İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Polyphenolic cocktail (PFK5120) treatment of breast cancer cell lines: superior anti-carcinogenic and anti-metastatic effects to doxorubicin
(Wiley, 2025) Özkara, Gamze Akın; Ceviz Çubukçuoğlu, Ayşe Begüm; Çelik, İrem Nur; Korkmaz, Nur Damla; Öztürk, Özmen; Yılmaz Aydoğan, Hülya
Polyphenolic cocktail (PFK5120) treatment of breast cancer cell lines: superior anti-carcinogenic and anti-metastatic effects to doxorubicin
Molecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance
(Wiley, 2025) Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; İbrahimova, Gülnar; Yılmaz Aydoğan, Hülya; Öztürk, Özmen
Molecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance.
AI-guided optimization of traditional bulgur pilafs: Enhancing sensory and bioactive properties through rsm-pso modeling
(Frontiers Media S. A., 2025) Yıkmış, Seydi; Türk Aslan, Sinem; Türkol, Melikenur; Şimşek, Mehmet Ali; Aljobair, Moneera; Karrar, Emad; Tokatlı, Nazlı; Mohamed Ahmed, Isam A.
This study aimed to enhance the sensory and bioactive properties of pilafs prepared from three geographically indicated bulgur varieties—Siyez, Firik, and Karakilçik—through an AI-guided optimization approach combining Response Surface Methodology (RSM) and Particle Swarm Optimization (PSO). Different bulgur (130–150 g) and water (350–450 mL) ratios were tested to determine optimal formulations. Sensory evaluation revealed that Firik bulgur pilaf achieved the highest overall acceptability (8.49), while Karakilçik bulgur pilaf scored highest in color (7.68) and aroma (8.58), and Siyez bulgur pilaf received the highest taste score (7.50). In terms of bioactive properties, Karakilçik bulgur pilaf showed the highest antioxidant capacity (75.57% DPPH radical scavenging activity), whereas Firik bulgur pilaf had the highest total phenolic (842.39 mg GAE/kg) and flavonoid contents (6.38 mg CE/g). Color analysis indicated that Siyez bulgur pilaf had the lightest color (L=52.18), while Firik pilaf exhibited the most intense red hue (a=8.12) and Karakilçik pilaf the darkest appearance (L=35.42). PSO-based validation confirmed the accuracy of RSM models by reaching global optima within 40 iterations and minimal deviation from experimental values. This is the first study to apply an integrated RSM–PSO modeling approach to traditional bulgur pilafs, enabling the prediction and optimization of their sensory and bioactive characteristics. The results provide a novel framework for enhancing the nutritional value and consumer appeal of heritage cereal-based foods and support the development of standardized, functional bulgur products for the food industry.
Arama yeteneklerinin geliştirilmesi yapay zeka tabanlı literatür taraması
(Kastamonu Üniversitesi, 2025) Yucal, Kubilay; Kasap, Ercan
Bilgi hacminin hızla artması, geleneksel anahtar kelime aramalarını yetersiz kılmakta ve önemli çalışmaların gözden kaçmasına yol açmaktadır. Yapay zekâ destekli sistemler, literatür taramalarının verimliliğini ve kapsamını artırma potansiyeline sahiptir.
Techno-economic and environmental analyses of the use of ammonia-diesel dual fuel in compression ignition engines
(Elsevier, 2025) Karagöz, Yasin; Pusat, Şaban; Tunçer, Erdal; Teksan, A. Emre
In this study, a single-cylinder diesel engine, normally running on diesel fuel, was converted to ammonia-diesel dual fuel. The effects of ammonia fuel at different energy content levels (0 %, 5 %, 10 %, 15 %, and 20 %) were investigated on thermal efficiency, CO, THC, NOx, and smoke emissions. Subsequently, GWP (Global Warming Potential) emission values and tax calculations were performed. Furthermore, economic and exergy analyses were performed using the present value method for converting the engine to ammonia-diesel dual fuel. Finally, the economic analysis was re-conducted by calculating the carbon tax based on the GWP emission value. Based on the results, the lowest GWP emission values were obtained with the addition of ammonia at 10 % energy content.
