İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Myomectomy in pregnancy
(GLOWM, 2026) Tinelli, Andrea; Pecorella, Giovanni; Panese, Gaetano; Morciano, Andrea; Mykhailo, Medvediev V; Hatırnaz, Şafak; Aydın, Gerçek; Bıyık, İsmail; Stojković, Marta; Sparic, Radmila; Stark, Michael
Uterine fibroids, or leiomyomas, are the most common benign tumors of the uterus, arising from the smooth muscle (myometrium). They represent a major global health concern due to their impact on physical health, quality of life and economic wellbeing.1 During a woman's life cycle, uterine fibroids typically occur less frequently before puberty, are more common during the reproductive years and reduce in size after menopause.1 Histological studies indicate that uterine fibroids are characterized by three main features: increased sensitivity to sex steroid hormones, altered extracellular matrix deposition and enhanced proliferation of smooth muscle cells.2 Epidemiological research has identified several risk factors associated with leiomyoma growth, including age, ancestry, family history, reproductive factors, hormonal influences, hypertension and certain infections. Furthermore, specific dietary components may influence hormone-related diseases and the development of fibroids.
Neurobiology of cancer: A review from psychooncologic and neuroscientific perspective
(Lut Tamam, 2026) Savaş, Esra
This review emphasizes the need to understand not only the biological but also the psychological and neurobiological aspects of cancer. Factors such as psychosocial stress, depression and social isolation have important effects on cancer initiation and progression through the neuroendocrine system and the immune system. In this context, the effects of interactions between the nervous system and the immune system on the tumor microenvironment, neuroinflammation and neurotransmitter levels are detailed. In addition, the neurobiological effects of cancer treatments (chemotherapy, radiotherapy, hormone therapy, immunotherapy) on cognitive and emotional functions were discussed; “chemobrain”, neuropathic pain and treatment-related neurocognitive impairments were explained. Recent research has shown that these effects can be mitigated by psychooncological approaches such as Cognitive Behavioral Therapy, Eye Movement Desensitization and Reprocessing Therapy and mindfulness. These interventions support neuroplasticity by regulating stress responses and their effects on brain regions are supported by neuroimaging studies. Finally, the critical role of neuropsychological assessments and cognitive rehabilitation programs in individualized intervention processes was emphasized and the importance of an interdisciplinary approach was revealed. This study aims to critically evaluate the existing literature and draw attention to the gaps in the research field by comprehensively examining the neurobiological and psychooncological effects of cancer.
Compliance pressure: What is it for social entrepreneurs?
(Nobel Akademik Yayıncılık, 2024) Liaqat, Muhammad Mohsen
In this chapter, I develop a fundamental understanding of compliance pressure for social entrepreneurs considering the theory of cognitive dissonance. I suggest that efforts to maintain the coexistence of social and business logic leave social entrepreneurs to behave counter to their convictions. I identify the threat of punishment, and dual compliance can create a discrepancy between public behaviour and the cognition of social entrepreneurs. However, the compliance pressure against social entrepreneurs does not always let them leave the situation or wind up the venture. Still, it allows them to uphold contradictory logic and manage compliance pressure.
Mathematical and numerical modeling of drilling system dynamics using CF fractional differentiation
(AIMS Press, 2026) Erdoğan, Mahir Ceylan
In this work, I propose a Caputo–Fabrizio fractional mathematical model of a drilling system (CFFMMDS) to investigate the coupled dynamics of an induction motor-driven drilling assembly within a unified fractional-order framework. The governing equations were formulated using a nonsingular Caputo–Fabrizio fractional derivative with an exponential memory kernel to characterize the temporal dependencies among the system state variables. The resulting fractional-order system was solved using the Caputo–Fabrizio q-Elzaki homotopy analysis transform method (CFq-EHATM) to derive semi-analytical solution series and to conduct a numerical investigation of the system response under varying fractional orders. The results indicated that a decrease in the fractional order 𝜇 results in attenuated growth and decay rates. This trend is consistent with the intrinsic memory structure of the Caputo–Fabrizio operator, which distributes the influence of past states over time. The proposed framework enables the analysis of the temporal evolution of coupled state variables in dynamic systems exhibiting history-dependent behavior.
Therapeutic potential of alpha‑tocopherol in reducing oxidative stress and inflammatory damage after experimental traumatic brain injury and pentylenetetrazol‑induced seizures
(Springer Nature Link, 2026) Demirtaş, Cumaali; Yıldırım, Hava; Demir, Hüseyin; Kıroğlu, Sezin; Şevgin, Kübra; Beyaztaş, Hakan; Güler, Eray Metin; Hekimoğlu, Gulam; Aykın, Uğur; Coşkunpınar, Ender Mehmet; Yıldırım, Mehmet
The effects of alpha-tocopherol on seizure parameters, locomotor-cognitive functions, inflammatory response, oxidative stress response, histopathological changes, immunohistochemical parameters, and miRNA fold changes were investigated in rats with traumatic brain injury (TBI) and pentylenetetrazol (PTZ)-induced seizures. Sprague–Dawley male rats were randomly divided into three groups: Control (n = 8), TBI + PTZ (n = 10), and TBI + PTZ + tocopherol (n = 10). After inducing TBI in animals using the weight-drop method, increased post-injury seizure susceptibility was achieved by administering subconvulsive doses of PTZ. Saline was administered intraperitoneally to the control and TBI + PTZ groups for 6 days, while 500 mg/kg alpha-tocopherol was administered intraperitoneally to the TBI + PTZ + tocopherol group. Seizure intensity, sei zure frequency, and total seizure duration were significantly reduced in the TBI + PTZ + tocopherol group compared to the TBI + PTZ group (p < 0.05). No significant adverse effects related to TBI and PTZ were observed in the animals’ locomotor activity, anxiety-like behaviors, or learning and memory test outcomes. In the TBI + PTZ + tocopherol group, significant reductions were observed in inflammatory cytokine response, oxidative stress, and SUR1-TRPM4 channel activity compared to the TBI + PTZ group (p < 0.001). While degenerative and apoptotic neurons and the number of 8-OHdG-positive cells in the CA1 and dentate gyrus regions were limited in the TBI + PTZ + tocopherol group, downregulated miR-324-5p increased (p < 0.05). Alpha-tocopherol reduced the severity and duration of seizures, reduced oxidative stress and inflammation, and stabilized the thiol-disulfide balance. It also reduced degenerative cell structures and DNA damage in the cortex, hippocam pus, and dentate gyrus. In conclusion, the findings of this study suggest that alpha-tocopherol is a potential neuroprotective agent that modulates early epileptogenic network instability in TBI and seizure susceptibility through multiple pathways, including oxidative stress, inflammation, and ion channel regulation.
