İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Unveiling the interplay of EBV, HSV-1, and ınflammatory biomarkers in psychiatric disorders
(MDPI Publishing, 2025) Akgül, Özer; Demirel, Ömer Faruk; Tosun, İlker; Kavla, Yasin; Kırkpınar, Mehmet Murat; Sapmaz, Burcu; Şenyiğit, Gülçin; Çalışkan, Reyhan; Öner, Yaşar Ali
Background/Objectives: Schizophrenia (SCH), bipolar disorder (BPD), and major depres sive disorder (MDD) are increasingly viewed as neuroimmune disorders shaped by viral exposure and inflammation. Disorder-specific immunovirological profiles, however, re main poorly defined. Methods: In this cross-sectional study, we assessed Epstein–Barr Virus (EBV) and Herpes Simplex Virus type 1 (HSV-1) seropositivity and measured serum CRP, IL-6, and IL-1β in 708 participants: 110 with SCH, 121 with BPD, 135 with MDD, and 342 healthy controls (HC). Statistical analyses included Shapiro–Wilk tests for nor mality; Kruskal–Wallis with Bonferroni-adjusted Dunn post hoc comparisons; and logistic regression adjusted for age, sex, and marital status. Results: EBV seropositivity was higher in SCH (90.9%) than in HC (78.9%) (OR = 3.46, 95% CI: 1.68–7.12; p = 0.001) but not in BPD or MDD. HSV-1 seropositivity was elevated in BPD (83.5%) versus HC (67.0%) (OR = 2.29, 95% CI: 1.34–3.92; p = 0.003), with no differences in SCH or MDD. Inflammatory biomarkers were significantly increased in SCH and MDD compared to HC (p < 0.001), while BPD showed no differences. Conclusions: The findings delineate distinct immunovi rological patterns across major psychiatric disorders. Schizophrenia was characterized by EBV seropositivity accompanied by systemic inflammatory activation, bipolar disorder by HSV-1 seropositivity in the absence of inflammatory changes, and major depressive disor der by inflammatory dysregulation independent of viral exposure. These disorder-specific profiles highlight heterogeneity in neuroimmune pathways and underscore the potential relevance of biomarker-based stratification for generating hypotheses regarding targeted antiviral or anti-inflammatory interventions in psychiatric populations.
Visual quality assessment of E-commerce product images using convolutional neural networks
(Springer Nature Link, 2025) Tbaileh, Imad; Bağrıyanık, Selami
High-quality product images are vital in shaping consumer trust and driving engagement on e-commerce platforms. This study proposes a deep learning-based approach for evaluating the visual quality of product images, with the aim of improving the overall customer experience and presentation standards in online marketplaces. A custom-labeled dataset was developed, containing thousands of product images categorized into five quality levels. A convolutional neural net work (CNN) was trained to classify these images based on their visual quality. In addition, two well-known architectures, MobileNetV2 and EfficientNetB0, were trained under identical conditions to serve as benchmarks for performance com parison. The proposed CNN model achieved an accuracy of 94.93%, outperforming both MobileNetV2 (76.60%) and EfficientNetB0 (92.77%). It also delivered the highest performance in terms of precision, recall, and F1-score, confirming its effectiveness in this domain. The results highlight the CNN model’s suitability for real-time quality assessment of e-commerce images. Its strong performance and efficiency make it a promising candidate for integration into commercial platforms. Future work will investigate the use of transformer-based models and more diverse training data to further improve accuracy and generalizability.
