İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Does combined pulmonary fibrosis and emphysema syndrome affect response to antifibrotic therapy and survival? A single-center retrospective cohort study
(Mattioli 1885, 2025) Teke, Nazlı Hüma; Ağca, Meltem; Türkar, Ayla; Sevim, Tülin; Tuncay, Eylem; Güngör, Sinem; Yıldırım, Elif; Özbaki, Fatma; Gündoğuş, Baran; Arınç, Sibel; Berk Takır, Huriye; Özmen, İpek
Objective: Combined pulmonary fibrosis and emphysema (CPFE) is a clinicoradiological syndrome characterized by upper lobe emphysema and lower lobe fibrosis, most commonly associated with idiopathic pulmonary fibrosis (IPF). This study compared the clinical characteristics, functional parameters, and mortality of patients with CPFE and IPF who received antifibrotic therapy. Methods: Between October 2015 and Au gust 2022, patients with IPF treated with antifibrotics for at least 6 months were retrospectively evaluated and divided into two groups: CPFE (emphysema present) and IPF (emphysema absent). Demographic data, antifi brotic therapy, functional parameters before and after treatment (FEV1%, FVC%, DLco %), clinical outcomes (hospital admissions, mortality) were compared. Results: Of the 204 patients with IPF, 90 (44%) had CPFE. CPFE patients were more often male, had greater smoking history, higher pack-years, and more lung cancer than IPF patients (p < 0.001 for all). Post-treatment FEV1% and FVC% did not significantly differ between the groups, whereas DLco% declined significantly in both (p < 0.001 and p = 0.002). DLco% decreased more in IPF than CPFE, but the difference was not statistically significant [−3 (−11–3) vs. −0.43 (−1.1–0.2), p = 0.36]. The hospital admission rates were similar. Independent risk factors for mortality included CPFE diagnosis (HR: 1.73, 95% CI: 1.06–2.83, p = 0.029), low FVC% (HR: 0.970, 95% CI: 0.96–0.98, p < 0.001), and device use (long-term oxygen therapy [LTOT] or home non-invasive mechanical ventilation [NIMV]) (HR: 2.48, 95% CI: 1.50–4.09, p < 0.001). Mean survival was shorter in patients with emphysema than in those without em physema (5.08 vs. 5.68 years, p = 0.08). Conclusions: Despite a decline in DLco%, changes remained below the futility threshold. Clinical outcomes and mortality were comparable. CPFE diagnosis, low FVC%, and LTOT/ NIMV use independently predicted higher mortality.
More than one century: Intravenous procaine therapy - A systematic review
(Salient Visionary Publications LLC, 2025) Oettmeier, Ralf; Nazlıkul, Hüseyin; Pinilla-Bonilla, Laura Bibiana; Ural Nazlıkul, Fatma Gülçin; Reuter, Rudolf
Procaine, traditionally introduced as a local anaesthetic, has revealed over more than a century a broad spectrum of systemic, pleiotropic pharmacological properties that far exceed its classical use. More than thirty distinct biological mechanisms have now been identified, including anti-inflammatory, vasodilatory, sympatholytic, membrane-stabilising, neuromodulatory, geroprotective, and epigenetically active effects. These actions provide the scientific foundation for its expanding clinical relevance in pain medicine, neuro-regulation, cardiovascular modulation, immune-related and degenerative disorders, and complementary oncology. Within Neural Therapy, Procaine occupies a central and irreplaceable role: its segmental, interference-field–oriented and autonomic-regulatory actions uniquely position it as the primary agent capable of restoring disturbed vegetative patterns, resolving chronic dysfunctions, and re-establishing physiological self-regulation. Beyond its local anaesthetic function, intravenous Procaine—especially in combination with bicarbonate—demonstrates profound regulatory effects on microcirculation, autonomic balance, inflammatory cascades, and mitochondrial and cellular resilience. The so-called “Procaine reset” reflects its capacity to transiently interrupt maladaptive neural patterns, modulate limbic activation, influence neurotransmitter systems, and restore homeostatic regulatory loops. The addition of bicarbonate prolongs Procaine’s plasma availability, enhances its intracellular penetration, and amplifies its eutrophic and anti-inflammatory properties. Although Procaine remains the primary therapeutic molecule in Neural Therapy, Lidocaine has also been utilised in selected clinical contexts. Lidocaine shares certain membrane-stabilising and anti-inflammatory features; however, its pharmacodynamics, autonomic influence, and regulatory depth are comparatively limited. Thus, Lidocaine may complement specific applications but cannot replace the superior vegetative-regulatory potential documented for Procaine. Procaine-Base infusion, when properly adapted to the patient's acid–base balance, represents a cornerstone therapy in regenerative medicine, improving pain thresholds, vascular perfusion, lymphatic drainage, and emotional equilibrium. Its safety profile—documented in hundreds of thousands of applications—is exceptionally favourable, with adverse effects being rare, transient, and mild. Given rising global burdens of chronic inflammatory, neurodegenerative, cardiovascular, metabolic, and oncologic disorders, Procaine emerges as a valuable multi-target regulatory agent capable of reducing symptom burden, complementing multimodal therapeutic strategies, and potentially lowering long-term health-care costs. Future high quality, large-scale studies are warranted to validate its systemic mechanisms, clarify dose–response relationships, and further integrate Procaine-based therapies into modern evidence-based frameworks.
