İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF
(AASLD, 2026) Hernandez Gea, Virginia; Paradis, Valerie; Guindi, Maha; Alves, Venancio A.F.; Aqul, Amal; Cerda, Eira; Darwish Murad, Sarwa; Das, Prasenjit; Örmeci, Necati; Rautou, Pierre Emmanuel
Noncirrhotic portal hypertension has historically been described using heterogeneous and region-specific terminology—such as idiopathic portal hypertension (IPH), noncirrhotic portal fibrosis (NCPF), obliterative portal venopathy, and nodular regenerative hyperplasia—leading to substantial variability in diagnosis, reporting, and international research collaboration. Differences in guideline definitions from major societies (AASLD, EASL, and APASL), together with the presence of characteristic histologic lesions in patients without clinically overt portal hypertension, have further complicated disease classification. To address these challenges, a large, multisociety, international initiative was convened to harmonize nomenclature and diagnostic criteria. Representatives from liver, pathology, and pediatric hepatology societies across the Americas, Europe, and Asia participated in a structured consensus process that included specialized working groups and external Delphi validation. The initiative produced a globally harmonized and implementable diagnostic framework. Consensus was reached that the terms porto-sinusoidal vascular disorder (PSVD) and NCPF may be used interchangeably when identical diagnostic criteria are applied, and that they should be written as PSVD or NCPF. The diagnosis was defined as fundamentally clinicopathological, requiring integrated assessment. Core principles include the need for a high-quality liver biopsy ( ≥ 10 mm), mandatory exclusion of cirrhosis, and systematic exclusion of specific alternative conditions. Importantly, the consensus recognizes that PSVD or NCPF may be diagnosed even without clinical portal hypertension and may coexist with other liver diseases, provided cirrhosis is excluded. Standard ized major and minor histologic criteria were developed collaboratively by expert pathologists and externally validated. Features of portal hypertension were harmonized into specific and nonspecific categories applicable to routine clinical practice. An integrated diagnostic scoring system incorpo rating histology, clinical features, associated conditions, and concommitant etiologies was developed and validated using the Delphi method. This consensus provides the first internationally endorsed, unified framework for the diagnosis of PSVD or NCPF. Its global implementation is expected to reduce diagnostic variability, improve comparability across regions, and facilitate the development of robust, internationally harmonized clinical and translational research cohorts.
Cognitive alignment and assessment validity in a high-stakes dental specialty examination: A Bloom’s taxonomy-based analysis
(BioMed Central, 2026) Çerçi Akçay, Hülya; Üstün, Nilüfer
Background: In high-stakes postgraduate examinations, the cognitive complexity of assessment items is central to evaluating advanced clinical reasoning and decision-making competencies. Alignment between examination content, cognitive demand, and competency based educational frameworks is essential for assessment validity. This study evaluated the cognitive structure of pediatric dentistry questions in the Turkish Dental Specialty Examination (DUS) using Bloom’s revised taxonomy and examined their alignment with curricular expectations. Methods: A retrospective cross-sectional analysis was conducted on 127 officially released pediatric dentistry questions administered between 2012 and 2021. Each item was independently classified according to Bloom’s revised cognitive levels. Curriculum relevance and scientific accuracy were rated using a 5-point Likert scale. Inter rater reliability was assessed using weighted Cohen’s kappa. Associations between cognitive level and curriculum relevance were analyzed, and temporal trends across examination years were explored. Results: Questions were predominantly concentrated at the Understand and Apply levels, with fewer items categorized at the Analyze level. No questions were classified at the Evaluate or Create levels. Although lower- and higher-order cognitive skills appeared proportionally balanced when dichotomized, higher-order items largely reflected procedural application rather than advanced analytical or evaluative reasoning. No significant temporal progression toward greater cognitive complexity was observed. Curriculum relevance ratings were high overall but showed no significant association with cognitive level. Conclusions: This high-stakes specialty examination predominantly assesses lower- and intermediate-level cognitive processes, with limited representation of advanced higher-order thinking. The findings indicate potential blueprint misalignment with postgraduate competency expectations and underscore the need for deliberate integration of higher cognitive-level items to strengthen assessment validity.
