İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Evaluation of seropositivity developed against specific antigens of helicobacter pylori in neurodegenerative diseases
(Turkish Neuropsychiatric Society, 2026) Akçin, Rüveyda; Tütüncü, Melih; Karagöz Sakallı, Nazan; Apaydın, Hülya; Bozluolçay, Melda; Can, Günay; Soysal, Aysun; Sirekbasan, Serhat; Dinç, Harika Öykü; Sarıbaş, Suat; Kocazeybek, Bekir
Introduction: It is suggested that Helicobacter pylori (Hp) can reach the brain via the oral-nasal-olfactory route, through Hp-infected monocytes in the disrupted blood-brain barrier (BBB), or through a rapid retrograde neural network leading to neurodegeneration from the gastrointestinal tract (GIS) and may lead to neurodegenerative diseases such as Alzheimer’s (AD), Parkinson’s (PD) and Multiple sclerosis (MS). In this study, we aimed to evaluate the possible immunopathogenesis relationship between Hp-specific antigens and neurodegenerative diseases by determining the frequency of seropositivity against different specific antigens of Hp in diseases such as AD, PD and MS. Methods: In our cross-sectional, retrospective case-control study, the immunoreactivity frequencies of Hp-specific and non-specific CagA (p120), VacA (p95), p75, FSH (p67), UreB (p66), HSP homolog (p57), flagellin (p54), p50, p41, p33, OMP (p30), UreA (p29), p26, OMP (p19), p17 antigens were determined by Western Blot method in 36 AD, 35 PD, 91 MS cases with Hp-IgG reactivity, and 55 controls without a neurodegenerative/demyelinating by ELISA method. Results: No significant difference was found between the immunoreactivity frequencies of Hp antigens between AD and control groups (p>0.05). In the multivariate logistic analysis performed for PD cases, age ≥ 50 and immunoreactivity frequency of p19 were found to be independent risk factors (OR: 36.752, p<0.05) (OR: 5.570, p<0.05). In MS cases, immunoreactivity frequency of p17 antigen was found to be a risk factor (OR: 2.646, p<0.05). In addition, the mean level of Hp-IgG reactivity was found to be negatively associated with MS development (indicating an inverse correlation) in the control group compared to the MS group (OR: 0.585, p < 0.05). Furthermore, logistic regression analysis in the total study group revealed that the immunoreactivity frequency of the p17 antigen was identified as a risk factor for MS (OR: 2.438, p<0.05). Conclusion: Our data on AD cases are insufficient. In PD cases, the significantly higher frequency of immunoreactivity to the Hp-p19 antigen in individuals aged ≥50 years (OR=5.570) is noteworthy. In the MS group, the significantly high detection of Hp p17 antigen and its presence as a risk factor (OR=2.646), and the significantly high detection of p26 antigen suggest the relationship between these antigens and the MS development process. However, it is a fact that new and many prospective cohort-based case-control studies are needed to reveal this more clearly.
Hemimyelomeningocele: A systematic review and meta‑analysis of the literature
(Springer Nature Link, 2026) Adıyaman, Ali Ekrem; Karakaş, Furkan; Hamzaoğlu, Can; Saban, Şevval; Kılınç, Tunahan; Acar, Burak; Nabili, Tabriz; Ekşi, Murat Şakir
Hemimyelomeningocele (HMM) is a rare split cord malformation where only one hemicord forms a myelomeningocele-like sac, and the opposite hemicord undergoes normal neurulation. We aimed to compile all published HMM cases to concisely summarize embryology, presentation, imaging, associated anomalies, management, and outcomes of the disorder. Following PRISMA 2020, we searched PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar (1968–Feb 2025) for studies with confirmed human HMM, extracting clinical, radiological, surgical, and follow-up data. Of 688 records screened, 25 articles met inclusion criteria, encompassing 67 patients. Most publications were single-patient case reports. Presentation occurred predominantly in newborns or early infancy. The dysraphic sac was lumbosacral in most cases, and type I split cord malformation with a bony spur outnumbered type II. Hemivertebrae and congenital scoliosis were the common vertebrae anomalies. Nearly all patients underwent surgery combining sac excision, detethering, and bony spur removal. Postopera tive neurological outcomes were favorable: the majority improved, and the other ones remained stable; no surgery-related mortality was reported. HMM can be recognized as a distinct clinic radiological entity within the split-cord spectrum. Early, ideally prenatal diagnosis, timely microsurgical repair, and coordinated multidisciplinary care yield favorable functional outcomes in most patients. This first systematic review compiles the available evidence and provides a practical basis for future diagnostic and treatment decisions.
