
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/ph19020240
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1326
dc.identifier.volume19
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorPirinçci Tok, Yağmur
dc.institutionauthorid0000-0001-6915-0283
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofPharmaceuticals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNanocrystal
dc.subjectSolidification
dc.subjectSpray-Drying
dc.subjectFluidized Bed Granulation
dc.subjectImproved Dissolution Rate
dc.titleInfluence of drying methods on redispersibility and dissolution of canagliflozin nanocrystals: A comparative approach
dc.typeArticle
dspace.entity.typePublication

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