İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Güncel Gönderiler
Sustainable synthesis of ZnO nanoparticles from melon (cucumis melo l.) by-products: RSM optimization, structural characterization, antioxidant activity, and photocatalytic performance
(Wiley, 2026) Bozkurt, Rabia Nur; Kaba, İbrahim; Kahraman, Yusuf Sezai; Altınkeser, Tuğçe
This study explores the eco-friendly synthesis of zinc oxide nanoparticles (ZnO-NPs) using polyphenol-rich extracts from melon (Cucumis melo L.) peel and seeds as naturalreducing and stabilizing agents. Optimization via response surface methodology (RSM) determined the ideal synthesis conditions at a 0.078 mol/L metal concentration, 14.73 mL extract, and pH 10.77. Characterization through XRD confirmed a hexagonal wurtzite crystal structure with an average size of 21.7 nm, while SEM and TEM imaging revealed predominantly spherical morphologies. UV–visible DRS analysis showed a 368 nm absorption edge with a calculated band gap of 3.21 eV. DLS measurements indicated a hydrodynamic diameter of 135.6 nm with a PDI of 0.206 and a zeta potential of −20.5 mV, confirming good colloidal stability. The resulting NPs exhibited strong antioxidant activity (IC50 = 40.7 µg/mL) and acted as effective heterogeneous photocatalysts for the degradation of organic dyes. Specifically, ZnO-NPs enabled the photodegradation of methyl orange (MO) and methylene blue (MB), achieving 63.56% degradation for 5 mg L−1 MO. These findings demonstrate that melon-waste-derived ZnO-NPs are sustainable and promising candidates for wastewater treatment and environmental remediation.
The impact of home-based telerehabilitation pranayama on sleep quality and wellbeing in mild to moderate obstructive sleep apnea syndrome. A randomized controlled trial
(BioMed Central, 2026) Kaçar Akkoç, Zeynep; Demir, Rengin; Mustafaoğlu, Rüstem; Önder, Ömer Önder; Naci, Baha; Atahan, Ersan
Background Obstructive sleep apnea syndrome (OSAS) is a common disorder that causes repeated airway obstruction, disrupted breathing, and fragmented sleep. This study aimed to investigate the effects of Pranayama on sleep quality, daytime sleepiness, quality of life, fatigue, depression, and anxiety in patients with OSAS. Methods This study was designed as an open-label, prospective, randomized controlled trial. OSAS patients meeting the inclusion criteria were randomly assigned to either an Intervention group or a Control group. Pranayama training was applied to the Intervention group for 8 weeks, 7 days a week, and 3 times a day for 15 min. In addition, a single 15-minute session, 3 days a week, was conducted online under the supervision of a physiotherapist. The control group did not receive any intervention. Primary outcome was sleep quality (Pittsburgh Sleep Quality Index, PSQI). Secondary outcomes included daytime sleepiness (Epworth Sleepiness Scale, ESS), Fatigue Severity Scale (FSS), Functional Outcomes of Sleep Questionnaire (FOSQ), Nottingham Health Profile (NHP), and Hospital Anxiety and Depression Scale (HADS). All outcome measures were assessed at baseline and reassessed after the 8-week intervention period. Results Thirty-eight OSAS patients meeting the inclusion criteria were randomly assigned to either an Intervention group (n = 19) or a Control group (n = 19). Four participants (two in each group) were lost to follow-up, leaving the data of 34 participants (17 per group) available for inclusion in the final analysis. In the intervention group, PSQI scores decreased from 9.12 ± 4.71 to 6.88 ± 4.45 (p < 0.001), whereas no improvement was observed in the control group. Regarding the primary outcome, the reduction in PSQI scores was significantly greater in the intervention group than in the control group (p < 0.001). The ESS scores also decreased significantly in the intervention group, from 9.41 ± 6.15 to 7.41 ± 6.18 (p = 0.006, with a significant between-group difference (p < 0.001). Fatigue severity decreased in the intervention group (FSS change: 0.53 ± 0.70; p = 0.006), with a significant between-group difference (p = 0.037). The FOSQ score improved markedly, with significant gains in FOSQ total score (− 0.38 ± 0.25 vs. 0.14 ± 0.22 in controls; p < 0.001) and in activity level and vigilance subdomains (both p < 0.001). The HADS-anxiety scores decreased by 1.94 ± 3.94 (p = 0.059) and depression scores by 3.06 ± 2.05 (p < 0.001) in the intervention group, with significant between-group differences for both anxiety (p = 0.008) and depression (p < 0.001). Conclusion Pranayama was an effective adjunct therapy for these OSAS patients, and incorporating it into treatment strategies may enhance patient outcomes. Clinical trial registration number/date NCT04632147/22.10.2020.
