İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Improving oral health in children with disabilities: A preventive home-based care model from Türkiye
(Wiley, 2025) Tunalı, Esra; Ataş, Cafer; Çağ, Yakup; Orhan, Ahmet Lütfullah; Özen, Buğra; Aydınbelge, Mustafa; Tunalı, Mustafa
Background: Children with Special Health Care Needs (CSHCN) face significant challenges in maintaining oral hygiene and accessing dental services due to disabilities. It has been reported that, because of these disadvantages, individuals with special needs experience oral health problems at a higher rate compared to the general population. This study aimed to assess factors influencing oral health in CSHCN within the dental home framework and propose preventive strategies. Methods: A total of 1229 children aged 0-8 years with disability health reports in Istanbul were examined through home visits by mobile dental teams. Caries experience was evaluated using combined indices (dfs + DMFS and dft + DMFT). Data on oral hygiene habits, dietary patterns, parental education level and dental visit history were collected through structured questionnaires. Statistical analyses included Mann-Whitney U, Kruskal-Wallis, chi-square and Spearman's correlation tests (significance set at p < 0.05). Results: A statistically significant positive correlation was found between age and all caries indices (p < 0.01) 0.57. 1% of children reported brushing their teeth, with irregular brushers showing significantly higher caries indices than regular brushers (p < 0.05). Children requiring > 45 min to eat had significantly higher dfs + DMFS (1 surface) (p = 0.036) and dft + DMFT values (p = 0.019). Those consuming snacks > 3 times daily showed significantly higher caries indices across all measures (p < 0.01). Moderate/severe plaque accumulation was detected in 50.5% of participants. Lower parental education levels were significantly associated with higher caries indices (p < 0.01). Conclusions: This study highlights the necessity of an interdisciplinary approach to protect the oral health of CSHCN. The widespread implementation of the dental home model and regular dental check-ups will be a significant step in addressing oral health needs.
Clinical outcomes following medial patellofemoral ligament reconstruction using ultra high-strength 2-mm-wide tape in non-elite athletes
(Elsevier, 2025) Erden, Tunay; Ağır, Muzaffer; Ali, Jotyar; Çelik, Malik; Batar, Suat; Toprak, Ali; Toker, Berkin; Taşer, Ömer
Background: The medial patellofemoral ligament (MPFL) reconstruction is commonly conducted using gracilis, semitendinosus, quadriceps or tensor fascia lata tendon autografts or allografts. This approach, however, can sometimes lead to complications or morbidity at the site from which the graft is harvested. This study reports the clinical outcomes of non-elite competitive athletes who undergone MPFL reconstruction using an ultrahigh strength 2-mm-wide tape. Patients and methods: This retrospective cohort study included 67 non-elite athletes with acute or recurrent lateral patellar instability who underwent surgical treatment between December 2015 and December 2020. Athletes who underwent tibial tubercle osteotomy due to severe patellofemoral arthritis or severe osteochondral damage (kissing lesions or >2.5cm2 ) (1), trochlear dysplasia (Dejour type D dysplasia) (5), open physis (19) and revison MPFL reconstruction (8), were excluded. The remaining 34 athletes were followed postoperatively for a mini mum of 48 months. Results: During the follow-up period, there was only one case and which was revised by adding Fulkerson Osteotomy. Two patients had limited range of motion and joint mobilization was performed under general anesthesia at the end of the second month. The International Knee documentation Committee (IKDC), Kujala, and visual analog scale (VAS) scores showed improvement postoperatively (p < 0.001). Moreover, the mean im provements in IKDC (≈+41), Kujala (≈+33), and VAS (≈− 3.8) scores exceeded the established minimal clini cally important difference (MCID) thresholds, indicating that the outcomes were not only statistically significant but also clinically meaningful for patients. When comparing the pre- and postoperative radiological measure ments, the mean tilt angle and mean congruence angle showed a significant decrease (p < 0.001) Conclusion: Suture tape may be a good alternative to autograft, as it does not cause donor site morbidity. However, its most important disadvantage is its higher cost. Level of evidence: IV; Retrospective case series.
