İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Güncel Gönderiler
Traumatic fibroma of the gingiva in a child: 4-year follow-up
(Cumhuriyet University Faculty of Dentistry, 2025) Taşdemir, Tülin; Erbaş Ünverdi, Gizem; Çehreli, Zafer Cavit
This case report presents a 3-year-old boy referred to the Department of Pediatric Dentistry with a hyperplastic soft tissue lesion in the maxillary anterior region, present for six months. The lesion began as small and gradually enlarged without pain or bleeding, as reported by the parents. The lesion was treated with surgical excision under local anesthesia. Histopathological analysis confirmed a diagnosis of traumatic fibroma, a benign reactive lesion often associated with chronic irritation. Postoperative recovery was uneventful, but recurrence was observed at one year, presenting as small punctate lesions. Over a subsequent four-year follow-up, no further growth was noted. This case highlights the importance of accurate diagnosis and long-term monitoring of reactive oral lesions in pediatric patients, given their potential for recurrence.
Protective roles of gallic acid and lycopene against 4-nonylphenol induced testicular damage in SD rats
(SAGE Publications, 2026) Güleş, Özay; Kum, Şadiye; Naseer, Zahid; Boyacıoğlu, Murat; Özel Armutoğlu, Emine; Yıldız, Mustafa; Kırıkkulak, Murat; Doğan, Göksel; Bilici, Esra; Türkmen, Aybike; Tuna, Bilginer; Eren, Ülker
4-Nonylphenol (4-NP), an endocrine disruptor, is known to induce mutagenic, toxic, or carcinogenic effects, including testicular toxicity via inducing oxidative stress and apoptosis. The objective of this work was to determine the capacity of lycopene (LC) and gallic acid (GA) to protect testicular histological structure, biochemical responses, and semen parameters in rats exposed to 4-NP. In this 28-day dietary trial, six groups (n= 6 per group) received treatment via oral gavage: a control (corn oil, 2 mL/kg/day), LC (10 mg/kg body weight (BW)/day), GA (50 mg/kg BW/day), 4-NP (125 mg/kg BW/day), LC + 4-NP (LC followed by 4-NP), and GA + 4-NP (GA followed by 4-NP) groups. The results indicated that 4-NP administration adversely affects the final body weight, testicular histology, seminiferous epithelium heights (SEHs) (4-NP: 57.95 ± 0.49, p: 0.000), follicle-stimulating hormone (FSH) level, testis antioxidant capacity, testis malondialdehyde (MDA) level, and sperm viability and morphology. LC and GA supplementation significantly improved SEHs, activities of testis superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), and sperm viability compared to the 4-NP group. Moreover, LC and GA exposures decreased histopathological lesions, including germinal epithelial degeneration, vacuolization, immature germ cells in the tubular lumen, and congestion in the interstitial area. Furthermore, they lowered TUNEL-positive cell counts and tubule percentages, testicular MDA levels, and abnormal sperm percentages. To our knowledge, this study provides one of the first systematic comparisons of lycopene and gallic acid in protecting against 4-NP-induced testicular toxicity under identical experimental conditions. The findings suggest that both compounds preserve testicular structure and function through their antioxidant and anti-apoptotic properties.
Efficacy-oriented approach for medium-sized follicles: A perspective on stimulation, expectation, and triggering strategy in IVF cycles
(Wiley, 2026) Aydın, Gerçek; Ergin, Elif; Araç, Merve; Bülbül, Mehmet; Çalışkan, Eray; Hatırnaz, Şafak; Dahan, Michael; Malvasi, Antonio; Tinelli, Andrea
Objective: To assess the therapeutic significance of routinely aspirating mid-sized fol licles (14.0–16.9 mm) during oocyte pick-up (OPU) by looking at procedural efficiency and embryo usage in cycles with varied follicular cohorts. Methods: In vitro fertilization (IVF) cycles with follicles classified as large (≥17 mm) or mid-sized (14.0–16.9 mm) at the time of OPU were included in this prospective cohort. Each group's oocytes were extracted and treated independently while main taining rigorous traceability. Analysis was performed on embryologic results, opera tive time factors, and embryo transfer utilization across successive transfer attempts. Pregnancy outcomes and the length of the operation were investigated. Laboratory results pertaining to trigger strategies were assessed descriptively. Results: When measured per mature oocyte, oocytes from mid-sized follicles showed comparable fertilization and blastocyst development rates. However, only a small percentage of embryo transfers included embryos from mid-sized follicles, especially in the initial two transfer attempts. Large follicles had a longer total OPU duration, and cycles that resulted in miscarriage had significantly longer operative times among large-follicle-derived embryo transfers. For mid-sized follicles, there were no differ ences in the length of the procedure based on the pregnancy outcome. Conclusion: The contribution of mid-sized follicle-derived oocytes to embryo trans fer selection seems to be restricted in everyday practice, despite their reassuring laboratory competence. Procedural efficiency is a potentially significant factor in customized IVF care, as evidenced by the correlation between longer operating times and worse clinical outcomes. In certain clinical situations, a focused stimula tion and aspiration approach might be suitable without obviously jeopardizing cu mulative results.
