İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Role of S100B, neuron-specific enolase, and adrenomedullin in differentiating central and peripheral vertigo
(Bayrakol Medical Publisher, 2026) Onur, Bahaeddin; Özdemir, Serdar; Koçak, Mehmet; Ünal Akoğlu, Ebru; Demir, Hasan; Cimilli Öztürk, Tuba; Onur, Özge Ecmel
Aim: This study aimed to evaluate S100B, adrenomedullin (ADM), and neuron-specific enolase (NSE) as diagnostic biomarkers to differentiate central and peripheral vertigo in patients with dizziness. Methods: A prospective cohort study was conducted with 88 patients (58% women) presenting with dizziness. Patients were categorized based on MRI findings into two groups: those with acute lesions (central vertigo) and those without lesions (peripheral vertigo). S100B, ADM, and NSE levels were measured and compared between the groups to assess their diagnostic value for central vertigo. Results: Significant differences were found in S100B, NSE, and ADM levels between the central and peripheral vertigo groups (p=0.003, 0.008, and 0.010, respectively). Factors predicting MRI-detected lesions included age, mean arterial pressure, movement-induced and positional vertigo, neurological findings, history of hypertension, lack of response to symptomatic treatment, and elevated S100B, ADM, and NSE levels. Logistic regression analysis identified the lack of response to symptomatic treatment as the only significant predictor (p=0.0148). Conclusion: S100B, ADM, and NSE levels significantly differ between central and peripheral vertigo, suggesting their potential as diagnostic biomarkers. However, only the lack of response to symptomatic treatment was a significant predictor. Further research is needed to validate these biomarkers alongside clinical assessments and imaging.
Combination of bilateral rectus sheath and modified BRILMA blocks for postoperative analgesia in pediatric liver transplantation: A tailored approach
(Edizioni Minerva Medica, 2026) Alver, Selçuk; Çiftçi, Bahadır; Büget, Mehmet İlke; Emek, Ertan; Erbiş, Halil; Öztürk, Nadi Nazım; Umutoğlu, Tarık
Combination of bilateral rectus sheath and modified BRILMA blocks for postoperative analgesia in pediatric liver transplantation: A tailored approach
Suboptimal LDL-cholesterol control under the 2019 ESC/EAS dyslipidemia guidelines: Results from the nationwide TEMD-2 study in type 2 diabetes
(Wiley, 2026) Telci Çaklılı, Özge; Haymana, Cem; Demirci, İbrahim; Kebapçı, Medine Nur; Sarıakçalı, Barış; Evren, Bahri; Dizdar, Oğuzhan Sıtkı; Salman, Serpil; Ersoy, Canan; Satman, İlhan; Bayram, Fahri; Sönmez, Alper
Background: Lowering LDL cholesterol (LDL-C) decreases cardiovascular risk substantially in type 2 diabetes. Despite stricter LDL-cholesterol targets in the 2019 ESC/EAS dyslipidemia guidelines, target achievement in clinical practice remains insuffi cient. TEMD-2 is designed to evaluate LDL-cholesterol target attainment in Turkish patients with type 2 diabetes in the context of the updated 2019 ESC/EAS guidelines. Methods: This multicenter cross-sectional study included adults with type 2 diabetes followed in 70 tertiary endocrine clinics across 36 cities between October 2022 and January 2023. Sociodemographic characteristics, comorbidities, lifestyle factors, com plications, laboratory measurements, and lipid-lowering therapies were assessed using standardized questionnaires and clinical evaluations. LDL-C target was assigned according to cardiovascular risk categories. Independent predictors of goal attainment were identified using multivariable logistic regression. Results: Among 4956 adults with type 2 diabetes, 99.5% required statin therapy, whereas 37.1% were on treatment. Overall, 8.3% of the cohort achieved LDL-cholesterol targets, with attainment lowest in those at very high risk (5.8%). Target achievement among statin users was 57.7% in moderate-risk, 18.1% in high-risk, and 9.4% in very-high-risk patients. Individuals on target had lower body mass index, haemoglobin A1c (HbA1c), triglycerides, and a lower prevalence of microvascular complications. Statin therapy was the strongest positive predictor of success (odds ratio 2.39), while smoking, presence of neuropathy, nephropathy, female sex, older age, and higher HbA1c were associated with lower likelihood of achieving LDL-cholesterol goals. Therapeutic inertia was present in 87.2% of patients, defined as no intensification of lipid-lowering therapy despite LDL-cholesterol levels above target.
