İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Güncel Gönderiler
Restless legs syndrome in children with celiac disease: Associations with vitamin D and iron deficiency and the role of gluten-free diet adherence
(BioMed Central, 2026) Cebe Tok, Ayşegül; Köle, Mehmet Tolga; Güven, Deniz; Tehçi̇, Ali Kansu; Kandemi̇r, İbrahim
Background Celiac disease (CD) is a systemic autoimmune disorder frequently associated with micronutrient deficiencies and extraintestinal manifestations, including neurological complications. Restless Legs Syndrome (RLS) is a sensorimotor disorder linked to dopaminergic dysfunction and iron and vitamin D deficiency, both of which are common in pediatric CD. Objective To evaluate the prevalence and severity of RLS in children with CD and to investigate the associations between RLS symptoms and serum vitamin D and iron parameters, as well as the potential effect of gluten-free diet (GFD) adherence. Methods This prospective cross-sectional study included 67 children with CD (aged 10–18 years) and 68 age- and sex-matched healthy controls. RLS was assessed using the International Restless Legs Syndrome Study Group rating scale. Demographic, anthropometric, clinical, and biochemical data—including serum iron, ferritin, folate, vitamin B12, and 25-hydroxyvitamin D—were recorded. Group comparisons were performed using appropriate parametric or non-parametric tests. Associations were evaluated using Spearman correlation and Bayesian correlation analyses. Results RLS scores were significantly higher in the CD group compared with controls (median 6 [0–13] vs. 0 [0–0]; p < 0.001), and RLS duration was also longer in children with CD (p < 0.001). Serum vitamin D levels showed a significant negative correlation with RLS scores (r = −0.251, p < 0.05). RLS duration demonstrated a strong positive correlation with RLS severity (r = 0.838, p < 0.001). Transglutaminase IgA levels were inversely correlated with ferritin (r = −0.417, p < 0.001) and folate levels (r = −0.332, p < 0.05), while transglutaminase IgG levels were negatively correlated with ferritin (r = −0.285, p < 0.05) and vitamin D (r = −0.304, p < 0.05). Bayesian correlation analysis revealed no strong associations between Marsh classification and most clinical or biochemical variables, except for a strong association between RLS duration and severity (BF₁₀ > 100). Adherence to a gluten-free diet was not significantly associated with RLS severity (p > 0.05). Conclusions Children with celiac disease exhibit significantly higher RLS symptom severity than healthy peers. Lower serum vitamin D levels and reduced iron stores appear to be associated with increased RLS severity, regardless of Marsh stage or dietary adherence. These findings highlight the potential value of screening for RLS and monitoring vitamin D and ferritin levels in pediatric patients with celiac disease.
Double materiality and SWOT analysis: A practical framework for environmental impact and sustainability assessment
(Inderscience, 2026) Yurtsever, Özlem; Çelik, Mustafa Cem; Uyar, Tanay Sıdkı
Double materiality is becoming a necessity in sustainability reporting, as it is essential for aligning organisational strategies with ESG priorities. This study proposes a framework to embed SWOT analysis within sustainability reporting, focusing on double materiality. By positioning SWOT as a bridge, the framework enables a holistic evaluation of internal capabilities and external ESG-related risks and opportunities. It encourages periodic updates to question sets, supporting an evolving, stakeholder-inclusive process aligned with annual reporting cycles. This approach offers organisations a practical reference to develop transparent, credible, and adaptable sustainability disclosures, reinforcing their strategic decision-making and compliance with increasingly complex reporting standards.
