İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Güncel Gönderiler
Long-term microbiome and clinical effects of a microbiome-guided personalized diet versus low-FODMAP diet in irritable bowel syndrome: A 12-month follow-up randomized controlled trial
(Taylor & Francis, 2026) Tunalı, Varol; Arslan, Çiğdem; Derviş Haki̇m, Gözde; Gündoğdu, Aycan; Ermi̇ş, Beyza Hilal; Hora, Mehmet; Nalbantoğlu, Özkan Ufuk
Dietary therapy is central to irritable bowel syndrome (IBS) management, yet the long-term durability of the low-FODMAP diet (LFD), and of microbiome-guided personalization, remains unclear. We assessed the long-term clinical and gut-microbiome effects of a microbiome-guided personalized diet (PD) compared with a standard LFD in adults meeting Rome IV criteria for IBS. In this multicenter, open-label randomized controlled trial with blinded outcome assessment, participants who completed a 6-week dietary intervention (PD or LFD) were followed at 6 and 12 months without further dietary intervention. Outcomes included the IBS Severity Scoring System (IBS-SSS), IBS Quality of Life (IBS-QOL), and the Hospital Anxiety and Depression Scale (HADS); gut microbiota were profiled by 16S rRNA sequencing. Longitudinal changes were evaluated using linear mixed-effects models, responder analyses, PERMANOVA, and PERMDISP. Both diets reduced IBS-SSS at 6 weeks. PD maintained symptom improvement at 6 and 12 months (−82.0 and −78.3 points from baseline), whereas LFD benefits regressed by 12 months (+29.3 points; between-group p = 0.001). At 12 months, IBS-SSS responder rates were higher with PD than LFD (62.5% vs 34.5%; absolute risk difference +28.0%, 95% CI 4.2–47.7; Fisher p = 0.029), and IBS-QOL, HADS-anxiety, and HADS-depression showed more favourable trajectories with PD. PD was associated with sustained Shannon alpha-diversity gains (+0.488 at 6 weeks; +0.205 at 12 months; both p < 0.01). A modest between-group beta-diversity difference at 6 months (R2 = 0.035; p = 0.011) was not significant at 12 months. This hypothesis-generating follow-up suggests more durable benefit with PD; larger trials powered for long-term clinical and microbiome outcomes are warranted.
A clinical mirage: The peril of improving laboratory markers in meningococcal-induced cardiac tamponade
(Elsevier, 2026) Özyüksel, Arda
In this issue of JACC: Case Reports, Pagotan et al describe a compelling case of immune-mediated meningococcal pericarditis progressing to car diac tamponade despite apparent microbiological resolution and improving laboratory parameters.
Bilateral circumferential ınternal jugular vein decompression for atlanto-styloid compression syndrome: Report of 14 cases
(Lippincott Williams and Wilkins Ltd., 2026) Aghayev, Kamran; Demir, Hüseyin; Özdöl, Çağatay; Comella, Zachary; Vrionis, Frank D.
BACKGROUND AND OBJECTIVES: External compression of the internal jugular vein (IJV) between the transverse process of the atlas (C1TP) and the styloid process is an emerging nosological entity. Various surgical treatment methods have been used, yet there is no consensus regarding the optimal surgical strategy. In this article, we present a novel surgical technique and clinical outcomes of 14 patients treated with circumferential decompression. METHODS: A retrospective chart review of 14 patients (9 men, 5 women) diagnosed with IJV stenosis between the C1TP and the styloid process was performed. The surgical technique included styloidectomy, C1 transversectomy, myectomy of the styloid muscles and posterior belly of the digastric muscle, transection of the occipital artery, and wide opening of the carotid sheath around the IJV. All but 1 patient underwent bilateral decompression. Clinical evaluation included self-reported improvement on a subjective improvement scale. Radiological assessment was performed by comparison of pre-and postoperative IJV cross-sectional area (CSA) at the point of maximal stenosis. A paired t-test was used for statistical analysis. RESULTS: The mean age was 44.7 yr (25-60), and the mean follow-up duration was 488 days (range 329-761). The right mean IJV CSA increased from 18.3 to 46.1 mm 2 (P = .0058). The left mean IJV CSA increased from 10.1 to 28.8 mm 2 (P = .000076). The IJVs shifted and expanded posteriorly toward the C1TP resection cavities in all cases. Nine patients reported significant and 5 moderate improvements. One patient developed transient trapezius muscle weakness because of XI nerve palsy. CONCLUSION: Bilateral circumferential IJV decompression is a feasible and safe technique and provides maximal IJV decompression.
