İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
A quality by design study of the use of microfluidic nanoprecipitation for the generation of sub-100 nm drug nanocrystals
(Elsevier, 2026) Pirinçci Tok, Yağmur; Abukhamees, Shorooq; Fitaihi, Rawan; Demiralp, Burcu; Özsoy, Yıldız; Craig, Duncan
Although drug nanocrystals have attracted considerable interest within the pharmaceutical industry, there remain issues with the production of nanocrystals with a size below 100 nm. The aim of the present study is to develop a stable, reproducible Canagliflozin (CFZ) sub-100 nm nanosuspension system using microfluidic nanoprecipitation and Quality by Design (QbD) techniques. By means of the circumscribed central composite design (CCCD), critical parameters of the microfluidic nanoprecipitation process and nanosuspension formula tion components were optimised. Optimal CFZ nanosuspension with Z-average of 89.52 ± 3.30 nm, PDI of 0.12 ± 0.01 and drug content of 92.49 ± 0.03 % was successfully fabricated using Soluplus as a stabiliser. An increase in saturation solubility corresponding to approximately 250 times the value of the pure CFZ in water was noted. The optimised CFZ nanosuspension was solidified by freeze-drying and electrospraying. Overall, the study has demonstrated that by using a combination of microfluidics and QbD it is promising to generate stable sub-100 nm nanocrystals with high yield, and narrow size distribution and favourable stability.
The effect of swot analysis on the sustainability approach of a leading Turkish maritime construction company
(Renewable Energy Association of Turkey, 2026) Özil, Eralp; Yurtsever, Özlem; Çelik, Mustafa Cem; Uyar , Tanay Sıdkı; Saydam, Alper
The EU’s mandatory Corporate Sustainability Reporting Directive (CSRD) is based on the widely used GRI framework but significantly introduc es the concept of “dual materiality”, which requires companies to report both their impacts on society and the environment, and how sustainability issues af fect the company itself. This study practically demonstrates the importance of a SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis to be applied at the initial stage to reveal this “double materiality” when preparing a sustaina bility report for a company. In the context of the application in question, the de sign of the SWOT analysis, the objectives of the questions, the interpretation of the analysis results, and the effects of the findings on the sustainability report study and sustainability goals are presented.
Retrospective analysis of outcomes following expandable titanium cage and iliac graft applications in patients undergoing corpectomy for cervical spinal canal stenosis
(Galenos Publishing House, 2026) Demir, Hüseyin; Şanlıer, Nafiye
Introduction This study aimed to compare the clinical and radiological outcomes of iliac crest autografts and expandable titanium cages in anterior cervical column reconstruction among patients undergoing cervical corpectomy for cervical spinal stenosis. Methods A retrospective analysis of 93 patients who underwent anterior cervical corpectomy between 2016 and 2023 was conducted; 61 were treated with iliac grafts and 32 with expandable cages. Clinical efficacy was assessed using the modified Japanese Orthopaedic Association (mJOA) score, while radiological outcomes were evaluated by measuring cervical lordosis (C2-C7 Cobb angle), intervertebral height, and fusion status, three months post-surgery. Complications, operative duration, and revision surgery rates were also analysed. Results Both the iliac graft and cage groups demonstrated significant postoperative improvements in mJOA scores (p<0.001). The iliac graft group exhibited superior early correction of cervical kyphosis, with the Cobb angle increasing from 3.17° to 9.12° (p<0.001), compared with the cage group’s increase from 0.99° to 5.83° (p=0.025). Cervical alignment remained more stable over time in the iliac graft group. Complication rates were comparable between the groups; however, graft displacement occurred more frequently in the iliac graft group. In contrast, cage malposition occasionally necessitated revision surgery. Conclusion Both iliac grafts and expandable cages are effective for anterior cervical reconstruction, yielding comparable clinical outcomes and complication rates. Iliac grafts may be better suited for achieving immediate postoperative correction and maintaining stable long-term alignment. The choice of surgical technique should take into account specific patient needs and the distinct risk profiles associated with each method.
