İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Predictors of re-biopsy in percutaneous musculoskeletal tumor biopsies: A single-center retrospective cohort study
(SAGE Publications, 2026) Yücesan, Ali; Arıkan, Yavuz; Doğukan, Fatih Mert; Mutlu, İlhan Nahit; Toy, Serdar; Atan, Tamer; Özer, Devrim
Purpose: This study aimed to evaluate the diagnostic success of percutaneous biopsies performed for suspected mus culoskeletal tumors and to identify clinical, anatomical, and procedural factors associated with the need for repeat biopsy (re-biopsy). The secondary objective was to assess the impact of multidisciplinary team (MDT) evaluation on reducing unnecessary re-biopsy procedures. Methods: A total of 565 patients (331 bone, 234 soft tissue lesions) who underwent percutaneous biopsy for suspected musculoskeletal tumors between 2020 and 2024 were retrospectively analyzed. Diagnostic success was defined as a biopsy yielding a definitive histopathological diagnosis sufficient to guide treatment planning without additional tissue sampling. Predictive factors including lesion size, depth, location, and performing specialty were evaluated using univariate and multivariate logistic regression analyses. Results: The initial diagnostic yield was 65.5%. Multivariate analysis revealed that lesion width <2 cm (OR = 2.01; 95% CI, 1.19–3.39; p = 0.009) and biopsy performed by an interventional radiologist (compared to an orthopedic surgeon) (OR = 5.25; 95% CI, 2.83–9.74; p < 0.001) were independent predictors of re-biopsy recommendation. Among 72 patients recommended for re-biopsy, MDT evaluation averted the need for a second procedure in 38 cases (52.8%). Conclusion: Smaller lesion size (<2 cm) and the medical specialty performing the biopsy were independent predictors of re-biopsy recommendation, with the latter likely reflecting systematic differences in case complexity and procedural environment rather than operator skill. Structured MDT evaluation significantly reduced unnecessary repeat procedures.
Thermoresponsive sol–gel system incorporating oleuropein-rich olive leaf extract for enhanced wound healing and antibiofilm activity
(MDPI Publishing, 2026) Alparslan, Levent; Özdemir, Samet; Karacan, Burak; Torkay, Gülşah; Bal Öztürk, Ayça; Tutar, Ömer Faruk; Özcan Bülbül, Ece; Sardaş, Semra; Kala, Zübeyde Merve; Özalp, Yıldız
Oleuropein, the principal secoiridoid phenolic compound of olive leaves (Olea europaea L.), is recognized for its broad-spectrum antimicrobial, antibiofilm, antioxidant, and tissue regenerative properties. However, its effective local therapeutic application remains chal lenging due to rapid clearance from the site of administration and limited residence time. In this study, an oleuropein-rich aqueous olive leaf extract was incorporated into a ther moresponsive sol–gel delivery system designed for localized application. The formulation was engineered to remain in a low-viscosity sol state at room temperature and to undergo a temperature-triggered sol-to-gel transition near physiological temperature (~33 ◦C), en abling in situ gel formation. Oleuropein content was quantified using a validated HPLC method, and the formulation was characterized with respect to physicochemical parame ters, thermoreversible gelation behavior, particle size distribution, mechanical properties, and spreadability. Biological performance was evaluated through in vitro cytocompati bility (MTT assay), fibroblast migration (scratch assay), and collagen deposition (Sirius Red staining) in L929 fibroblasts, as well as antibiofilm activity against representative Gram-positive and Gram-negative bacterial strains. The developed sol–gel system demon strated stable physicochemical characteristics, rapid and reversible thermogelation, suitable mechanical and spreading properties, concentration-dependent inhibition of biofilm for mation, and acceptable cytocompatibility within the tested concentration range. Notably, the formulation supported fibroblast viability and collagen-associated responses at opti mized concentrations. Overall, the results indicate that the proposed thermoresponsive sol–gel formulation represents a promising strategy for the localized delivery of oleuropein rich olive leaf extract, combining physicochemical stability with dual wound-healing and antibiofilm functionality.