Effect of magnification and press-on force on resin composite polishing
(BioMed Central, 2025) Ünal, Tuna; Korkut, Bora; Tağtekin, Dilek
Objective To evaluate surface roughness (Ra) and gloss (GU) of two resin composites after polishing with two systems, using a novel press-on force guided (PFG) polishing simulator. Materials and methods Eighty specimens were prepared using Essentia Universal (EU) and G-aenial Universal Injectable (GUI) composites. Surface roughness and gloss were assessed by a profilometer (Marsurf Ps10), and a glossmeter (Novo-Curve). They were polished with Sof-Lex and Twist Dia systems with or without magnification and PFG. Each polishing material was used for 30 s. Ra1 and GU1 measurements were repeated by the same operator. Data were analyzed using One-way ANOVA, Three-way ANOVA, and Robust ANOVA with Bonferroni Correction for multiple comparisons and Spearman’s rho Correlation Coefficient (<0.050). Results Higher Ra values were observed in GUI group for Twist Dia (0.33±0.05z ) compared to SofLex (0.22±0.08y ). Roughness was higher when PFG was uncontrolled (0.31±0.07x ), compared to the controlled (0.25±0.09w). No Ra difference was observed in EU group between SofLex (0.33±0.04) and Twist Dia (0.29±0.04)(P=.440). Uncontrolled PFG provided higher gloss for GUI and EU composites (69.7±2.91x , 54.63±18.68x , respectively). Twist Dia presented higher gloss for GUI and EU composites (72.3±2.57z ,58.88±13.73z , respectively). Magnification did not affect the roughness or gloss for both composites (P≥.05). A moderate negative correlation was found between roughness and gloss in GUI (r=-.546)(P<.001), while no correlation was observed in EU (r=-.110)(P=.449). Conclusion Higher surface roughness and gloss were observed with uncontrolled (not constant) press-on force. Even though SofLex may provide a lower surface roughness, Twist Dia can generate a greater surface gloss regardless of the composite type. 3.5X loupe magnification was not effective on surface roughness and gloss within a limited polishing time. Clinical Relevance Press-on force is an important factor affecting the composite polishing quality. Spiral polishing wheels can be advantageous for composite restoration polishing, as they better preserve the secondary and tertiary anatomies and provide a higher gloss. The effect of magnification on composite polishing can be related to the time spent using it.
Long-term outcomes of extended versus segmental resection for transverse colon cancer: A population-based analysis based on the SEER database
(Galenos Publishing House, 2025) Benlice, Çiğdem; Erkaya, Metincan; Aghayeva, Afag; Özben, Volkan; Görgün, Emre; Atasoy, Deniz; Baca, Bilgi
Objective: To investigate long-term cancer-specific outcomes associated with extended versus segmental colectomy (SC) in patients with stage I-III transverse colon adenocarcinoma using a large, population-based cohort. Material and Methods: Patients who diagnosed with transverse colon cancer undergoing curative-intent colectomy were identified from the surveillance, epidemiology, and end results database (2013-2019). Surgical procedures were categorized as extended colectomy (EC) or SC based on standardized procedural coding. 1:1 propensity score matching was performed to reduce selection bias and balance baseline characteristics. Cancer-specific survival (CSS) was analyzed using multivariable Cox proportional hazards regression. Results: Among 18,799 eligible patients, 58% underwent EC. EC was more frequently performed in individuals with higher tumor stage (p<0.01) and those receiving adjuvant chemotherapy (26% vs. 23%, p<0.01). After matching (n=7.904 in each group), EC was associated with a higher rate of adequate lymphadenectomy (>12 lymph nodes retrieved: 94% vs. 89%, p<0.01). Five-year overall survival did not differ significantly between groups (65.6% for EC vs. 66.9% for SC, p=0.074). However, SC was associated with a modest but statistically significant improvement in CSS (84.3% vs. 81.7%, p<0.01). In adjusted analysis, surgical extent (HR=0.8376, p<0.001), along with age, sex, tumor grade, stage, and lymph node yield, were independently associated with CSS. Conclusion: While EC is more commonly utilized in advanced-stage disease and facilitates higher lymph node retrieval, SC offers comparable—and potentially superior—CSS in selected patients. These findings support the consideration of a tailored surgical strategy based on tumor biology and individual patient characteristics.
Small molecule influenza virus fusion inhibitors targeting viral hemagglutinin: Chemical insights and antiviral evaluation
(Bentham Science Publishers, 2025) Çınar, Gözde; Tekin, Mahmut Can; Cihan Üstündağ, Gökçe
Influenza viruses are major human pathogens that cause widespread respiratory infec tions, affecting millions of people globally and contributing to significant morbidity and mortality. Several currently available anti-influenza drugs are facing increasing levels of viral resistance. Therefore, the discovery of therapeutics targeting novel mechanisms of action is becoming increas ingly important. A key viral protein involved in the infection process is the envelope glycoprotein Hemagglutinin (HA), which facilitates both host cell receptor binding and membrane fusion, two essential steps required for viral entry and replication. Due to its central role in the early stages of infection, HA has emerged as a highly promising target for antiviral drug development. Many small molecule HA inhibitors have been identified with potential anti-influenza activity by stabilizing the HA structure and preventing its conformational change during the membrane fusion process. This review presents a detailed chemical evaluation of these HA-targeting compounds based on studies reported in the literature, highlighting their core chemical scaffolds and structural features. The antiviral efficacy of these compounds is discussed based on in vitro and in vivo data, along with insights into their mechanisms of action. A comprehensive literature search was conducted, and studies meeting the predefined inclusion criteria were thoroughly reviewed. By focusing on the chemical structure of these inhibitors, this review provides information for the rational design of new therapeutic agents aimed at preventing or limiting influenza virus infections.