Anxiety levels and associated sociodemographic factors in mothers of children with first febrile seizures: A case-control study
(Elsevier, 2026) Küçük, Elif; Köle, Mehmet Tolga; Erkin, Gökşen; Kandemir, İbrahim; Hüsrevoğlu Esen, Feyza; Güven, Deniz; Uysal, Feride; Akın, Yasemin
Objective: The prognosis of febrile seizures (FS) is generally favorable; however, a child's first febrile seizure can be distressing for parents. The aim of this study was to assess the anxiety levels of mothers whose children present to the pediatric emergency department with FS for the first time and to examine the relationship between these anxiety levels and the sociodemographic characteristics of the mothers. Methods: This case-control study included mothers presenting for the first time to the pediatric emergency department of our hospital with children aged 6 months to 6 years, either for simple FS or for fever without seizures. Maternal anxiety levels were assessed using the State–Trait Anxiety Inventory (STAI) approximately 12 h after the initial seizure. Sociodemographic characteristics were also collected, and the relationship between these characteristics and anxiety levels was analyzed. Results: A total of 103 participants (52 in the FS group, 51 controls) were included. Higher maternal education and family income were associated with lower STAI-S and STAI-T scores. The FS group had significantly higher mean STAI-S (p < 0.001) and STAI-T (p = 0.007) scores, by 14.6 and 3.6 points, respectively. Multivariate analyses revealed that income was a significant confounder for both STAI-T and STAI-S. Conclusion: Mothers of children with FS report higher levels of anxiety. Sociodemographic factors, such as income and maternal education level, play a significant role in maternal anxiety levels. Targeted educational and support programs addressing income inequalities in healthcare could help reduce maternal anxiety and improve the management of FS.
Assessment of antioxidant performance of silybum marianum extract as a natural antioxidant additive in polyethylene by time-dependent melt rheology tests
(Springer Nature Link, 2026) Alanalp, Mine Begüm; Şıdım, Gizem; Mirmahmutoğulları, Esra; Pınar, Özlem; Durmuş, Ali
In this study, Silybum marianum (SM) extract as a natural primary antioxidant (PAO) additive was introduced into low density polyethylene. This primary antioxi dant was supported by a commercial grade secondary antioxidant (SAO, Irgafos® 168). The effect of compositional variations, mainly amount of SM and the weight ratio of PAO: SAO in the composition, on the thermooxidative stability of low density polyethylene (LDPE) was characterized by determining the thermal param eters, oxygen induction time (OIT) and oxidation onset temperature (OOT) using conventional thermal analysis methods performed in a DSC in air atmosphere. Fur thermore, time-dependent rheology test procedures were suggested for monitoring the thermooxidative degradation behavior of antioxidant-loaded compounds. It was found that SM loading of 0.2 or 0.5 wt% provided sufficient oxidation stability in polyethylene, at least 5 min at 240 °C under air when supported by introducing two- or three-fold of SAO. It can be concluded that these SM-Irgafos® 168 antioxi dant packages can be successfully used in polyethylenes processed in conventional melt processing windows that can be varied in 180–240 °C, in processing devices (e.g., compounder, kneader, extruders, injection molding, rotomolding) because the obtained thermorheooxidative stability times are longer than the residence time of polymer melts, approximately in the range of 1–4 min from the melting zone to die during the extrusion process.
Survival at stake: Surgical decision-making in metastatic femoral
(Acta Medica Belgica, 2025) Yücesan, Ali; Arıkan, Yavuz; Toy, Serdar; Karaduman, Volkan; Özer, Devrim
Pathological femoral fractures resulting from primary or metastatic tumors represent a complex clinical challenge for orthopedic surgeons, often requiring individualized treatment strategies. This retrospective study aimed to evaluate and compare the outcomes of different surgical approaches used in the management of pathological femoral fractures secondary to metastatic disease. A total of 46 patients (52 femoral fractures) who underwent surgical treatment between 2020 and 2023 were included in the study. Data collected encompassed demographic characteristics, tumor histology, surgical techniques employed, and clinical outcomes. Statistical analysis was conducted using appropriate parametric and non-parametric tests, depending on data distribution. Of the patients included, 51% underwent tumor resection followed by endoprosthetic reconstruction, 40% were treated with intramedullary nailing, and 9.4% underwent plate osteosynthesis. The highest postoperative mortality rate was observed among patients with lung cancer metastases. Blood transfusions were necessary in 66% of cases. The overall mean survival time following surgery was 4.5 months, with significant variation according to tumor type and metastatic burden. The findings of this study underscore the importance of a multidisciplinary approach in the surgical management of pathological femoral fractures caused by metastatic tumors. Surgical interventions such as intramedullary nailing, plate fixation, and endoprosthetic reconstruction can effectively restore mechanical stability and contribute to improved patient quality of life. Selection of the optimal surgical technique should be guided by tumor histopathology, anatomical location and extent of bone involvement, number of metastatic lesions, and overall patient prognosis. Timely and appropriate surgical intervention remains critical to minimizing complications and enhancing survival outcomes in this patient population.
