İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Clinical characteristics of peripheral joint disease in axial and peripheral spondyloarthritis: Findings from a multicentre cross sectional study
(2025) Sarıyıldız, Emine; Duruöz, Mehmet Tuncay; Gezer, Halise Hande; Aktaş, İlknur; Akar, Servet; Hizmetli, Sami; Şahin, Nilay; Akgül, Özgür; Alkan Melikoğlu, Meltem; Sezer, İlhan; Ataman, Şebnem; Ural Nazlıkul, Fatma Gülçin; Çapkın, Erhan; Yılmaz, Figen; Kalyoncu, Umut
Peripheral joint disease (PJD) is the most common peripheral manifestation in spondyloarthritis (SpA) patients. This study aimed to determine PJD characteristics and associated factors in patients with axial SpA (AxSpA) and peripheral SpA (pSpA). This cross-sectional and multicenter study involved 13 different rheumatology and physical medicine & reha bilitation clinics, and patients diagnosed with axSpA or pSpA were included in the study. PJD was defined as the ‘ever’ related to SpA according to the physician. Multivariable analyses were conducted to identify factors associated with PJD. A total of 394 patients were enrolled in the study (57.6% male, mean age 40.8 years), of whom 359 (91.1%) were clas sified as AxSpA and 35 (8.9%) as pSpA. Peripheral arthritis was reported in 118 patients (29.9%), comprising 85 (72%) with AxSpA and 33 (28%) with pSpA. Among the whole population with PJD, the main joint involvement pattern was monoarticular (33.9%, n=40) and oligoarticular (49.2%, n=58). The rate of predominantly lower limb and large joint involvement was approximately 60% (n=68) and the major course of PJD was transient (42.4%, n=50) and intermit tent (40.7%, n=48). pSpA patients had a higher rate of persistent (33.3% vs. 14.3%, p=0.021) and progressive arthritis (15.2% vs. 1.2%, p=0.007). The coexistence of PJD with other peripheral involvement and extra-articular manifestations excluding psoriasis was widespread. Dactylitis, enthesitis, and high CRP level were positively associated with PJD; on the contrary, ever alcohol intake, presence of sacroiliitis on MRI, and family history for SpA were negatively associated. PJD was accompanied by both other peripheral involvements and extra-articular manifestations, excluding psoriasis and the course of PJD was more persistent in pSpA patients. This undoubtedly contributes to an increased disease burden.
Insufficient impact of the aldose reductase inhibitor cemtirestat on the skeletal system in type 2 diabetic rat model
(Public Library of Science, 2025) Martiniakova, Monika; Prnova, Marta Soltesova; Kovacova, Veronika; Mondockova, Vladimira; Svik, Karol; Londzin, Piotr; Folwarczna, Joanna; Omelka, Radoslav; Dikmen, Tayfun
Cemtirestat, a multi-target drug combining aldose reductase inhibition with antiox idant properties, is considered a promising therapeutic agent for chronic diabetic complications. Current evidence suggests that long-standing diabetes adversely affects skeletal health, leading to diabetic bone disease. As the impact of cemtirestat on the skeletal system in an animal model of type 2 diabetes mellitus (T2DM) is still unknown, our study first investigated its effect on impaired bone health in Zucker dia betic fatty (ZDF) rats. Adult rats were divided into four groups: L (untreated lean ZDF rats), D (untreated obese ZDF rats), DT2.5 (obese ZDF rats treated with 2.5mg/kg/ day cemtirestat), and DT7.5 (obese ZDF rats treated with 7.5mg/kg/day cemtirestat), with cemtirestat treatment lasting 2 months. Group D had increased levels of plasma glucose, insulin, triglycerides, glycated hemoglobin, total cholesterol, alkaline phos phatase, alanine aminotransferase, C-terminal telopeptide of type 1 collagen, greater body weight, femoral weight, structure model index, reduced cortical bone volume fraction, cortical bone thickness, trabecular bone volume fraction, and trabecular thickness compared to group L. Cemtirestat supplementation only elevated plasma phosphate levels in group DT2.5, trabecular bone volume fraction and trabecu lar thickness in group DT7.5, but the treatment had no effect on other parameters demonstrated in ZDF rats by macroscopic analysis, micro-CT cortical bone analysis, and mechanical testing. These findings indicate that the efficacy of cemtirestat in restoring deteriorated bone health caused by T2DM is not substantiated due to its insufficient effect on the skeletal system in the ZDF rat model.
