İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Integrating green chemistry principles into the fabrication of MIP electrochemical sensors for heavy metal monitoring
(Taylor & Francis, 2026) Dorreh, Setareh; Kaya, Beril Sena; Aydemir, Zeynep; Al Faysal, Abdullah; Gölcü, Ayşegül
Heavy metal contamination remains a critical global environmental issue due to the persistence, bioaccumulation, and toxicity of metal ions such as Pb2+, Cd2+, Hg2+, and As³+. Although conventional analytical techniques provide high sensitivity and accuracy, they often rely on energy-intensive instrumentation, hazardous reagents, and generate considerable chemical waste, raising concerns regarding their environmental sustainability. In this context, molecularly imprinted polymer (MIP)-based electrochemical sensors have emerged as promising alternatives, offering high selectivity, operational simplicity, and compatibility with miniaturized and in situ analysis. This review critically examines the integration of Green Analytical Chemistry (GAC) principles into the design and fabrication of MIP-based electrochemical sensors for heavy metal monitoring. Particular attention is given to material selection, polymerization strategies, template removal approaches, and electrode modification techniques, with emphasis on their environmental implications. The applicability of quantitative greenness assessment tools, including the Analytical Eco-Scale, GAPI, AGREE, and AGREEMIP, is discussed in the context of sensor development workflows, highlighting both their strengths and current limitations in addressing fabrication stages, nanomaterial synthesis, and end-of-life considerations. By identifying methodological bottlenecks, particularly solvent-intensive template removal and limited reusability, this review outlines practical directions for advancing more sustainable sensor platforms. Overall, the work provides a critical framework for aligning analytical performance with environmental responsibility in next-generation MIP-based electrochemical sensing systems.
Fluoxetine attenuates hepatic ischemia–reperfusion injury through antioxidant, anti‑inflammatory and anti‑apoptotic mechanisms
(Springer Nature Link, 2026) Işık, Musab; Şahin, Gülderen; Kervancıoğlu, Gülnaz; Güner, İbrahim; Yaman, Muhittin Onur; Yelmen, Nermin
Hepatic ischemia–reperfusion injury is a major clinical problem associated with liver surgery, trauma, and transplantation, characterized by oxidative stress, inflammation, microcirculatory dysfunction, and apoptosis. Fluoxetine, a selective sero tonin reuptake inhibitor, has been reported to exert antioxidant, anti-inflammatory, and antiapoptotic effects. The present study aimed to investigate the potential protective effects of fluoxetine against experimental hepatic ischemia–reperfusion injury in rats. Male Wistar rats were randomly assigned to three groups: control, ischemia–reperfusion and fluoxetine-treated ischemia–reperfusion (n = 7 each). Hepatic ischemia–reperfusion injury was induced by infrarenal abdominal aortic cross clamping for 60 min followed by 120 min of reperfusion. Fluoxetine (20 mg/kg/day, intraperitoneal) was administered for three consecutive days prior to ischemia. Oxidative stress markers, antioxidant parameters, inflammatory and anti-inflamma tory cytokines, apoptotic markers, and specific tissue injury biomarkers were measured in liver homogenates using ELISA. Histopathological alterations were evaluated by light microscopy. Ischemia–reperfusion significantly increased oxidant markers, inflammatory cytokines, NF-κB activation, apoptotic indices, liver enzyme levels, and histological damage, while reducing antioxidant capacity. Fluoxetine treatment markedly restored antioxidant defenses, suppressed oxidative stress, inflammation, apoptosis, and microcirculatory injury, and significantly improved histopathological findings compared with the untreated ischemia–reperfusion group. Fluoxetine exerts a protective effect against hepatic ischemia–reperfusion injury through antioxidant, anti-inflammatory and antiapoptotic mechanisms, suggesting its potential as a therapeutic agent in conditions associated with hepatic ischemia–reperfusion.
Inhibition of c-jun n-terminal kinase attenuates diabetic testicular damage via endoplasmic reticulum stress reduction
(Universidad de la Frontera, 2026) Bayram, Şinasi; Ersoy, Onur; Deveci, Engin; Kızılay, Gülnur
The underlying causes of many diabetes-related complications are well known. However, the reasons for the complication related to male reproductive health remain unclear. Hyperglycemia disrupts the balance between oxidants and antioxidants, causing damage to cells, especially ER stress. ER stress triggered by the proteins accumulating in the ER lumen causes apoptosis by activating various pathways. c-Jun N-terminal kinase (JNK) is a key protein in systemic diseases like diabetes, and SP600125 is a widely used JNK inhibitor. This study focuses on whether JNK inhibition by SP600125 prevents diabetic testicular damage by reducing ER stress. In our study, animals were divided into three groups: Control group, the diabetes group, and the JNK inhibition group. Blood glucose level, body and testicular weights, and seminiferous tubule diameters were measured. Seminiferous tubules were evaluated by the Johnsen score in Hematoxyline and Eosin stained sections. Protein expressions of caspase 3, phospho (p)-JNK, caspase 12, and CHOP were evaluated. The Inhibitor group had significantly decreased active caspase-3, (p)-JNK, caspase-12, CHOP values, and blood glucose levels, increased body and testicular weights, seminiferous tubule diameter, and Johnsen score values compared to the diabetes group. JNK inhibition significantly ameliorated the histopathological damage in testicular tissue by preventing diabetes-induced ER stress and apoptosis.
