İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Three-dimensional automatic segmentation of root canals with focus on the second mesiobuccal canal using nnU-Netv2 on CBCT images: Deep learning approach
(BioMed Central, 2026) Güllü, Deniz Meltem; Orhan, Kaan; Kartal, Nevin
Background Artificial intelligence (AI) has the potential to reduce interpretation errors and save time during the evaluation of cone beam computed tomography (CBCT) images. This study aimed to assess the performance of AI in identifying and segmenting the second mesiobuccal canal (MB2), with concurrent segmentation of the main root canals, in the maxillary first molar prior to endodontic treatment. Methods In this study, 202 CBCT images that met the inclusion criteria were obtained from an anonymized database provided by Craniocatch (Eskişehir, Türkiye), with no associated personal data. The nnU-Netv2 model implemented with the PyTorch library was used for the detection and three-dimensional (3D) automatic segmentation of root canals. Owing to the narrow structure of the MB2 canal, labels were preprocessed via binary dilation with SciPy (v1.10.1), and training was conducted in two stages by applying different dilation levels. The performance of the artificial intelligence model was evaluated via the confusion matrix and further assessed with additional metrics, including the Dice score (DC), Jaccard index (JI), 95% Hausdorff distance (HD), and area under the curve (AUC). Results In this study, the nnU-Netv2 model achieved a sensitivity of 0.538, a precision of 0.719, a DC of 0.616, a JI of 0.445, a 95% HD of 0.874, and an AUC of 0.8 for 3D automatic segmentation of MB2. Conclusions This study is the first to apply the nnU-Netv2 model for 3D automatic segmentation of the MB2 canal in untreated teeth and highlights its potential utility in endodontic imaging. Further refinements in these systems may enable rapid and reliable 3D automatic segmentation of MB2 and enhance endodontic treatment quality and patient outcomes.
Comparison of neuropsychological side effects between contemporary radiofrequency ablative neurosurgery for psychiatric disorders and conventional neurosurgical procedures: Systematic review and meta-analysis
(BMJ Publishing Group, 2026) Vilela Filho, Osvaldo; Bannach, Matheus A.; Martins Lino Filho, Adriano; Hamani, Clement; Nuttin, Bart; Hariz, Marwan; Schulder, Michael; David Greenberg, Benjamin; Yılmaz, Atilla; Gonçalves Ferreira, António
Background Psychiatric disorders are increasingly contributing to global disability. Despite advances in conservative management, the prevalence of treatment-resistant cases remains high. Meanwhile, neurosurgery for psychiatric disorders (NPD) remains underused, largely due to strict regulations and historical concerns, particularly those related to neuropsychological side effects (NPSE). Objective To address this issue, we conducted a systematic review with meta-analysis to compare NPSE associated with radiofrequency ablative NPD to those observed in neuro-oncological, neurovascular and epilepsy surgeries. Methods PubMed, Embase and LILACS databases were searched in April 2024 for articles published in English/Spanish from 1990 to 2022, following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Results A total of 48 articles with 2678 participants were included. The frequency of transient and permanent NPSE in the NPD group ranged from 0.94% to 11.50% and 0.94% to 2.03%, respectively, comparable to the other surgical groups (epilepsy: 0.31–11.70%; vascular: 0.52–22.90%; oncology: 0.94–17.60% for transient NPSE; epilepsy: 0.31–12%; vascular: 0.40–1.96% and oncology: 0.84–1.48% for permanent NPSE). Regarding permanent NPSE, arguably the most critical consideration, the NPD group showed better outcomes in memory, language and social cognition than the epilepsy group, but worse outcomes in executive and perceptual-motor functions. Compared with the vascular group, the NPD group had better executive function but worse complex attention. Finally, the NPD group had fewer permanent deficits than the oncology group in executive function, complex attention and perceptual-motor domains, although language performance was lower. Conclusions Contemporary NPD apparently carries a similar risk of NPSE as other conventional neurosurgical procedures, challenging misconceptions and this unjustified barrier to its broader use.