Preparation and in vitro characterisation of nanofibers for enhancing the water solubility of poorly soluble drugs
(İstanbul University Press, 2025) Karamürsel, Elif; Uzel, Egemen; Aydilek, Neriman; Durgun, Meltem Ezgi; Özsoy, Yıldız
Background and Aims: As the drug discoveries of the modern century have led to a rapid increase in the number of new drug candidates with low water solubility, nanofiber drug delivery systems have become a promising technology to increase the water solubility of drugs with a high surface-to-volume ratio. In this study, we aimed to prepare a nanofiber of a molecule with low water solubility and investigate its changing solubility properties. Methods: Three nanofiber dosage forms containing olanzapine (OLZ) active substance were developed by the electrospinning method using polyvinyl alcohol (PVA) polymer. Drug loading efficiency, zeta potential determination, electrical conductivity, rheology, field emission scanning electron microscopy (FESEM), Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) analyses were performed to evaluate the in vitro characterisation of the formulations. The solubility profile of the optimised formulations in pH 7.4 phosphate buffer was evaluated. The stability of optimised formulations was evaluated in terms of physical properties (colour, shape, weight, diameter, and thickness) and drug amount for 35 days. Results: It was determined that the electrospinning property of the nanofiber preparation solution increased with the addition of ethanol to the polymer solvent medium. The active substance distribution in the nanofiber layer was more homogeneous in the N78 and N79 coded formulations with high zeta potential values compared to N69. Contrary to the homogeneous distribution problem, the loading efficiency of the N69-coded formulation containing chloroform (~29%) was higher than that of N79 (~9.8%). A 24-h solubility study in pH 7.4 phosphate buffer of the N78-coded formulation, which has an active ingredient loading efficiency of ~80.4%, confirmed the increased solubility of OLZ in water in the nanofiber drug delivery system. Conclusion: Further studies are needed to convert these model formulations into final drug products.
Logistics operations management in the industry 4.0 era: A case study for transition of an automotive company′s operations to fourth-party logistics structure
(Vilnius Gediminas Technical University, 2025) Döner, Hülya; Vayvay, Özalp; Vardarlıer, Pelin; Kalender, Zeynep Tuğçe
In recent years, the understanding of minimum inventory and customer satisfaction in the flow of goods and services from manufacturers to end-users is of great importance among the factors that make businesses more interested in outsourcing logistics activities. Additionally, technological transformation and customer requests for complicated technology and services caused the appearance of new circumstances, which is progressively altering the industry. In this regard, choosing, managing and coordinating between multiple vendors become very difficult and time consuming so, companies outsource more functions while supply chain operations getting more complex. Companies generally preferred 3PL providers for their logistics functions including packaging design and management of company-owned assets. On the other hand, with technological transformation in logistic sector, businesses are looking to outsource 4PL more than ever. 4PL system transitions are difficult processes since it requires comprehensive system integration and should be well understood by the company′s supply chain team. Today, although the importance of 4PL systems is more understood and this structure is becoming more widespread, many companies still face similar adaptation problems. From this point of view, it is believed that this study creates important insights into the business world. In this study, the transition process of an automotive company is examined which successfully completed after a 5-month project period. As a detailed case study, the Transportation Management Module (TTM) is selected since the whole transition process was very comprehensive and included many dimensions. Study revealed that adaptation of the new system, developed by the partnership of the automotive company and 4PL company, provided several benefits. In this sense, with the transition of Transportation Management (TM), TTM is reduced by 2 days, almost 10% savings are reported in the whole company and only in the Turkey branch, 243311 € cost saving is achieved in the 1st year. The study proves that focusing on the core business via outsourcing supply chain activities not only increases efficiency in the selected automotive company but also increases supply chain quality as well.
