İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Functional and esthetic outcomes of full-mouth rehabilitation following vertical dimension reestablishment using posterior composite build-ups: A case report
(Dennis Barber Journals, 2025) Papatya, Zeynep; Güler, Edanur; Karabulut, Dicle; Özdal, Umut
Introduction: Loss of vertical dimension of occlusion (VDO) is a clinical condition that can significantly impact both function and esthetics. It may lead to impaired mastication, temporomandibular joint (TMJ) discomfort, facial disharmony, and reduced quality of life. Restoring VDO requires a systematic approach involving proper evaluation, neuromuscular adaptation, and establishment of a stable occlusal and TMJ relationship. This case report presents the functional and esthetic outcomes of full-mouth rehabilitation following VDO reestablishment using posterior composite build-ups and a gradual increase in occlusal height to promote TMJ stabilization. Case Description: A patient with reduced VDO was treated with posterior composite resin build-ups. The vertical dimension was increased by 1 mm per week over five weeks, allowing neuromuscular adaptation and TMJ repositioning. After successful adaptation, definitive restorations were completed. Pressable ceramic (e.max) laminate veneers were placed from first premolar to first premolar (5–5) in both arches. Zirconia crowns were used on the first and second molars (6 and 7). Throughout the procedure, esthetic, functional, and occlusal parameters were carefully monitored to ensure optimal outcomes. The patient adapted well to the new VDO, showing marked improvement in facial esthetics and occlusal function. High patient satisfaction was reported at the conclusion of treatment. Discussion: This case highlights the effectiveness of a controlled, stepwise approach to VDO restoration. Using composite build-ups allowed reversible testing of neuromuscular tolerance before final restorations. The combination of e.max veneers and zirconia crowns restored function and esthetics while preserving TMJ stability. No complications were observed during the one-month follow up, supporting the short-term success of the approach. Long term monitoring is essential to confirm the durability of results.
Endocrown-based restoration of a structurally compromised tooth using additive manufacturing in a fully digital workflow: A case report
(Dennis Barber Journals, 2025) Keskin, Muhammed Furkan; Altaş, Zeynep Tuğçe; Dilaverler Yardım, Esra Ayşe
Introduction: The rapid advancement of digital technologies in dentistry has facilitated the effective integration of CAD/CAM systems into restorative treatment protocols. These systems enable both subtractive and additive manufacturing methods to be incorporated into clinical workflows. Endocrowns, preferred for restoring endodontically treated teeth with compromised structural integrity, offer significant advantages in terms of precision and time efficiency when digitally planned and fabricated. Case Description: A 33-year-old male patient presented to the clinic with complaints of acute dental pain. Clinical and radiographic evaluations revealed deep dentinal caries and extensive coronal substance loss in the affected tooth, for which endodontic treatment was indicated. Following root canal therapy, an endocrown restoration was selected to preserve the remaining tooth structure and restore functional integrity. The treatment was carried out entirely using a digital workflow. An intraoral scanner (TRIOS® 3 Color, 3Shape, Denmark) was used to capture the digital impression. The restoration was designed using CAD software (Exocad, Germany) and subsequently fabricated using additive manufacturing technology with a 3D printer (Asiga MAX, Australia) and high-precision dental resin. The restoration was cemented using adhesive techniques in a clinical setting. Discussion: Endocrowns fabricated through a fully digital workflow demonstrate superior accuracy, workflow standardization, and time efficiency compared to conventional methods. Additive manufacturing enables the precise production of complex morphologies, eliminates the need for physical models, reduces material waste, and enhances cost-effectiveness. These restorations exhibit high clinical compatibility and improve patient comfort while reducing operator dependency during production. However, limitations such as high system acquisition costs, the need for technical proficiency, and limited long-term clinical data must be considered for widespread adoption.