Parental awareness, knowledge, and hesitancy toward HPV vaccination for adolescents: A cross-sectional study
(Sociedad Argentina de Pediatria, 2026) Güven, Deniz; Köle, Mehmet Tolga; Örün, Emel; Çaylan, Nilgün; Küçük, Elif; Kandemir, İbrahim; Öztürk, Seval; Kondolot, Meda
Background. Human papillomavirus (HPV) is a prevalent sexually transmitted infection and major cause of cervical and anogenital cancers. This study aimed to assess parental knowledge, vaccine hesitancy, and health beliefs concerning HPV infection and vaccination. Methods. This cross-sectional study was conducted using convenience sampling among parents of adolescents aged 9–18 attending outpatient clinics at a tertiary hospital. The study collected sociodemographic characteristics and used the Health Belief Model Scale for HPV Infection and Vaccination to assess health beliefs, in order to identify factors associated with parental perceptions and vaccination attitudes. Results. A total of 320 parents participated in the study; 82.8% were mothers. Self-reported HPV infection was low (1.9%), and only 3.4% of parents and 2.8% of their children had been vaccinated. Awareness about HPV infection was 75%, and that of the HPV vaccine was 67.2%. However, only 30% of parents were willing to vaccinate their children, while 47.5% were uncertain. The most commonly reported barriers were lack of awareness (33.9%) and concerns about side effects (26.4%). Higher parental education, family income, and prior HPV knowledge were positively associated with both awareness and willingness to vaccinate children, whereas having multiple adolescents was associated with increased vaccine hesitancy. Conclusion. Parental awareness of HPV infection and vaccination was 75% and 67.2%, respectively, while vaccination rates among adolescents were very low. Higher parental education, income, and prior HPV knowledge were associated with favorable perceptions of vaccination. Addressing knowledge gaps and reducing perceived barriers through educational interventions may help increase HPV vaccination uptake among adolescents.
An innovative approach in gynecologic cancer care: Patient education and symptom management through gamification
(Nobel Tıp Kitabevleri, 2026) Turgut, Ruveyda; Baştarcan, Çisem
Department of Midwifery, Faculty of Health Sciences, Istanbul Beykent University, Istanbul, Turkiye Gyneco logic cancers are among the leading causes of morbidity and mortality in women and lead to multidimen sional physical and psychosocial problems that negatively affect patients’ quality of life. Therefore, the use of innovative approaches in patient education and symptom management has gained increasing importance. The aim of this paper is to examine the contributions of gamification based applications to patient education and symptom management in gynecologic cancer care. This study is a literature based review that addresses the challenges faced by patients with gynecologic cancer during the care process and the potential effects of gamification based interventions. In line with current studies, the theoretical foundations of gamification, its application areas, and its effects on patient outcomes were evaluated. Patients with gynecologic cancer expe rience not only physical symptoms such as pain, fatigue, and limited mobility, but also psychosocial problems including anxiety, depression, and social isolation. These conditions negatively affect treatment adherence and overall quality of life. Gamification is an innovative approach that increases motivation and engagement by incorporating game elements such as points, badges, rewards, feedback, and competition. The literature indicates that gamified mobile applications facilitate medication adherence, improve compliance with treat ment, and support patients in taking a more active role in symptom management. In addition, gamified exercise programs have been shown to enhance physical activity and contribute to the rehabilitation process, while strengthening motivation and self efficacy in psychosocial support processes. It is emphasized that gamification based systems support sustainable learning, particularly through personalized education and feedback mechanisms. In conclusion, gamification stands out as an effective and innovative approach that supports patient education and symptom management in gynecologic cancer care. This approach has the potential to improve quality of life by increasing patients’ active participation in their treatment processes. However, there is a need for large scale, randomized controlled studies to evaluate the effectiveness of gam ification applications in the field of gynecologic oncology. It is recommended that healthcare professionals integrate gamification based applications into patient centered care models.