LuminaConsent: AI-driven standardization and quality enhancement of urological informed consent documentation
(Kare Publishing, 2026) Topçu, İbrahim; Soylu, Tuncay; Şimşekoğlu, Muhammed Fatih; Tuzcu, Esra Melis; Salman, Zeynep; Demir, Perihan; Kaç, Beyzanur; Kartal, Muhammed Yusuf; Suzan, Serhat; Karaman, Muhammet İhsan
Objective: Informed consent is the cornerstone of modern medical ethics, but current documentation systems negatively impact patient autonomy and clinical quality due to deficiencies in readability, comprehensibility, and standardization. These is sues hinder patient participation and require innovative solutions. This study introduces the AI-powered LuminaConsent system to address standard deficiencies, comprehensibility issues, and efficiency constraints in urological informed consent documents. Methods: In a three-armed comparative study, LuminaConsent (artificial intelligence), Turkish Urological Surgery Asso ciation standard forms, and expert-developed documents were evaluated in 10 urological procedures. The system is based on the RAG architecture, which uses OpenAI’s GPT-4o-mini model and a special knowledge base consisting of 12 clinical publications. Three independent urology specialists conducted a blind evaluation using a 100-point scale across five areas: scientific content accuracy, patient communication effectiveness, quality of risk-benefit information, perioperative guidance, and legal-ethical compliance. RESULTS: LuminaConsent achieved higher performance with mean scores of 82.33 points (SD±4.2) versus 78.77 points (SD±6.1) for professional society standards and 57.43 points (SD±3.8) for specialist documentation, representing statisti cally significant improvements of 43.3% over specialist practices (p<0.001) and 4.5% over professional society standards (p<0.05). The system demonstrated consistent high-quality output across all procedures while generating comprehensive documentation within 96-180 seconds compared to traditional processes requiring multiple days. Conclusion: LuminaConsent offers a pioneering model for systematic AI integration in clinical practice with its evidence based content generation and bilingual processing capabilities. The findings support the potential to empower patient auton omy, reduce application variations, and improve ethical standards.
Saúde ambiental: Enfermagem e manejo de resíduos hospitalares
(Even3 Publicacoes, 2026) Aydoğdu, Ana Luiza Ferreira
São considerados geradores de Resíduos de Serviços de Saúde (RSS) os locais que prestam atendimento a seres humanos e produzem resíduos perigosos, ou seja, aqueles com potencial de risco, como materiais biológicos, objetos perfurocortantes, produtos químicos perigosos e materiais radioativos. Diante disso, entende-se que o descarte desses resíduos deve ser adequadamente gerenciado, de modo a não causar prejuízos ao meio ambiente nem à saúde pública. A enfermagem, por estar envolvida em praticamente todas as ações de saúde realizadas nas instituições hospitalares, desempenha papel fundamental no manejo e no descarte de resíduos hospitalares. Nesse contexto, a presente revisão da literatura teve como objetivo analisar o papel da enfermagem no manejo de resíduos gerados em hospitais. Trata-se de uma revisão narrativa da literatura, baseada em cinco artigos científicos identificados na Biblioteca Virtual em Saúde (BVS), por meio de buscas realizadas em dezembro de 2025. Foram incluídos artigos publicados em língua portuguesa, sem delimitação temporal, que apresentavam, em seus títulos, os descritores “enfermagem” e “resíduos”. Inicialmente, foram identificados vinte estudos, dos quais cinco atenderam aos objetivos da revisão e foram incluídos na análise. Ressalta-se que não foi adotada uma metodologia sistemática para a seleção dos artigos. Os estudos analisados indicaram que os profissionais de enfermagem apresentam boa compreensão acerca da importância do descarte adequado dos resíduos hospitalares, da supervisão do manejo adequado e de sua responsabilidade socioambiental. Contudo, fatores como a escassez de materiais e a sobrecarga de trabalho configuram obstáculos à tomada de decisão, favorecendo práticas inadequadas de descarte de resíduos. Além disso, embora a equipe de enfermagem reconheça a relevância do gerenciamento de resíduos de serviços de saúde, a insuficiência de conhecimentos específicos evidencia a necessidade de educação continuada sobre o tema, especialmente para o reconhecimento das etapas do gerenciamento desses resíduos. O descarte adequado inicia-se com a segregação correta, seguida do acondicionamento e da identificação apropriados, abrangendo a coleta e o tratamento, e culmina na disposição final ambientalmente segura, garantindo a proteção da saúde dos profissionais, da comunidade e do meio ambiente. Dessa forma, enfatiza-se o papel fundamental dos formuladores de políticas públicas, dos administradores das instituições hospitalares e dos gestores de enfermagem no que se refere ao ensino, à capacitação e à supervisão do descarte adequado dos resíduos de serviços de saúde, visando à proteção das comunidades por meio da preservação do meio ambiente.
