İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Güncel Gönderiler
Inhibition of c-jun n-terminal kinase attenuates diabetic testicular damage via endoplasmic reticulum stress reduction
(Universidad de la Frontera, 2026) Bayram, Şinasi; Ersoy, Onur; Deveci, Engin; Kızılay, Gülnur
The underlying causes of many diabetes-related complications are well known. However, the reasons for the complication related to male reproductive health remain unclear. Hyperglycemia disrupts the balance between oxidants and antioxidants, causing damage to cells, especially ER stress. ER stress triggered by the proteins accumulating in the ER lumen causes apoptosis by activating various pathways. c-Jun N-terminal kinase (JNK) is a key protein in systemic diseases like diabetes, and SP600125 is a widely used JNK inhibitor. This study focuses on whether JNK inhibition by SP600125 prevents diabetic testicular damage by reducing ER stress. In our study, animals were divided into three groups: Control group, the diabetes group, and the JNK inhibition group. Blood glucose level, body and testicular weights, and seminiferous tubule diameters were measured. Seminiferous tubules were evaluated by the Johnsen score in Hematoxyline and Eosin stained sections. Protein expressions of caspase 3, phospho (p)-JNK, caspase 12, and CHOP were evaluated. The Inhibitor group had significantly decreased active caspase-3, (p)-JNK, caspase-12, CHOP values, and blood glucose levels, increased body and testicular weights, seminiferous tubule diameter, and Johnsen score values compared to the diabetes group. JNK inhibition significantly ameliorated the histopathological damage in testicular tissue by preventing diabetes-induced ER stress and apoptosis.
Parental awareness, knowledge, and hesitancy toward HPV vaccination for adolescents: A cross-sectional study
(Sociedad Argentina de Pediatria, 2026) Güven, Deniz; Köle, Mehmet Tolga; Örün, Emel; Çaylan, Nilgün; Küçük, Elif; Kandemir, İbrahim; Öztürk, Seval; Kondolot, Meda
Background. Human papillomavirus (HPV) is a prevalent sexually transmitted infection and major cause of cervical and anogenital cancers. This study aimed to assess parental knowledge, vaccine hesitancy, and health beliefs concerning HPV infection and vaccination. Methods. This cross-sectional study was conducted using convenience sampling among parents of adolescents aged 9–18 attending outpatient clinics at a tertiary hospital. The study collected sociodemographic characteristics and used the Health Belief Model Scale for HPV Infection and Vaccination to assess health beliefs, in order to identify factors associated with parental perceptions and vaccination attitudes. Results. A total of 320 parents participated in the study; 82.8% were mothers. Self-reported HPV infection was low (1.9%), and only 3.4% of parents and 2.8% of their children had been vaccinated. Awareness about HPV infection was 75%, and that of the HPV vaccine was 67.2%. However, only 30% of parents were willing to vaccinate their children, while 47.5% were uncertain. The most commonly reported barriers were lack of awareness (33.9%) and concerns about side effects (26.4%). Higher parental education, family income, and prior HPV knowledge were positively associated with both awareness and willingness to vaccinate children, whereas having multiple adolescents was associated with increased vaccine hesitancy. Conclusion. Parental awareness of HPV infection and vaccination was 75% and 67.2%, respectively, while vaccination rates among adolescents were very low. Higher parental education, income, and prior HPV knowledge were associated with favorable perceptions of vaccination. Addressing knowledge gaps and reducing perceived barriers through educational interventions may help increase HPV vaccination uptake among adolescents.
An innovative approach in gynecologic cancer care: Patient education and symptom management through gamification
(Nobel Tıp Kitabevleri, 2026) Turgut, Ruveyda; Baştarcan, Çisem
Department of Midwifery, Faculty of Health Sciences, Istanbul Beykent University, Istanbul, Turkiye Gyneco logic cancers are among the leading causes of morbidity and mortality in women and lead to multidimen sional physical and psychosocial problems that negatively affect patients’ quality of life. Therefore, the use of innovative approaches in patient education and symptom management has gained increasing importance. The aim of this paper is to examine the contributions of gamification based applications to patient education and symptom management in gynecologic cancer care. This study is a literature based review that addresses the challenges faced by patients with gynecologic cancer during the care process and the potential effects of gamification based interventions. In line with current studies, the theoretical foundations of gamification, its application areas, and its effects on patient outcomes were evaluated. Patients with gynecologic cancer expe rience not only physical symptoms such as pain, fatigue, and limited mobility, but also psychosocial problems including anxiety, depression, and social isolation. These conditions negatively affect treatment adherence and overall quality of life. Gamification is an innovative approach that increases motivation and engagement by incorporating game elements such as points, badges, rewards, feedback, and competition. The literature indicates that gamified mobile applications facilitate medication adherence, improve compliance with treat ment, and support patients in taking a more active role in symptom management. In addition, gamified exercise programs have been shown to enhance physical activity and contribute to the rehabilitation process, while strengthening motivation and self efficacy in psychosocial support processes. It is emphasized that gamification based systems support sustainable learning, particularly through personalized education and feedback mechanisms. In conclusion, gamification stands out as an effective and innovative approach that supports patient education and symptom management in gynecologic cancer care. This approach has the potential to improve quality of life by increasing patients’ active participation in their treatment processes. However, there is a need for large scale, randomized controlled studies to evaluate the effectiveness of gam ification applications in the field of gynecologic oncology. It is recommended that healthcare professionals integrate gamification based applications into patient centered care models.
