Utilization patterns and clinical outcomes following oocyte cryopreservation in Turkey: A multicenter cohort study within a nationally regulated setting

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dc.authorid0000-0002-5638-3675
dc.authorid0000-0002-7678-6981
dc.authorid0000-0002-1197-1326
dc.authorid0000-0001-6994-0269
dc.authorid0000-0002-8941-5469
dc.contributor.authorAydın, Gerçek
dc.contributor.authorTavuz, Aziz İhsan
dc.contributor.authorUzelli Şimşek, Hayal
dc.contributor.authorSimavlı, Serap
dc.contributor.authorDoğer, Emek
dc.date.accessioned2026-11-11T14:05:56Z
dc.date.available2026-11-11T14:05:56Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractPurpose: To analyse the utilization patterns, patient characteristics, and reproductive outcomes of oocyte cryopreservation (OC) performed under the current fertility preservation (FP) framework in Turkey. Methods: This retrospective multicenter cohort study analyzed data from Ministry of Health-accredited FP programs across Turkey between 2005 and 2026. The study included women who underwent OC for approved medical indications, predominantly diminished ovarian reserve and FP before gonadotoxic treatment. Primary outcomes were oocyte utilization rates and reproductive outcomes among women who returned to use their cryopreserved oocytes. Secondary outcomes included socio-demographic profiling and cycle-level characteristics. Results: A total of 1,582 women were included. Mean age at cryopreservation was 33.5±7.2 years. Most women underwent OC for diminished ovarian reserve (92.3%), while 7.6% underwent FP before treatment for malignant disease. Most participants were university-educated (63.9%) and employed (65.7%), with obstetrics and gynecology specialists being the primary source of awareness (53.3%). Mean anti-Müllerian hormone was 0.6±0.6 ng/mL, and a mean of 3.6±3.0 mature oocytes were cryopreserved per cycle. During the observation period, only 39 women (2.4%) returned to utilize their cryopreserved oocytes. Among thaw cycles, the clinical pregnancy rate per transfer was 15.6%, and the implantation rate was 12.7%. Conclusion: In this large multicenter cohort, OC was predominantly performed in women with diminished ovarian reserve, resulting in relatively limited oocyte yield and low observed utilization during the available follow-up period. These findings provide real-world data on the characteristics, utilization patterns, and reproductive outcomes of FP programs in Turkey and may help inform future clinical practice and policy discussions.
dc.identifier.citationAydın, G., Tavuz, A. İ., Uzelli Şimşek, H., Simavlı, S., & Doğer, E. (2026). Utilization patterns and clinical outcomes following oocyte cryopreservation in Turkey: A multicenter cohort study within a nationally regulated setting. Anatolian Journal of Obstetrics and Gynecology Research, 3(2), pp. 79-85. https://doi.org/10.4274/anajog.galenos.2026.77486
dc.identifier.doi10.4274/anajog.galenos.2026.77486
dc.identifier.endpage85
dc.identifier.issn3023-7920
dc.identifier.issue2
dc.identifier.startpage79
dc.identifier.urihttps://doi.org/10.4274/anajog.galenos.2026.77486
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1709
dc.identifier.volume3
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAydın, Gerçek
dc.institutionauthorid0000-0002-5638-3675
dc.language.isoen
dc.publisherGalenos Publishing House
dc.relation.ispartofAnatolian Journal of Obstetrics and Gynecology Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFertility Preservation
dc.subjectOocyte Cryopreservation
dc.subjectRestrictions
dc.subjectUtilization Rate
dc.titleUtilization patterns and clinical outcomes following oocyte cryopreservation in Turkey: A multicenter cohort study within a nationally regulated setting
dc.typeArticle
dspace.entity.typePublication

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