Santral sinir sistemi ve bilişsel süreçler üzerine fitoterapötik etkiler: Lavandula angustifolia, melissa officinalis ve salvia rosmarinus
(Orient Yayınları, 2025) Ekici, Miraç; Tuncay, Hüseyin Onur; Koçyiğit, Mine; Haspolat, Yusuf Kenan
Nörodejeneratif hastalıklar, anksiyete bozuklukları ve bilişsel işlev bozukluk ları, çağdaş toplumların karşı karşıya olduğu majör halk sağlığı problemleri arasında yer almaktadır. Dünya genelinde yaşlanan nüfus profili ve değişen yaşam koşulları, bu hastalıkların prevalansında belirgin bir artışa yol açmaktadır. Sentetik farmakolojik ajanların tedavide önemli başarılar sağlamasına karşın, bu ilaçların kullanımına eşlik eden advers etkiler, ilaç etkileşimleri ve kronik kullanı ma bağlı potansiyel riskler hem klinisyenleri hem de hastaları tamamlayıcı tedavi seçenekleri arayışına yönlendirmiştir. Bu bağlamda, uzun süredir geleneksel tıp sistemlerinde kullanılan ve güvenlik profillerinin görece daha iyi olduğu düşünülen bitkisel kökenli bileşikler, bilim insanlarının dikkatini çekmektedir (1).
Lumbar spine: Diagnosis and therapy with neural therapy
(Springer Nature Link, 2026) Ural Nazlıkul, Fatma Gülçin; Nazlıkul, Hüseyin
The lumbar spine, due to its topographical location and the significant load it bears, is frequently a center for chronic and acute conditions. Typical symptoms include pain and movement restrictions caused by various factors such as degeneration, postural imbalances, structural changes, or functional disorders. Neural therapy offers an effective method for both diagnosis and treatment by specifically targeting interference fields and influencing the body’s autonomic regulation. Notably, neural therapy has shown positive results in the treatment of lumbalgia, sciatica, and degenerative diseases of the lumbar spine. It supports tissue regeneration, improves circulation, and reduces pain perception by modulating the autonomic nervous system. These outcomes are achieved through precise injection techniques, such as facet joint injections and spinal nerve injections, allowing for direct and localized treatment. Neural therapy aims to activate the body’s self-healing powers and eliminate interference fields by targeted injections into the autonomic nervous system. By modulating the sympathetic and parasympathetic nervous systems, pain syndromes can be alleviated, and functional disorders corrected. The importance of comprehensive diagnosis, which considers both functional and autonomic factors, is essential to maximize the effectiveness of neural therapy and ensure holistic treatment.
The cervical spine
(Springer Nature Link, 2026) Nazlıkul, Hüseyin; Ural Nazlıkul, Fatma Gülçin
The cervical spine (CSS) is the most mobile part of the spine, consisting of seven vertebrae that connect the head and trunk. Neural therapy and manual medicine offer effective approaches to treating CSS dysfunction through targeted injections and mobilization techniques. These therapies can reduce pain, improve mobility, and normalize autonomic functions. Case studies demonstrate the effectiveness of these combined approaches in treating cervical spine disorders.