Effects of sunflower oil biodiesel blends on diesel engine performance and emissions
(International Researcher Association, 2026) Tunçer, Erdal; Kaya, Yalçın; Akal, Dinçer
The environmental impacts and limited reserves of fossil fuels have increasingly highlighted the importance of alternative fuel sources. In this study, the effects of a sunflower oil biodiesel–diesel blend on the performance, fuel consumption, and exhaust emissions of a single-cylinder diesel engine were experimentally investigated. During the tests, pure diesel fuel (B0) and a blend containing 90% diesel and 10% sunflower biodiesel (B10) were evaluated under various load conditions. After the engine reached steady-state operating temperature, power output, fuel consumption, and exhaust emissions were measured. The findings indicate that the biodiesel blend does not adversely affect engine power and provides performance comparable to pure diesel at all load levels. While fuel consumption was similar at low and medium loads, a measurable reduction was observed at high loads when using the biodiesel blend, which is attributed to the improved combustion associated with the fuel’s higher oxygen content. Regarding exhaust emissions, the addition of biodiesel resulted in reductions in CO and HC emissions, whereas a slight increase in NOₓ emissions was observed. This increase is attributed to higher combustion temperatures and is considered manageable through appropriate emission-control strategies. In conclusion, the sunflower biodiesel blend enhances fuel efficiency while maintaining engine performance and offering environmental benefits; however, additional measures may be required to mitigate elevated NOₓ emissions.
Prospective MRI-based comparison of graft maturation after ACL reconstruction using quadriceps versus hamstring tendon autograft
(SAGE Publications, 2026) Erden, Tunay; Ağır, Muzaffer; Kayaalp, M. Enes; Toker, Berkin; Taşer, Ömer
Background: Biological graft maturation after anterior cruciate ligament (ACL) reconstruction is a prolonged and heterogeneous process that may not directly correlate with clinical recovery. Magnetic resonance imaging (MRI)–based signal intensity ratio (SIR) is widely used as an indirect marker of graft remodeling and early maturation. However, comparative data regarding MRI-based graft maturation between quadriceps tendon (QT) and hamstring tendon (HT) autografts remain limited. Purpose: To compare graft maturation between all–soft tissue QT autografts and HT autografts using quantitative MRI-based SIR at 6 and 12 months after primary all-inside ACL reconstruction in athletes. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 76 athletes undergoing primary all-inside ACL reconstruction were prospectively enrolled. QT autografts were used in 39 patients and HT autografts in 37 patients. All patients followed a standardized postoperative rehabilitation protocol and underwent 3.0-T MRI evaluation at 6 and 12 months. Graft maturation was assessed using SIR measurements obtained from standardized regions of interest along the intra-articular graft, with the posterior cruciate ligament used as reference. Interob server reliability was evaluated using intraclass correlation coefficients (ICCs). Results: Baseline patient characteristics and associated surgical procedures did not differ between groups (all P . .05). At both 6 and 12 months postoperatively, the mean SIR values were similar between QT and HT autografts (P . .05). Within-group analysis showed a significant decrease in SIR values from 6 to 12 months in both groups (P\.05), indicating progressive graft maturation. The magnitude of SIR change did not differ between groups (P . .05). Interobserver reliability was excellent, with ICC(2,1) values of 0.98 at 6 months and 0.98 at 12 months. Conclusion: Quantitative MRI-based assessment using SIR demonstrated no significant difference in graft maturation between all–soft tissue QT and HT autografts at 6 and 12 months after primary all-inside ACL reconstruction. Both graft types showed comparable MRI-based maturation profiles during the early postoperative period, supporting QT autografts as a reliable alterna tive to HT autografts in athletic populations.