Digitally planned prosthetic rehabilitation of a patient with inadequate interocclusal space
(Dennis Barber Journals, 2025) Olkun, Abdullah Yaşar; Özkan, Yiğit Alp; Albayrak, Berkman
Introductıon: In cases where missing teeth are not replaced for a long time, the opposing teeth may come into supra-occlusion and this can make the prosthetic rehabilitation to be applied quite difficult. Digital wax-up enables planning a predictable treatment for patients and to perform rehabilitation in the appropriate vertical dimension. Case Description: A 46-year-old male patient with moderate periodontal health who had lost his centric stop due to posterior tooth loss applied to our clinic for prosthetic treatment. During the clinical examination, it was noticed that the antagonist teeth had erupted over time and deep-bite had occurred because the missing teeth was not replaced. Both digital and conventional impressions were made and the diagnostic casts with face-bow registration were transferred to a semi-adjustable articulator. Then, it was planned to increase the vertical dimension by 3 mm and to provide sufficient interocclusal distance by extracting the right maxillary second molar and the left mandibular first and second molars. Accordingly, digital wax-up was prepared on the anterior teeth and a 3D-printed wax-up with denture bases was prepared for the posterior teeth. After the aesthetic and functional analyses were performed, anterior teeth were prepared in the guidance of mock-up and silicone indexes to ensure obtaining sufficient clearance. The maxillary arch was rehabilitated with 3 separate metal-ceramic fixed partial denture and the mandibular jaw was rehabilitated with a single 9-unit fixed partial denture. By increasing the vertical dimension and obtaining sufficient interocclusal distance, posterior edentulous areas were also rehabilitated with removable partial dentures. Discussion: In cases where prosthetic planning and predict both aesthetics and function after treatment are difficult, more precise treatment plans can be offered to patients by performing digital design prior to any intervention. In this case, a predictable rehabilitation was achieved by increasing the vertical dimension thanks to digital wax-up.
Comparative evaluation of a new-generation HBsAg assay versus a conventional method in occult HBV infection and low-level HBsAg positivity
(Ankara Microbiology Society, 2026) Daşdemir, Ferhat Osman; Dinç, Harika Öykü; Sirekbasan, Serhat; Hamzeli, Nur; Alaçam, Sema; Karabulut, Nuran; Türk, Süreyya; Dereli, Nida; Akçin, Rüveyda; Kocazeybek, Bekir
This study aimed to comparatively evaluate the conventional hepatitis B surface antigen (HBsAg) assay and the next-generation HBsAg NEXT (HBsAgNx) assay in samples with low-level HBsAg positivity and in cases of occult hepatitis B infection (OBI). A total of 497 individuals were included in the study, comprising 300 individuals with low-level HBsAg positivity, 100 OBI cases (64 seropositive and 36 seronegative) and 97 healthy controls. Serum samples were analyzed using the Abbott ARCHITECT HBsAg Qualitative II assay (Abbott Diagnostics, Wiesbaden, Germany) and the Abbott Alinity i HBsAg NEXT assay (Abbott Diagnostics, Wiesbaden, Germany). The presence of HBV DNA was confirmed by real-time polymerase chain reaction (Rt-PCR) using the COBAS AmpliPrep/COBAS TaqMan HBV test v2.0 (Roche Diagnostics, Mannheim, Germany). HBV DNA (Rt-PCR) was accepted as the gold standard reference for diagnostic performance evaluation. To minimize potential bias arising from sample selection, individuals with low level HBsAg positivity and OBI cases were analyzed separately. In the low-level HBsAg-positive group, semi-quantitative S/CO values of the assays were compared, whereas in the OBI group, only the detection rates of HBV DNA–positive cases were evaluated. A total of 17 OBI cases (17%) were identified that were tested negative by the conventional assay but positive by the HBsAgNx assay. Differences between the assays were evaluated using the McNemar test and p< 0.05 was considered statistically significant. Median values obtained with the HBsAgNx assay were significantly higher than those obtained with the conventional assay (p< 0.001). The HBsAgNx assay provides clinically significant contributions particularly in the OBI group, by detecting cases that cannot be identified by conventional assays. These findings indicate that the integration of high-sensitivity HBsAg assays into current HBV diagnostic algorithms would increase case detection and contribute to both transfusion safety and the clinical management of OBI.
Comparative benchmarking of 2d lidar slam algorithms with ros 2 on raspberry pi 5
(IEEE, 2026) Şahin, Ulaş; Can, Göktürk; Altıok, Ezgi; Çavdar, İbrahim; Gözüaçık, Necip
Mobile robotics increasingly relies on SLAM for robust autonomous navigation. While many algorithms exist, systematic comparisons within the ROS 2 framework under real-world conditions remain limited. This study addresses this gap by benchmarking three widely used 2D LiDAR-based methods—GMapping, Hector SLAM, and Cartographer—on a wheeled mobile robot. Using both simulation and on-device experiments, we evaluate mapping accuracy, localization quality, and computational efficiency. Results show that Cartographer achieves the highest accuracy in structured environments, Hector SLAM demonstrates robustness without odometry, and GMapping performs reliably only in small-scale settings. These findings highlight trade-offs relevant to embedded deployment. The main contributions are: (i) a reproducible evaluation pipeline on ROS 2, (ii) quantitative analysis of accuracy versus resource usage on Raspberry Pi 5, and (iii) practical guidelines for algorithm selection in autonomous systems. This work advances the understanding of ROS 2-based SLAM and supports informed deployment in robotics applications.