Tannic acid and copper-modified ZIF-8 metal organic framework as a cefotaxime delivery system for antimicrobial activity
(Galenos Publishing House, 2026) Pirinççi Tok, Yağmur; Özsoy, Münteha; Damar Çelik, Damla
Objectives: Antibiotic resistance has become a global public health threat. Cefotaxime (CTX), a third-generation cephalosporin, is approved for use in infants, children, and adults with various microbial infections, particularly those affecting the central nervous system. This study aimed to synthesize and characterize zeolitic imidazolate framework (ZIF)-8-based drug delivery systems (DDSs) to enhance antimicrobial activity and control CTX release. Materials and Methods: ZIF-8 was synthesized via the coordination network of Zn ions and 2-methylimidazole and subsequently modified with tannic acid (TA) and copper ions (Cu2+). ZIF-8 MOF and its derivatives were characterized by Fourier Transform Infrared, zeta potential, in vitro dissolution rate, and in vitro antimicrobial activity. Results: The drug loading capacity and encapsulation efficiency were found to be 39.50 ± 1.19% and 98.75 ± 2.96%, respectively, for ZIF-8@TA@CTX, and 40.75 ± 1.22% and 97.75 ± 2.93%, respectively, for ZIF-8@TA@Cu@CTX. Following 48 hours, the drug released from ZIF-8@TA@Cu@CTX was detected at 62.83 ± 1.89% at pH 5.0 and 83.19 ± 2.50% at pH 7.4 after 48 h, with dissolution profiles best fitting the Korsmeyer–Peppas model. The synthesized DDSs demonstrated a higher antibacterial activity against gram-positive bacteria than against gram-negative bacteria. Conclusion: ZIF-8 MOF DDs may serve as an alternative for delivering drugs to infected areas due to their controlled release under low pH conditions.
A dual-drug nanocarrier strategy for ocular fungal infections: Micelles embedded in electrospun nanofibers
(MDPI Publishing, 2026) Uzel, Egemen; Durgun, Meltem Ezgi; Aydilek, Neriman; Hacıoğlu, Mayram; Güngör, Sevgi; Özsoy, Yıldız
Ocular fungal diseases are associated with severe infection and pain and, in advanced stages, can lead to vision loss. Current treatment options are limited to the topical ap plication of conventional drugs, and the bioavailability of these drugs is quite limited due to ocular barriers. In this study, a dual-drug nanodelivery system was developed to improve intraocular drug delivery by combining antifungal and anti-inflammatory therapies. Posaconazole (PSC), a broad-spectrum triazole antifungal agent, and dexke toprofen trometamol (DKP), a rapidly acting nonsteroidal anti-inflammatory drug, were co-loaded onto polymeric micelles and then incorporated into electrospun poly(vinyl alco hol)/poly(vinylpyrrolidone) (PVA/PVP) nanofiber intraocular implants. DSC, XRD, FTIR, and FESEM analyses showed that both APIs were successfully converted into nanofiber form without disrupting the micelle structure. Comparative studies with DKP solution and PSC commercial oral suspension (Noxafil® 40 mg/mL) showed that the produced micelle loaded nanofibers provided sustained release and significantly increased ex vivo ocular permeation and penetration. In vitro antifungal activity tests demonstrated efficacy against Candida albicans, and HET-CAM toxicity tests showed that the micelle-loaded nanofibers were non-irritating and suitable for ocular application. Overall, the micelle-loaded electro spun nanofiber ocular inserts developed in this study represent a promising platform for combined antifungal and anti-inflammatory ocular therapy.