The impact of culture conditions on mitochondrial dynamics in different cell types
(Bursa Uludağ Üniversitesi, 2025) Köm, Doğa Buse; Çataltepe, Sude Naz; Budak, Gülden; Dal Yöntem, Fulya
Aim: Mitochondria continuously undergo fusion and fission processes to maintain their structural integrity and function and mitochondrial dynamics can vary between cells representing various pathologies. Culture conditions such as seeding density, passage number, and incubation time, which are commonly manipulated in cell culture studies, may influence mitochondrial morphology. The observation that the same cell line can exhibit both fusion and fission dominant phenotypes suggests that culture conditions play a role in shaping mitochondrial dynamics. This study aims to investigate the effects of in vitro culture conditions on mitochondrial dynamics. Material and Method: A549 (human lung cancer cells), BEAS-2B (human bronchial epithelial cells), MCF7 (human breast cancer cells), A375 (human malignant melanoma cells), and RPE1 (human retinal pigment epithelial cells) were incubated at early (passage 10–12) and late (passage 20–22) passages under varying seeding densities and durations (24, 48, and 72 hours). Mitochondria were stained with MitoTracker Green, and morphological analysis was performed using fluorescence microscopy. Mitochondrial fragmentation was assessed using ImageJ Fiji software, and statistical analyses were conducted using GraphPad software. Results: In all cell lines, the culture condition of 100,000 cells for 24 hours was used as the control group, and mitochondrial fragmentation was observed to vary depending on cell type, incubation duration, and cell density. In A549 cells, fragmentation at 48 hours with 100,000 cells was found to be five times higher compared to 72 hours with 80,000 cells. In MCF-7 cells, fragmentation at 72 hours with 80,000 cells was approximately 1.6 times higher than at 48 hours with 170,000 cells. In BEAS-2B and RPE1 cells, no significant changes in mitochondrial dynamics were observed in response to incubation time or cell density. Conclusion: Prolonged culture duration increases mitochondrial fusion in A549 cells, whereas both incubation time and cell density notably affect mitochondrial fission in MCF7 cells. In contrast, mitochondrial dynamics in BEAS-2B and RPE1 cells are not significantly influenced by incubation time or cell density. These findings suggest that cell type–specific culture conditions can have distinct impacts on mitochondrial morphology.
Branching patterns and variations of the anterior choroidal artery: A detailed cadaveric morphometric analysis
(Springer Nature Link, 2025) Kaçur, İdil; Nteli Chatzioglou, Gkionoul; Nas, Emine; Gayretli, Özcan
The aim of our study was to investigate the morphometric and morphological characteristics of the anterior choroidal artery (AChA) and its branches. Also, the branching patterns and cortical termination sites of the AChA were examined by detailed morphometric analysis. For this purpose, 62 fresh cadavers (124 hemispheres) were included in the study. AChA diameter, length, and distances of branches to the AChA origin were measured using ImageJ software. The distribution of the branches according to arterial origin and their distances to the target regions was quantitatively defined. Although a total of 594 branches originating from AchA were observed, only 587 of these branches reached or terminated in the regions observed. Accordingly, 220/587 were found to go to the optic tract, 214/587 to the cerebral peduncle, 130/587 to the uncus, and 23/587 to the anterior perforated substance. Our study provides novel morphometric ratios that map the branching architecture of the AChA, confirming that branches originate predominantly from its midpoint (overall ratio:0.45). We found that 73.07% of AChA branches supply the optic tract and cerebral peduncle, highlighting their central role, while a minimal proportion (3.87%) serve the anterior perforated substance. These data elucidate the topo graphical relationships that are crucial for understanding pathologies like Moyamoya disease and proximal aneurysms. The established ratios offer invaluable benchmarks for anatomical navigation, potentially reducing risks in neurosurgical procedures involving the AChA territory.
Sustainable human resource management: A proposal of comprehensive model
(Emerald Insight, 2025) Yalırsu, Hazal Yaren; Tüzüner, Vala Lale
The significance of human resource management (HRM), which positively impacts the organization’s strategical development and sustainability, has progressively increased and has undergone a transformation throughout time. It is important to highlight that whereas literature emphasizes the role and goals of human resources for fostering sustainability, there is no widely accepted approach. Aside from considering the organization’s competitive advantages, it also takes into consideration social and environmental aspects while considering all its stakeholders. In doing so, it must also ensure its financial sustainability. Despite the existence of several fundamental methods, the absence of a comprehensive approach that encompasses every component leads to the ongoing discussions in the literature on sustainable HRM. Furthermore, the sustainable human resources literature lacks to address the impact of institutional pressures, resulting in an insufficient approach. In this study, many core approaches and alternative perspectives in literature have been evaluated from a comprehensive perspective, leading to the development of a recommended approach which institutional pressures were added.