Evaluation of the prevalence and location of second mesiobuccal canals in 2100 upper first and second molar teeth: A cone beam computed tomography study
(Inonu University, 2025) Kaplan, Bahar; Adıgüzel, Özkan; Öner Talmaç, Ayşe Gül; Aslan Öztürk, Elif Meltem
It is essential to undertake thorough preparation, debridement and filling of all root canals in order to achieve a clinically successful treatment outcome. A total of 525 CBCT images of both maxillary first and second molars were analyzed. The observations and measurements were positioned 1 millimeter (mm) apically from the pulp base to standardize the methodology for the detection of the second mesiobuccal canal (MB2). To assess the distances between the canals and the relationship between the presence of MB2 and mesiobuccal (MB) root length, MB root length was quantified in millimeters. IBM SPSS Version 21.0 was employed for statistical analyses, with a type I error level of 5% accepted. MB2 was identified in 36.5% of the first maxillary molar (1MM) and second maxillary molar (2MM) teeth of the patients included in the study. When the frequency of MB2 was evaluated according to gender and right-left side, no statistically significant difference was found (p>0.05). When examining the relationship between the presence of MB2 and the length of the MB root, it was observed that only in the left second molars with MB2 present, the root length was slightly shorter. It is our contention that this study will furnish dentists with crucial data that will enhance the efficacy of root canal therapy for these teeth.
Challenges and strategies in effective nursing leadership: Viewpoints of nurses in management positions – A qualitative study
(Emerald Publishing, 2025) Aydoğdu, Ana Luiza Ferreira
Purpose – To explore the viewpoints of nurses in management positions on the challenges they face and the strategies they use to promote effective leadership in the nursing workplace. Design/methodology/approach – This qualitative study involved 42 Brazilian nurses in management positions, working in various settings across Brazil, who responded to open-ended online questions between January 1, 2025 and February 15, 2025. Findings – Five themes were identified: (1) highlighted leadership styles, (2) difficulties of leading the nursing team, (3)strategies used to solve problemsin the leadership process, (4) learning to lead and (5) making nursing leadership more effective. Research limitations/implications – The study presents important perspectives from nurses in managerial positions on the key role that effective leadership plays in fostering healthy work environments in nursing. Nevertheless, it hassome limitations, including the use ofself-report questionnaires, regional imbalance among participants, potential bias due to data analysis being conducted by a single researcher and the absence of an assessment based on the leader–member exchange framework. Practical implications – Nurses in management positions recognize the importance of empowering team members. Nurse managersshould receive proper education to competently assume theirleadership responsibilities. Originality/value – The study highlights the need to revise nursing curricula to incorporate early and continuous leadership education, supported by ongoing in-service programs. It also emphasizes the importance of fostering team cohesion through open communication, mutual respect and shared goals. Additionally, it is pointed out that upper managementshould empower nurse leaders at all levels and provide regular, constructive feedback to support effective leadership.
Investigation of the effects of fluoride varnish, silver diamine fluoride and peptide P11-4 on dentin nanostructure in an in-vitro dentin caries model via SEM, FTIR spectroscopy and SAXS methods
(MRE Press, 2025) Yoğurucu Değerli, Gizem; Güven Polat, Günseli; İde, Semra; Bülbül, Onurcan
Background: To evaluate and compare the structural effects of fluoride varnish, silver diamine fluoride (SDF), and peptide P11-4 on dentin nanostructure in an in vitro dentin caries model. Methods: Forty dentin discs were demineralized and treated with either SDF, fluoride varnish or P11-4. Structural changes were assessed using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and small angle X-ray scattering (SAXS) to evaluate topographical, molecular and nanoscale modifications. Results: SEM revealed morphological differences across groups: the P11-4 group showed fibrillar structures and narrowed dentinal tubules; the SDF group exhibited blocked tubules with a granular appearance; and the fluoride varnish group presented partially occluded tubules. FTIR analysis showed a reduction in Amide A and Amide I bands in the P11-4 group, suggesting enhanced interaction with dentin collagen and early-stage remineralization. In contrast, the SDF group showed higher Amide A values, indicating limited interaction with the organic matrix. These spectral shifts imply differential impacts on the preservation and reorganization of the dentin matrix. SAXS analysis confirmed that the P11-4 group exhibited the closest nanostructural resemblance to healthy dentin, whereas the SDF group showed the least similarity. Both the P11-4 and fluoride varnish groups demonstrated organized fibrillar alignment and improved mineral patterning. Conclusions: The findings suggest that P11-4, through its biomimetic action, facilitates favorable nanostructural and molecular changes in demineralized dentin. These effects may contribute to enhanced mechanical stability and long-term clinical outcomes. Broader in vivo studies are warranted to validate these results before clinical application.