Under-resourced EFL students’ perceptions about the causes and consequences of unfair AI-mediated education
(Taylor & Francis, 2025) Wanga, Yongliang; Lib, Hang; Savaş, Hasan
The use of Artificial Intelligence (AI) technologies in education imposes various social influences on different stakeholders across diverse contexts. However, the voices of under-resourced second language (L2) learners have remained unheard regarding the fairness of AI adoption. To fill this gap, the present qualitative study examined 33 Chinese English as a foreign language (EFL) students’ perceived causes and consequences of unfair AI-mediated education. Thematic analysis of online interviews indicated four causes and four consequences for unfair AI adoption in under-resourced communities. The causes included biased algorithms and databases, digital divide and unequal access, lack of AI-related training and support, and sociocultural mismatch and inappropriateness of AI tools in poor settings. Regarding consequences, it was found that unfair AI adoption may lead to educational inequality, diminished motivation, academic deskilling, and technophobia among under-resourced EFL students. The findings are discussed, and implications for raising AI literacy and readiness of L2 educators and policymakers are enumerated.
Women’s experiences of breastfeeding during pregnancy: A Turkish descriptive study
(Springer Nature Link, 2025) Bayraktar, Sema; İnce, Zeynep; Yıldız, Nevin; Eski, Nuray; Çoban, Emine Asuman
Background Breastfeeding is generally terminated when the mother becomes pregnant again within two years because there is no clear consensus on how to manage breastfeeding during pregnancy. Additionally, health professionals may not have accurate information about this issue. This study aimed to determine women’s attitudes towards breastfeeding during pregnancy and why they stopped breastfeeding when they became pregnant. Methods This study is a descriptive one, involving pregnant mothers with a breastfeeding infant under 2 years old (n=101). The participants were followed up regarding those who had given birth to a new child and chosen the BDP. The researchers surveyed them after birth. The data were collected using a survey form that included a total of 26 questions created by the researchers, which aligned with the existing literature. Data were collected using a questionnaire that included information about maternal, neonatal, and obstetrical data, as well as breastfeeding experience and problems encountered during pregnancy. Data were handled and analyzed using IBM SPSS Statistics v22.0 (SPSS Inc., Chicago, IL, USA). Results The mean age of the mothers was 29.3 years (SD±4.9), gravidity was 3.2 (SD±1.7), and parity was 2.5 (SD±1.1). The mean age of the breastfed children was 12.6 months (SD±5.3) when the mothers became pregnant again. The reasons for stopping breastfeeding were professional advice (35%, n=34), their own decision (30%, n=30), believing that breastfeeding could have adverse effects on the unborn baby, and social pressure (16%). Only 5% (n=5) of mothers continued breastfeeding between 7 and 9 months after pregnancy. Conclusions Our results indicate that when a mother wishes to breastfeed during pregnancy, providing breastfeeding counseling by healthcare professionals with accurate information is essential to sustain lactation and maintain the well-being of the breastfeeding child without harm to the unborn baby.
Evaluation of mesiodistal tip accuracy in mandibular anterior teeth following incisor extraction with clear aligners
(Elsevier, 2025) Erdem, Buket; Özcan, Mustafa; Şar, Çağla
Introduction: Single mandibular incisor extraction is sometimes necessary in clear aligner treatment, yet the accuracy of mesiodis tal tooth positioning in such cases remains unclear. This retro spective study evaluates the discrepancy between predicted and achieved mesiodistal movements of the remaining mandibular an terior teeth in Invisalign (Align Technology, Santa Clara, CA) treat ments. Additionally, it examines the effects of aligner attachments and change frequency on movement accuracy. Material and Methods: A total of 40 Invisalign patients with single mandibular incisor extraction were retrospectively analyzed. Geomagic Control X (3D Systems, Rock Hill, SC) was used to mea sure pretreatment positions, predicted movements, and achieved outcomes. Predicted and actual mesiodistal tip movements were compared. Results: Regression analysis revealed significant discrepancies (P < 0.001) between predicted and achieved mesiodistal movements for both incisors and canines. Only 70% of the predicted incisor tip movement (R² = 0.4171) and 60% of the predicted canine tip move ment (R² = 0.5789) were achieved. Neither the number of aligners, change protocol (1-week vs. 2-week), nor attachments significantly affected accuracy (P > 0.05). However, incisors were less likely than canines to follow the predicted movement direction (P = 0.025). Conclusion: A significant discrepancy exists between predicted and achieved mesiodistal movements after single mandibular in cisor extraction with Invisalign. The number of aligners, wear dura tion, and attachments do not significantly influence accuracy. Fur ther research is needed to optimize treatment planning and im prove predictability in clear aligner therapy.
