İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Hepatoprotective potential of urtica dioica
(Orient Yayınları, 2025) Ekici, Miraç; Tuncay, Hüseyin Onur; Dündar, Ahmet; Koçyiğit, Mine; Haspolat, Yusuf Kenan
Liver diseases represent a significant global health burden, a ecting millions of people worldwide and contributing substantially to morbidity and mortality (1). e spectrum of hepatic disorders ranges from acute drug-induced liver injury to chronic conditions such as non-alcoholic fatty liver disease (NAFLD), viral hepatitis, cirrhosis, and hepatocellular carcinoma (2). Despite advances in conventional pharmacotherapy, many existing treatments are associated with limited e#cacy, adverse e ects, and high costs, prompting increased interest in comple mentary and alternative therapeutic approaches (3).
Finite element analysis and production of a balance robot designed to be used in the field of advertising
(Kerim ÇETİNKAYA, 2025) Coşkun, Yusuf; Aydın, Diyar Can; Aktoz, Halil; Özyılmaz, Lale
This study presents the finite element analysis and prototype development of a self-balancing robot designed for applications in the advertising sector. The structural behavior and dynamic properties of the robot were analyzed using static, modal, and rigid body simulations in ANSYS software. Static analysis confirmed the mechanical durability of the robot by evaluating the forces acting on the motors and body, while modal analysis identified potential resonance conditions. Notably, in the third vibration mode, a deformation of 330.24 mm at 52.169 Hz was observed, indicating a critical resonance issue. To enhance structural efficiency, topology optimization was applied to the outer casing, resulting in a 14% reduction in mass (from 0.45392 kg to 0.39069 kg) while maintaining structural integrity. During the experimental phase, the prototype successfully demonstrated autonomous movement using integrated distance sensors. However, initial tests revealed a wobbling motion due to insufficient motor power, which will be addressed in future iterations by incorporating higher-torque motors. The proposed robot has the potential to serve as an interactive advertising tool, capable of attracting attention through dynamic motion and engaging promotional content display. Future work will focus on enhancing stability and refining control algorithms to improve performance in real-world advertising environments.
Obezite ve meme kanseri arasındaki biyolojik bağlantılar: Hücresel ve moleküler düzeyde etkileşimler
(Orient Yayınları, 2025) Tüzüner, Mete Bora; Teoman AKÇAY; Haspolat, Yusuf Kenan; Akçay, Teoman; Orbak, Zerrin
Obezite, başta meme kanseri olmak üzere pek çok kanser türünün görülme sıklığını ve ilerleyişini artıran önemli bir risk faktörüdür. Obezite ile meme kanseri arasındaki ilişki, karmaşık ve çok katmanlı biyolojik süreçlerle şekillenir; bu süreçlerin merkezinde metabolik ve immün sistem bozuklukları yer alır. Özellikle beyaz adipoz dokusunda (WAT) ortaya çıkan kronik düşük dereceli inflamasyon, proinflamatuvar sitokinlerde artış, alternatif makrofaj aktivasyonu ve T hücresi işlevlerinde azalma gibi bağışıklık sistemi düzensizliklerine yol açar. Meme dokusunun büyük ölçüde WAT’tan oluşması, gelişmekte olan tümör hücrelerinin obezite ile yeniden programlanmış mikroçevreyle doğrudan etkileşim hâlinde ol masına olanak tanır.
A quality by design study of the use of microfluidic nanoprecipitation for the generation of sub-100 nm drug nanocrystals
(Elsevier, 2026) Pirinçci Tok, Yağmur; Abukhamees, Shorooq; Fitaihi, Rawan; Demiralp, Burcu; Özsoy, Yıldız; Craig, Duncan
Although drug nanocrystals have attracted considerable interest within the pharmaceutical industry, there remain issues with the production of nanocrystals with a size below 100 nm. The aim of the present study is to develop a stable, reproducible Canagliflozin (CFZ) sub-100 nm nanosuspension system using microfluidic nanoprecipitation and Quality by Design (QbD) techniques. By means of the circumscribed central composite design (CCCD), critical parameters of the microfluidic nanoprecipitation process and nanosuspension formula tion components were optimised. Optimal CFZ nanosuspension with Z-average of 89.52 ± 3.30 nm, PDI of 0.12 ± 0.01 and drug content of 92.49 ± 0.03 % was successfully fabricated using Soluplus as a stabiliser. An increase in saturation solubility corresponding to approximately 250 times the value of the pure CFZ in water was noted. The optimised CFZ nanosuspension was solidified by freeze-drying and electrospraying. Overall, the study has demonstrated that by using a combination of microfluidics and QbD it is promising to generate stable sub-100 nm nanocrystals with high yield, and narrow size distribution and favourable stability.
The effect of swot analysis on the sustainability approach of a leading Turkish maritime construction company
(Renewable Energy Association of Turkey, 2026) Özil, Eralp; Yurtsever, Özlem; Çelik, Mustafa Cem; Uyar , Tanay Sıdkı; Saydam, Alper
The EU’s mandatory Corporate Sustainability Reporting Directive (CSRD) is based on the widely used GRI framework but significantly introduc es the concept of “dual materiality”, which requires companies to report both their impacts on society and the environment, and how sustainability issues af fect the company itself. This study practically demonstrates the importance of a SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis to be applied at the initial stage to reveal this “double materiality” when preparing a sustaina bility report for a company. In the context of the application in question, the de sign of the SWOT analysis, the objectives of the questions, the interpretation of the analysis results, and the effects of the findings on the sustainability report study and sustainability goals are presented.