Sun-macerated hypericum perforatum oleates in fixed oils: Analytical characterization and comparative wound-healing activity
(The Scientific and Technological Research Council of Türkiye (TÜBİTAK), 2026) Çapar, Cihan; Küpeli, Esra; Yaba, Aylin; Parmaksız, Ayhan; Sümer, Engin; Yeşilada, Erdem
Background/aim: Hypericum perforatum L. oleates prepared in fixed oils have long been used for wound management due to their antiinflammatory, antibacterial, and tissue-regenerative properties. The bioactivity of these oleates is mainly attributed to hypericin, hyperforin, and pseudohypericin. In the present study, the wound-healing potential of H. perforatum oleates prepared in different fixed oils, including Olea europaea L. (olive), Sesamum indicum L. (sesame), Helianthus annuus L. (sunflower), and Nigella sativa L. (black seed), is compared. Materials and methods: Fixed oils were characterized by gas chromatography–mass spectrometry, while oleuropein (olive oil) and thymoquinone (black seed oil) were quantified by high-performance liquid chromatography, and sesamin and sesamol (sesame oil) by spectrophotometry. Oleates were prepared using the traditional sun maceration method. Hypericin, hyperforin, and pseudohypericin were quantified by liquid chromatography–mass spectrometry and ultraviolet spectrophotometry. In vitro and in vivo assays were performed to assess the wound-healing activities of both the fixed oils and their respective oleates. Results: All oleates exhibited significantly greater wound-healing activity than the corresponding fixed oils. The most pronounced synergistic effects were observed with the olive oil and sesame oil oleates. Conclusion: Maceration of H. perforatum in fixed oils enhances the intrinsic therapeutic properties of oils and contributes to improvements in multiple wound-healing parameters. The findings of the present study support the traditional use of H. perforatum oleates and provide a scientific basis for their pharmacological development.
Machine learning insights into nurse retention through job satisfaction and financial incentives
(Frontiers Media S. A., 2026) Atılgan Sarıdoğan, Ayşe; Küçükgergerli, Nabi; Ertürk, Muzaffer; Emeç, Murat; Yaman, Adem
The global nursing shortage has reached a critical inflection point, where the financial sustainability of healthcare institutions is increasingly determined by their ability to maintain a stable, high-quality workforce. This study investigates the structural determinants of nurse staffing quality—operationalized as an institutional-level proxy for retention capacity—by integrating financial incentives, workload demands, and job-satisfaction metrics into an advanced machine-learning framework. Using the comprehensive CMS Provider Information dataset (N = 15,640 nursing facilities), we developed and validated a predictive architecture comparing Random Forest, Support Vector Machines, and Histogram-based Gradient Boosting (HGB) models. Our analysis reveals a clear hierarchy of influence: while Financial Incentives and penalties (Total Fines, importance weight: 0.083) and Job Satisfaction Proxies (QM Rating, 0.079) serve as significant secondary drivers, the primary boundaries of staffing stability are governed by Workload and capacity constraints, specifically the Number of Residents (0.309) and Number of Certified Beds (0.287). The Gradient Boosting model emerged as the superior predictive tool (Balanced Accuracy: 0.42; Macro F1: 0.41), demonstrating that institutional scale and patient volume are the dominant predictors of staffing quality ratings. These findings suggest that financial interventions alone are insufficient; sustainable nurse retention requires a dual-strategy that aligns fiscal incentives with rigorous workload management and capacity optimization. By identifying these high-impact variables and explicitly acknowledging the limitations of proxy-based operationalization, this research provides a data-driven roadmap for policymakers and healthcare executives to mitigate turnover and enhance the financial and operational resilience of nursing care systems.
Preliminary effects of MBCT on coping, self-compassion, and empowerment in early-stage breast cancer
(Selcuk University Press, 2026) Savaş, Esra
Aim: The objective of the study was to evaluate the effects of a Mindfulness-Based Cognitive Therapy (MBCT) program on coping attitudes, self-compassion, and cancer-related empowerment among women diagnosed with early-stage breast cancer. Materials and Methods: Eighty women with stage 0–II breast cancer were assigned to either an intervention group (n = 40) or a control group (n = 40). The intervention group completed an eight-week group-based MBCT program, while the control group received a single three-hour informational seminar after the completion of the intervention group program. All participants completed the Coping Attitudes Scale, the Self-Compassion Scale–Short Form, and the Cancer Empowerment Scale from pre-to-post. Due to violations of normality assumptions, data were analyzed using Wilcoxon signed-rank tests and Mann–Whitney U tests. False discovery rate correction was applied to control for multiple comparisons. Results: Significant improvements were observed in coping attitudes, self-compassion, and empowerment levels within the intervention group (p < .05). Notably, the increase in self-compassion may be attributed to the gender- and culturally sensitive structure of the intervention delivered in the Turkish context. Compared with the control group, the intervention group showed sizable pre to post gains (CAS: 83.9→115.4; SCS SF: 19.9→39.8; CES: 154.4→160.8), while controls showed minimal change or decline (CAS: 84.3→80.9; SCS SF: 24.0→25.2; CES: 151.0→140.2); group differences favored MBCT at post test (FDR adjusted p’s ≤ .005). Conclusion: These findings suggest that mindfulness-based group interventions may serve as an effective psychosocial approach for supporting psychological well-being in female cancer patients. In addition to reducing psychological symptoms, the MBCT program enhanced coping flexibility and internal empowerment. These preliminary findings warrant consideration of culturally sensitive MBIs within oncology services; however, time matched randomized trials are required before making firm recommendations.
