İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Long-term outcomes of extended versus segmental resection for transverse colon cancer: A population-based analysis based on the SEER database
(Galenos Publishing House, 2025) Benlice, Çiğdem; Erkaya, Metincan; Aghayeva, Afag; Özben, Volkan; Görgün, Emre; Atasoy, Deniz; Baca, Bilgi
Objective: To investigate long-term cancer-specific outcomes associated with extended versus segmental colectomy (SC) in patients with stage I-III transverse colon adenocarcinoma using a large, population-based cohort. Material and Methods: Patients who diagnosed with transverse colon cancer undergoing curative-intent colectomy were identified from the surveillance, epidemiology, and end results database (2013-2019). Surgical procedures were categorized as extended colectomy (EC) or SC based on standardized procedural coding. 1:1 propensity score matching was performed to reduce selection bias and balance baseline characteristics. Cancer-specific survival (CSS) was analyzed using multivariable Cox proportional hazards regression. Results: Among 18,799 eligible patients, 58% underwent EC. EC was more frequently performed in individuals with higher tumor stage (p<0.01) and those receiving adjuvant chemotherapy (26% vs. 23%, p<0.01). After matching (n=7.904 in each group), EC was associated with a higher rate of adequate lymphadenectomy (>12 lymph nodes retrieved: 94% vs. 89%, p<0.01). Five-year overall survival did not differ significantly between groups (65.6% for EC vs. 66.9% for SC, p=0.074). However, SC was associated with a modest but statistically significant improvement in CSS (84.3% vs. 81.7%, p<0.01). In adjusted analysis, surgical extent (HR=0.8376, p<0.001), along with age, sex, tumor grade, stage, and lymph node yield, were independently associated with CSS. Conclusion: While EC is more commonly utilized in advanced-stage disease and facilitates higher lymph node retrieval, SC offers comparable—and potentially superior—CSS in selected patients. These findings support the consideration of a tailored surgical strategy based on tumor biology and individual patient characteristics.
Small molecule influenza virus fusion inhibitors targeting viral hemagglutinin: Chemical insights and antiviral evaluation
(Bentham Science Publishers, 2025) Çınar, Gözde; Tekin, Mahmut Can; Cihan Üstündağ, Gökçe
Influenza viruses are major human pathogens that cause widespread respiratory infec tions, affecting millions of people globally and contributing to significant morbidity and mortality. Several currently available anti-influenza drugs are facing increasing levels of viral resistance. Therefore, the discovery of therapeutics targeting novel mechanisms of action is becoming increas ingly important. A key viral protein involved in the infection process is the envelope glycoprotein Hemagglutinin (HA), which facilitates both host cell receptor binding and membrane fusion, two essential steps required for viral entry and replication. Due to its central role in the early stages of infection, HA has emerged as a highly promising target for antiviral drug development. Many small molecule HA inhibitors have been identified with potential anti-influenza activity by stabilizing the HA structure and preventing its conformational change during the membrane fusion process. This review presents a detailed chemical evaluation of these HA-targeting compounds based on studies reported in the literature, highlighting their core chemical scaffolds and structural features. The antiviral efficacy of these compounds is discussed based on in vitro and in vivo data, along with insights into their mechanisms of action. A comprehensive literature search was conducted, and studies meeting the predefined inclusion criteria were thoroughly reviewed. By focusing on the chemical structure of these inhibitors, this review provides information for the rational design of new therapeutic agents aimed at preventing or limiting influenza virus infections.