Robotic eTEP-TAR abdominal wall reconstruction for complex post liver transplant incisional hernia with concomitant inguinal hernia repair: A video vignette
(Springer Nature Link, 2026) Bayrakçeken, Serra; Benlice, Çigdem; Aghayeva, Afag; Kudsi, Omar Yusef; Baca, Bilgi
Introduction Complex incisional hernias after major upper abdominal surgery are technically challenging because of altered anatomical planes, multiple fascial defects, and expected adhesions. Robotic enhanced-view totally extraperitoneal repair with transversus abdominis release may provide a minimally invasive option for selected patients by enabling retromuscular dissection, fascial closure, and wide extraperitoneal mesh reinforcement while limiting intraperitoneal manipulation. Case presentation This video vignette presents an 84-year-old man with multiple incisional hernia defects along a previous Mercedes incision after liver transplantation and a concomitant left direct inguinal hernia. Preoperative imaging demon strated a wide subxiphoid abdominal wall defect and a fat-containing left inguinal hernia. Surgical technique A robotic eTEP-TAR approach was performed. Bilateral retromuscular dissection was completed, the inguinal and incisional hernia contents were reduced, and bilateral transversus abdominis release was performed to facilitate medial fascial advancement and lateral extension of the working space. The fascial and peritoneal defects were closed intra corporeally, and wide mesh reinforcement was achieved using a 30 × 30 cm polypropylene mesh, with additional meshes placed for the inguinal and lower quadrant defects. The postoperative course was uneventful, and the patient was discharged on postoperative day 2. At postoperative day 7 follow-up, he had no complaints, and the wounds were clean. Conclusion This case demonstrates the feasibility of robotic eTEP-TAR abdominal wall reconstruction with concomitant inguinal hernia repair in a selected post-transplant patient with complex abdominal wall defects.
Low-cost mobile lidar and RTK GNSS integration for georeferenced HBIM of cultural heritage: A scan-to-BIM workflow based on multi-sensor data fusion for accuracy enhancement
(The Association for Computer-Aided Architectural Design Research in Asia, 2026) Aş Çemrek, Handan; Işıkdağ, Ümit
This study discusses a scan-to-BIM workflow based on the integration of low-cost mobile LiDAR and RTK GNSS, focusing on cultural heritage, and compares the performance of two different portable scanning systems. An 18th-century Sibyan School was selected as a case study, managed by Mimar Sinan Fine Arts University (MSGSU), Istanbul. The study employed a viDoc RTK-enabled iPad Pro (photogrammetry + LiDAR) and a Realsee Galois M2 tripod mounted panoramic 3D LiDAR scanner. Point cloud data obtained from both systems were georeferenced with RTK GNSS control points, and their location accuracies were comparatively assessed. The generated point cloud datasets were combined using a multi-sensor data fusion approach and fed into an HBIM-based modeling process. Component geometries were analyzed for detail, data gaps, and noise. The findings indicate that the RTK-enabled viDoc method offers advantages in terms of location accuracy and level of detail, while the Realsee Galois M2 stands out for its rapid deployment, indoor coverage, and practical field use. In conclusion, the study suggests that low-cost mobile systems should be considered as part of a multi-sensor hybrid cultural heritage documentation and digital twin production strategy rather than completely replacing terrestrial laser scanning and suggests a repeatable workflow for similar projects.