Using AI-driven chatbots to enhance EFL students' ICC levels: Turkish context
(Piri Reis University, 2026) Yılmaz, Kübranur; Keleş, Eren Doğukan
As the internationalization of higher education accelerates, Intercultural Communicative Competence (ICC) has emerged as a foundational outcome of English as a Foreign Language (EFL) education. Contemporary models of ICC conceptualize intercultural competence as a multidimensional construct encompassing affective dispositions(openness, curiosity, empathy), cognitive knowledge (cultural self awareness and sociocultural understanding), and behavioral skills (adaptability and effective interaction). Developing these dimensions requires sustained engagement with cultural difference; however, many EFL contexts provide limited opportunities for authentic intercultural contact. In response to this gap, artificial intelligence (AI) technologies, particularly conversational agents, offer new forms of digitally mediated interculturalsimulation. Thisstudy investigatesthe extent to which AI driven chatbot interaction can support the development of ICC among EFL learners in a Turkish higher education context.
Development of biodegradable alginate films with aloe vera and quince seed mucilage: Physical, chemical, and biological properties
(Elsevier, 2026) Keke, Zeynep Serra; Temizkan Özdamar, Kevser; Alanalp, Mine Begüm; Altıner Kurt, Eda
In this study, novel biodegradable hydrogel films derived from quince seed mucilage and Aloe vera gel were developed and evaluated for their physical, chemical, and biological properties. Four film formulations prepared by solvent casting were characterized for swelling capacity (2.61–11.95 g), solubility (61.70–99.15%), thermal stability (TGA/DTG), chemical structure (FT-IR), surface morphology (SEM), optical properties (UV–Vis), me chanical performance (tensile strength ranging from 7.4 to 12.7 MPa), antibacterial activity, antioxidant ca pacity, and biodegradability. Quince seed mucilage enhanced the mechanical strength and thermal stability of the films due to its high-viscosity polysaccharide structure. In contrast, Aloe vera gel significantly increased the films' biological activity, particularly their antioxidant potential. Films with higher quince seed content exhibited greater structural stability, whereas Aloe vera–rich films showed increased short-term bioactivity and stronger antioxidant performance. Overall, the results indicate that hydrogel films produced from environmentally friendly and sustainable natural components can serve as functional, biologically active, and promising alter native packaging materials.
Effectiveness of fissure sealants following different silver fluoride application protocols in MIH-affected molars: Randomized clinical study
(Springer Nature Link, 2026) Çayıroğlu, Nagihan; Ballıkaya, Elif; Erbaş Ünverdi, Gizem; Çehreli, Zafer Cavit
Objectives To compare the clinical efficacy of glass ionomer sealants (GIS) and resin-based sealants (RBS) applied imme diately or one week after silver fluoride (SF) application to permanent molars affected by molar incisor hypomineralization (MIH) in children at high risk for caries. Methods A total of 216 MIH-affected molars (ICDAS 1–2) from 102 children aged 6–14 years were randomly allocated to six groups: Resin- or glass ionomer–based fissure sealants were placed either one week after the application of silver fluoride or during the same clinical session. In the same-visit protocols, sealants were applied immediately after silver fluoride treatment, either following gentle blot drying with cotton or after immediate rinsing. Hypersensitivity, caries progression, and sealant retention were assessed at 1, 6, and 12 months. Hypersensitivity was evaluated using the Schiff Cold Sensitivity Scale (SCASS). Sealant performance was analyzed using modified USPHS criteria. Statistical analyses included Fisher’s Exact Test and the Friedman test. Results Full retention was achieved in all resin-based sealant groups, while the lowest retention rate (88.9%) was recorded in the glass ionomer sealant group applied one week after silver fluoride. Caries occurred in 2.8% of teeth and was confined to three groups: glass ionomer sealants placed one week after silver fluoride, resin-based sealants applied immediately following blot drying, and glass ionomer sealants applied immediately after rinsing. All other groups showed complete clinical success. No statistically significant differences were found among groups regarding caries prevention (p=1.000) or sealant retention (p=0.062). Hypersensitivity decreased significantly over time in all groups. Conclusion Resin-based and glass ionomer fissure sealants placed either one week after silver fluoride application or immediately following treatment, using rinsing or blot-drying protocols, showed similar outcomes over a 12-month follow-up period in terms of caries prevention and reduction of hypersensitivity. Nonetheless, within the limitations of this study, sealants placed immediately following silver fluoride application demonstrated a greater frequency of discoloration. Clinical significance Both glass ionomer and resin-based fissure sealants can be successfully applied either immediately or one week following silver fluoride treatment to provide protection for MIH-affected permanent molars. Clinical trials registration number NCT06641011.