Development and validation of an ICF-based new scale—Atılım Kinesiophobia Scale: A methodological study
(Wolters Kluwer, 2025) Uluğ, Naime; Parmaksız, Ayhan; Begen, Sena Nur; Can Karahan, Zehra; Yılmaz, Seval; Adalı, Mehmet Fatih; Aslan, Sema Nur; Uysal, Özgür Selim; Er, Dudu Melek; Tunca, Öznur; Kılıç, Erden
It is important to assess kinesiophobia, which increases the risk of disability by limiting physical activity. In this cross-sectional study, we aimed to develop a scale that assesses kinesiophobia with the multidimensional structure of International Classification of Functioning, Disability and Health (ICF). Atılım Kinesiophobia Scale (AKS) was developed in Turkish by an expert panel using questionnaires replied by 367 subjects. Finally, 38 questions based on the sub-domains of the ICF described by World Health Organization. In the scope of this cross-sectional study content validity and reliability were assessed; construct validity (both convergent and divergent validity) was checked against Tampa Kinesiophobia Scale-17 and Visual Analog Scale. AKS demonstrated good internal consistency and convergent validity, with significant correlations observed with the Tampa Scale for Kinesiophobia-17 (r = 0.478, P < .001). Divergent validity was supported by insignificant correlations with the Visual Analog Scale (r = 0.019, P = .855). The Cronbach alpha coefficient of 0.862 indicates a high level of internal consistency for the AKS. Based on these findings, the final version of AKS was refined to include 4 factors and 14 items, demonstrating good internal validity. We developed and validated the AKS to assess kinesophobia in patients with acute and/or chronic musculoskeletal pain. This new ICF-based scale can be used to assess kinesiophobia; however further studies are required to prove its validity and reliability in other languages. Abbreviations: AKS = Atılım Kinesiophobia Scale, CFA = confirmatory factor analysis, CFI = comparative fit index, EFA = exploratory factor analysis, ICF = International Classification of Functioning, Disability and Health, KMO = Kaiser–Meyer–Olkin, RMSEA = root mean square error of approximation, SRMR = standardized root mean square residual, TSK = Tampa Kinesiophobia Scale, VAS = Visual Analog Scale.
Safety monitoring of colistin therapy in critically ıll neonates with late-onset sepsis: A retrospective observational study
(British Pharmacological Society, 2025) Acargök, Baran Cengiz; Yaman, Akan; Rzayev, Turkay; Jalalzada, Nazlı; Kandemir, İbrahim; Memişoğlu, Aslı; Bilgen, Hülya Selva
This study aimed to evaluate the safety of colistin therapy by monitoring renal function and electrolyte levels in critically ill neonates with late-onset sepsis (LOS) hospitalized in the neonatal intensive care unit (NICU) between 2015 and 2021. This ret rospective case–control study included 58 critically ill neonates treated with colistin for late-onset sepsis and 22 control neonates with late-onset sepsis who did not receive colistin. Data were analyzed to compare patient outcomes, microbiological profiles, and side effects of treatment. Statistical analyses were performed using repeated-measures ANOVA and Bayesian calculations to evaluate serum creatinine levels and biochemical parameters over time. Serum creatinine levels showed similar alterations within the first 7days of colistin treatment with moderate evidence. However, serum magnesium and sodium levels were lower on the 7th day in the colistin-treated group compared with the control group. Colistin therapy in critically ill neonates with late-onset sepsis appears to be a viable treatment option with an acceptable short-term safety profile. These findings emphasize the importance of routine monitoring of renal function and electrolyte levels during colistin use in neonatal intensive care to minimize potential complications.
The effects of light and vibration on the correction of lower incisor crowding with aligners
(Galenos Publishing House, 2025) Özcan, Mustafa; Nalbantgil, Didem
Objective: To compare the effects of low-frequency vibration (LFV), photobiomodulation (PBM), and their combination (HOT) on the rate of mandibular incisor alignment during clear aligner therapy. Methods: This retrospective study included 89 patients treated with a single clear aligner system for mild-to-moderate mandibular anterior crowding. Patients were assigned to four groups: control (n=19), LFV (n=26), PBM (n=21), and HOT (n=23). LFV [30 Hz, 0.25 N (≈25 g)] and PBM (850 nm, 16×5 mm LEDs, ≈9.5 J/cm2 ) devices were used daily for 20 minutes in relevant groups. The primary outcome was the change in Little’s Irregularity Index at baseline (T0), 28 days (T1), 48 days (T2), and 62 days (T3). Statistical analyses included one-way ANOVA, repeated measures ANOVA, and Pearson’s correlation. Results: The HOT group showed significantly greater crowding reduction compared to all other groups (p<0.05). LFV and PBM alone were not significantly different from the control. Within-group analysis revealed significant reductions in all groups over time, with the HOT group showing consistent improvements at each interval. Correlation analyses revealed no significant associations between device usage or aligner wear time and crowding reduction. Conclusion: Combining LFV and PBM during clear aligner therapy produced greater short-term acceleration of mandibular incisor alignment than either modality alone. Further randomized controlled trials are warranted to confirm long-term efficacy and safety.