Artificial intelligence applications across the spectrum of malnutrition: From undernutrition to obesity
(Elsevier, 2026) Günalan, Elif; Tartıcı, Gülser; Aladağ, Esra; Çonak, Özge
Background: Malnutrition is a significant global public health challenge, with rising prevalence and vital consequences. Recent advances in artificial intelligence (AI) have transformed approaches to understanding, monitoring, and managing these conditions. In this context, a multidimensional approach, integrating digital anthropometry and precision nutrition with image processing and AI-based mobile applications, has progressed in the field. Objectives: This study provides a comprehensive bibliometric and critical analysis of AI applications in malnutrition, including undernutrition and obesity. Methods: Using RStudio software (version 4.1.3) and the bibliometrix R package, 716 publications were identified in the Scopus database, of which 191 original research articles were analyzed. This context focuses on subfields such as digital anthropometry, precision nutrition, image processing technologies, and AI-supported mobile applications. Results: The findings highlight AI as a rapidly growing and interdisciplinary field of research. Engineering journals frequently publish cutting-edge studies, with the United States, China, Spain, and Korea leading in productivity and citations. Although diet, nutrition, and diabetes themes dominate the literature, undernutrition and obesity remain underrepresented. Conclusions: This study emphasizes the importance of transitioning the current fragmented research landscape into a standardized and ethically governed framework for the sustainable development of AI in nutrition. By bridging identified thematic imbalances and prioritizing scalable digital tools, AI can be repositioned as a strategic pillar of public health, rather than just a clinical instrument. Such a shift is essential for effectively addressing the global double burden of malnutrition and ensuring long-term, sustainable progress in the field.
Multi-target neuroprotective compound exhibits EAAT2-modulating and alzheimer’s pathology–attenuating effects in in vitro and in vivo models
(American Chemical Society, 2026) Hacımüftüoğlu, Ahmet; Saraçoğlu, Nurullah; Saffour, Sana; Abad, Nadeem; Kesgun, Yunus; Zegheb, Nadjiba; Gündeğer, Ersin; Yeşilyurt, Fatma; Ataş, Merve Nur; Türkez, Hasan
Alzheimer’s disease (AD) is a debilitating neuro degenerative disorder characterized by cognitive decline and memory loss. Current treatments offer limited efficacy, necessitat ing the development of innovative multitarget therapeutic strategies. Here, we present N3 ,N5 -bis(2-(5-methoxy-1H-indol-3- yl)ethyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxa mide (HCM-01), a novel compound developed to target multiple neurodegenerative pathways implicated in AD. In vitro assays included MTT-based cell viability analyses performed in two complementary experimental settings: primary neuronal cultures and astrocyte-based in vitro cell culture models exposed to glutamate. In primary hippocampal neuronal cultures, glutamate exposure induced a statistically significant reduction in cell viability compared with vehicle-treated controls, consistent with glutamate-induced excitotoxicity. Under these conditions, HCM-01 treatment resulted in a statistically significant improvement in neuronal viability, showing a greater protective effect compared with donepezil and memantine. In contrast, in astrocyte-based in vitro cultures, the applied glutamate concentration did not induce overt cytotoxicity, in line with the intrinsic neuroprotective and glutamate-buffering role of astrocytes. Accordingly, astrocytic experiments were designed to assess functional modulation of glutamate-handling mechanisms rather than cell survival. Western blot analysis in C8-D1A astrocytic cells demonstrated increased expression of excitatory amino acid transporter 2 (EAAT2) following HCM-01 treatment compared with control and reference drug-treated groups, suggesting modulation of astrocyte-mediated glutamate homeostasis. In parallel, redox analyses revealed that HCM-01 improved oxidative/antioxidative balance, as evidenced by increased total antioxidant capacity (TAC) and reduced total oxidant status (TOS), supporting an indirect antioxidant contribution to its functional effects. In vivo behavioral assessment of HCM-01 in a streptozotocin (STZ)-induced Alzheimer’s model in female Sprague−Dawley rats demonstrated that administration of HCM-01 at doses of 50 mg/kg orally (oral, P.O. and intraperitoneal, I.P.) and 100 mg/kg (P.O.), significantly improved cognitive and memory functions in the passive avoidance (PA), Morris water maze (MWM), and locomotor activity tests. Moreover, histopathological and immunohistochemical analyses of different hippocampal regions revealed reduced neuronal damage, attenuation of tau pathology, antiamyloidogenic effect, and restoration of cholinergic function. Complementary in silico studies, including molecular docking, molecular dynamics simulations (MDS), and free energy calculations, suggested potential interactions of HCM-01 with the allosteric site of EAAT2. Taken together, these findings suggest that HCM-01 exerts neuroprotective effects against glutamate-induced excitotoxicity in primary hippocampal neurons while additionally modulating glutamatergic homeostasis and redox balance through functional mechanisms in astrocyte-based models, supporting its relevance as a multitarget preclinical candidate for early stage AD mechanisms.
Genel Patoloji
(Güneş Tıp Kitabevleri, 2026) Alatlı, Fatma Canan; Balcıoğlu, Hüseyin Avni
Sağlık kısaca vücudun hastalık belirtisi olmadan, işlevlerini sürdürebildiği durumdur. Dünya Sağlık Örgütü (DSÖ) sağlığı, hem fiziksel, hem ruhsal, hem de sosyal olarak tam bir iyilik hali şeklinde tanımlamaktadır.