A green electrochemical sensor based on molecular imprinting for etoposide detection in environmental matrices
(Elsevier, 2026) Al Faysal, Abdullah; Kaya, Beril Sena; Dorreh, Setareh; Erdoğan, Taner; Gölcü, Ayşegül
A semisynthetic form of podophyllotoxin, etoposide (ETO), is frequently used to manage multiple types of cancer, including lung, testicular, bladder, prostate, and gastric malignancies. Having been utilized in clinical settings for over twenty years, it is one of the most frequently prescribed anticancer agents globally. The primary cytotoxic mechanism of ETO involves the inhibition of topoisomerase II. In the present work, an innovative electrochemical detection platform utilizing MIP was successfully established to enable both highly selective and exceptionally sensitive determination of ETO in pharmaceutical injection forms and environmental specimens. An ETO-specific MIP sensor was fabricated through a photopolymerization process and immobilized onto a GCE, where AMPS served as the active monomer, and EGDMA functioned as the cross-linking agent. This study marks the first instance of a MIP-based electrochemical sensor designed explicitly for ETO identification. The AMPS ETO@MIP/GCE sensor was subjected to electrochemical and morphological assessments through FTIR, SEM, CV, and EIS. An indirect measurement approach was employed using a 5.0 mM potassium ferricyanide/ferro cyanide system to ascertain the analytical detection range from 1.0 to 10.0 pM. The sensor demonstrated excellent sensitivity, reproducibility, and selectivity, enabling effective discrimination of ETO from structurally similar compounds while retaining reliable performance in complex matrices such as soil and tap water. Results from validation experiments in pharmaceutical matrices indicated superior recovery, supporting the sensor's practical effectiveness and stability. To further investigate the experimental results and better understand the nature of template–monomer interactions, a series of DFT calculations was performed. Binding energies were evaluated for ETO–AMPS complexes across varying template-to-monomer ratios.
Group-based CBTgrief for complicated grief: Cultural implementation of a manualized protocol in Türkiye
(Wiley, 2026) Savaş, Esra
Group-based CBTgrief for complicated grief: Cultural implementation of a manualized protocol in Türkiye
Anthropometric analysis of nasal widening following bimaxillary orthognathic surgery
(Wolters Kluwer, 2026) Öztürk Muhtar, Merve; Yey Özkeskin, Sabahat Zeynep; Küçükçakır, Osman; Keskin Yalçın, Başak; Cansız, Erol
Orthognathic surgery aims to improve jaw function and aesthetics, but these procedures can also cause undesired changes in the nasal region, a crucial component of facial ap pearance. An alar cinch suture has been proposed to mitigate such nasal widening. This study aimed to evaluate changes in the interalar distance (distance between the right and left alar curvature points) and alar base distance (distance between the right and left alar base points) in patients who underwent bi maxillary orthognathic surgery with an alar cinch suture. This retrospective study included patients who underwent bimaxil lary orthognathic surgery at the Istanbul University Faculty of Dentistry Department of Oral and Maxillofacial Surgery from 2012 to 2018. Interalar and alar base distances were measured on standardized frontal photographs taken preoperatively and at 6 months postoperatively. Statistical evaluation was per formed using nonparametric methods, including the Wilcoxon signed-rank test applied for preoperative and postoperative comparisons and Spearman rho used to assess correlations, with the significance level set at P < 0.05. The interalar distance increased significantly from preoperative to postoperative measurements (median value: 8.04%; mean change: 7.33 ± 5.38%; P = 0.001). Similarly, the alar base distance showed a significant increase from preoperative to post operative measurements (median value: 11.90%, mean change: 12.49 ± 9.57%; P = 0.001). No statistically significant correla tion was found between the percentage changes in interalar and alar base distances (Spearman ρ = 0.201, P = 0.359). A tendency toward nasal soft tissue widening was noted after Le Fort I advancement, despite alar cinch suture application.
